University Of Colorado, Denver

This study tested whether using fresh frozen plasma (FFP) works better than albumin (a common protein solution) when treating people with severe burns. Researchers wanted to see if FFP helps patients recover with fewer complications, like lung problems, and reduces the total amou…

This study tested whether a 12-week treatment with the medication semaglutide works better than an active diet program for teenage girls with obesity and PCOS. The main goal was to see which approach more effectively reduces dangerous fat in the liver and improves how the body us…

This study tested whether two types of CBD (one with a tiny amount of THC, one without) could help people reduce their opioid use and manage pain. 126 adults with opioid use disorder were randomly assigned to take either CBD or a placebo pill daily for 12 weeks. Researchers measu…

This large study tested whether a high-intensity rehabilitation program could help older adults recover better after being discharged from the hospital to a skilled nursing facility. It involved over 4,300 participants across 32 facilities, comparing the new rehab approach to usu…

This study tested whether a drug called rucaparib could help keep metastatic or recurrent endometrial cancer from worsening after initial chemotherapy. It involved 79 women who had completed 1-2 prior treatments. Participants were randomly assigned to receive either rucaparib or …

This early-stage study tested a specialized, high-precision form of radiation therapy for women whose ovarian or uterine cancer has returned in a few specific spots. The main goal was to find the highest dose that is safe and causes manageable side effects. Researchers also wante…

This early-stage study tested a new approach for men with advanced prostate cancer that has stopped responding to standard hormone-blocking therapy. Researchers wanted to see if it was practical and safe to give testosterone through a skin patch, alternating with a cancer drug ca…

This study tested whether the drug tofacitinib is safe and effective for treating several common autoimmune skin conditions in adolescents and adults with Down syndrome. Researchers wanted to see if reducing overactive immune signaling could improve skin health, quality of life, …

This study tested a new support program for pregnant women with HIV in Kenya. The goal was to see if using a risk calculator to identify women who might struggle with their treatment, and then offering them tailored counseling and support, could help them stay in medical care and…

This study tested three different computer alert tools designed to help doctors quickly check a state database of controlled medication prescriptions before writing new orders for opioids or sedatives. The goal was to see if these alerts made doctors more likely to check the data…

This study tested two approaches to help doctors communicate better with patients who have speech, hearing, or language disabilities. Researchers compared doctor training alone versus doctor training plus a simple checklist patients could use to tell doctors their communication p…

This study tested whether a medication called semaglutide (brand name Rybelsus), which is used for diabetes and weight loss, could help people with alcohol use disorder. Fifty adults seeking treatment for their drinking were randomly assigned to take either the real medication or…

This study looked at whether weight-loss surgery (sleeve gastrectomy) could improve the health of the pancreas, kidneys, and heart in young people (ages 12-21) with type 2 diabetes. Researchers measured organ function in about 50 participants before and after surgery to understan…

This study tested whether intermittent fasting is an effective long-term weight loss strategy compared to traditional daily calorie counting. For one year, 165 adults with obesity followed either a fasting diet (severe restriction 3 days a week) or a daily reduced-calorie diet, w…

This early-stage study tested whether a vaccine called MER3101 could safely help reset the immune system in people with recent-onset type 1 diabetes. The trial involved 21 adults who had been diagnosed within the past two years, comparing different vaccine doses against a placebo…

This early-stage study tested the safety and highest tolerable dose of a new oral drug called KPT-9274. It involved 16 adults with acute myeloid leukemia that had returned or stopped responding to previous treatments. The main goal was to see if the drug was safe and to find the …

This study tested a new device designed to better secure a gastrostomy button (G-button), a small feeding tube placed into a child's stomach. Researchers wanted to see if this new securement device could reduce common problems like leakage, skin irritation, and the tube accidenta…

This small pilot study tested whether adding a nutrition program (BfedBwell) to an existing exercise program (BfitBwell) is practical and acceptable for cancer survivors. It involved 20 survivors who were overweight and had finished active cancer treatment. The main goal was to s…

This study tested whether sprinkling antibiotic powder directly into severe open fracture wounds before surgery helps prevent infections. Researchers compared patients who received the powder (vancomycin or tobramycin) to those who did not, looking at infection rates and healing.…

This study tested a new imaging technique called electrical impedance tomography (EIT) to see if it can monitor lung changes in children and young adults with cystic fibrosis. Researchers compared EIT to standard CT scans to see if it could detect areas of trapped air and lung da…

This study tested whether memory and thinking tests given over a video call at home are as effective as traditional in-person visits for diagnosing Alzheimer's disease. Researchers compared the two methods in 116 older adults being evaluated for memory problems. The goal was to s…

This study tested whether adding a new 2D 'antiscatter grid' to a specialized CT scanner could produce clearer images for cancer patients. It involved 43 adults receiving radiation therapy for prostate, head/neck, or abdominal cancers. Each participant received both a standard sc…

This study tested whether giving pregnant women a nutritional supplement called phosphatidylcholine (a form of choline) could help their children's brain development. Researchers gave either the supplement or a placebo to 216 healthy pregnant women and then tracked their children…

This study tested whether a culturally adapted mobile app could help young American Indian and Alaska Native women prevent alcohol-exposed pregnancies, which can cause lifelong disabilities in babies. Researchers recruited 439 women aged 16-20 from urban areas across the U.S. thr…

This study followed over 1,000 low-income, first-time mothers and their children for 29 years to see if a program of nurse home visits during pregnancy and early childhood could prevent chronic diseases later in life. The program, called the Nurse-Family Partnership, aimed to see…

This early-stage study tested whether a dietary supplement called alpha lipoic acid could help reduce pain and mouth sores for people undergoing combined chemotherapy and radiation for head and neck cancer. Five patients participated to find the safest and most effective dose. Th…

This small pilot study tested whether a voice journaling app called Kintsugi is easy and acceptable for teenagers with cystic fibrosis (CF) to use. Researchers wanted to see if using the app for three months could help with feelings of anxiety and depression, which are common in …

This study tested a drug called riociguat in 10 patients who still had trouble exercising and felt short of breath at least six months after surgery to remove old blood clots from their lungs. The goal was to see if the drug could improve their exercise capacity and breathing sym…

This study tested a special recovery plan for children having surgery to remove cancer in the belly or pelvic area. Researchers compared children who followed the new plan to children who had surgery in the past. They wanted to see if the plan helped kids have fewer complications…

This study investigated whether therapeutic horseback riding could help reduce problem behaviors and improve social skills in children and teens with autism who also have other mental health conditions. Researchers compared 10 weeks of riding lessons to barn activities without ho…

This study looked at whether women could safely go home the same day as their mastectomy and breast implant reconstruction surgery, instead of staying in the hospital overnight. It compared complications, pain, and patient satisfaction between the two discharge times. The goal wa…

This study tested whether two types of CBD (one with a tiny amount of THC and one without) could help people with traumatic brain injury. 43 adults with ongoing symptoms like memory problems, anxiety, pain, or poor sleep took either CBD or a placebo pill daily for 12 weeks. Resea…

This small pilot study explored whether a supervised high-intensity interval training (HIIT) exercise program could improve fitness and reduce symptoms in veterans who developed new breathing problems after deployment. Twelve veterans with deployment-related respiratory symptoms …

This study aimed to create better guidelines for birth control counseling for transgender and gender-diverse youth. Researchers talked with 35 teens and young adults to understand their experiences and satisfaction with a specific birth control injection. The goal is to help heal…

This study aimed to understand why women with chronic kidney disease have a higher risk of heart problems. Researchers compared blood vessel function and hormone levels in 51 women with kidney disease to healthy women. The goal was to see if changes in sex hormones, which protect…

This research study aimed to understand how weight-loss surgery affects liver fat and metabolism in obese teenagers. Researchers followed 20 adolescents aged 13-20 before and one year after their surgery, measuring liver fat, insulin sensitivity, and metabolic markers. The study …

This study aimed to understand how combining alcohol with high-THC cannabis concentrates affects people. Researchers brought a mobile lab to participants' homes to measure intoxication, heart rate, and thinking skills after they used both substances. They specifically tested whet…

This study looked at why some cancer patients who get a second opinion decide to stay with their original doctor, while others switch to the new doctor. Researchers reviewed the records of 236 patients with breast, pancreatic, or colorectal cancer who got a second opinion at the …

This small research study aimed to understand if short-term night shift work disrupts the body's natural bone maintenance process. Researchers studied 20 healthy young adults to see if simulated night shifts temporarily altered blood markers related to bone building and breakdown…

This small, early study tested whether short-term use of anti-inflammatory drugs—fish oil capsules or the medication celecoxib—could change the biology of breast cancer diagnosed around pregnancy. Researchers gave one of these treatments to 42 young women for 1-3 weeks before the…

This study looked at how pelvic radiation treatment affects bladder function and bone strength in people who survived childhood cancer. Researchers compared 32 survivors who received pelvic radiation with those who didn't, measuring urinary symptoms and bone density. The goal was…

This study aimed to understand how breast cancer treatment affects women's sexual well-being and what kind of education they need about it. Researchers followed 93 women from diagnosis through treatment to learn about their experiences and preferences. The goal was to identify ga…

This study aimed to understand how physical fitness and daily activity levels relate to diabetes risk in breast cancer survivors taking hormone-blocking therapy. Researchers measured 40 women's fitness, body composition, and activity over two weeks to see connections. The goal wa…

This study aimed to see if children and young adults with cancer could reliably report on their experiences with complementary therapies like massage, acupuncture, or Reiki. Researchers wanted to test if it was feasible to collect this data electronically to understand if these t…

This study aimed to understand why some women reject or disagree with their personalized breast cancer risk estimate. Researchers surveyed 781 Black women aged 39-74, giving them a risk score and asking for their reaction. The goal was to see if rejecting the risk number affected…

This study aimed to understand how teenagers with asthma actually use their daily controller and emergency rescue medications in real life. Researchers tracked 80 teens for a full year using electronic monitors on their inhalers. The goal was to identify patterns of medication us…

This study aimed to understand how women aged 39-49 react to information about the benefits and risks of mammograms. Researchers surveyed over 600 women to learn why some distrust this information or feel it doesn't apply to them. The goal was to improve how health information is…

This study aimed to understand why screening for Barrett's esophagus, a condition that can lead to esophageal cancer, isn't happening as often as recommended. Researchers surveyed over 700 patients with chronic heartburn and their doctors across seven U.S. health systems. The goa…

This study aimed to understand why a common prostate cancer treatment (androgen deprivation therapy or ADT) increases the risk of high blood pressure and heart disease. Researchers measured how the nervous system and kidneys control blood pressure in a small group of men before a…

This study aimed to understand how using legal cannabis affects alcohol drinking, cravings, and the connection between the gut and brain. Researchers observed 77 adults who regularly used both alcohol and cannabis over one month. They collected blood and stool samples and measure…

The purpose of this study is to assess the acceptability, appropriateness, and feasibility of a educational video series for patients going through breast cancer treatment.