University Of Colorado, Denver

This small study is testing whether a 3-month lifestyle program can help breast cancer survivors who are overweight or obese. The program involves three modified fasting days per week and aims to increase physical activity. Researchers want to see if this approach is safe, feasib…

This study is testing whether a shorter, 4-week course of radiation is as safe and effective as the standard 6-week treatment for breast cancer patients whose cancer has spread to their lymph nodes. The trial involves 108 women who have already had breast cancer surgery. Research…

This study is testing whether the timing of meals is more effective for weight loss than simply counting calories. Researchers are comparing three approaches: eating all meals within an early 8-hour window, eating within a late 8-hour window, or traditional daily calorie restrict…

This study is testing whether adding an oral drug called DEC-C to standard immunotherapy (nivolumab) can make treatment more effective for people with advanced mucosal melanoma. The goal is to see if this combination can better activate the immune system against the cancer. The t…

This study is testing a new, two-step treatment plan for people with a type of esophageal cancer that can be removed by surgery. First, patients receive a strong course of chemotherapy (called FLOT). Then, they get a standard course of chemotherapy combined with radiation. The go…

This early-stage study is testing whether adding a new drug called amivantamab to standard targeted therapies can help control advanced lung cancer that has started growing again. It will involve about 12 adults whose cancer has specific genetic changes and has become resistant t…

This early-stage study is testing whether tocilizumab, a drug used for arthritis, can reach and potentially control a rare childhood brain tumor called craniopharyngioma. The trial has two parts: first checking if the drug gets into the tumor after one dose before surgery, then t…

This study aims to understand exactly how the medication vericiguat helps people with chronic heart failure. Researchers will test 30 patients to see if the drug improves how the heart and blood vessels work, especially during exercise. Participants will take either the real drug…

This study is testing whether a combination of two drugs, cabozantinib and nivolumab, can help control advanced colorectal cancer that has stopped responding to standard treatments. It will involve about 48 adults whose cancer has spread and is a specific type called microsatelli…

This study is testing a new clinic program to help spot and address sleep issues in teenagers with type 1 diabetes. About 50 teens will fill out a sleep questionnaire before their regular doctor's visit. If a problem is found, their doctor gets information and suggestions to disc…

This study tests whether doctors can choose effective drug combinations for patients with multiple myeloma that has returned or stopped responding to previous treatments. Eighteen participants will receive one of three different drug combinations based on their doctor's judgment,…

This early-phase study is testing a new way to treat children whose brain cancer (ependymoma) has come back. Researchers are giving a targeted drug directly into the spinal fluid, along with an immune-boosting shot, to see if the drug reaches the tumor and to check for side effec…

This study is testing whether an automated system can better control oxygen levels for hospitalized patients with serious injuries or illnesses. It compares the AI system, which adjusts oxygen flow automatically, to the standard method where nurses manually adjust it. The goal is…

This study is testing three different treatments for Down Syndrome Regression Disorder (DSRD), a serious condition where individuals with Down syndrome suddenly lose skills, stop speaking, and experience other severe symptoms. The trial will compare the safety and effectiveness o…

This study tests if an online training program helps people who recently quit smoking stay smoke-free. The program teaches them how to have supportive conversations with other smokers in their life. Researchers want to see if this approach helps the quitter build a more supportiv…

This study is testing a combination of two drugs, omacetaxine and azacitidine, for people newly diagnosed with a high-risk type of bone marrow disorder called myelodysplastic syndrome (MDS). The first part of the study aims to find the safest and most effective dose of the combin…

This study is testing whether a combination of three immunotherapy drugs can help control advanced colorectal cancer that has stopped responding to standard chemotherapy. It is for adults whose cancer has spread and has a specific genetic profile called 'microsatellite stable.' T…

This study is testing a family coaching program to see if it can lower the risk of obesity and heart disease in children. It involves 500 children, aged 5 to 10, and their families. The program uses smartphone tips, home visits, and video feedback of family meals over 6 months to…

This study is testing if a pop-up alert in a patient's electronic health record can help doctors follow guidelines to prescribe naloxone, a drug that can reverse an opioid overdose, at the same time they prescribe high-risk opioid painkillers. It will involve about 200,000 patien…

This study is testing whether a drug called nivolumab can reverse abnormal, pre-cancerous cells in the lungs of high-risk current and former smokers. The goal is to see if boosting the immune system can prevent these abnormal cells from turning into lung cancer. Participants rece…

This study is testing whether listening to music for one hour daily during a long hospital stay can help patients feel better. It involves 35 adults who are undergoing stem cell transplants and will be hospitalized for 3-4 weeks. The main goal is to see if using a music app is pr…

This study is testing whether a new talk therapy called Pain Reprocessing Therapy (PRT) works better than standard Cognitive Behavioral Therapy (CBT) or usual care for adults with chronic back pain. Researchers are enrolling 150 racially and ethnically diverse adults to try these…

This study is testing a smartphone app called 'Forward to Quit,' which was designed with input from transgender people to help them stop smoking. Researchers are checking if the app is easy to use, acceptable to participants, and shows early signs of helping people quit. The goal…

This study is testing whether psilocybin, the active compound in 'magic mushrooms,' combined with psychological support, can help people with treatment-resistant depression who struggle with anhedonia—the inability to feel pleasure. The trial involves 40 adults who have not respo…

This study is testing a new 40-week training program designed to help people with above-the-knee amputations walk more evenly with their bone-anchored prosthetic leg. Researchers will compare the new training, which uses real-time feedback on weight-bearing, to standard rehabilit…

This study aims to find tiny molecules called miRNAs in saliva, blood, and tissue samples that could help detect or monitor head and neck cancer. Researchers are enrolling 225 people, including those with cancer and those without, to compare these molecular markers. The goal is t…

This study is testing a new, simpler way to measure how much energy a person's body uses each day. Researchers will compare water samples from the breath and saliva of 60 healthy adults to the standard method that uses urine. The goal is to see if the new method works as well but…

This study aims to understand why some women reject or disagree with their personalized breast cancer risk estimates. Researchers will survey 750 women aged 39-74 to identify factors that lead to risk rejection and see how this affects their actual mammogram screening behavior ov…

This study aims to find new drug targets for a rare childhood brain tumor called craniopharyngioma. Researchers will analyze tumor tissue from up to 250 children and young adults (ages 0-21) to identify specific molecules that could be targeted by future medications. The goal is …

This study follows 192 toddlers who have already experienced wheezing episodes to learn how asthma develops in early childhood. Researchers will track these children over time to identify patterns and factors that lead to persistent asthma. The goal is to gather information that …

This study aims to understand why obesity makes it harder for women to get pregnant. Researchers are putting healthy-weight women on a temporary high-fat diet to see if it causes changes in hormones linked to fertility, similar to what happens in obese women. The goal is to learn…

This study is checking in with people three years after they finished an 18-month weight loss program. Researchers want to see how their weight has changed and measure their current daily habits like physical activity, sleep, and eating patterns. The goal is to learn which daily …

This study aimed to test a new monitoring plan to help spot early signs of fertility problems in young women who had cancer treatments. It planned to look back at past patient records and follow new patients to see if the new plan could identify risks sooner and help women access…

This study is testing whether a decision guide helps women aged 39-49 make more informed choices about mammogram screening. 700 participants will read the guide and complete surveys over one year to see how it affects their knowledge, conversations with doctors, and final screeni…

This study is testing a new system designed to give doctors a more complete picture of an older patient's overall health and life circumstances when planning cancer treatment. It combines questions about aging, daily function, mental health, and social needs like housing and food…

This study is testing a new support framework for clinics that run lung cancer screening programs. Researchers are asking staff at up to 8 clinics across the US to try this new approach and give their feedback. The goal is to see if the framework is practical, acceptable, and som…

This study aimed to learn if exercising in the morning or evening is better for improving the body's blood sugar control in adults with prediabetes and obesity. It planned to have participants complete short periods of morning exercise, evening exercise, and no exercise while clo…

This study aims to see if measuring a medication's level in a simple dried blood spot can help predict whether a person's HIV will stay under control. Researchers will follow 384 adults with HIV who are already taking a specific medication (TAF) for 48 weeks. The goal is to learn…

This pilot study is testing whether a new care planning framework called ABC123 is practical and acceptable for older adults with advanced, incurable cancer. The framework combines expertise from geriatrics, oncology, and palliative care to help ensure treatment plans match what …

This study aims to learn if following a specific low-fat diet for one month changes reproductive hormone levels in women with obesity. It involves 30 women who will track their menstrual cycles and provide urine and blood samples over about four months. The goal is to gather info…

This study aims to learn how different first foods, especially protein-rich ones, affect a baby's growth and the development of their gut bacteria from infancy through school age. Researchers will observe 267 healthy, full-term babies who have not yet started solid foods. The goa…

This study is testing whether a wearable glucose monitor is practical and useful for children and young adults in the hospital. It involves 120 young patients (ages 2-26) who need frequent blood sugar checks. The main goal is to gather feedback from patients, families, and nurses…

This study aims to understand how total joint replacement surgery affects the daily function and quality of life of children and young adults. It follows up to 1,000 patients aged 10-25 who received a hip or knee replacement for reasons like side effects from cancer treatment, in…

This study aims to learn how the time of day you exercise and whether you eat beforehand affects how your body burns energy and fat. Researchers will measure these effects in 20 healthy, active adults who are overweight or have obesity. The goal is to gather basic knowledge about…

This study aims to find signs in the blood that might predict which cancer patients will experience serious side effects from a newer type of drug called immune checkpoint inhibitors. It involves 69 adults with metastatic cancer who are starting either this immunotherapy or stand…

This study tests whether group discussions help older adults plan for future medical decisions. It compares two 2-hour group sessions led by a doctor and social worker to simply mailing information packets. The goal is to see which approach better helps people document their care…

This study aims to understand how stopping cannabis affects memory, attention, and mental health. Researchers are recruiting 100 pairs of identical twins who both use cannabis regularly. One twin in each pair will be paid to stop using cannabis for 42 days, while the other contin…