University Of Colorado, Denver

This study tests a combination of two drugs, cabozantinib and nivolumab, in people with advanced colorectal cancer that has not responded to standard treatments. The goal is to see if the combination can stop or shrink the cancer for at least 16 weeks. About 48 adults with a spec…

This study tests whether an online training program helps people who recently quit smoking stay smoke-free and support others in their social network. About 940 adults who have been smoke-free for 2 to 8 weeks will take the training and be followed for 12 months. Researchers will…

This study tests a combination of three drugs (tiragolumab, atezolizumab, and bevacizumab) in people with advanced colorectal cancer that has not responded to prior treatment and is microsatellite stable (a type that typically doesn't respond to immunotherapy). The goal is to see…

This study tests a combination of two drugs, omacetaxine and azacitidine, in people with a high-risk type of myelodysplastic syndromes (MDS), a bone marrow disorder. The goal is to find the safest dose and see how many patients achieve remission. About 28 adults with untreated hi…

This study looks at how vericiguat, a new heart failure drug, improves heart function during rest and exercise. Thirty adults with heart failure will take either vericiguat or a placebo for about three months. Researchers will measure blood flow, blood pressure, and quality of li…

This early-phase trial tests whether adding an oral drug (DEC-C) to the immunotherapy nivolumab can help the immune system better fight advanced mucosal melanoma, a rare and hard-to-treat skin cancer. The study includes 8 adults with unresectable or metastatic disease. The main g…

This study tests whether using an over-the-counter continuous glucose monitor (CGM) every 30 or 90 days helps people with type 2 diabetes who do not use insulin better manage their blood sugar. About 188 participants will wear the Dexcom Stelo sensor periodically over six months.…

This study tests a new treatment approach for people with advanced stomach or gastroesophageal junction cancer that has spread. Participants first receive targeted radiation and a drug called olaparib, followed by a combination of olaparib and pembrolizumab. The goal is to see if…

This study looks at whether taking omega-3 fatty acid supplements can help control high triglyceride levels in pregnant women. High triglycerides are linked to larger babies and potential birth complications. The study involves 40 pregnant women with elevated triglycerides and ai…

This study tests whether the drug nivolumab can reverse pre-cancerous spots in the lungs of heavy smokers or former smokers who are at high risk for lung cancer. Nineteen participants received the drug to see if their lung tissue improved over six months. The goal is to stop thes…

This study tests three medications—lorazepam, IVIG, and tofacitinib—in 66 people with Down syndrome (ages 8-30) who have developed a serious condition called Down Syndrome Regression Disorder (DSRD). DSRD causes sudden loss of skills, catatonia, and other severe symptoms. The goa…

This study looks at whether eating only during certain hours of the day (time-restricted eating) helps adults with obesity lose weight and improve health. About 162 participants will be assigned to eat early in the day, late in the day, or simply reduce daily calories for one yea…

This study tests a new treatment plan for people with a certain type of esophageal cancer. Before surgery, patients receive a combination of chemotherapy drugs (FLOT) followed by chemoradiation. The goal is to see if this approach can completely eliminate the tumor before surgery…

This early-phase study tests a new drug, amivantamab, combined with standard targeted therapies (TKIs) in 12 adults with advanced non-small cell lung cancer that has specific gene changes (ALK, ROS1, or RET). The cancer has stopped responding to current treatments. The goal is to…

This study tests whether helping families eat more meals together and improve meal quality can lower obesity risk in children ages 5-10. Over 12 months, 500 families will use mobile tools and video feedback to track and improve their meals. The goal is to reduce BMI and improve d…

This study tests a new drug called NT219 combined with either pembrolizumab or cetuximab in people with head and neck cancer that has come back or spread. The goal is to see if the combination can shrink tumors. About 29 adults with incurable head and neck squamous cell carcinoma…

This study looks at whether a special alert in doctors' computer systems can increase the number of patients who get naloxone (a medicine that reverses opioid overdoses) along with their high-risk opioid prescriptions. Over 200,000 patients aged 12 to 89 who are prescribed opioid…

This study tests a personalized approach using the drug selinexor combined with other medications for people whose multiple myeloma has returned or stopped responding to treatment. 18 participants receive one of three drug combinations chosen by their doctor. The goal is to see h…

This early-phase study looks at whether giving trastuzumab directly into the spinal fluid, along with an immune-boosting drug called GM-CSF, can help children whose ependymoma brain tumor has come back. The main goals are to see if the drug reaches the tumor and to find the safes…

This study tests whether a drug called empagliflozin, currently used for diabetes, is safe and tolerable for people with autosomal dominant polycystic kidney disease (ADPKD). About 50 adults with moderate kidney function will receive either the drug or a placebo for 12 months. Th…

This study tests whether adding two immunotherapy drugs (zalifrelimab or botensilimab plus balstilimab) to standard chemotherapy (doxorubicin) can keep advanced soft tissue sarcoma from growing longer than chemo alone. About 65 adults with sarcoma that has spread or cannot be rem…

This study looks for markers in blood, sputum, or urine that can help doctors decide if a lung nodule found on a CT scan is cancer or not. The goal is to reduce the need for invasive biopsies. 550 adults aged 18-85 with lung nodules between 8-30 mm are being followed.

This study looks at whether offering the HPV vaccine to children at age 9 or 10, instead of the usual age of 11 or 12, makes parents more likely to agree to it. The goal is to get more kids fully vaccinated before they are exposed to the virus, which can cause several cancers lat…

This study tests a 3-month intermittent fasting program (fasting 3 days a week) in 36 adults who have had breast cancer and are overweight or obese. The goal is to see if the program helps with weight loss, sticking to the diet, and increasing physical activity. Participants also…

This study tests a new music listening tool for people undergoing stem cell transplants, who often spend weeks in the hospital. About 35 adults will listen to music for one hour daily using a web-based platform. The goal is to see if this simple, self-guided activity is practical…

This study looks at whether Pain Reprocessing Therapy (PRT) can help adults with long-term back pain. It compares PRT to Cognitive Behavioral Therapy (CBT) and usual care. The goal is to see which approach works best for lowering pain and improving daily life. About 150 diverse a…

This study tests whether a smartphone app and remote therapy sessions can help military members and active young adults recover from a mild concussion. Participants use the app to track progress and do virtual exercises designed to improve balance and thinking. The goal is to see…

This study looks at whether a low-fat diet that maintains weight can increase reproductive hormones in women with obesity. Researchers will measure hormone levels in urine before and after the diet. The goal is to see if diet alone can improve hormone function related to fertilit…

This study tests whether psilocybin, the active ingredient in magic mushrooms, combined with psychological support can reduce anhedonia (loss of interest or pleasure) in adults with treatment-resistant depression. About 40 participants will receive the drug and therapy, and resea…

This study looks at three different ways to manage pain after surgery for pectus excavatum, a common chest wall deformity in teens. The goal is to find which method works best to reduce pain and the need for strong painkillers. About 158 patients aged 12 to 21 will be randomly as…

This study tests a mobile health program called "Forward to Quit" designed specifically for transgender adults who smoke. About 44 participants will use the app and provide feedback on how easy and helpful it is. The goal is to see if the app can help people quit smoking and redu…

This study looks at whether quitting cannabis for 42 days can improve memory, attention, and mood. Researchers will use 100 identical twins who both use cannabis regularly. One twin will be asked to stop using cannabis with support, while the other continues as usual. The goal is…

This study looks at whether doctors can easily screen teens with type 1 diabetes for sleep problems during regular clinic visits. About 50 teens who use a continuous glucose monitor will take part. The goal is to see how often the sleep discussion can be completed, not to test a …

This study looks at whether a 2-year weight loss program can improve how the kidneys use oxygen and how the body responds to insulin in people with autosomal dominant polycystic kidney disease (ADPKD) who are overweight. Researchers will use PET scans and insulin tests to measure…

This early-stage study tests whether the drug tocilizumab can reach craniopharyngioma tumors in children. In the first part, 9 children with new or recurring tumors receive one dose before surgery to see if the drug enters the tumor. If it does, a second part will give the drug e…

This online study with 1,900 women ages 39-49 tests whether changing how mammography results are described affects how skeptical women feel about screening. Some women hear about "benefits and harms," others hear about "outcomes that can happen," and some get extra info on surviv…

This study checks if measuring natural water markers in breath and saliva works as well as urine for tracking energy use. Researchers will collect samples from 60 healthy adults aged 18-45. The goal is to make it easier to study human energy expenditure without needing urine samp…

This study is trying to find blood markers that could warn doctors ahead of time if a cancer patient will have serious side effects from immunotherapy drugs. About 69 adults with advanced solid tumors are being followed to see if certain inflammatory or autoimmune markers in thei…

This study looks at whether group discussions with a doctor and social worker help older adults (70+) complete advance care planning documents, like living wills, more than just receiving materials by mail. About 516 people from primary care clinics are taking part. The goal is t…

This study tests whether a 40-week limb-load biofeedback training program helps people with a leg prosthesis walk more symmetrically. Researchers will compare 10 participants who receive the training with 5 who receive standard care. The goal is to see if the training is feasible…

This study looks at tumor samples from 250 children with a rare brain tumor called craniopharyngioma. Researchers will analyze the tumors to find specific targets that could lead to better, less harsh treatments. The goal is to improve how we treat this disease in the future.

This study follows 267 healthy, full-term babies from about 5 months to school age to see how different protein-rich foods affect their growth and gut bacteria. Researchers measure weight, length, body fat, and gut microbes. The goal is to learn which foods support healthy develo…

This study is testing whether a nutrition program called BfedBwell can work for cancer survivors who are overweight or have obesity. The program includes one-on-one counseling with a dietitian, learning new skills, and group support. The main goal is to see if people will join an…

This study aimed to see if a new monitoring schedule could catch early signs of ovarian damage after chemotherapy or radiation. It planned to compare women who used the new schedule with those who received standard care. However, the study was withdrawn before enrolling anyone, s…

This study tests whether adding a sleep health program to a standard weight loss plan helps overweight adults lose weight and improve sleep. About 25 participants will follow the program for 6 months. The main goal is to see if the program is practical and acceptable, not to prov…

This study tests whether a new method for lung cancer screening, called the Engaged Approach, is practical and acceptable for different screening programs. About 40 staff members from up to 8 programs across Colorado and the US will try it and give feedback. The goal is to see if…

This study looked at whether exercising in the morning or evening changes how the body handles sugar in adults with prediabetes. Participants completed short periods of no exercise, morning exercise, and evening exercise while their blood sugar, sleep, and activity were tracked. …

This study looks at how exercising in the morning versus the evening, and on an empty stomach versus after eating, changes the way your body burns energy and fat. Twenty healthy adults with overweight or obesity will complete treadmill tests to measure these effects. The goal is …

This study collects saliva, blood, and tissue samples from 225 adults with or without head and neck cancer. Researchers are searching for tiny genetic markers called miRNAs that might help predict how the disease will behave or aid in diagnosis. The goal is to improve future trea…

This study looks at whether a new care planning method, called ABC123, is practical and acceptable for people over 60 with advanced, incurable cancer. The framework combines geriatric, oncology, and palliative care into the initial treatment discussion. Researchers will track how…

This study looks at why some women disagree with their personal breast cancer risk estimate given during mammogram screening. Researchers will survey 750 women aged 39-74 to understand how they react to their risk score and whether it affects their screening plans. The goal is to…

This study looks at how obesity may cause fertility problems by disrupting hormones that control the menstrual cycle. Researchers will measure hormone levels and insulin response in 84 women with regular cycles. The goal is to understand the link between obesity and infertility t…

This study looks at how cannabis use changes the body's natural endocannabinoid and opioid systems in 30 adolescents aged 14-25 who use cannabis at least twice a week. Researchers measure cannabinoid and endorphin levels in blood to find biomarkers that might predict which teens …

This study looks at whether continuous glucose monitors (CGMs) are practical and helpful for youth and young adults (ages 2 to 25) admitted to the hospital with high blood sugar from diabetes or other conditions. Researchers will compare CGM readings with standard finger-stick te…

This study measures certain substances in the blood (biomarkers) of infants with a rare heart condition called single-ventricle. The goal is to see how these biomarkers relate to lung blood flow before and after a surgery called the superior cavo-pulmonary anastomosis (SCPA). Res…

This study tests a new computer tool that helps doctors prescribe the right heart failure medications during phone or video visits. Researchers will compare the new tool to an existing one in 20 cardiology clinics. The goal is to see if the tool works well and is easy to use in v…

This study tests a new computer tool that gives doctors personalized reminders when prescribing heart failure medications. The goal is to see if tailoring alerts to each doctor's past prescribing habits leads to more patients getting the right drugs. About 764 doctors from cardio…

This study follows 192 toddlers aged 18 to 36 months who are at high risk for asthma. Researchers track their health over time to learn how asthma starts and progresses in early childhood. The goal is to help doctors find better ways to prevent and treat asthma in the future. No …

This study follows 60 adults who completed an 18-month weight loss program 3 years ago. Researchers will measure changes in weight, body fat, physical activity, sleep, and eating patterns. The goal is to understand how daily behaviors help or hinder keeping weight off long-term.

This study tests a new system that helps doctors better understand the needs of older adults with cancer. The system combines checks on aging, mental health, lifestyle, and social factors. About 35 patients aged 65 and older will try it during their first cancer visit. The goal i…