University Of Colorado, Denver

This study tested whether the drug Acthar can prevent focal segmental glomerulosclerosis (FSGS) from coming back in people who receive a kidney transplant. Fifteen adults with FSGS and advanced kidney disease took part. Researchers measured how many had FSGS return by looking at …

This study tests whether adding visual and sound reminders to a standard breathing exercise device (incentive spirometer) helps patients use it more often after surgery. About 231 adults who had surgery under general anesthesia will be split into two groups: one using the device …

This study tested whether taking two doses of sodium bicarbonate (baking soda) over 24 hours could reduce uric acid crystals in the urine of adults with type 1 diabetes. Uric acid crystals can harm the kidneys, so lowering them might help prevent diabetic kidney disease. The tria…

This phase 2 trial is testing whether a combination of two drugs, venetoclax and azacitidine, can effectively treat adults aged 18 to 59 who have been newly diagnosed with acute myeloid leukemia (AML) and have not yet received any treatment. Participants take both drugs in cycles…

This study tested whether dornase alfa (Pulmozyme) ear drops can unclog tympanostomy tubes in children better than standard ofloxacin drops. 41 children aged 1 to 18 with clogged tubes received either treatment for 7 days. The main goal was to see if the tube was open at day 14.

This phase 2 trial tested a combination of radiation, a targeted drug (olaparib), and an immunotherapy (pembrolizumab) in 9 people with advanced stomach or gastroesophageal junction cancer that had spread. The goal was to see if this approach could shrink tumors that were not dir…

This study tested whether a lifestyle guide called GEM (Glycemic Excursion Minimization), combined with a continuous glucose monitor (Freestyle Libre 2) and a Fitbit activity tracker, could help people with prediabetes better manage their blood sugar. Sixty-one adults aged 25-70 …

This study tested whether tolcapone, a drug used for Parkinson's disease, could change how people with both alcohol use disorder and ADHD respond to alcohol and make decisions. 23 adults completed the trial, which involved taking tolcapone or a placebo and then undergoing alcohol…

This study looked at a shorter course of radiation for women with breast cancer that had spread to nearby lymph nodes after surgery. The goal was to see if this faster treatment was safe and had manageable side effects like arm swelling or shoulder stiffness. 108 women took part,…

This study tested a counseling program for couples in Zambia to help pregnant women living with HIV stay healthy. Nearly 500 couples took part. The program aimed to improve HIV medication adherence and viral suppression through relationship strengthening.

This study tested a device that automatically adjusts oxygen levels for hospitalized patients with serious injuries or illnesses. 300 adults received either the automated device or standard manual oxygen adjustments. The goal was to see if the device kept oxygen levels in a safer…

This study tested whether giving young women (ages 14-22) birth control pills alongside their contraceptive implant helps them keep using the implant longer. 600 participants either received the pills or standard counseling. The goal was to see if the pills reduce early implant r…

This study tested a combination of two drugs, azacitidine and venetoclax, in 42 elderly patients (age 60+) with newly diagnosed acute myeloid leukemia (AML) who could not have standard chemotherapy. The treatment was given as an initial 'induction' phase, followed by a 'maintenan…

This study tested whether eating less fat and more fiber can reduce the chance of a repeat Clostridioides difficile infection in cancer patients. Eight participants with leukemia, lymphoma, or other cancers followed a specific diet. Researchers tracked diarrhea and measured C. di…

This study tested whether the drug rucaparib can help keep metastatic or recurrent endometrial cancer from growing. 79 women who had already received chemotherapy took either rucaparib or a placebo pill twice daily. The goal was to see if rucaparib could delay cancer progression …

This study tested whether putting antibiotic powder (vancomycin or tobramycin) directly into open fracture wounds right after injury can prevent infections. Twenty adults with severe open fractures of the arm or leg took part. The goal was to see if this simple step reduces surgi…

This study tested a new device called Button Huggie that secures gastrostomy buttons (feeding tubes) in children. The goal was to see if it reduces problems like leakage, tube dislodgement, skin irritation, and infection compared to standard dressings. 182 children aged 1 month t…

This study tested whether intermittent fasting (eating only during certain hours) helps people with obesity lose more weight than the traditional approach of cutting calories every day. Over one year, 165 adults followed either an intermittent fasting plan or a daily calorie goal…

This early-stage study tested a new treatment called IBC with MAS-1 in 21 adults recently diagnosed with type 1 diabetes. The goal was to see if it is safe and can retrain the immune system to stop attacking the pancreas, potentially helping the body control blood sugar naturally…

This study tested a drug called riociguat in 10 adults who still had trouble exercising at least 6 months after surgery for chronic blood clots in the lungs. The goal was to see if the drug could improve blood pressure in the lungs and make exercise easier. Participants took the …

This early-stage study tested an experimental drug called KPT-9274 in 16 adults whose acute myeloid leukemia (AML) had come back or did not respond to standard treatments. The main goal was to find a safe dose and check for side effects. The study is now complete, and results wil…

This study looked at whether weight-loss surgery (vertical sleeve gastrectomy) can improve kidney, heart, and pancreas function in teens aged 12-21 with type 2 diabetes and obesity. Researchers measured blood flow to the kidneys, kidney filtering ability, and insulin production b…

This study tested whether semaglutide (Rybelsus), a drug used for diabetes, can help people with alcohol use disorder drink less. Fifty adults who wanted to cut down took either the drug or a placebo for 8 weeks. Researchers measured changes in alcohol cravings and daily drinking…

This study tested whether tofacitinib, a drug already approved for arthritis, is safe and helpful for immune-related skin conditions in people with Down syndrome. 47 adolescents and adults with Down syndrome and skin issues like eczema or psoriasis took the drug. Researchers chec…

This pilot study tested whether screening pregnant women with HIV for their risk of dropping out of care, then offering tailored support (counseling sessions in person or by phone), could help them stay in treatment and keep the virus under control. The study involved 120 women i…

This completed study tested whether the diabetes drug semaglutide (Rybelsus) could help 60 adolescent girls with PCOS and obesity reduce liver fat and improve insulin sensitivity, compared to a weight loss diet. Participants took a daily oral tablet for 4 months or followed a pre…

This study tested whether fresh frozen plasma (FFP) works better than albumin for fluid replacement in adults with severe burns covering over 20% of their body. Fifty-nine participants were randomly assigned to receive either FFP or albumin within 8 hours of injury. The goal was …

This early-phase study tested a new treatment schedule for men with castration-resistant prostate cancer. The approach alternates between giving testosterone through the skin and the drug enzalutamide, aiming to control the disease. The main goals were to see if this schedule is …

This study tested a culturally adapted mobile health program called Mobile CHOICES to help urban American Indian and Alaska Native young women (ages 16-20) avoid drinking alcohol during pregnancy. The goal was to reduce the risk of Fetal Alcohol Spectrum Disorders, which cause li…

This study looked at whether 8 weeks of low-load leg exercises with a blood flow restriction cuff is safe and doable for people with multiple sclerosis who have moderate to severe walking problems. Sixteen adults with MS took part, doing exercises like knee extensions and hip lif…

This study looked at whether high-intensity interval training (short bursts of hard exercise) can improve physical function and reduce fatigue in adults aged 50-80 living with HIV who are sedentary and tired. Participants were randomly assigned to either high-intensity training o…

This small pilot study tested whether a single 25mg dose of psilocybin, given with psychological support, could help people with treatment-resistant depression who still struggle with anhedonia—the inability to feel pleasure or interest. Twenty adults took either the full dose or…

This study tested a Spanish-language program called Unstuck and On Target with 20 families in Ecuador. Children aged 8-11 with autism or ADHD took part in an 8-week program to improve flexibility and problem-solving. The goal was to see if the program was practical and helpful fo…

This early-phase study tested whether alpha lipoic acid, a dietary supplement, can reduce pain and side effects in people with head and neck cancer undergoing chemoradiation. Only 5 patients were enrolled to find a safe and tolerable dose. The goal was to see if it's worth studyi…

This pilot study looked at whether high-intensity interval training (HIIT) can improve fitness and symptoms in veterans who developed breathing problems after deployment to Southwest Asia. Twelve veterans completed a 12-week program of supervised HIIT on a stationary bike plus ho…

This study tested whether cannabidiol (CBD) can improve thinking, mood, and other symptoms in people who have had a traumatic brain injury (TBI). 43 adults with mild or moderate TBI took either CBD or a placebo for 12 weeks. Researchers measured changes in cognition, neuropsychia…

This study tested whether CBD (a compound from cannabis) can help people who want to reduce their pain and opioid use. 126 adults took either CBD or a placebo for 12 weeks. Researchers measured changes in pain, opioid use, and other factors like anxiety and sleep.

This study tested whether a voice journaling app called Kintsugi is easy and acceptable for teens with cystic fibrosis to use. Twenty teens aged 14-18 with a history of anxiety or depression tried the app for three months. The goal was to see if it could help improve their emotio…

This study tested whether therapeutic horseback riding can improve behavior, social skills, and emotional control in 250 autistic youth who also have a mental health condition. Participants were randomly assigned to riding, barn activities without riding, or a hybrid group. Resea…

This early-phase study tested a precise type of radiation called stereotactic body radiation therapy (SBRT) in 15 women whose ovarian or uterine cancer had come back in a limited area. The main goal was to find the safest dose and check for side effects. Researchers also looked a…

This completed study looked at 340 people to understand how certain proteins in the lungs, called autoantibodies, might be linked to the start of rheumatoid arthritis (RA). Researchers collected sputum (mucus from the lungs) from people at risk for RA, those already diagnosed, an…

This study tested a nutrition program for cancer survivors who are overweight or have obesity. The program included one-on-one counseling with a dietitian, behavioral skills training, and group support. The goal was to see if the program was easy to run and acceptable to particip…

This study looked at how two common oral antibiotics, amoxicillin and cephalexin, work in newborns and young infants. Researchers enrolled 72 babies already receiving these or other antibiotics in the hospital. By taking small blood samples over time, they measured drug levels to…

This study followed 59 nurses during their first year of work to see if night shifts harm bone health. Researchers measured bone density and markers of bone turnover in night shift nurses compared to day shift nurses. The goal was to understand if shift work increases the risk of…

This observational study looked at how legal cannabis use changes alcohol drinking habits, gut bacteria, and brain function in people who regularly use both alcohol and cannabis. 77 heavy drinkers who also smoke cannabis took part, providing blood and stool samples and completing…

This completed trial tested an online tool called 'Safety in Dementia' that guides caregivers through decisions about firearm access for a person with dementia. 500 informal caregivers across the U.S. participated. The tool helps clarify options, risks, and personal values, aimin…

This study looked at whether biofortified maize—corn grown to have higher zinc and iron—helps school-aged children in Guatemala absorb more of these nutrients compared to traditional maize. Fifty-six children aged 10-14 ate tortillas made from either biofortified or regular maize…

This completed study looked at two new ways to understand why some labors slow down or stall (called labor dystocia). Researchers measured lactate levels in amniotic fluid and electrical signals from the uterus in 42 healthy women giving birth at term. The goal was to gather info…

This study followed 384 people with HIV who were already taking the medication TAF. Researchers used a special blood test to measure how well participants were taking their pills and whether that predicted if the virus stayed under control. The goal was to see if this test could …

This pilot study tested whether a special 2D antiscatter grid can improve the quality of cone-beam CT (CBCT) images used during radiation therapy for prostate, head and neck, and upper abdomen cancers. 43 participants received one extra CBCT scan with the grid, and researchers co…

This study looked at how hospital doctors, nurses, and social workers feel about treating opioid use disorder (OUD) while patients are in the hospital. Researchers surveyed 400 healthcare workers across 12 hospitals in Colorado. The goal was to understand current practices and se…

This completed study looked at how women ages 39-49 make decisions about breast cancer screening. Participants read a decision aid explaining the pros and cons of mammograms and then answered surveys about their reactions, knowledge, and screening plans. The goal was to understan…

This study tested a computer alert that pops up when a doctor prescribes an opioid or sedative, reminding them to check Colorado's prescription drug monitoring program (PDMP). The goal was to see if the alert helps doctors follow state law and reduce risky prescribing. Researcher…

This study looked at how women aged 39 to 49 react to scientific information about mammography's benefits and harms. Researchers measured feelings like disbelief, distrust, and thinking the information doesn't apply to them. The goal was to understand how these reactions influenc…

This study looked at whether a special recovery plan (ERAS) helps children recover faster after surgery for pelvic cancer. Researchers tracked 74 children at five hospitals to see if the plan reduced complications and hospital stays. The goal is to find the best ways to help kids…

This study looked at 10 men to understand why androgen deprivation therapy (ADT) for prostate cancer can lead to high blood pressure. Researchers checked if problems with the nervous system or kidneys were to blame. The goal is to find ways to prevent heart disease in prostate ca…

This study tested whether an educational video series about sexual health is acceptable and useful for women undergoing breast cancer treatment. 32 women with early-stage breast cancer watched the videos over six months. Researchers measured how well the videos were received and …

This completed study looked at why some women reject personalized breast cancer risk estimates. Researchers gave 781 Black or African American women aged 39-74 a personal risk score based on the Gail Model and asked if they agreed with it. The goal was to understand risk rejectio…

This study looked at how to improve contraceptive counseling for transgender and gender diverse adolescents who use or want to use the Depo shot (DMPA). Researchers held focus groups with 35 teens assigned female at birth, aged 15-21, to understand their needs and satisfaction. T…

This study looked at whether adding a nutrition program to an existing exercise program is practical and well-liked by cancer survivors who are overweight or obese. Twenty adults who finished cancer treatment joined a 12-week program combining diet advice with exercise. The goal …

This completed study looked at how physical activity, fitness, and sitting time relate to insulin resistance (a diabetes risk factor) in 40 breast cancer survivors taking hormone therapy. Participants wore activity monitors and underwent tests for fitness, body composition, and i…

This study looked at 236 adults with breast, colorectal, or pancreatic cancer who sought a second opinion at the University of Colorado. Researchers reviewed medical records to see if patients stayed for treatment or went elsewhere. The goal was to understand what factors influen…

This study looked at how to better educate women with breast cancer about sexual health during treatment. Researchers held focus groups with 93 patients to understand their needs and preferences. The goal was to create educational materials that could improve sexual well-being th…

This study looked at 32 childhood cancer survivors who had pelvic radiation at least one year earlier. Researchers measured bladder function and bone density to understand long-term side effects. The goal was to gather knowledge, not to test a new treatment.

This early-phase study tested whether two anti-inflammatory drugs—fish oil (omega-3 fatty acid) and celecoxib (Celebrex)—could reduce inflammation and slow cancer growth in women aged 18-50 with pregnancy-associated breast cancer. The 42 participants took one of the drugs for at …

This study checks on families who took part in a nurse home-visiting program during pregnancy and early childhood, about 29 years ago. Researchers are measuring things like weight, blood pressure, and cholesterol in both mothers and their now-grown children. The goal is to see if…

This study looked at how to gather information about complementary therapies (like massage, yoga, or acupuncture) for children with cancer. Researchers worked with 100 kids to see if it's possible to measure things like pain, nausea, and quality of life during these treatments. T…

This study looked at whether a more intense physical therapy program helps older adults recover better after a hospital stay in skilled nursing facilities. Over 4,300 people took part. The goal was to see if this approach improves walking speed and overall physical function.

This study tested whether giving pregnant women a nutritional supplement called phosphatidylcholine could improve their child's brain development. About 216 healthy pregnant women took either the supplement or a placebo from around 16 weeks of pregnancy until birth. Researchers t…

This study looked at whether doing memory and thinking tests over a video call at home works as well as doing them in person for people with suspected Alzheimer's disease. 116 older adults (ages 60-90) with mild memory problems took part. The goal was to see if video assessments …

This study looked at whether working night shifts for just three nights in a row can disrupt bone health. Twenty healthy adults aged 20-40 either followed a normal sleep schedule or stayed awake at night and slept during the day. Researchers measured bone turnover markers to see …

This study tested two approaches to help healthcare providers communicate better with patients who have speech, language, voice, or hearing disabilities. One approach trained healthcare teams on communication strategies, and the other added a patient prompt list that lets patient…

This study looked at how drinking alcohol and using high-THC cannabis concentrates together affects people. 146 heavy drinkers who also use cannabis regularly took part. Researchers measured things like blood alcohol level, heart rate, and how impaired they felt, depending on whe…

This study tested whether electrical impedance tomography (EIT), a non-invasive imaging technique, can detect lung damage in children and young adults with cystic fibrosis (CF). Researchers compared EIT results to CT scans to see if it can identify air trapping and other lung cha…

This study followed 80 teens with asthma to see how well they used their daily controller and rescue inhalers. Participants used an electronic device that reminded them to take their medication and shared their usage patterns with their doctor and family. The goal was to group te…

This study looked at 123 women who had a mastectomy with immediate implant-based breast reconstruction. Half were sent home the same day, and half stayed overnight. Researchers compared complications, pain, and satisfaction within 30 days to see if same-day discharge is a safe op…

This completed study surveyed over 700 primary care doctors, gastroenterologists, and patients across seven U.S. health systems. The goal was to find out what knowledge gaps, attitudes, and practical barriers prevent people from getting screened for Barrett's esophagus, a conditi…

This study looked at 20 teens aged 13-20 with severe obesity who were scheduled for bariatric surgery. Researchers measured liver fat and how the body processes energy before and one year after surgery. The goal was to understand how the surgery affects liver health and metabolis…

This study looked at how sex hormones, especially estradiol, affect blood vessel function in women with chronic kidney disease (CKD). Researchers compared pre- and post-menopausal women with CKD to healthy women of the same age. They measured blood vessel dilation and stiffness, …

This study tested whether pop-up alerts in electronic medical records help doctors check a state database before prescribing opioids or sedatives. Over 3,600 providers were randomly assigned to different alert designs. The goal was to see if the alerts increase use of the Prescri…