Immunotherapy drug shows promise for reversing Pre-Cancerous lung changes in heavy smokers

NCT ID NCT03347838

First seen Dec 15, 2025 · Last updated May 13, 2026 · Updated 14 times

Summary

This study tests whether the drug nivolumab can reverse pre-cancerous spots in the lungs of heavy smokers or former smokers who are at high risk for lung cancer. Nineteen participants received the drug to see if their lung tissue improved over six months. The goal is to stop these spots from turning into cancer, though ongoing monitoring is still needed.

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Contacts and locations

Locations

  • Denver VA Hospital

    Denver, Colorado, 80220, United States

  • University of Colorado Anschutz Medical Campus

    Aurora, Colorado, 80045, United States

Conditions

Explore the condition pages connected to this study.