New heart valve device could help patients with heart pumps avoid open surgery

NCT ID NCT06594705

Recruiting now Disease control Sponsor: JenaValve Technology, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing a new heart valve device (JenaValve Trilogy) placed through a tube in an artery, without open surgery. It is for 50 adults who have a mechanical heart pump (LVAD) and also a leaky aortic valve that makes the pump work less effectively. The goal is to see if the device is safe and works well to fix the leak.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

JenaValve Trilogy Heart Valve System (a replacement heart valve delivered through a catheter)

What this could lead to

If this works, it could provide a less invasive way to fix a leaky aortic valve in people who already have a heart pump, potentially improving their heart function and quality of life.

What could go wrong

This is a small, early-stage study with only 50 participants, so results may not apply to everyone. The procedure carries risks like bleeding, stroke, or the new valve not working as intended.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

Aortic Valve Disease aortic valve disorder aortic valve insufficiency left ventricular failure Ventricular Dysfunction, Left

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AORTIC INSUFFICIENCY AORTIC REGURGITATION AORTIC VALVE DISEASE AORTIC VALVE INSUFFICIENCY LEFT VENTRICULAR DYSFUNCTION

Contacts and locations

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Study contacts

Contact

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Contact

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Locations

Advocate Christ Medical Center
RECRUITING

Oak Lawn, Illinois, 60453, United States
Baylor
RECRUITING

Plano, Texas, 75024, United States
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Columbia University Medical Center/New York-Presbyterian Hospital
RECRUITING

New York, New York, 10032, United States
Emory University
RECRUITING

Atlanta, Georgia, 30308, United States
Henry Ford Hospital
RECRUITING

Detroit, Michigan, 48202, United States
Houston Methodist Research Center
RECRUITING

Houston, Texas, 77030, United States
Intermountain
RECRUITING

Murray, Utah, 84107, United States
Medstar Washington Hospital Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Minneapolis Heart Institute Foundation
RECRUITING

Minneapolis, Minnesota, 55407, United States
Piedmont
RECRUITING

Atlanta, Georgia, 30309, United States
Sentara Norfolk General Hospital
RECRUITING

Norfolk, Virginia, 23507, United States
Sutter Health
RECRUITING

San Francisco, California, 94109, United States
University of Michigan
RECRUITING

Ann Arbor, Michigan, 48109, United States
Washington University, St. Louis
RECRUITING

St Louis, Missouri, 63130, United States