Should you fix a leaky heart valve early? new study seeks answers

NCT ID NCT05438862

Recruiting now Disease control Sponsor: Na Homolce Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether early surgery to repair or replace the aortic valve is better than waiting until symptoms appear in people with severe aortic regurgitation (a leaky heart valve). About 217 adults with no symptoms but severe valve leakage will be randomly assigned to either early surgery or standard watchful waiting. The goal is to see which approach better preserves heart function and prevents serious events like heart failure or stroke.

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Conditions

The condition(s) this trial relates to.

aortic valve insufficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC VALVE REGURGITATION

Contacts and locations

Locations

2nd Department of Internal Cardiovascular Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague
RECRUITING

Prague, 128 08, Czechia
Cardiovascular Center OLV Clinic Aalst
RECRUITING

Aalst, 9300, Belgium
Center of Cardiovascular and Transplant Surgery
RECRUITING

Brno, 65691, Czechia
International Clinical Research Center, St. Anne´s University Hospital Brno
ACTIVE_NOT_RECRUITING

Brno, 656 91, Czechia
Na Homolce Hospital
RECRUITING

Prague, 150 30, Czechia
Nemocnice AGEL Třinec-Podlesí
RECRUITING

Třinec, 73961, Czechia
University Clinical Center of Serbia
RECRUITING

Belgrade, 11000, Serbia
University Hospital Hradec Králové
RECRUITING

Hradec Králové, 50005, Czechia

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