Vascular insufficiency disorder

This study tests whether injecting botulinum toxin (Botox) into fat pads around the heart's veins during cardiac surgery can prevent atrial fibrillation (AFib), a common and serious complication. About 220 adults undergoing heart surgery will receive either Botox or a placebo inj…

This early study tests a new procedure called TRAIPTA for people with severe tricuspid valve regurgitation, a condition where a heart valve leaks and causes breathlessness and fluid buildup. The procedure uses a catheter to place a belt-like device around the heart from inside, t…

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This Phase 3 study tests a weekly injection called retatrutide in about 1,946 people with severe obesity (BMI ≥35) and established heart disease. The goal is to see if it helps with weight loss and improves heart-related health measures over 113 weeks compared to a placebo. Parti…

This phase 3 trial compares two laser wavelengths (1940 nm vs 1470 nm) for closing off faulty veins in people with symptomatic varicose veins. 220 adults will be randomly assigned to one laser or the other. The main goal is to see which laser achieves complete vein closure at 6 m…

This study tests whether a weekly injection of CagriSema (a combination of two drugs) can reduce the risk of heart attacks, strokes, and other heart-related events in people with established cardiovascular disease. About 7,100 participants will receive either CagriSema or a place…

This early study tests a new device called the Cook® Venous Valve System in just 4 people with chronic venous insufficiency (leg veins that don't pump blood back to the heart properly). The valve is implanted through a small tube into a deep leg vein to help blood flow one way. T…

This study is tracking 511 patients with severe tricuspid regurgitation who are treated with the Abbott TriClip device in real-world settings. The main goal is to see if the device can successfully reduce the valve leak by at least one grade at discharge. Researchers are also mon…

This study planned to test a new device called the Cardiovalve for people with severe tricuspid regurgitation (a leaky heart valve). The goal was to see if the device could safely replace the valve and reduce leakage. However, the study was withdrawn before any participants were …

This study tests a new device called the Cardiovalve TR system for people with a leaky tricuspid heart valve (tricuspid regurgitation). The goal is to see if the device is safe and can reduce the leak. The study involves 157 participants with moderate to severe symptoms. Research…

This study looks at 3,500 people with severe tricuspid regurgitation, a common heart valve problem in older adults. It compares medical therapy (diuretics), surgery, and a less invasive transcatheter procedure to see which works best and when to treat. The goal is to improve surv…

This study is testing a custom-made artificial heart valve, called TRICENTO, in 15 people with carcinoid heart disease who have severe leakage of the tricuspid valve and cannot have surgery. The valve is delivered through a catheter, avoiding open-heart surgery. The goal is to se…

This study is testing a device called the Edwards Cardioband FIT, which is used to repair the tricuspid valve in people with tricuspid regurgitation (a leaky heart valve). The device is delivered through a catheter, avoiding open-heart surgery. The trial includes 75 participants …

This study is testing a new device called the Edwards EVOQUE system, which replaces the tricuspid valve using a thin tube (catheter) instead of open-heart surgery. The trial includes 228 people with moderate or severe tricuspid regurgitation who still have symptoms despite medica…

This early study is testing a new device called the DurAVR™ THV System, which is a replacement heart valve placed through a small tube in the leg (TAVI procedure). The study includes 40 people with severe aortic stenosis or a failed surgical valve. The main goal is to see if the …

This phase 3 trial tests whether a monthly injection of pelacarsen can reduce major heart problems like heart attacks and strokes in people with high levels of Lp(a), a genetic risk factor. Over 8,000 participants with existing heart disease are being followed for several years. …

This study is testing a new surgical heart valve (Model 400) in over 1,300 people with aortic valve disease. The valve is designed to replace the damaged aortic valve and improve blood flow. Researchers are checking how safe the valve is and how well it works over one year, looki…

This trial is testing a new stent (a small mesh tube) to treat blockages in the large vein in the abdomen (inferior vena cava) and nearby leg veins. The study involves 136 adults with symptoms like leg ulcers, pain, or swelling. Doctors will place the stent to keep the vein open …

This study compares two surgical techniques—flexible band and rigid ring—to repair a leaky tricuspid heart valve. About 300 adults with tricuspid regurgitation will be followed to see which method better prevents the need for repeat surgery, worsening of the leak, or death. The g…

This large study is testing whether a lower blood pressure target can reduce major heart problems like heart attacks, strokes, and heart failure in people with type 2 diabetes. About 9,500 participants with high blood pressure and high cardiovascular risk are being randomly assig…

This study compares two types of TAVI valves (Edwards and CoreValve Evolut) in 102 people with small, failing surgical aortic valves. The goal is to see which valve leads to fewer problems like high pressure or leakage after the procedure. Results could guide doctors in choosing …

This study compares two ways to replace a narrowed heart valve in elderly patients (65+) who have a small valve opening. One method is less invasive (TAVR, through a tube in an artery), the other is open-heart surgery. The goal is to see which approach gives better blood flow and…

This study tests a device that uses radiofrequency energy to close off damaged veins in the legs, helping blood flow better and easing symptoms like pain and swelling. About 200 adults with chronic venous insufficiency are taking part. The main goals are to see if the treated vei…

This study tests a new device called LuX-Valve Plus, which is a replacement heart valve delivered through a vein, for people with severe tricuspid regurgitation (a leaky heart valve). The 15 participants have symptoms and are not candidates for surgery. The goal is to see if the …

This study tests a new device called EVOQUE that replaces the tricuspid valve in people with severe leakage (tricuspid regurgitation). The goal is to see if it is safe and can reduce leakage, improve symptoms, and enhance quality of life compared to standard medical therapy alone…

This study tests whether a device called Sonablate can safely use high-intensity focused ultrasound (HIFU) to treat vein problems like varicose veins, leg ulcers, and certain birth defects. About 30 adults with these conditions will receive the treatment, which does not involve c…

This study tests whether using 3D simulation before a minimally invasive aortic valve replacement helps doctors place the valve more accurately. It involves 354 adults aged 65 and older with severe aortic regurgitation (a leaky heart valve). Participants are randomly assigned to …

This study tests a special plug device to close leaks that can form around surgically implanted heart valves. These leaks can cause serious problems like heart failure or anemia. The procedure is done through a catheter, avoiding the need for another open-heart surgery. The study…

This study tests whether a catheter-based procedure can reduce the severity of post-thrombotic syndrome (PTS) — a painful, long-term leg condition that can follow a deep vein clot. About 225 adults with disabling PTS and a blocked iliac vein will receive either the procedure plus…

This study tests whether giving patients capsules containing gut bacteria (called Probacine) before and after heart surgery can reduce gut injury and organ failure. Researchers will enroll 500 adults undergoing cardiovascular surgery. The goal is to see if changing the gut microb…

This study tests whether enavogliflozin, a diabetes drug, can improve outcomes in people with heart failure and a leaky tricuspid valve. About 541 participants will receive either the drug or a placebo for 18 months. Researchers will track heart-related events, valve worsening, a…

This study tests a special dressing called EDX110 on 43 people with hard-to-heal wounds from diabetes or poor leg circulation. The dressing creates a gas called nitric oxide to help clean and heal the wound. Researchers will measure how much the wound shrinks over 12 weeks and ho…

This study is testing whether a donated mitral valve can safely replace a diseased tricuspid valve in 30 patients with primary tricuspid valve disease. The goal is to see if this approach is safe and works well in the short term. Researchers will track complications like bleeding…

This program allows individual patients with vascular disease or end-stage kidney disease on dialysis to request an experimental lab-grown blood vessel (ATEV) if they have no other treatment options and cannot join a clinical study. The vessel is designed to replace or bypass dam…

This study explores whether a simple, non-invasive leg movement test can measure blood vessel health in older adults. Researchers will use ultrasound to track blood flow changes after a passive leg movement, comparing young healthy people and older patients undergoing heart tests…

This large study tested whether taking daily vitamin D3 and omega-3 (fish oil) supplements can lower the risk of developing cancer, heart disease, or stroke. Over 25,000 healthy older adults (men 50+, women 55+) took the supplements or placebos for about 5 years. The goal is to s…

This study tests whether kinesio taping (a special elastic tape) and interval exercise (short bursts of activity) can help people with mild chronic venous insufficiency feel better and improve their quality of life. About 33 adults aged 18 to 65 will be split into three groups: o…

This study tests whether wearing a virtual reality headset during laser treatment for varicose veins can lower anxiety and pain. About 100 adults will use VR during the procedure, and researchers will measure their heart rate, blood pressure, and comfort levels. The goal is to se…

This study tests a nurse-led education program designed to help women in cardiac rehab address sexual concerns after a heart event. Sixty-six women will be randomly assigned to either the program or usual care. The goal is to see if the program improves sexual function, mood, and…

This study looks at whether adding pelvic floor exercises to a regular exercise program and compression stockings can improve symptoms, blood flow, and quality of life in people with chronic venous insufficiency (a condition where leg veins have trouble sending blood back to the …

This study looks at whether wearing compression stockings for a longer time after foam sclerotherapy (a treatment for varicose veins) can reduce skin darkening (hyperpigmentation) above the treated veins. About 140 adults with varicose veins will be followed for 28 days after the…

This study follows 100 people with and without varicose veins to see how often the condition appears and how it changes over time. Participants get yearly checkups including ultrasound exams. The goal is to learn what factors make vein disease worse and how it naturally progresse…

This study tracks 120 adults with heart disease and at least two other long-term illnesses to see how often dangerous drug interactions happen. Researchers check medications, including over-the-counter and herbal products, and follow participants for a year. The goal is to unders…

This study collects tissue samples from 1,000 people having heart valve surgery to find genetic causes of calcific aortic valve disease. Researchers will compare normal and diseased tissue to understand why the disease develops. Participants must be at least 20 years old and have…

This study collects data from 1,200 patients undergoing surgery for aortic dissection, a life-threatening tear in the heart's main artery. Researchers will track death rates, strokes, and other complications to identify the safest surgical strategies. The goal is to improve outco…

This study looks at whether a special MRI scan can detect early scarring in the heart muscle of people with leaky heart valves. The goal is to find a way to predict when the heart might start to fail, so doctors can decide on surgery sooner. About 316 adults with moderate to seve…

This study tracks over 1,700 heart patients who had hip or knee replacement surgery. Researchers want to see how often bleeding or blood clots happen in the months after surgery. The goal is to find better ways to prevent these complications.

This study will observe 200,000 Chinese adults with heart disease to see how their heart and lung function changes over 5 years. Participants will take a special exercise test to measure their fitness. Researchers hope to find better ways to predict future heart problems like hea…

This study investigates chronic mesenteric ischemia, a condition where blood flow to the gut is reduced, causing pain. Researchers will measure oxygen levels in the stomach and small intestine using a special scope before and after treatment. The goal is to better understand the …

This study follows 2000 people with dilated cardiomyopathy (a weakened, enlarged heart) over several years to learn how genetics and heart scarring affect the disease. Participants give blood for genetic testing and have heart MRI scans. The goal is to improve diagnosis and pave …

This study planned to compare virtual clinic visits (using video calls on tablets) with in-person visits for people with vascular diseases. Doctors would classify patients as low, moderate, or high risk for treatment after each visit type. The goal was to see if virtual visits co…

This study looks at how the heart changes after a procedure to replace a leaky tricuspid valve in people with severe heart failure who cannot have open-heart surgery. It focuses on patients who develop unstable blood pressure right after the procedure. Researchers will track surv…

This study looks at how being in a hospital intensive care unit (ICU) after heart surgery affects your body's natural sleep-wake cycle. Researchers will track sleep patterns and thinking ability in 15 adults to see if disrupted rhythms slow down recovery. The goal is to understan…

This study aimed to see if using a special pad along with a standard closure device could help patients get out of bed sooner after a heart catheterization. It was planned for adults having the procedure through the groin. However, the study was withdrawn before any participants …

This study follows 347 heart surgery patients to understand why some develop swallowing problems (dysphagia). Researchers will use special camera tests to watch how patients swallow and look for risk factors. The goal is to create simple tools that doctors can use at the bedside …

This study is following 10,000 adults who are having a heart MRI for medical reasons. Researchers want to see if the MRI results can help predict who will have heart problems in the future, like heart attacks or heart failure. The goal is to better understand how MRI scans can gu…

This study aimed to create a 12-month profile of patients admitted for vascular surgery at University Hospital Limerick in Ireland. The goal was to understand patient characteristics like frailty and other health conditions to improve hospital services and reduce length of stay. …

This study looks at whether a pneumatic compression device can improve lymphatic function in people with leg swelling from chronic venous disease. 34 participants will be split into two groups: one gets standard compression bandages, the other adds daily pneumatic compression at …