University Of Colorado, Denver

This study tests whether a daily supplement called equol can improve blood vessel function in postmenopausal women with moderate chronic kidney disease (CKD). The 12-week trial will measure changes in artery health and blood pressure. Researchers hope to find a simple way to lowe…

This study looks at whether a single injection of platelet-poor plasma (a part of your blood) can help athletes recover from muscle injuries better than standard treatment. About 90 athletes aged 18-45 with leg muscle strains will get the injection and be monitored for 6 months u…

This study tests whether completing methadone clinic intake while still in the hospital helps people with opioid use disorder stay connected to treatment after they leave. About 1,440 adults will be enrolled across four hospitals. The goal is to reduce the high risk of relapse an…

This early-phase study tests a new treatment called CD64 CAR T cells for people with acute myeloid leukemia (AML) or high-risk myelodysplastic syndromes (MDS) that have come back or not responded to standard therapy. The treatment involves taking a patient's own immune cells, mod…

This study tests if montelukast, a medicine used for asthma, can help protect the kidneys and blood vessels in teens and young adults (ages 14-24) with type 2 diabetes. The drug works by blocking inflammation that can harm these organs. Researchers will measure changes in kidney …

This study tests whether adding the drug epoprostenol to standard frostbite care can lower the number of amputations. About 66 adults with severe frostbite will receive either epoprostenol or a placebo through an IV. The goal is to see if the drug helps restore blood flow and sav…

This study will test a clinical decision support tool that helps primary care providers safely taper opioid doses in patients. The tool provides guidelines and reminders to reduce withdrawal and overdose risk. About 200,000 patients will be involved, and researchers will compare …

This study compares two minimally invasive needle treatments for gluteal tendinosis, a painful tendon condition in the buttock area. About 110 adults who haven't improved with standard care will receive either a traditional needle tenotomy or a newer ultrasound-guided needle teno…

This study tests whether taking iron supplements can improve exercise performance in low-oxygen conditions, like at high altitudes. Five healthy adults will take iron pills and then exercise on a bike while researchers measure their maximum workload and oxygen use. The goal is to…

This study tests whether banana leaves can be used as a natural dressing for second-degree burns. About 30 adults with small burns will receive banana leaf dressings, and their pain and healing will be compared to past patients. The goal is to see if this low-cost, widely availab…

This study looks at whether watching online videos about sexual health can help women with breast cancer feel more confident talking to their doctors about this topic. About 200 women newly diagnosed with stage I-III breast cancer will either get access to the videos or receive u…

This study tests whether a high-CBD cannabis extract is safe and tolerable for people with moderate to severe restless legs syndrome (RLS). About 60 adults aged 18-79 will receive either the CBD extract or a placebo for several weeks. Researchers will track side effects and sympt…

This study tests a new therapy for children ages 7-12 who have self-injurious thoughts and behaviors (SITBs). The goal is to see if the new therapy helps families engage more, reduces symptoms, and is practical to use. Participants will be randomly assigned to the new therapy or …

This study aims to see if a fully online mindfulness program is a practical and acceptable option for teens aged 12-17 who have migraines. Researchers will compare a group mindfulness program to a group headache education program, both delivered via telehealth. The main goal is t…

This early-phase trial tests whether a fluorescent dye called 5-ALA can help surgeons see soft-tissue sarcoma tumors during surgery. The dye is given to patients a few hours before the operation and makes tumor tissue glow under a special light. The study will enroll 20 adults wi…

This study looks at whether a small device worn on the thigh can reliably measure daily activity in people with Functional Neurologic Disorder (FND). Current doctor assessments only capture a single moment, missing day-to-day changes. The study will involve 40 participants (20 wi…

This study aims to see if text message reminders can encourage more adults aged 45-75 to complete at-home colorectal cancer screening. Researchers will work with community health centers to design and test different message versions. About 7,220 participants will receive texts, a…

This study is creating a decision aid to help people with early dementia, their caregivers, and doctors talk through medication options together. Researchers will test if the tool reduces uncertainty and improves shared decision-making. About 100 patients, caregivers, and clinici…

This study tests whether a computer alert that reminds doctors about treatment options can increase the use of medications for opioid use disorder. About 200,000 patients will be involved, with some doctors getting the alert and others not. The goal is to see if the alert leads t…

This study tests a short program in the emergency department for people with dementia who have fallen. The program includes the caregiver and aims to reduce future fall-related ER visits. About 700 participants will be split into two groups: one gets the new program, the other ge…

This study is testing a new program called Movámonos, designed to help Spanish-speaking adults with overweight or obesity become more physically active. The program will be tested with 20 participants to see if it is acceptable and practical. The goal is to gather feedback to imp…

This study will check how often bone loss happens around PEEK (a type of plastic) anchors used in hand and wrist surgeries, compared to metal or dissolving anchors. Researchers will review X-rays from 180 patients who had these anchors placed in the last 10 years. The goal is to …

This study tests a computer alert that notifies doctors when a patient is about to move into a new phase of opioid therapy (like from short-term to long-term use). The goal is to help doctors pause and check if the opioid is still needed, reducing the risk of addiction or overdos…

This study will compare the costs and patient satisfaction of two different tools used for ACL knee surgery: a smaller 'NanoScope' versus the standard arthroscope. About 42 adults aged 18 to 60 with a confirmed ACL tear will take part. The goal is to see if the newer, smaller too…

This study looks at whether a simple blood test (ctDNA) can help doctors decide which patients with stage 2 or 3 rectal cancer can safely avoid surgery and just be watched closely. About 200 adults will be followed to see if the test can also catch any cancer coming back early. T…

This study tests a program called ThriveCircle, where small groups of faculty members meet over shared meals to talk about work and support each other. The goal is to see if these guided conversations help reduce burnout and improve well-being. About 160 faculty from the Universi…