University Of Colorado, Denver

This study tests a new program to help more children get their flu shot while in the hospital. The program brings together doctors, nurses, and families to make vaccination simple and routine. Researchers will track how many eligible kids receive the vaccine across 22,000 partici…

This study looks at how well the shingles vaccine (Shingrix) works in adults with kidney failure who are waiting for a kidney transplant. Researchers want to see if giving an extra dose after the transplant boosts the immune response. About 132 participants will be followed for u…

This study looks at how well the shingles vaccine Shingrix works in people who have had a stem cell transplant. About 55 adults who received the vaccine at least a year after their transplant will have their immune responses measured. Researchers want to see if the timing of the …

This study tests whether montelukast, a common allergy medication, can lower protein levels in urine and improve kidney and blood vessel function in people with type 1 diabetes who have early signs of kidney disease. Inflammation is thought to play a role in diabetic kidney damag…

This early-phase trial tests a new treatment called CD64 CAR T cells for adults with acute myeloid leukemia (AML) that has come back or not responded to standard therapy. The treatment uses a patient's own immune cells, modified in a lab to target and attack leukemia cells. The m…

This study tests whether full-spectrum or broad-spectrum CBD can help people with alcohol use disorder drink less. 180 adults who want to reduce or quit drinking will receive either CBD or a placebo for 12 weeks. Researchers will track changes in drinking habits, cravings, and an…

This study tests whether cannabidiol (CBD) can slow the progression of Alzheimer's disease in people aged 55-85 with mild cognitive impairment (early memory loss). Over 236 participants will receive either CBD or a placebo for a period, and researchers will measure changes in mem…

This early-phase study tests a combination of two drugs—losartan (a blood pressure medicine) and sunitinib (a cancer drug)—in people aged 10 and older with osteosarcoma (a type of bone cancer) that has returned or not responded to treatment. The main goal is to find the safest do…

This study compares the iLet Bionic Pancreas, an automated insulin delivery system, to standard care for adults with type 1 or type 2 diabetes who use insulin. About 240 participants will use the device for 13 weeks or continue their usual routine. The goal is to see if the devic…

This study is testing whether a combination of two drugs, mirvetuximab soravtansine and olaparib, can help keep ovarian, peritoneal, or fallopian tube cancer from coming back after initial treatment. About 53 women with cancer that responded to platinum-based chemotherapy will re…

This early-phase study tests whether combining two drugs, Cirtuvivint and Olaparib, is safe for women with ovarian cancer that no longer responds to platinum chemotherapy. About 50 participants will take the medications on different schedules and visit the clinic regularly for ch…

This study looks at whether metformin, a drug used for diabetes, can help prostate cancer patients who have high blood sugar or are overweight. About 100 men will either take metformin plus get lifestyle advice, or just get lifestyle advice. The main goal is to see if it's possib…

This phase 2 trial is testing whether two dietary supplements—nicotinamide riboside (a vitamin B3 derivative) and pterostilbene (a plant compound)—can safely improve low blood counts in people with lower-risk myelodysplastic syndrome (MDS) or high-risk clonal cytopenia of undeter…

This study tests whether taking equol, a compound from soy, for 12 weeks can improve blood vessel function in postmenopausal women with moderate chronic kidney disease (stages 3-4). The goal is to lower their high risk of heart disease. Researchers will measure changes in artery …

This study is testing whether giving people with type 2 diabetes a Fitbit and sending them personalized text messages from an AI chatbot can help them become more active and improve their health. Thirty-six sedentary adults will wear the Fitbit daily for 12 weeks and receive week…

This study tests whether tofacitinib, a drug used for arthritis, can improve thinking skills and immune function in people with Down syndrome aged 6 to 22. Half of the 92 participants will receive the drug for 6 months, and the other half a placebo. Researchers will measure chang…

This study is testing the safety of fenfluramine, a drug already approved for children 2 and older with Dravet syndrome, in younger children aged 12 to 23 months. Dravet syndrome is a severe genetic epilepsy that starts in the first year of life. The study will enroll 5 children …

This study tests a program called Tunawiri (meaning 'thrive') that adds mental health screening, counseling, and support to regular HIV care for pregnant and postpartum women in Kenya. The goal is to improve depression, anxiety, and HIV treatment success. Nine hundred women will …

This study tests whether hemp-derived CBD can reduce the harmful effects of cannabis in young adults aged 18-25 who use cannabis at least five days a week but aren't looking to quit. Participants will take either CBD or a placebo for 8 weeks, and researchers will measure changes …

This study tests whether a community health worker program can help people with advanced kidney disease start treatment more smoothly. The program provides support, education, and help with social challenges. Researchers will compare this to standard care in 448 adults with chron…

This study tests whether cannabidiol (CBD), a non-psychoactive compound from cannabis, can reduce cannabis concentrate use and cravings in people who use concentrates regularly but aren't trying to stop. 120 participants will take either 200 mg or 400 mg of CBD or a placebo daily…

This study is testing a medication called brexpiprazole to see if it can help people with alcohol use disorder drink less. Researchers want to know if a person's genes affect how well the drug works. The study involves 250 adults who are not currently seeking treatment for their …

This study tests whether a set of lifestyle interventions can help women going through menopause reduce inflammation, improve heart health, slow biological aging, and ease symptoms like hot flashes. Researchers will enroll 200 women aged 45-55 who are in late menopause transition…

This phase 2 trial is testing whether sargramostim, a drug already approved to stimulate bone marrow, is safe and effective for people with mild-to-moderate Alzheimer's disease. Over 6 months, 42 participants will receive either the drug or a placebo. The study will monitor side …

This study tests a program called Pediatric Medication Therapy Management (pMTM) for children with complex medical conditions who take five or more medications. The program involves a thorough review of all medicines, optimizing the regimen, and creating a clear medication plan. …

This study tests a new type of CAR-T cell therapy, called UCD19 CAR-T, in children and young adults with B-cell acute lymphoblastic leukemia (B-ALL) or B-cell non-Hodgkin lymphoma (B-NHL) that has come back or not responded to standard treatment. The therapy is made locally to sp…

This study tests two school-based programs to help children aged 5-12 with asthma in low-income communities. The goal is to reduce asthma attacks and missed school days. Researchers will enroll 300 children across rural Colorado schools and compare a standard program to an enhanc…

This study tests whether giving two drugs (pembrolizumab and axitinib) before surgery can shrink a tumor-related blood clot in the main vein of the abdomen in people with kidney cancer. The goal is to make surgery safer and improve long-term outcomes. About 17 adults with clear c…

This study is for people with rectal cancer that didn't fully go away after standard chemotherapy and radiation. Researchers want to see if giving a few extra doses of internal radiation (brachytherapy) can finish off the tumor and let patients keep their rectum instead of needin…

This study is testing whether cannabidiol (CBD) can help people who drink alcohol regularly cut down on their drinking. Researchers are giving 150 adults either full-spectrum CBD, broad-spectrum CBD, or a placebo daily for 12 weeks. They will measure how much participants drink i…

This early-stage trial tests a new type of immunotherapy (CAR T cells) in adults with B-cell acute lymphoblastic leukemia (B-ALL) who still have tiny amounts of cancer cells after their first round of treatment. The goal is to see if the therapy is safe and can eliminate these le…

This phase 3 trial is testing whether semaglutide, a drug already used for type 2 diabetes and weight loss, can improve heart and kidney function in adults with type 1 diabetes. The study will measure artery stiffness, insulin sensitivity, and kidney blood flow in 60 participants…

This study tests whether giving the chemotherapy drug doxorubicin weekly at a lower dose is effective and easier to tolerate for people aged 65 to 100 with advanced leiomyosarcoma, a type of soft tissue cancer. The standard dose often causes harsh side effects, especially in olde…

This early-phase trial tests whether adding chemotherapy directly into the abdomen (intraperitoneal paclitaxel) to standard IV chemotherapy (NALIRIFOX) is safe and effective for adults with pancreatic cancer that has spread to the lining of the belly. Ten participants will receiv…

This early-stage study tests whether adding mitoxantrone to the usual venetoclax+azacitidine regimen can help adults with acute myeloid leukemia (AML) whose cancer did not respond or came back after initial treatment. About 30 participants will receive different doses to find the…

This early-stage trial is testing two oral drugs, CC-486 and venetoclax, together in people with acute myeloid leukemia (AML) that has relapsed or not responded to prior treatment. The main goal is to find the safest dose of CC-486 when combined with venetoclax, and to monitor si…

This study looks at what happens to the body after bariatric surgery in people aged 12 to 24. It also tests whether adding semaglutide (a weekly injection) can help those who haven't lost enough weight 1 to 2 years after surgery. The goal is to understand why some respond better …

This early-phase study tests a new type of immunotherapy called CD19x22 CAR T cells for teenagers and adults with B-cell non-Hodgkin lymphoma that has come back or not responded to treatment. The therapy uses a patient's own immune cells, modified to attack two targets on cancer …

This phase 2 trial tests a combination of two drugs, cladribine and venetoclax, in 20 adults with a specific form of acute myeloid leukemia (monocytic AML) that has stopped responding to or returned after standard treatment. The goal is to see if this new combo can shrink or elim…

This study tests a new type of CAR T cell therapy that targets two proteins (CD19 and CD22) on leukemia cells. It is for children whose B-cell acute lymphoblastic leukemia has come back or not responded to standard treatments. The main goal is to find a safe dose and see if the t…

This study compares two standard approaches for Barrett's esophagus with low-grade dysplasia: regular monitoring with biopsies (surveillance) versus a procedure to remove or burn away precancerous cells (endoscopic eradication therapy). Researchers want to find out which method i…

This study tests whether an accelerated form of Transcranial Magnetic Stimulation (TMS) can help people with moderate to severe methamphetamine use disorder. Twenty participants will receive either real or sham TMS to the brain's prefrontal cortex. Researchers will check if the t…

This study tests a special dissolvable hydrogel placed between the metal plate and tendons during wrist fracture repair. The goal is to see if it helps tendons move more smoothly and reduces the chance of tendon rupture. Fifty adults having wrist fracture surgery will be randomly…

This study tests whether a single dose of equol, a compound made from soy, can improve blood vessel function in postmenopausal women with and without chronic kidney disease (CKD). Researchers will measure changes in artery health over a few hours after taking equol. The goal is t…

This study is for people under 30 with disorders of sex development who are at risk of infertility or ovarian cancer. When they have surgery to remove their ovaries for medical reasons, a portion of the tissue will be frozen and stored. The goal is to see if this tissue can later…

This study looks at whether it's possible and safe to freeze testicular tissue for males of any age who face infertility due to medical treatments like chemotherapy or radiation. Researchers will collect a small sample of testicular tissue through a biopsy and freeze it for poten…

This study looks at whether people with stable relapsing multiple sclerosis can safely switch from anti-CD20 therapies (like rituximab or ocrelizumab) to ozanimod (Zeposia), an oral pill. About 100 participants who have had no new MS activity for at least two years will be follow…

This trial compares two ways to sample tissue in people with Barrett's esophagus, a condition that raises the risk of esophageal cancer. The standard method takes four small tissue samples every 2 centimeters, while the newer method uses a brush to collect cells over a wider area…

This study tests a simple questionnaire to help doctors identify sexual health concerns in teenagers and young adults who have or had childhood cancer. The goal is to improve communication between patients and providers. About 205 participants aged 15-24 will use the screening to…

This pilot study is testing whether an at-home urine test can accurately measure hCG levels in women with a pregnancy of unknown location (PUL). Participants will collect their first morning urine at home and compare it to a blood test done at a lab. If the home test proves accur…

This study is testing a new, single-use scope called the Dragonfly™ Digital Pancreaticobiliary System. It is designed to help doctors see inside the bile and pancreatic ducts during an endoscopy. The study will enroll up to 75 adults with bile duct stones or narrowings (stricture…

This study tests whether giving older adults (65+) who are at high risk for falls a link to a chatbot (Livi) can help them find and join fall prevention programs. The goal is to reduce repeat ER visits for falls. Over 20,000 participants will be enrolled across multiple ERs.

This study tests a brief, one-hour counseling session designed to prevent mood, anxiety, and trauma symptoms after cesarean delivery. The session includes education about anxiety sensitivity and a short exposure to the operating room environment. Researchers will refine the progr…

This study tests whether giving older adults telehealth physical therapy and pharmacy advice right in the emergency department can help prevent future falls. Forty people aged 65 and older who came to the ER after a fall will take part. Researchers will check if the program is pr…

This study is testing whether an educational video and toolkit can help more people from underserved groups start and finish the HPV vaccine series. The vaccine protects against HPV, a virus that can cause certain cancers. The trial will enroll 1,000 patients and parents at Denve…

This study tests whether the asthma inhaler Advair HFA can prevent high altitude pulmonary edema (HAPE), a dangerous buildup of fluid in the lungs at high altitudes. Researchers will give the drug or a placebo to 60 healthy volunteers and people prone to HAPE, then measure their …

This study tests a sleep health program for teens aged 10-19 who recently had a concussion. The goal is to see if better sleep helps symptoms go away faster and improves sleep quality, mood, and school engagement. Participants will be randomly assigned to the sleep program or sta…

This study compares a combination of ibuprofen and acetaminophen against ibuprofen alone or a placebo for pain after getting braces. 375 people scheduled for braces will take one of the three treatments for four days and rate their pain. The goal is to see if the combo offers bet…

This study tests whether coating orthodontic miniscrews with an antimicrobial liquid called K21 can reduce gum inflammation and keep the screws stable. Thirty people needing at least two miniscrews will have one screw coated with K21 and the other with a placebo (ethanol). The re…

This study looks at three different types of wires used in braces to see which one causes the least pain after they are first put in. About 126 healthy people getting braces will rate their pain over the first week. The goal is to help orthodontists choose the wire that makes tre…

This study is testing whether a high-intensity exercise program and a sleep-tracking headband can be used safely and effectively at home by people with Parkinson's disease. Sixteen participants in Colorado will try the remote program and give feedback. The goal is to make exercis…

This study tests whether high-dose aerobic exercise (over 150 minutes per week at a safe intensity) helps teens aged 13–18 recover faster from a concussion compared to standard care. Researchers will track symptom resolution, brain inflammation markers, and changes in anxiety and…

This study tests if a short course of intravenous steroids can reduce throat swelling and improve swallowing in people recovering from a breathing tube in the ICU. About 80 adults with confirmed laryngeal edema will receive either steroids or a placebo. The goal is to see if ster…

This study tests whether socks made with semiconductor fabric can improve healing and reduce symptoms after an ankle sprain. About 100 adults with ankle injuries will wear either the special socks or regular compression socks and report their pain and function over time. The goal…

This study tests whether a one-month treatment combining the allergy drug clemastine fumarate with engineered sound can improve the ability to hear speech in background noise for people aged 45-65 with age-related central auditory processing disorder (CAPD). About 344 participant…

This early-phase study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can reduce fear of cancer returning in 20 women with early-stage breast or ovarian cancer who are currently in remission. Participants receive a moderately high d…

This study tests a Spanish-language program called Unstuck and On Target for children ages 8-11 with autism and/or ADHD. The program helps kids improve skills like planning and flexibility, and supports their caregivers. About 40 families will either join the program right away o…

This study tests whether a newer therapy called Pain Reprocessing Therapy (PRT) works better than standard Cognitive Behavioral Therapy (CBT) or usual care for veterans with chronic back or neck pain. About 360 veterans will be randomly assigned to one of three groups and complet…

This study tests Pain Reprocessing Therapy (PRT) for adults with ongoing knee pain after knee replacement surgery. PRT uses eight weekly video sessions to help retrain how the brain processes pain. Researchers will compare PRT to usual care in 110 participants to see which better…

This study tests a procedure called genicular artery embolization (GAE) to see if it can reduce knee pain and inflammation in adults with knee osteoarthritis. Researchers will compare knee fluid samples and MRI scans before and after the procedure to see if changes in inflammatio…

This study tests a new exercise program using a flywheel device to improve stair-climbing in people with knee osteoarthritis. The training focuses on the muscle-lengthening phase of movement, which may build better muscle and coordination. Researchers will measure changes in move…

This study tests whether special behavioral exercises can change how your brain reacts to food, helping you eat less and lose weight. About 228 adults with a BMI of 27 or higher will participate. Researchers will use brain scans and food diaries to see if these exercises work.

This study looks at whether a continuous pain pump delivering bupivacaine (a numbing medicine) after a C-section reduces the need for stronger opioid painkillers compared to a placebo pump with salt water. One hundred pregnant women having C-sections will be randomly assigned to …

This study tests a 12-week telehealth exercise program for rural cancer survivors who have ongoing fatigue after treatment. Participants receive personalized exercise sessions via video calls and an app, and provide small blood samples at home. The goal is to see if the program r…

This study tests a program called CARES that provides nurse navigators and counselors to rural cancer patients. The goal is to see if this support helps patients start and finish treatment more quickly and improves their quality of care. About 320 adults with solid tumors like lu…

This study tests a digital program called TPA4You for older adults (50+) who care for a family member with heart failure. The program uses a Fitbit, video coaching, and text messages to encourage physical activity. The goal is to see if it's feasible and helps improve caregivers'…

This study is testing whether taking cannabis by mouth can safely reduce chronic back or neck pain and help people cut down on strong painkillers like opioids. About 157 adults with pain lasting at least 3 months will receive either cannabis or a placebo. The goal is to see if ca…

This study tests whether 12 weekly sessions of parent management training can reduce irritability, anger outbursts, and cranky moods in children aged 10-14. Parents attend the training while children are assessed before, during, and after treatment. The goal is to see if this app…

This study looks at whether a supervised exercise program (cardiac rehab) can improve quality of life and physical ability in people with Long COVID. Researchers will also study how the heart and lungs work in these patients. The study needs 30 adults who have had Long COVID symp…

This study tests whether using mild electrical pulses on the thigh muscle can help people regain strength and movement faster after total knee replacement. About 3,250 patients will be randomly assigned to receive either standard physical therapy or standard therapy plus electric…

This study is testing whether psilocybin, the active ingredient in magic mushrooms, is safe and tolerable for healthy adults aged 65 to 85. Researchers will monitor side effects and how the drug moves through the body. The goal is to gather safety data, not to treat any disease.

This study looks for proteins and other factors that might predict whether a teenager's scoliosis curve will get worse. Researchers will compare blood samples and health information from 500 teens with and without scoliosis over 6–12 months. The goal is to better understand what …

This study aims to find the best text messages to remind people to complete at-home colorectal cancer screening. Researchers will work with 7,220 adults aged 45-75 at community health centers. They will test different message versions to see which ones lead to more screening and …

This study compares three strategies to help adults improve diet, exercise, stress, and sleep. Participants will get either text reminders, phone coaching, or usual care. The goal is to see which approach works best and is most cost-effective. About 1,000 adults from participatin…

This study looks at how menstrual cycles and birth control pills impact blood sugar levels and exercise in women with type 1 diabetes. Researchers will monitor 150 women for three months using continuous glucose monitors and offer personalized insulin and diet adjustments. The go…

This study follows 200 babies diagnosed with poor growth in the womb (IUGR) using advanced ultrasound and MRI scans. Researchers want to understand how the baby's brain, heart, and placenta change over time. The goal is to link these changes to the child's development after birth…

This study looks at how accurate continuous glucose monitors (CGMs) are in children and young adults with type 1 diabetes when they have surgery. Researchers will compare CGM readings to standard blood glucose tests during the procedure. The goal is to see if these devices can be…

This study looks at whether short-term use of NSAID pain relievers (like ibuprofen) after surgery increases the risk of acute kidney injury in children with mild-to-moderate chronic kidney disease. About 164 children over 18 months old with CKD stages 2-3a who are having urologic…

This study looks at whether improving sleep and circadian timing can reduce heart disease risk in adolescents with type 1 diabetes who typically sleep less than 7 hours per night. Fifty teens will follow a one-month program that includes a longer sleep schedule, a low dose of mel…

This study looks at how bone tumors respond to treatment in people with non-small cell lung cancer. Researchers will measure bone health markers in urine and blood before and after treatment. The goal is to see if targeted pills (TKIs) or standard treatments like chemotherapy or …

This study is testing whether a small monitor worn on the thigh can reliably measure daily activity in people with Functional Neurologic Disorder (FND). The goal is to see if this remote tool gives a better picture of how symptoms affect real-world function than a single clinic v…

This study looks at how romantic partners who both smoke can support each other when trying to quit. Researchers will ask 250 couples to fill out daily surveys for two weeks while attempting to quit, tracking their smoking, cravings, and stress. The goal is to understand which ty…

This study looks at how losing weight changes the fat stored inside your muscles, called intermuscular adipose tissue (IMAT). Researchers want to see if weight loss reduces inflammation and improves how your muscles respond to insulin. Seventy adults with obesity will follow a 12…

This study looks at how triglyceride (a type of fat) levels in pregnant women relate to their baby's body fat. Researchers will have 140 pregnant women with a higher BMI monitor their triglycerides and blood sugar at home. After birth, the babies' total body fat and liver fat wil…

This study looks at how the right side of the heart works in people with COPD, both at rest and during different levels of exercise. Researchers want to find patterns of heart strain to help develop better treatments in the future. About 60 adults aged 40 and older with COPD will…

This study tests whether training ICU staff to keep oxygen levels between 90-96% helps patients on breathing machines recover faster. Researchers will track how many days patients are free from the ventilator and how often dangerously low oxygen goes unnoticed. The goal is to imp…

This study looks at how the right side of the heart works in people with COPD, both at rest and during exercise. Researchers will use heart imaging and other tests to identify different patterns of heart dysfunction. The goal is to better understand these patterns so that future …

This study is testing a new ultrasound method that uses tiny, safe bubbles to measure blood flow in the pancreas. The goal is to see if changes in blood flow can help detect type 1 diabetes early, before symptoms appear. Researchers will compare 50 healthy adults and people recen…

This study looks at how the autonomic nervous system—which controls heart rate and blood pressure—works in people with Down syndrome. Researchers will measure stress responses using virtual reality, cold water, pain patches, caffeine, and exercise in 200 participants. The goal is…

This study tests a program called ALIGN, which uses palliative care social workers and patient navigators to support older adults with advanced cancer who are moving from the hospital to a skilled nursing facility. The goal is to see if the program is practical and can help align…

This study looks at 750 people with rheumatoid arthritis (RA) who are 45 or older to find early signs of interstitial lung disease (ILD), a serious lung complication. Researchers will use CT scans and track changes over 3-5 years to identify risk factors. The goal is to better un…

This study tests a wearable smart underwear device that measures hydrogen sulfide gas from gut microbes. 25 healthy adults will eat high-cysteine and low-cysteine diets to see if the device can detect diet-related changes in gas production. The goal is to develop a non-invasive t…

This study is testing a 24-week program that combines nutrition counseling, exercise, sleep tips, and stress management for cancer survivors who are overweight. Researchers want to see if the program is practical and helpful for improving sleep quality, reducing stress, and boost…

This study looks at how the stiffness of a prosthetic foot affects people who have a leg amputation below the knee and use a bone-anchored limb or a standard socket. Researchers will measure bone stress, walking ability, pain, and fall risk as participants walk on different types…

This study looks at how children and young adults (ages 10 to 25) who had a joint replacement for reasons other than cancer are doing. Researchers will collect information from medical records and questionnaires about quality of life and joint function. The goal is to understand …

This study tests whether giving primary care clinics extra coaching and support helps them better use a suicide prevention program for youth ages 12-24. 360 participants will be split into two groups: one gets basic training, the other gets training plus 6 months of hands-on coac…

This study looks at how exercise affects insulin resistance and heart function in people with type 2 diabetes. Researchers will have 150 participants do 15 weeks of cardiovascular exercise, 3 times a week. They will measure changes in oxygen use and insulin sensitivity to see if …

This study looks at how different snacks (walnuts or pretzels) change brain activity related to food cravings and fullness during a 12-week weight-loss diet. Researchers will use brain scans to measure responses to food pictures and track changes in body fat and appetite. The goa…

This study is testing whether people with HIV can collect small blood samples at home using a finger prick or a simple device. The goal is to see if these home-collected samples are as good as clinic-drawn blood for measuring levels of HIV medications. About 150 adults already on…

This study partners with community organizations to improve participation in health research among Black, Latino, and Native American communities in Colorado. Researchers will track changes in diet, transportation access, and social support over time. The goal is to build lasting…

This study looks at whether changes in the bacteria living in your mouth and gut (the microbiome) are linked to head and neck cancer. Researchers will collect stool and saliva samples from 60 people—half with cancer and half without—to compare their microbial makeup. The goal is …

This study aims to create a mindfulness program designed for couples where one partner has metastatic colorectal cancer. Researchers will interview patients, their partners, and clinicians to understand their needs and preferences for such a program. The goal is to design a progr…

This study uses a safe, radiation-free device called electrical impedance tomography (EIT) to take pictures of the lungs in infants, children, and young adults up to age 25. Researchers will compare images from patients with chronic lung or heart conditions to healthy controls to…

This study looks at why people move their eyes differently when searching for something. Researchers will measure attention and self-control skills in 225 healthy adults aged 18-65, then see how these skills relate to eye movement patterns. The goal is to understand individual di…

This study looks at why some lung cancer cells survive targeted treatment. Researchers will take small tissue samples (biopsies) from 100 patients before and two weeks after starting therapy. By comparing the samples, they hope to find early signs of resistance and identify ways …

This study tests whether a mild electrical pulse to the ear—called transcutaneous auricular vagus nerve stimulation—can improve decision-making and problem-solving. Researchers will compare results in healthy adults, people with mild cognitive impairment, and those with Parkinson…

This study looks at tumor samples from 500 adults with lung or other chest cancers to find out why some treatments stop working. Researchers will study genetic changes in the cancer cells. The goal is to learn how to better choose the next treatment for each person.

This study looks at why pregnant women living at high altitudes have higher rates of preeclampsia and poor fetal growth. Researchers will collect tissue samples from women having scheduled C-sections in Denver (low altitude) and Summit County (high altitude) to compare how their …

This study looks at whether using a menstrual cup can pull an IUD out of place. Researchers will ask 80 women to insert and remove a menstrual cup the recommended way, then check if the IUD has moved. The goal is to understand how suction affects IUD position so doctors can give …

This study works with Spanish-speaking parents and doctors to create educational videos about childhood cancer. The goal is to help caregivers better understand their child's care when English is not their first language. The project will test if these videos are easy to use and …

This study collects placenta, cord blood, and maternal blood samples from 1,250 pregnant women—both healthy and those with complications like preterm birth or diabetes. Researchers will analyze these samples to learn how the placenta works and how changes in it can lead to pregna…

This study interviews Spanish-speaking families of children with leukemia or lymphoma to learn about their experiences and challenges. Researchers want to understand what works well and what barriers exist in communication and access to care. The goal is to use these insights to …

This study looks at how a woman's past pregnancies may change her immune system's response to breast cancer. Researchers will follow 800 young women with breast cancer to see if pregnancy history affects how long they live without the cancer getting worse. The goal is to better u…

This study collects blood and tissue samples from 2,000 people being tested or treated for lung cancer. The samples are stored for future research into earlier detection, better treatments, and prevention strategies. No direct benefit is offered to participants, but the bank coul…

This study looks at whether exercising in the morning or evening makes a difference in weight loss for people who are overweight. Researchers will track weight, body fat, sleep, and eating habits in 128 adults over 13 months. The goal is to find out if timing your workouts can he…

This study is testing a device called Electrical Impedance Tomography (EIT) that uses electrodes to create images of the lungs without radiation. Researchers want to see if it can provide useful information about lung function in children with chronic respiratory diseases, includ…

This study does not test any new treatment. Instead, it collects blood, tissue, and health information from 20,000 adults who have cancer or are at risk for it. Researchers will use this data to better understand cancer and improve future care. Participants simply donate samples …

This study looks at how cancer treatment impacts the work life and overall well-being of 400 men, ages 21 to 70, who have been newly diagnosed with solid tumors like colorectal, lung, or head and neck cancer. Participants will fill out questionnaires about their work hours, finan…

This study looks at how drinking alcohol and the way couples talk about sex can lead to sexual violence between partners. Researchers will bring in 240 couples from the Denver area to a lab, where some will drink alcohol and others won't, and then test their reactions. The goal i…

This study creates a large collection of blood, saliva, urine, and other samples from 2,500 people with and without Down syndrome. The goal is to help researchers better understand Down syndrome and its related medical conditions. Participants must be between 6 months and 89 year…

This study looks at how two common chemotherapy drugs, vincristine and doxorubicin, affect bladder function and urine composition in children who have finished cancer treatment. Researchers will use simple, non-invasive tests to measure urine flow and check for bladder-related pr…

This research study collects sputum and tissue samples from 700 people with precancerous changes or certain cancers (lung, head and neck, esophageal). The goal is to find biomarkers—biological signs—that could help understand or detect these cancers earlier. Participants include …

This study uses a tiny, high-density brain probe to record activity from thousands of neurons during awake brain surgery in 15 Parkinson's patients. The goal is to understand how different layers of the brain's cortex handle tasks like planning and decision-making. It does not te…