University Of Colorado, Denver

This study tested a counseling program for couples in Zambia to help pregnant women living with HIV stay healthy. Nearly 500 couples took part. The program focused on improving medication adherence and viral suppression through relationship strengthening.

This study tested whether fresh frozen plasma (FFP) works better than albumin for fluid replacement in adults with severe burns covering over 20% of their body. Fifty-nine patients were randomly assigned to receive either FFP or albumin within 8 hours of injury. The main goal was…

This study looked at whether eating less fat and more fiber can lower the chance of a repeat Clostridioides difficile infection in people being treated for cancer. Eight patients with leukemia, lymphoma, or other cancers who had a recent C. diff infection took part. Researchers t…

This study tested if weight-loss surgery (vertical sleeve gastrectomy) could improve pancreas, kidney, and heart health in teens aged 12-21 with type 2 diabetes and severe obesity. Researchers measured kidney function, blood flow, and insulin production before and after surgery. …

This study tested whether semaglutide (Rybelsus), a drug used for diabetes, can help people with alcohol use disorder drink less. Fifty adults who wanted to cut down took either the drug or a placebo for 8 weeks. Researchers measured changes in alcohol cravings and daily drinking…

This early-stage trial tested a new immunotherapy (IBC with MAS-1) in 21 adults recently diagnosed with type 1 diabetes. The goal was to see if the treatment is safe and can retrain the immune system to stop attacking the pancreas, potentially preserving the body's ability to mak…

This study tested whether the drug rucaparib can help keep metastatic or recurrent endometrial cancer from growing after initial chemotherapy. About 79 women with advanced disease who had already received 1-2 prior treatments were randomly assigned to receive either rucaparib or …

This study tested a simple idea: giving young women birth control pills along with their contraceptive implant to reduce early removal. 600 participants aged 14-22 who were new implant users either received the extra pills or standard counseling. The goal was to see if the pill '…

This study tested a shorter course of radiation for 108 women with breast cancer that had spread to their lymph nodes after surgery. The goal was to see if this faster treatment was safe and had manageable side effects like arm swelling or shoulder stiffness. Researchers tracked …

This study tested a smart, automated oxygen system (O2matic PRO100) in 300 hospitalized adults with serious injuries or illnesses. The goal was to see if the machine could keep oxygen levels in a safe range better than standard manual methods. The approach aims to prevent both to…

This study tested the drug Acthar in 15 people with a kidney disease called FSGS who were getting a kidney transplant. The goal was to see if Acthar could lower the chance of FSGS coming back in the new kidney. Researchers measured how many patients had signs of FSGS in their tra…

This study looked at 60 girls with obesity and polycystic ovarian syndrome (PCOS). They were given either a weekly semaglutide injection or a special diet for 12 weeks. The goal was to see which approach better reduced liver fat and improved how the body uses insulin. The results…

This study tested a two-drug combination (azacitidine and venetoclax) as an initial treatment for adults aged 60 and older with acute myeloid leukemia (AML) who had not received prior therapy. Participants first received both drugs together, and those who responded continued on v…

This study looked at whether intermittent fasting (eating only during certain hours) helps people with obesity lose more weight than a standard daily calorie-restricted diet. Over one year, 165 adults aged 18-60 with a BMI between 27 and 46 followed either an intermittent fasting…

This study tested whether giving extra support to pregnant women with HIV who are at higher risk of dropping out of care can help them stay in treatment and keep the virus under control. The study took place in Kenya and involved 120 women. Researchers used a risk calculator to i…

This early-phase study tested a new treatment schedule for men with castration-resistant prostate cancer. The approach alternates between giving testosterone through the skin and the drug enzalutamide. The main goal was to see if this treatment plan is practical and safe. Thirty …

This study tested whether putting antibiotic powder directly into open fracture wounds can help prevent infections. Open fractures are severe bone breaks that often get infected. The study included 20 adults with certain types of open fractures. Researchers applied vancomycin or …

This study tested whether tofacitinib, a drug already approved for other conditions, is safe and helpful for people with Down syndrome who also have immune-related skin problems like eczema, psoriasis, or hair loss. The study included 47 adolescents and adults. Researchers measur…

This early-phase study tested an oral drug called KPT-9274 in 16 adults whose acute myeloid leukemia (AML) had returned or not responded to prior treatments. The main goal was to find the safest dose and check for side effects. The study did not aim to cure the disease, but to ga…

This study tested a culturally adapted mobile health program called mobile CHOICES to help urban American Indian and Alaska Native young women (ages 16-20) prevent alcohol-exposed pregnancy, which can cause lifelong disabilities like Fetal Alcohol Spectrum Disorders. Researchers …

This study tested a Spanish-language program called Unstuck and On Target for children aged 8-11 with autism or ADHD in Ecuador. Twenty families took part to see if the program was easy to use and helpful for improving thinking and problem-solving skills. Some families received t…

This study looked at how therapeutic horseback riding affects youth with autism who also have mental health conditions. Researchers measured changes in behavior, social skills, and emotional control in 250 participants. The goal was to understand how riding helps and how long the…

This study tested a new device to hold a gastrostomy button (feeding tube) in place for children. The goal was to see if it reduces common problems like leaking, skin irritation, or the tube coming out. About 182 children were randomly assigned to use either the new device or sta…

This study tested whether CBD (a compound from cannabis) can help people use fewer opioids and feel less pain. 126 adults with opioid use disorder were given either CBD or a placebo for 12 weeks. The goal was to see if CBD could reduce pain, opioid use, and anxiety while improvin…

This pilot study looked at whether high-intensity interval training (HIIT) can improve fitness and ease breathing symptoms in veterans who developed lung problems after deployment to Southwest Asia. Twelve veterans completed 12 weeks of supervised cycling and home exercise. The s…

This early-phase study tested a precise type of radiation called stereotactic body radiation therapy (SBRT) in 15 women with ovarian or uterine cancer that had come back in a limited area. The goal was to find the safest dose and see how well it controls tumor growth. Researchers…

This study tested whether a voice journaling app called Kintsugi is easy and acceptable for teens aged 14–18 with cystic fibrosis. Twenty participants used the app over three months to track their feelings. The goal was to see if it could help reduce anxiety and depression sympto…

This study tested whether two types of CBD (a cannabis compound) could improve thinking and reduce symptoms in people who had a mild or moderate traumatic brain injury. 43 adults took either CBD or a placebo for 12 weeks. Researchers measured changes in memory, attention, and oth…

This study looked at 123 women who had a mastectomy with immediate breast implant reconstruction. Half went home the same day, the other half stayed overnight. Researchers compared complications, pain, and satisfaction within 30 days to see if same-day discharge is safe and effec…

This study tested a drug called riociguat in 10 people who still felt short of breath during exercise at least 6 months after lung surgery for chronic blood clots. The goal was to see if the drug could improve lung blood pressure and heart function during exercise. Participants t…

This early-phase study tested alpha lipoic acid, a dietary supplement, in 5 adults with head and neck cancer undergoing chemoradiation. The goal was to find a safe dose that might reduce treatment-related pain and side effects. Researchers monitored for side effects and drug leve…

This study tested a special recovery program (ERAS) for children having surgery for pelvic or abdominal cancer. The goal was to see if the program could reduce complications and help kids heal faster. 74 children from five hospitals took part, and researchers tracked their recove…

This study looked at whether it's possible to collect information on how integrative therapies (like yoga, massage, or acupuncture) affect the quality of life of children with cancer. About 100 children referred by their pain or palliative care team took part. The goal was not to…

This study looked at how sex hormones, especially estrogen, affect blood vessel function in women with chronic kidney disease (CKD). Researchers compared pre- and post-menopausal women with CKD to healthy women of the same age. The goal was to understand why women with CKD have h…

This study looks at the long-term health of mothers and their first-born children 29 years after they took part in a program where nurses visited them at home during pregnancy and early childhood. Researchers measured things like weight, blood pressure, cholesterol, and other mar…

This study looked at whether doing memory and thinking tests over a video call at home works as well as doing them in person for people with suspected Alzheimer's disease. 116 older adults (ages 60-90) with mild memory problems took part. The goal was to see if video testing is a…

This study looked at 20 obese teenagers aged 13-20 who were scheduled for bariatric surgery. Researchers measured liver fat and how the body processes energy before and one year after surgery. The goal was to understand how surgery affects liver health and metabolism.

This study looked at 32 childhood cancer survivors who had pelvic radiation at least one year earlier. Researchers measured bladder function and bone density to understand long-term side effects. The goal was to gather information, not to test a new treatment.

This study followed 384 people with HIV who were already taking the medication TAF. Researchers measured drug levels in dried blood spots to see if those levels could predict whether the virus stays suppressed. The goal was to better understand how medication adherence relates to…

This study looked at how women ages 39-49 react to scientific information about mammography's benefits and harms. Researchers measured feelings like disbelief, distrust, and thinking the information doesn't apply to them. The goal was to understand what drives women's decisions a…

This study tested a computer tool that reminds doctors to check Colorado's prescription drug database before prescribing opioids (painkillers) or benzodiazepines (sedatives). The goal was to see if the tool helps doctors follow state law and reduce risky prescribing. Nearly 90,00…

This study followed 59 nurses during their first year of work to see if those working night shifts had worse bone health compared to day shift nurses. Researchers measured bone density and markers of bone turnover in the blood. The goal was to understand if chronic night shift wo…

This study tested whether a special 2D grid can make CT scans clearer for people with prostate, head/neck, or upper abdomen cancers. Researchers compared standard scans to those taken with the new grid in 43 patients. The goal was to see if the grid reduces image errors and impro…

This study looked at whether it is possible to add a nutrition program called BfedBwell to an existing exercise program for cancer survivors. Twenty adults who had finished cancer treatment and were overweight or obese took part. The goal was to see if the program was easy to fol…

This study looked at how combining alcohol with high-THC cannabis concentrates changes intoxication. 146 heavy drinkers who also use cannabis regularly took part. They drank a set amount of alcohol and used their own cannabis product, then had their heart rate, blood alcohol, and…

This study tested whether an educational video series about sexual health is acceptable and useful for women going through breast cancer treatment. 32 women with early-stage breast cancer watched the videos and gave feedback. The goal was to see if the videos were appropriate and…

This study looked at whether two anti-inflammatory drugs—fish oil and celecoxib (a COX-2 inhibitor)—can reduce inflammation and slow tumor growth in pregnancy-associated breast cancer. 42 women with breast cancer took one of these drugs for at least a week before their planned su…

This study tested three different computer tools to help doctors check a state database before prescribing strong painkillers or sedatives. The goal was to reduce the risk of medication abuse and overdose. Over 3,600 patients and their doctors took part. The tools gave doctors ex…

This study tested whether a few nights of simulated shift work can temporarily change how the body builds and breaks down bone. Twenty healthy adults aged 20-40 were monitored during two short hospital stays. The goal was to see if night work disrupts bone turnover and whether re…

This study looked at why men with prostate cancer who receive hormone therapy (ADT) often develop high blood pressure. Researchers measured how the nervous system and kidneys control blood pressure in 10 men before and after starting ADT. The goal was to understand the causes so …

This study looked at how physical fitness, daily activity, and sitting time relate to insulin resistance (a diabetes risk factor) in 40 breast cancer survivors taking hormone therapy. Participants completed fitness tests, body scans, and wore activity monitors. The goal was to un…

This study looked at 236 adults with breast, pancreatic, or colorectal cancer who came to the University of Colorado for a second opinion. Researchers wanted to understand what factors, like patient background or disease type, influence whether someone decides to stay at the new …

This study looked at how 80 teenagers with asthma use their daily controller and rescue inhalers. Participants used an electronic device that recorded when they took their medication. Researchers then grouped teens based on how well they controlled their asthma and how consistent…

This study looked at how women aged 39 to 49 make decisions about mammography screening after reading a guide that explains both the benefits and harms. About 500 women completed surveys over a year to share their thoughts, intentions, and whether they actually got screened. The …

This study looked at how a drug called tolcapone affects people who have both alcohol use disorder and ADHD. Researchers measured how the drug changed their response to alcohol, decision-making, and brain activity. The goal was to learn more about the connection between these con…

This study looked at how to better counsel transgender and gender diverse teens about birth control, specifically a shot called DMPA. Researchers talked to 35 teens aged 15-21 to understand what they need and want from these conversations. The goal is to help doctors provide more…

This study tested two ways to improve communication between healthcare providers and patients with speech, language, voice, or hearing disabilities. About 687 patients and their healthcare teams took part. One group of providers received special training, while another group also…

This study looked at whether a type of corn with extra nutrients (biofortified maize) can help children absorb more zinc and iron than regular corn. Researchers studied 56 school-aged children in Guatemala who ate tortillas made from this special corn. The goal was to see if this…

This study looked at whether giving pregnant women a nutritional supplement called phosphatidylcholine could help their child's brain development. About 216 healthy pregnant women took either the supplement or a placebo from around 16 weeks of pregnancy until birth. Researchers t…

This study looked at how legal cannabis use changes alcohol drinking habits, gut bacteria, and brain function in 77 adults who regularly use both alcohol and cannabis. Participants tracked their drinking and cravings over a month, gave blood and stool samples, and completed think…

This study looked at how breast cancer treatment affects women's sexual well-being and what kind of educational resources they want. Researchers surveyed 93 women to understand their needs and preferences. The goal is to create better educational materials to help women manage se…

This study looked at how hospital staff across 12 Colorado hospitals treat patients with opioid use disorder. Researchers surveyed 400 doctors, nurses, and social workers to understand current practices and improve care. The goal was to increase prescribing of medications like bu…

This study surveyed over 700 doctors and patients to find out why people at risk for Barrett's esophagus (a condition that can lead to esophageal cancer) don't get screened. The goal is to identify barriers and improve screening rates. No treatments were tested.

This study looked at whether high-intensity rehabilitation can improve recovery for older adults admitted to skilled nursing facilities after a hospital stay. Over 4,300 people took part. The goal was to see if this approach works and can be put into practice widely.

This study looked at why some women disagree with their personalized breast cancer risk score. Researchers gave 781 Black or African American women their Gail Model risk estimate and asked if they agreed. The goal was to understand this rejection and improve how risk information …

This study tested whether electrical impedance tomography (EIT), a non-invasive imaging method, can detect lung changes in children and young adults with cystic fibrosis (CF). Researchers compared EIT to CT scans to see if it could identify air trapping and other lung problems. T…