University Of Colorado, Denver

This study investigates how semaglutide (the drug in Ozempic and Wegovy) changes brain activity related to appetite and eating in people with obesity. Researchers will compare teenagers (ages 12–18) and adults (ages 30–45) using brain scans and meal tests to see if the drug affec…

This study looks at whether improving sleep habits can help teenagers with overweight or obesity better regulate blood sugar and energy. Researchers will enroll 60 teens aged 14-19 who get less than 7 hours of sleep on school nights. For two weeks, participants will follow a slee…

This study tests whether completing methadone clinic intake during a hospital stay helps people with opioid use disorder stay connected to treatment after leaving. Researchers will compare usual care (a referral at discharge) to a program where hospital staff complete key steps l…

This study tests whether montelukast, a medicine used for asthma, can help protect the kidneys and blood vessels in 50 teens and young adults (ages 14-24) with type 2 diabetes. The drug works by blocking harmful inflammatory chemicals linked to diabetes complications. Researchers…

This study tests whether a single injection of platelet-poor plasma (PPP) into an acute muscle injury helps athletes heal better than standard care. About 90 athletes aged 18-45 with leg muscle strains will receive the injection plus physical therapy. Researchers will use MRI sca…

This study tests whether the drug epoprostenol, given alongside standard care, can reduce the need for amputation in people with severe frostbite. About 66 adults with grade 2-4 frostbite will receive either the drug or a placebo within 72 hours after rewarming. The goal is to se…

This study tests a clinical decision support tool that helps primary care providers safely taper opioid doses in patients. The tool provides guidelines and reminders to reduce withdrawal and overdose risks. About 200,000 patients will be involved, and researchers will compare out…

This study tests a new group self-management program for adults with brain cancer. The goal is to see if the program is practical and helps improve mental health and quality of life more than standard care. Researchers will compare changes in well-being between the group program …

This study tests whether an online program called Man Therapy can help male military members with anger problems, including those who have had a mild traumatic brain injury. About 226 participants will either use the program right away or wait. Researchers will measure anger, PTS…

This study tests a program called ThriveCircle, where small groups of faculty at the University of Colorado School of Medicine meet six times over six months for guided conversations and shared meals. The goal is to see if these peer-led groups can reduce burnout and improve well…

This study tests if a newer ultrasound-guided needle works better than a standard needle to treat gluteal tendinosis—a painful tendon condition in the buttock area. About 110 adults who haven't improved after 3 months of other treatments will be randomly assigned to one of the tw…

This study tests a new therapy for children ages 7-12 who have self-injurious thoughts and behaviors (SITBs). The goal is to see if the new therapy helps families engage better and improves symptoms compared to usual care. About 52 children and their families will take part in we…

This early-phase study tests whether taking iron supplements for 30 days can improve exercise performance in low-oxygen conditions. Five healthy adults will take ferrous sulfate pills daily and then exercise on a stationary bike. The goal is to see if iron helps the heart and lun…

This study tests whether a fully virtual mindfulness program (BREATHE-HA) is feasible and acceptable for teens aged 12–17 with migraine. Participants will either join a 6-session mindfulness group or a headache education group, both delivered via telehealth. The goal is to see if…

This study tests whether banana leaves can be used as a natural dressing for second-degree burns. About 30 adults with small burns will have their wounds covered with banana leaves, and their pain and healing will be compared to past patients. The goal is to see if this simple, l…

This study tests whether an online sexual health video series can help women newly diagnosed with breast cancer feel more confident talking to their doctors about sexual health. About 200 women will be randomly assigned to watch the videos or receive usual care. Researchers will …

This study tests whether a high-CBD cannabis extract is safe and helps relieve symptoms in people with moderate to severe restless legs syndrome (RLS). About 60 adults aged 18-79 will receive either the CBD extract or a placebo for several weeks. Researchers will track side effec…

This study looks at whether exercise can help protect the body from health problems caused by shift work, which disrupts natural sleep-wake cycles. Sixteen healthy but inactive adults will spend 5 days in a lab, simulating day shifts then night shifts, with some doing exercise. R…

This study tests whether transcranial magnetic stimulation (TMS), a noninvasive brain stimulation technique, can temporarily improve social cognition and brain function in 60 adults with high psychopathic traits. Participants will receive either real or sham TMS over three sessio…

This study tests a short program in the emergency department for people with dementia who have fallen. The program includes the patient and their caregiver and aims to reduce future fall-related ER visits. About 700 participants will be split into two groups: one gets the new pro…

This study is testing a new physical activity support program called Movámonos for Spanish-speaking adults who are overweight or obese and not very active. The goal is to see if the program is something people like and can stick with. About 20 people will take part to help resear…

This pilot study will compare the costs and patient satisfaction of ACL knee surgery using a smaller, newer camera system (NanoScope) versus the traditional arthroscopy method. About 42 adults aged 18-60 with an ACL tear will be randomly assigned to one of the two surgical approa…

This study tests a computer alert that notifies doctors when a patient is about to move into a new phase of opioid therapy, such as from short-term to long-term use. The alert prompts doctors to review the patient's pain and goals, following CDC guidelines. Researchers will study…

This study tests whether a computer alert can help doctors identify and treat patients with opioid use disorder. About 200,000 adults will be involved, and doctors will either get an alert or not. The goal is to see if the alert increases the use of medications like buprenorphine…

This early-stage study tests whether a fluorescent dye called 5-ALA can make soft-tissue sarcoma tumors glow during surgery, helping surgeons see the edges more clearly. About 20 adults with grade 2 or 3 sarcoma will take the dye by mouth before their standard surgery. The main g…

This study will check how often bone loss happens around PEEK (a type of plastic) suture anchors used in hand and wrist surgeries, compared to metal or dissolving anchors. Researchers will review X-rays from 180 patients who had surgery in the past 10 years. They want to see if P…

This study aims to create a decision aid to help people with dementia, their caregivers, and doctors talk through medication options together. Researchers will test the tool with 100 patients, caregivers, and clinicians to see if it reduces confusion and improves shared decision-…