Can MS patients safely switch to a gentler drug?
NCT ID NCT06529406
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looks at whether people with stable relapsing multiple sclerosis can safely switch from anti-CD20 therapies (like rituximab or ocrelizumab) to ozanimod (Zeposia), an oral pill. About 100 participants who have had no new MS activity for at least two years will be followed for new brain lesions and infections. The goal is to see if this de-escalation approach keeps the disease under control while reducing treatment burden.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ozanimod (Zeposia)
What this could lead to
If successful, this could offer a way for people with stable MS to switch from stronger anti-CD20 therapies to a potentially safer, oral medication.
What could go wrong
This is a small pilot study, so results may not apply to everyone. There is a risk of new MS activity or infections when switching treatments.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Email: •••••@•••••
Locations
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Cleveland Clinic
RECRUITINGLas Vegas, Nevada, 89106, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cleveland Clinic
RECRUITINGCleveland, Ohio, 44195, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Colorado Anschutz Medical Campus
RECRUITINGAurora, Colorado, 80045, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••