Vascular insufficiency disorder

This study tests a new device called the VDyne System, which is placed inside the heart through a tube in a blood vessel to replace a leaky tricuspid valve. The trial will include 730 people with severe symptoms who have not improved with medication. Researchers will compare the …

This study tests a new device called the VDyne System, which is placed through a tube in a blood vessel to replace the tricuspid valve in the heart. It is for people with severe tricuspid regurgitation, a condition where the valve does not close properly, causing blood to leak ba…

This study tests whether placing a stent in a blocked pelvic vein can help heal chronic leg ulcers in people with post-thrombotic syndrome, a complication of deep vein thrombosis. Twenty adults with non-healing venous ulcers will receive the stenting procedure plus standard ulcer…

This study tests whether a newer, less invasive procedure called transcatheter aortic valve replacement (TAVR) using the J-VALVE device is as safe and effective as traditional open-heart surgery for people with severe aortic regurgitation (a leaky heart valve). About 1,250 adults…

This study tests two blood-thinning strategies in people with severe aortic regurgitation who have had a new heart valve placed without open surgery. Participants receive either daily aspirin for a year or warfarin for six months followed by aspirin. The goal is to see which appr…

This study tests if delivering oxygen directly into the gut through a thin tube can help people with ischemic-hypoxic bowel disease, a condition where the bowel doesn't get enough oxygen. About 90 adults with symptoms like belly pain, bloating, and trouble pooping will receive ei…

This study is checking how safe and well a device called TriClip works for people with a leaky heart valve (tricuspid regurgitation). The device is already approved for use, and this study will watch 1000 adults who get it to see how they do. The goal is to make sure the device w…

This study follows over 500 people with chronic venous disease who are taking Ruscus aculeatus L., a plant extract also known as butcher's broom, as part of their routine care. Researchers will track changes in vein-related symptoms, pain, and quality of life over 90 days. The go…

This registry will follow 500 adults with severe aortic stenosis who receive a SAPIEN 3 Ultra Resilia heart valve through a minimally invasive procedure. Researchers will track how well the valve works and how safe it is over 10 years. The goal is to see if this newer valve desig…

This study tests a new device called LuX-Valve Plus for people with a severely leaky heart valve (tricuspid regurgitation). About 680 adults will get either the new device or a standard one to see which is safer and works better. Participants will have one procedure and be follow…

This study tests a new device, the Medtronic Intrepid™ TTVR System, to replace a leaky tricuspid heart valve without open-heart surgery. It is for people with severe symptoms despite medication. About 1,186 participants will be followed to see if the device reduces complications …

This study is testing a new heart valve called the SAPIEN X4 in 200 people whose existing artificial aortic valve is failing. The valve is placed using a thin tube through an artery, avoiding open-heart surgery. The goal is to see if it is safe and effective at improving survival…

This trial compares two minimally invasive procedures for treating incompetent perforating veins—veins that fail to close properly and can cause leg swelling, skin changes, or ulcers. One method uses a needle to deliver an electric current to seal the vein, while the other inject…

This early study is testing a new device called the TRiCares Topaz, which is threaded through a vein to replace the tricuspid valve in the heart. It is for adults with severe tricuspid valve leakage who are not good candidates for open-heart surgery. The study will check if the d…

This trial tests a new device, the Laplace Transcatheter Tricuspid Valve Replacement (TTVR) System, designed to replace the tricuspid valve in people with severe, symptomatic tricuspid regurgitation. The procedure is done through a catheter, avoiding open-heart surgery. The study…

This pilot study is testing whether a low dose of colchicine, a drug usually used for gout, can reduce the risk of post-thrombotic syndrome (PTS) after a deep vein thrombosis (DVT) in the leg. PTS can cause chronic pain, swelling, and skin changes. The trial will enroll 150 adult…

This study compares a device that physically removes blood clots from leg veins (ClotTriever) to standard blood-thinning medication alone for people with deep vein thrombosis (DVT). About 300 participants with recent, severe DVT in one leg will be randomly assigned to either trea…

This early study tests a new device called the Laplace TTVR System, which is designed to replace the tricuspid valve without open-heart surgery. It involves 15 people aged 60-90 with severe tricuspid regurgitation that continues despite medication. The main goal is to see if the …

This trial tests a new device called the TruGamma system, which replaces the tricuspid valve without open surgery. It is for people aged 65 and older with severe tricuspid regurgitation who are not candidates for surgery. The study compares the device plus standard medication to …

This study tests a new, less invasive way to replace a leaky aortic heart valve (aortic regurgitation) using a device called the JenaValve Trilogy, compared to standard open-heart surgery. About 1,000 people with moderate to severe aortic regurgitation will be randomly assigned t…

This study tests a device called the Edwards PASCAL System, which is threaded through a blood vessel to repair a leaky tricuspid valve in the heart. It is for people with severe symptoms who are not good candidates for open-heart surgery. About 1,270 participants will be randomly…

This Phase 2 study tests whether weekly injections of MTX-001, a substance made from human amniotic fluid, can help heal venous stasis ulcers that haven't improved after at least 4 weeks of standard care. About 80 adults aged 18 to 90 with non-infected leg ulcers will receive eit…

This study compares two different devices (Allegra and Sapien) used to replace a failing surgically implanted aortic heart valve without open-heart surgery. About 104 adults with a deteriorated biological aortic valve will be randomly assigned to get one of the two devices. The m…

This study tests a new device called DragonFly-T that clips a leaky tricuspid heart valve closed, avoiding open-heart surgery. About 236 people with severe symptoms who are too high-risk for surgery will be randomly assigned to get the clip or continue medical therapy. The goal i…

This early study is testing a new device called the DUO System, which is placed through a catheter to reduce leakage in the tricuspid valve. The study will include 15 people with severe tricuspid regurgitation who still have symptoms despite medical therapy. The main goal is to s…

This study looks at whether starting rhythm control early—using drugs or procedures like ablation—can improve outcomes for people with both atrial fibrillation and tricuspid regurgitation (a leaky heart valve). About 5,800 participants will be randomly assigned to early rhythm co…

This study tests a new catheter system designed to remove blockages in leg veins caused by old blood clots. About 20 adults with painful swelling or pain from chronic vein blockages will receive the treatment. The main goals are to ensure the procedure is safe and to check if it …

This study follows 550 people who receive Abbott annuloplasty rings or bands during surgery to fix leaky mitral or tricuspid heart valves. Researchers will track survival, need for repeat surgery, and symptom improvement for five years. The goal is to confirm the devices work wel…

This study is testing a new device called the inQB8 MonarQ system, which replaces the tricuspid valve using a thin tube (catheter) instead of open-heart surgery. It includes 50 people with severe tricuspid regurgitation, a condition where the valve leaks. The goal is to see if th…

This study tests a home-based cardiac rehabilitation program delivered through a custom app for people who have had a heart valve procedure. Participants who choose not to attend center-based rehab are randomly assigned to usual care, the app with self-guided content, or the app …

This study follows 100 adults with severe tricuspid regurgitation who receive the TricValve implant. Researchers will track survival, heart failure hospitalizations, kidney function, and quality of life for up to one year. The goal is to understand how well the device works and i…

This study tests a new device called the Cardiovalve system to treat severe tricuspid regurgitation, a condition where a heart valve leaks. About 150 people aged 18-84 who are too high-risk for open-heart surgery will receive the valve. The goal is to see if the valve safely redu…

This study tests a small implantable sensor that monitors pressure in the lung artery for patients with severe tricuspid regurgitation and heart failure. The sensor is placed before a minimally invasive valve repair, and pressure readings are tracked for a year. The goal is to se…

This study is testing a new device called the Recana Thrombectomy Catheter System to treat chronic blockages in veins. It will include 30 adults with symptoms like leg swelling or pain due to venous obstruction. The device is inserted into the vein to remove the blockage and rest…

This study is testing a new device called the J-Valve, which is a replacement heart valve delivered through a tube in the leg, to treat severe aortic regurgitation (a leaky heart valve). The trial will include 194 people with severe symptoms who are at high risk for open-heart su…

This study is testing a new device called the TRiCares Topaz system to replace a leaky heart valve (tricuspid valve) without open-heart surgery. It will enroll 80 adults with severe leakage who are at high risk for traditional surgery. The goal is to see if the device is safe and…

This study compares a new, less invasive heart valve implant (TAVR) with standard medication for people who have severe aortic regurgitation, a condition where the heart's aortic valve doesn't close properly. The trial will enroll 210 participants across multiple centers. The goa…

This early study tests a robotic catheter system to replace the tricuspid valve in 10 patients with severe leakage (regurgitation) who are too high-risk for open surgery. The robot aims to improve precision and safety while reducing radiation exposure for doctors. The main goal i…

This study is checking how well the TriClip device works and how safe it is for people in Japan with a leaky tricuspid valve. The device is already approved for use, and this study will follow 250 patients to confirm its benefits in everyday medical practice. The main goal is to …

This study tests a new device called the VDyne System to replace the tricuspid valve in people with severe tricuspid regurgitation (a leaky heart valve). The goal is to see if the device is safe and can improve symptoms, exercise ability, and quality of life. About 30 adults with…

This study looks at whether a procedure to repair a leaky tricuspid heart valve can improve kidney function, reduce swelling, and boost physical activity in older adults. Researchers will follow 100 participants for changes in kidney health, walking ability, and daily function. T…

This study tests two different laser wavelengths (1470 nm and 1940 nm) for a procedure called laser crossectomy to treat varicose veins. The goal is to see which wavelength better prevents vein reflux from returning at the groin junction, while also checking for pain and side eff…

This trial tests a new device that clips together the leaflets of a leaky tricuspid valve, aiming to fix it without open-heart surgery. It will enroll 132 people with severe tricuspid regurgitation who are already on standard medications. The study compares the clip plus medicati…

This study looks at whether early surgery to repair or replace the aortic valve is better than waiting until symptoms appear in people with severe aortic regurgitation (a leaky heart valve). About 217 adults with no symptoms but severe valve leakage will be randomly assigned to e…

This Phase 3 trial tests whether a gel called TR987, applied to the skin, can help heal chronic leg ulcers caused by poor blood flow. About 312 adults with venous leg ulcers will receive either the gel plus standard wound care or standard care alone. The main goal is to see if th…

This study tests whether special wraps made from human placental membrane can help heal diabetic foot ulcers and venous leg ulcers that won't close on their own. About 50 adults with diabetes or venous disease will receive weekly applications of one of four placental membrane pro…

This trial tests a device called 'Pivot Bridge' for people with a severe leaky heart valve (tricuspid regurgitation). The device is inserted through a leg vein and sits in the valve to help it close better. It is only used for about a week. The study involves 20 adults who have a…

This study tests a new way to replace the aortic valve in people with severe aortic regurgitation (a leaky heart valve). About 180 patients will get either the new VitaFlow valve or another device through a tube in the leg. The goal is to see if the new valve is safe and effectiv…

This study tests whether using a simple urine test to guide the dose of a water pill (furosemide) can safely and effectively remove excess fluid after heart surgery. About 102 adults having heart surgery with a heart-lung machine will be randomly assigned to either standard care …

This study is testing whether adding rosuvastatin (a common cholesterol-lowering drug) to standard blood thinner treatment can lower the risk of another blood clot in people who have recently had a deep vein thrombosis or pulmonary embolism. About 2,700 participants will receive …

This study is testing a device called JenaValve Trilogy to replace the aortic valve without open-heart surgery in 75 people with severe aortic regurgitation (a leaky heart valve). Participants are at high risk for surgery. The main goal is to see if the device works safely and st…

This early study tests a new device called the Pivot Extend in 10 adults with severe tricuspid regurgitation (a leaky heart valve) who are too high-risk for surgery. The device is threaded through a vein in the leg to the heart, where it helps the valve flaps close tightly. The g…

This early study tests a new device called the Trisol System, which replaces the tricuspid valve using a tube inserted through blood vessels, avoiding open-heart surgery. It includes 30 adults with moderate or severe tricuspid regurgitation who have symptoms like shortness of bre…

This clinical trial is testing two different surgical methods to repair a bicuspid aortic valve, a common heart defect where the valve has two flaps instead of three. The study will enroll 100 people with this condition who also have a leaky valve (aortic regurgitation). Half wil…

This study is testing a new replacement valve for the tricuspid valve, which controls blood flow in the heart. The valve is made from natural materials and is designed to treat tricuspid valve disease in both adults and children. Researchers want to see if the valve can be safely…

This study tests whether a quick blood test (CT-ADP) can help doctors detect and fix leaks around a new heart valve during a minimally invasive TAVI procedure. Currently, doctors often use general anesthesia and an ultrasound probe in the throat to check for leaks, but this study…

This study tests whether a portable electronic stethoscope, combined with machine learning, can accurately detect valvular heart disease. About 125 people with and without the condition will use the device and also receive standard heart tests. Researchers will compare the device…

This study explores whether kinocardiography (KCG), a portable device that measures chest vibrations from heartbeats, can diagnose aortic valve disease and thoracic aortic aneurysm. Researchers will compare KCG readings with standard imaging in 180 adults, including those with an…

This study tests whether an artificial intelligence (AI) tool can diagnose aortic regurgitation—a leaky heart valve—more accurately than standard manual methods. About 540 adults with confirmed aortic regurgitation will be randomly assigned to either AI-assisted or traditional di…

This study compares two heart imaging methods—echocardiography (ultrasound) and cardiac MRI—to see which measures heart valve disease more accurately. Researchers will enroll 200 adults with suspected moderate or severe valve problems. The goal is to improve how doctors assess va…

This trial tests a device called the Pedal Pump, which moves the feet for 10 minutes to help reduce lower leg swelling (edema) in hospitalized patients. The study includes 60 adults with edema due to conditions like heart failure, kidney disease, or chronic venous insufficiency. …

This study tests whether a 3-week thermal spa treatment at the Saint-Eloy center can relieve symptoms of severe chronic venous insufficiency (a condition where leg veins have trouble sending blood back to the heart). About 84 adults with severe vein disease will receive either th…

This study is testing a new portable device called Dayspring that uses active compression to reduce leg swelling from lymphedema or phlebolymphedema. It will involve 100 veterans and measure cost savings, mobility, and symptom severity. The device is non-pneumatic, meaning it doe…

This study compares two treatments for varicose veins: foam sclerotherapy (injecting a foam to close the vein) and mechanochemical ablation (using a device and medication). Both are done with local anesthesia and allow quick recovery. 50 patients will be randomly assigned to one …

This study tests whether combining virtual reality with pleasant smells can lower pain and anxiety in people recovering from heart or lung surgery. About 80 adults scheduled for cardiothoracic surgery will either receive the VR-and-scent therapy or standard care. The goal is to s…

This study looks at whether different exercise programs can improve blood flow in the legs of older adults with poor circulation. About 425 participants will be split into groups doing either mixed exercise, high-intensity rowing, or vibration exercise for 12 weeks. The goal is t…

This study tests whether using virtual reality during varicose vein surgery can reduce pain and anxiety enough to avoid standard sedation. About 400 adults will either receive virtual reality or standard medication. The goal is to see if VR can make the procedure more comfortable…

This study aims to see if a common vein treatment called radiofrequency ablation is safe and helpful for people aged 80 and older with severe chronic venous insufficiency. About 50 participants will receive the procedure and be followed for 6 months. The goal is to measure how we…

This observational study will follow 50 adults and children who are starting long-term parenteral nutrition (IV nutrition) to measure the buildup of advanced glycation end-products (AGEs) in their skin. AGEs are harmful compounds that form when sugar binds with proteins, and they…

This study follows 141 adults with atrial fibrillation and moderate-to-severe functional mitral or tricuspid valve regurgitation (leaky valves). Researchers will use echocardiograms, exercise tests, and blood work to identify patterns and predict how the disease progresses over o…

This study looks at whether vein problems are linked to pain, swelling, and daily function in women with lipedema. Researchers will use ultrasound to check leg veins and ask participants about their symptoms. The goal is to better understand how these conditions interact, which c…

This study looks at 400 people with a first-time deep vein thrombosis (DVT) in the leg. Researchers want to see if the amount of clot seen on an ultrasound can predict who will develop post-thrombotic syndrome (PTS), a condition causing long-term leg pain, swelling, and skin chan…

This study is observing 400 adults with moderate or severe tricuspid regurgitation, a condition where a heart valve does not close properly. Researchers will track participants over time to learn how the disease progresses and what factors affect survival. No new treatments are b…

This study is for people getting a minimally invasive procedure to fix leaky heart valves. Researchers will use MRI scans to see how the heart changes shape and works better after the procedure. The goal is to learn which patients benefit most and why, helping doctors improve fut…

This study uses 3D echocardiography to track changes in the tricuspid valve of 66 people with atrial fibrillation (AF) who do not yet have significant valve leakage. Researchers want to see if the valve's shape changes as AF becomes more persistent. The goal is to better understa…

This study is a registry that collects information from routine care to see how well minimally invasive heart valve procedures work over 5 years. It includes adults over 18 who have had a transcatheter aortic valve replacement or similar treatment. No new treatments are given; th…

This study looks at whether people with hemorrhoids are more likely to have varicose veins in their legs. Researchers will use ultrasound to check the leg veins of 400 adults—200 with hemorrhoids and 200 without. No treatments or procedures are given; the goal is simply to see if…

This study looks at two ways to teach medical residents how to use a special ultrasound technique (VExUS) to check for fluid overload in patients with acute heart failure. About 23 residents will be trained either in-person or remotely, and their ultrasound skills will be compare…

This study tests whether artificial intelligence (AI) can help cardiologists read echocardiograms (heart ultrasounds) more quickly and consistently. Researchers will give AI analysis to doctors in real time as they review heart images from 50 participants with valve disease. The …

This study compares two methods—ultrasound (echocardiography) versus direct pressure measurements (catheterization)—to guide additional balloon inflation after valve-in-valve TAVR. About 310 people with failing surgical aortic valves will be randomly assigned to one method. The g…

This study tests a new system that uses a special bandage with electrodes to monitor how well venous leg ulcers are healing. The system measures electrical signals through the wound and sends data to a phone app. Twenty adults with chronic leg ulcers will be monitored up to three…

This study follows 200 adults who have had or will have a procedure to fix a leaky or narrowed valve in the right side of the heart. Researchers track survival, unplanned hospital stays, and heart function using blood tests and ultrasound. The goal is to learn which treatments wo…

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery. Researchers want to see how the surgery changes body composition and improves related health issues like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease. The go…

This observational study is testing whether a noninvasive finger imaging device can detect and evaluate two types of heart valve disease: aortic regurgitation and aortic stenosis. Researchers will record arterial waveforms from participants' fingers and see if the patterns can di…

This study aims to measure how often a heart valve leak (tricuspid regurgitation) develops or worsens after getting a pacemaker or defibrillator with a lead that crosses the valve. About 200 adults who need their first device will have heart ultrasounds before and after the proce…

This study aims to find biological differences between men and women with heart valve disease using advanced MRI techniques. Researchers will enroll 200 adults with moderate to severe aortic or mitral valve problems. The goal is to better predict how the heart recovers after valv…

This study is a large registry that will follow 10,000 people who have had a procedure called TAVR to replace a faulty heart valve. The goal is to see how patients do over the long term in everyday medical practice. No new treatment is being tested; instead, researchers are colle…

This study is following 10,000 adults with heart valve disease to see how their condition changes over time. Researchers will use scans, blood tests, and health records to track progression and the effects of treatments like surgery or medication. The goal is to better predict ou…

This study uses artificial intelligence to analyze data from 21,000 patients who had heart valve procedures. The goal is to make AI tools that can predict surgery outcomes, like which device to use and risks of complications, with over 90% accuracy. This is a non-interventional s…

This study looks at 48 people with chronic leg swelling to find out why some respond to compression therapy and others don't. Participants will have an MRI and genetic testing to measure fat, muscle, and fluid in their legs. The goal is to better understand the condition, not to …

This study involves 70 adults with severe heart valve disease who are already scheduled for a routine heart catheterization. Researchers will use special catheters to measure how well the right side of the heart works with the lungs. The goal is to see if simpler, non-invasive te…

This study from King's College London focuses on how to better identify early skin changes from chronic venous insufficiency (CVI) in people with dark skin tones. Researchers will interview patients about their experiences and test new assessment techniques, like using touch and …

This observational study will follow 1900 people with moderate mixed aortic valve disease (a combination of aortic stenosis and regurgitation) to see how symptoms and heart function relate to survival and the need for valve replacement. Researchers hope to identify which patients…

This study looks at fetal cells that remain in a mother's blood after pregnancy, called fetal microchimeric cells, in women with chronic skin ulcers like venous or diabetic ulcers. Researchers will analyze these cells' genetic activity to see if they might help with wound healing…

This global registry will follow 800 patients receiving a new, less-invasive tricuspid valve replacement (TTVR) for leaky heart valves. Researchers aim to track complications like pacemaker needs and how well the valve works over time. The study does not test a new drug but gathe…

The European Venous Registry (EVeR) is collecting data from 100 patients with deep vein disease in the legs to track how different treatments work over 10 years. Researchers will measure symptoms and quality of life to find out which approaches are most effective. This is an obse…