University Of Colorado, Denver

This study is testing if adding a drug called ruxolitinib to a stem cell transplant can help prevent the body from rejecting the new cells, which is a major risk. It aims to improve the chance of a cure for children and young adults with severe sickle cell disease. Up to 24 parti…

This study is testing whether using an over-the-counter continuous glucose monitor periodically—every 30 or 90 days—can help adults with type 2 diabetes who don't use insulin better manage their blood sugar. Researchers will compare these monitoring schedules to see if less frequ…

This is a first-in-human study testing a new type of CAR T-cell therapy for adults with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS) that has come back or not responded to other treatments. Doctors will collect a patient's own immune cells, genetically…

This study tests whether a computer alert system helps primary care doctors better identify and treat patients with opioid use disorder. The system reminds doctors to use a treatment pathway that includes medications like buprenorphine. Researchers will track whether the alerts l…

This early-stage study is testing whether montelukast, a medication commonly used for asthma and allergies, can help protect the kidneys and blood vessels in teenagers and young adults with type 2 diabetes. Researchers believe diabetes causes inflammation that damages these organ…

This study is developing and testing a new outpatient therapy program for children ages 7-12 who experience thoughts of self-harm or suicide. It aims to teach kids better emotion control and thinking skills while helping families stay engaged in treatment. Researchers will compar…

This study is testing a computer alert system for doctors. The alert pops up when a painkiller prescription would move a patient into a new, longer-term phase of opioid therapy, like from short-term to chronic use. It reminds doctors to review the patient's pain and treatment goa…

This study is testing if adding a medication called epoprostenol to standard frostbite treatment can help save more tissue and prevent amputations. It will involve 66 adults with severe frostbite at the University of Colorado Hospital. Participants will receive either the new med…

This study aims to see if taking a daily full-spectrum CBD product can help people who regularly drink alcohol to reduce their drinking and improve related problems. Researchers will enroll 180 adults who drink alcohol and have tried CBD or cannabis before. Participants will take…

This study is testing whether taking a supplement called equol, which comes from soy, for 12 weeks can improve blood vessel function in postmenopausal women with moderate chronic kidney disease. The goal is to see if this natural compound can help lower their high risk of heart d…

This study aims to test a package of evidence-based health interventions for women going through menopause. Researchers want to see if these approaches can reduce bothersome symptoms like hot flashes, lower inflammation, improve heart health markers, and potentially slow biologic…

This early study is testing whether a special drink can make soft tissue sarcoma tumors glow under a special light during surgery. The goal is to help surgeons better see the tumor's edges to remove it more completely while sparing healthy tissue. About 20 adults with a confirmed…

This study aims to prevent falls in older adults by automatically notifying them if they screen as high-risk during an emergency room visit. It then connects them to proven local fall prevention programs. The goal is to see if this simple, automated alert system can reduce the nu…

This study tests whether a computer tool helps doctors follow safe guidelines when reducing patients' opioid painkiller doses. The tool provides recommendations to prevent withdrawal symptoms and overdose risks during medication tapering. Researchers will track 200,000 patient re…

This small pilot study will test if banana leaves can be used as a dressing for second-degree burns to help reduce pain and improve healing. It will involve 30 adult patients with recent, small burns and compare their results to past patients. The main goal is to see if using ban…

This study is testing whether online educational videos can help women newly diagnosed with breast cancer feel more comfortable discussing sexual health concerns with their doctors. Researchers will enroll 200 women and randomly assign them to either watch the video series or rec…

This small pilot study is testing whether a combined nutrition and exercise program is practical and helpful for cancer survivors who have finished treatment and are overweight. The 6-month program includes education, counseling, group support, and using wearable devices to track…

This study is testing a program called ThriveCircle, which aims to reduce burnout and improve well-being among doctors and scientists at a medical school. Small groups of faculty will meet over shared meals for guided conversations to build community and support each other. Resea…

This study aims to find out which type of talk therapy works better for veterans living with long-term back or neck pain. Researchers will compare a newer approach called Pain Reprocessing Therapy (PRT) against the standard Cognitive Behavioral Therapy (CBT) and against the usual…

This study aims to test the safety and effectiveness of a high-CBD cannabis extract for treating Restless Legs Syndrome (RLS). Researchers will compare the extract against a placebo in 60 adults with moderate to severe RLS to see if it reduces symptoms and improves sleep quality.…

This study aims to understand how the body's automatic nervous system responds to stress in adults with Down syndrome. Researchers will measure heart rate, blood pressure, and stress hormones in 200 participants (half with Down syndrome, half without) during six common stressors …

This study aims to see if a small activity monitor worn on the thigh can reliably track how Functional Neurologic Disorder (FND) affects people's daily movement and function. It will enroll 40 people, including those with FND and healthy volunteers, to wear the device for a week …

This study aims to understand how often bone loss occurs after hand and wrist surgery when doctors use different types of suture anchors to reattach tissues. Researchers will look back at 180 patients who had surgery over the past 10 years, comparing plastic (PEEK), metal, and di…

This study is creating a decision aid to help patients with early dementia, their families, and doctors make shared choices about medications. Researchers will test how well the tool reduces uncertainty and improves confidence in decision-making. The study involves 100 participan…

This study aims to understand how eating different daily snacks (walnuts or pretzels) affects brain activity related to food and feelings of fullness during a 12-week weight-loss program. Researchers will use brain scans and questionnaires to measure changes in cravings, appetite…

This study aims to see if a special blood test (ctDNA) can help doctors better choose which patients with stage 2 or 3 rectal cancer can safely enter a 'watch and wait' program after initial treatment, instead of having immediate surgery. It will also see if the blood test helps …