Traumatic brain injury

This pilot study tested a standardized 5-step weaning procedure to safely remove tracheostomy tubes in 30 brain-injury patients. The procedure involves steps like deflating the tube cuff and using a speaking valve, with a team of doctors and nurses monitoring stability. The goal …

This study tested a freeze-dried plasma product that can be mixed with water in 6 minutes, avoiding the long thaw time of standard plasma. It included 42 trauma patients with severe bleeding who needed blood transfusions. The goal was to see if faster plasma delivery could improv…

This study looked at over 2,000 trauma patients who needed help breathing before arriving at the hospital. Half were given a supraglottic airway device (like an LMA or King tube) first, while the other half received standard care. The goal was to see which approach led to more pa…

This pilot study tested whether adding a special type of electrical stimulation to standard wound care helps heal chronic pressure injuries (bedsores) in people with spinal cord or brain injuries. Twenty adults with stage II-IV pressure sores that hadn't healed after four weeks o…

This study looked at whether a ketogenic or modified Atkins diet can help people recover from moderate to severe traumatic brain injury. The diet aims to change how the brain uses energy, potentially improving function. Twenty-one participants were enrolled, and researchers measu…

This study tested whether stem cells taken from a patient's own fat and given by IV are safe and might help the brain heal after a traumatic brain injury. 24 adults with long-term brain damage received the treatment. Researchers checked vital signs and measured inflammation marke…

This study tested whether adding two drugs—cerebrolysin and amantadine sulfate—to standard care helps people with moderate to severe traumatic brain injury recover in the ICU. 150 adults aged 18-70 took part. Researchers measured consciousness, disability, and recovery over 6 wee…

This study tested whether using the World Health Organization's trauma care checklist helps injured patients recover better. Sixty adults with trauma were randomly assigned to standard care or care with the checklist. Researchers measured pain, injury severity, complications, and…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study looked at whether measuring two proteins in the blood (GFAP and UCH-L1) can help doctors safely avoid CT scans in children with mild traumatic brain injury. Over 1,500 children across Europe participated. The goal was to see if these blood tests are accurate enough to …

This study tested whether a bedside ultrasound (POCUS) can accurately detect skull fractures in children aged 2-18 with mild closed head injuries. Researchers enrolled 95 children in the emergency department and compared ultrasound results to CT scans. If effective, this approach…

This study tested whether measuring a protein called S100B in the blood can help doctors decide if a child with a mild head injury needs a CT scan. Over 2,200 children were assigned to either standard care or care guided by the S100B test. The goal was to see if the test could sa…

This study tested whether a special ultrasound of the eye's main artery can help doctors diagnose increased pressure inside the skull. Researchers measured blood flow in the central retinal artery of 66 patients with stroke or traumatic brain injury. The goal was to see if change…

This study tested a blood test called VIDAS TBI on 903 adults with mild head injuries in the emergency room. The test measures two brain proteins to see if it can reliably rule out brain damage. If it works well, it could help doctors decide who truly needs a CT scan, saving time…

This study tested a handheld device that uses near-infrared light to quickly detect bleeding inside the skull after a head injury. Researchers compared the device's results to CT scans in 180 patients in Uganda. The goal was to see if this portable tool could help diagnose brain …

This study tested whether a special goggle system (Neurolign Dx_100 I-PAS) and standard tests can reliably detect mild traumatic brain injury (concussion) in people who recently had a head injury. Researchers compared 161 people with concussions to those with minor injuries. The …

This study tested whether measuring S100B protein levels in the blood can safely rule out serious brain injuries in adults with minor head trauma who take antiplatelet drugs (blood thinners). 720 participants had a blood test upon arriving at the emergency room, followed by a CT …

This study looked at whether measuring two proteins in the blood (GFAP and UCH-L1) can safely tell doctors when an older adult with a mild head injury does not need a CT scan. Over 2,200 participants aged 65 and older were enrolled. The goal is to reduce unnecessary radiation and…

This study tested whether an ultrasound of the optic nerve sheath (the lining around the nerve connecting the eye to the brain) can accurately detect dangerously high pressure inside the skull in children. Researchers measured the nerve sheath diameter in 230 children with brain …

This study tested a portable device called the Infrascanner that uses light to check for expanding brain bleeds in people with traumatic brain injury. About 400 participants who had a head injury and a brain bleed seen on a CT scan were monitored hourly with the scanner. The goal…

This study tested whether a portable goggle system with eye-tracking technology can accurately diagnose mild traumatic brain injury (mTBI) in community settings like emergency rooms. Researchers enrolled 120 adults aged 18-50 who had a head injury with symptoms. The goal was to s…

This pilot study tested a non-invasive device that stimulates the vagus nerve (nVNS) in patients hospitalized with mild-to-moderate traumatic brain injury. The goal was to see if adding nVNS to standard care could prevent severe lung inflammation and the need for a breathing mach…

This study tested whether a 3-month home exercise program on an elliptical machine and 3 months of bright light therapy could improve movement, balance, and mood in adults with traumatic brain injury. Thirty-four participants (including healthy volunteers) were enrolled. The goal…

This study looked at whether a 12-week treadmill exercise program can improve cardiorespiratory fitness, reduce fatigue, and boost mood in people with traumatic brain injury (TBI). Thirteen physically inactive adults with TBI walked on a treadmill three times a week for 30 minute…

This study tested a home-based program to help aging veterans with a history of traumatic brain injury (TBI) improve their thinking skills, such as attention and planning. Twenty-nine veterans aged 65 and older used telehealth technology to complete cognitive exercises from home.…

This study tested whether a guided, telehealth-based aerobic walking program could improve thinking, mood, and quality of life in people who had a traumatic brain injury (TBI). Researchers enrolled 112 participants and measured changes in brain blood flow, walking ability, and me…

This study tested whether a device that gently stimulates a nerve in the ear, used at home for one hour a day over two weeks, could help improve thinking and memory in people with mild to moderate traumatic brain injury. Seven adults took part to see if the treatment was practica…

This study tested a 20-minute neck-strengthening program in 50 amateur rugby players to see if it could speed up their neck muscle reactions to head impacts. The program used isometric contractions and stroboscopic glasses to improve visual processing and reflex force. Researcher…

This study tested three different treatment approaches for teens aged 13-19 who had a concussion within the past three weeks and were still experiencing moderate to severe symptoms like headaches, dizziness, and neck pain. The goal was to see if early, symptom-specific treatments…

This study tested whether guided emotional and sensory stimulation from family members could help coma patients with traumatic brain injury recover. 120 patients were split into two groups: one received standard care, the other added structured family interaction like talking, ge…

This small pilot study looked at whether a single yoga-based physical therapy session could improve heart rate variability (a measure of stress resilience) in people with traumatic brain injury. Thirteen adults participated in three different activities on separate days: yoga the…

This study tested a new memory training program for people who have memory problems after a brain injury (like a stroke or head injury). Six participants either received standard treatment or a shorter program that included a special memory game to practice at home. The goal was …

This study tested whether giving N-Acetylcysteine (a supplement) along with multivitamins and minerals can help older adults (60+) recover from a traumatic brain injury. The goal was to see if it reduces thinking, emotional, and physical symptoms like headaches or memory problems…

This study tested whether a social robot could reduce fear and pain in children aged 5 to 10 during wound dressing. Sixty children were split into two groups: one interacted with the robot while getting their wound dressed, and the other received standard care. Researchers measur…

This small study tested whether shining special LED lights on the head could help veterans with mild traumatic brain injury (TBI) and PTSD think more clearly and feel better. Eight veterans received the noninvasive light treatment, and researchers measured changes in memory, atte…

This study tested a structured cognitive rehabilitation program in 77 veterans and active-duty personnel who had mild traumatic brain injury from blasts. The program aimed to improve thinking skills and quality of life. Participants were aged 21 to 50 and had brief loss of consci…

This study tested whether taking creatine monohydrate daily for seven weeks could reduce persistent symptoms after a mild concussion. 34 adults aged 20-45 who had symptoms for 6-18 months took part. The results showed no clear benefit compared to placebo or usual care, but the st…

This study tested a special nursing approach, called the Tidal Model, to help caregivers of people with traumatic brain injury. 18 caregivers took part and the program aimed to reduce their anxiety, depression, and burnout. The approach focused on understanding each caregiver's p…

This study tested whether prazosin, a drug used for high blood pressure and PTSD nightmares, can reduce headaches in veterans and service members who had a mild traumatic brain injury. 89 participants received either prazosin or a placebo for 12 weeks. Researchers tracked headach…

This study tested whether buspirone (Buspar), a drug used for anxiety, can reduce irritability and aggression in people who have had a traumatic brain injury. 81 adults with a closed head injury at least 6 months prior took either buspirone or a placebo for 91 days. The goal was …

This study tested a gentle electric current (tDCS) on the brain to see if it could help people with a past traumatic brain injury find words more easily. Fourteen adults with long-term word-finding problems took part. They received either real or fake stimulation while doing memo…

This study looked at whether giving a low dose of ketamine continuously could lower the amount of strong painkillers (opioids) needed by people with serious injuries. The goal was to see at least a 25% reduction in opioid use over 48 hours while still controlling pain just as wel…

This small study tested whether a gentle electric current applied to the scalp (tDCS) could improve word-finding in 5 civilians who had a traumatic brain injury more than a year ago. Participants received both real and sham stimulation to see if the real treatment boosted verbal …

This study tested a robotic leg brace called the ABLE Exoskeleton in 14 people with acquired brain injury (including stroke). Participants used the device during 10 walking training sessions over up to 6 weeks. The main goals were to see if the device is safe and easy to use, and…

This study tested a personalized magnetic brain stimulation therapy called MeRT for people with PTSD. 158 adults received either real or sham treatment. The goal was to see if MeRT could safely reduce PTSD symptoms. The approach tailors the stimulation to each person's brain wave…

This study tested whether giving lidocaine as a mist before suctioning the breathing tube can prevent dangerous spikes in brain pressure in children with severe traumatic brain injury. Ten children in the pediatric ICU received either nebulized lidocaine, lidocaine dripped into t…

This study tested whether a device that delivers a very mild electrical current to the scalp could improve memory in 26 older adults with mild cognitive impairment and a past traumatic brain injury. Participants received ten sessions of either real or fake stimulation to a brain …

This study tested a mobile app called Back2Play that guides youth through step-by-step return to school and physical activity after a concussion. Researchers wanted to see if using the app reduces symptoms, speeds up recovery, and lowers the chance of getting another concussion. …

This small study tested a technique called acute intermittent hypoxia (AIH) — breathing low-oxygen air for short periods — to see if it could improve swallowing safety in people with chronic mild-to-moderate traumatic brain injury (TBI). Five adults completed the study, which com…

This study tested whether taking branched-chain amino acids (BCAAs) can improve sleep and thinking in veterans who have had a mild traumatic brain injury. 160 veterans were randomly assigned to receive different doses of BCAAs or a placebo for 12 weeks. The main goal was to see i…

This study looked at whether different types of physical exercise can help adults recover from a mild traumatic brain injury (concussion). 37 adults who had a concussion within the past year took part in a 3-month program of either balance or aerobic exercises. Researchers measur…

This study tested a program called ABC ANSWERS for veterans with Alzheimer's disease or traumatic brain injury and their informal caregivers (family or friends). The program added extra support and education to regular primary care. Researchers measured changes in quality of life…

This study tested a nerve block (stellate ganglion block) combined with either dexmedetomidine or low-dose ketamine to treat 'neurostorm' — a dangerous overreaction of the body's stress system after a traumatic brain injury. The goal was to calm symptoms like high blood pressure,…

This study tested a distance-learning program for family caregivers of people with Alzheimer's dementia or traumatic brain injury. The goal was to reduce care-resistant behaviors like agitation and aggression, and improve quality of life for both patients and families. 88 caregiv…

This study tested whether an online program combining cognitive exercises and mindfulness training could help soldiers and veterans with mild traumatic brain injury (TBI) improve their memory, attention, and thinking speed. Twenty-three participants used either a specialized brai…

This study tested whether using a touch screen device (BITS) can improve visual field awareness in people recovering from a stroke or brain injury. 37 adults in inpatient rehab were assigned to either standard pen-and-paper vision exercises or exercises on the BITS touch screen. …

This study tested whether virtual reality (VR) exercises can improve memory and thinking in adults aged 65 and older who had a mild traumatic brain injury. Thirty participants used VR at home for six weeks. The goal was to see if VR could help with attention, memory, and visual s…

This study tested whether cannabidiol (CBD) can improve thinking, mood, and other symptoms in people who have had a traumatic brain injury (TBI). 43 adults with mild or moderate TBI took either CBD or a placebo for 12 weeks. Researchers measured changes in cognition, neuropsychia…

This study tested a short talk therapy called behavioral activation for veterans with traumatic brain injury (TBI) and depression. About 46 veterans took part, with some receiving the therapy plus usual care and others only usual care. The goal was to see if the therapy was pract…

This study tested whether adding ear acupuncture (auricular thumbtack needle therapy) to standard care and nerve stimulation could help people with traumatic brain injury regain consciousness. Sixty patients with a Glasgow Coma Scale score of 4-8 were randomly assigned to receive…

This completed study tested two different anesthetic drugs—dexmedetomidine and sufentanil—in 28 people having surgery for traumatic brain injury. The goal was to see which one keeps the brain's oxygen levels more stable during and after the operation. Researchers measured oxygen …

This study tested a 12-session telemedicine support group for people with brain injuries and their caregivers. The group taught coping skills and emotional support to improve confidence and well-being. Only 13 people took part, so the results are preliminary but suggest remote su…

This study tested a free service called Resource Facilitation for people with traumatic brain injury (TBI). Participants worked one-on-one with a specialist to set goals and connect with services. The goal was to see if this support improves quality of life and reduces disability…

This study tested a 12-week telemedicine coping skills group for brain injury survivors and their caregivers. Participants learned strategies to manage stress, depression, and communication challenges. The goal was to see if a virtual format could be as effective as in-person ses…

This completed pilot study tested whether a gentle brain stimulation technique called tDCS, combined with computer-based cognitive training, can improve attention and working memory in 56 active-duty service members who had a mild traumatic brain injury at least 6 months earlier.…

This study tested a new device called Incremental Velocity Error (IVE) that uses a headband to help retrain the brain's balance system. It compared the device to standard eye and head exercises in 24 adults with dizziness from mild traumatic brain injury or inner-ear nerve damage…

This study looked at whether walking with a therapy dog helps adult trauma patients move more during their hospital stay. Sixty-four patients each took two walks—one with a dog and one without—and reported their pain, anxiety, and motivation. The goal was to see if animal-assiste…

This study tested whether a high-intensity exercise program, run by physical therapy students, can help people with neurologic disabilities move better in everyday life. Fifteen participants with conditions like cerebral palsy, stroke, or spinal cord injury completed the program.…

This study looked at whether a non-invasive brain training method called neurofeedback can help veterans who have had a mild traumatic brain injury and still suffer from chronic headaches, trouble sleeping, and attention problems. 87 veterans were randomly assigned to receive neu…

This study tested a workshop called STEP-Home for 221 post-9/11 Veterans who had trouble reintegrating into civilian life. The workshop taught skills like emotional control, problem solving, and attention to improve daily function and reduce anger. It was designed as a non-stigma…

This study tested an experimental drug called AVP-786 in 168 people with traumatic brain injury who had symptoms like aggression, agitation, and irritability. The goal was to see if the drug could safely reduce these difficult behaviors. Participants received either the drug or a…

This study tested whether a program that combines talk therapy, brain training, and healthy lifestyle advice is practical and helpful for people with conditions like mild traumatic brain injury, multiple sclerosis, long COVID, or mild cognitive impairment. Fifteen participants we…

This study tested a personalized treatment plan for people with mild traumatic brain injury (concussion) that targets specific symptoms like anxiety, headaches, vision problems, and sleep issues. 169 adults with recent concussions were assigned to either the targeted treatment or…

This study tested a one-day life skills workshop for veterans with mild traumatic brain injury, chronic pain, and mental health conditions like PTSD and depression. The workshop taught coping strategies to reduce distress and improve reintegration into civilian life. 176 veterans…

This study tested whether playing an immersive video game called Bandit the Dolphin could improve thinking and movement in adults who had a traumatic brain injury years ago. The game involves moving your arms to control a dolphin in an ocean environment, combining physical and me…

This study tested a 12-week exercise program set to music for adults with physical disabilities like spinal cord injury, stroke, or Parkinson's disease. Participants exercised three times a week via video calls, doing movements adapted to their ability. The goal was to see if the…

This study looked at whether the drug tolcapone can help veterans with mild traumatic brain injury improve memory and self-regulation. Fifty-five veterans underwent brain scans and cognitive tests while taking either tolcapone or a placebo. The goal was to see if the drug changes…

This study tested whether personalized rehabilitation treatments help adults with persistent concussion symptoms better than usual care. 40 participants received either individualized therapy (aerobic exercise, mindfulness, or physical therapy) or standard care for 6 weeks, then …

This study tested whether sitting in front of a bright lightbox for an hour each morning could improve sleep, reduce pain, and boost quality of life in 77 veterans with chronic mild traumatic brain injury (mTBI). Participants used either a lightbox or a negative ion generator (pl…

This study looked at whether teaching military members to train service dogs can improve symptoms of PTSD, anxiety, depression, and concussion. 156 participants spent one hour twice a week working with professional dog trainers. Researchers measured changes in stress, mood, sleep…

This study looked at 886 adults with suspected traumatic brain injury to better understand how the brain changes after injury. Participants had MRI scans, blood tests, and thinking tests within 48 hours of injury, with optional follow-ups up to a year. The goal was to find better…

This study did not test any treatment. Instead, it screened over 1,300 adults with traumatic brain injury (TBI) or post-concussive symptoms to create a database for future research. Participants provided medical history, blood samples, MRI scans, and brain function tests. The goa…

This completed study tested whether brain wave recordings (event-related potentials) can detect cognitive processing in people with brain injuries, including those with altered consciousness. Researchers compared 320 patients and healthy adults using high-density EEG. The goal wa…

This study looked at how receiving rehabilitation services at home (telerehabilitation) versus in a clinic affects the well-being and quality of life of people recovering from a traumatic brain injury. Five participants were followed for four months, completing questionnaires abo…

This study looks at two ways to give oxygen to people with acute brain injury after their breathing tube is removed. One method uses a high-flow nasal cannula, which delivers warm, moist oxygen through the nose. The other is conventional oxygen therapy, like a face mask or nasal …

This study looked at blood and saliva samples from 260 people, including those with traumatic brain injuries, to find protein markers that appear before dangerous pressure builds up inside the skull. The goal is to see if a simple blood test could warn doctors early. No treatment…

This study aims to create a simple bedside tool that helps doctors quickly identify motorcycle accident victims with chest injuries who are at high risk of dying. Researchers will analyze data from 1250 patients to build and test the tool, focusing on factors like helmet use and …

This study looked for protein markers in the blood and saliva of 96 people with long-term traumatic brain injury (TBI). Researchers compared samples from blast injury and non-penetrating injury patients to find common changes. The goal is to better understand the lasting effects …

This completed study looked at 510 trauma patients who had no signs of nerve damage. Researchers wanted to see if getting a full-body CT scan actually changed how doctors managed their care. The goal is to find out if these scans are truly helpful or just add cost and time.

This study tested whether a special sound stimulation (a tone pulsed at 40 times per second) could detect and improve brain function in veterans who were exposed to blasts. Researchers measured brain waves before and after the stimulation in 5 veterans. The goal was to see if thi…

This completed study tested a standard way to select seriously brain-injured patients who might become brain dead within 48 hours. Researchers tracked 83 patients in intensive care to see how many progressed to brain death. The goal was to improve the process for organ donation c…

This study looked at 55 adults with arm or leg injuries to see if using a tourniquet before reaching the hospital made a difference. Researchers compared those who had a tourniquet placed to those who did not, checking for shock, blood transfusions, and other complications. The g…

This study looked at 265 severely injured adults in France to see if getting them to the hospital within the recommended 60 minutes (the 'golden hour') improves their chances of survival. Researchers checked if following these time guidelines helped patients live at least 24 hour…

Researchers looked at records from over 58,000 adults who had fall injuries to build a simple scoring system that estimates the chance of dying within 30 days. The tool uses age, sex, and vital signs taken in the emergency room. This study did not test any treatment—it only aimed…

This study looked at how different amounts of mannitol, a medicine used to reduce brain swelling, change blood osmolarity (a measure of blood thickness) in people with traumatic brain injury. Researchers observed 64 patients aged 18-40 with mild to moderate head injuries. The goa…

This pilot study tested whether a personalized nutrition plan using up to three Ensure shakes a day is practical for older adults (60+) recovering from a serious injury. Forty participants were randomly assigned to either the nutrition plan or standard care. The study did not mea…

This study looked at how heading a soccer ball changes the brain and whether wearing a mouthguard makes a difference. Twenty-one male soccer players did 10 headers in two sessions—once with a mouthguard and once without. Before and after, they had brain scans, cognitive tests, an…

This small pilot study tested whether a non-invasive eye scan called OCTA can detect changes in the brain related to stroke and other neurological conditions. Researchers compared eye scans from 7 people with brain diseases and healthy volunteers. The goal was to gather early dat…

This study looked back at the medical records of 137 severely injured trauma patients who needed large blood transfusions between 2020 and 2025. Researchers analyzed how different transfusion strategies, such as balanced ratios and whole blood use, affected 30-day survival and ot…

This study developed and tested a program to help nurses better support relatives of patients with acquired brain injury or malignant brain tumors. The program included nurse training, a dialog tool, a peer support list, videos, and documentation guidelines. Researchers tested it…

This study looked at 98 people with severe traumatic brain injury who needed a breathing tube. Researchers compared two ways of giving nutrition: a new method called Intermittent Oro-esophageal Tube Feeding (IOE) versus the standard Nasogastric Tube Feeding. They measured blood n…

This pilot study tested a web-based tool designed to improve communication and decision-making between doctors and families of patients with severe acute brain injuries, such as stroke or traumatic brain injury. The tool helps prepare families for their role as decision-makers an…

This study looked at whether veterans with traumatic brain injury (TBI) and insomnia can reliably measure their internal body clock at home. Thirty-one veterans wore a wrist device for a week and collected saliva samples to track melatonin levels. The goal was to see if these hom…

This study looked at whether tiny molecules in the blood, called microRNAs, can help tell if someone with a mild head injury has actual brain damage visible on a CT scan. Researchers took blood samples from 155 people with mild traumatic brain injury and compared those with and w…

This study looked at how parents cope emotionally after their child is hospitalized in intensive care for a severe injury. Researchers checked for signs of anxiety, depression, and post-traumatic stress in 62 parents, 3 to 6 months after the child left the ICU. The goal was to un…

This study looked at 29 children with brain injuries to test two new methods for checking how well the brain controls its own blood flow. The goal was to see if these methods could help doctors better understand and treat brain injuries. The study did not test a treatment, but ai…

This study looked at whether a portable brain scanner called fNIRS can safely and effectively measure brain activity in people with chronic traumatic brain injury while they walk on a treadmill with virtual reality. Eight participants completed the session, and researchers checke…

This study tested a simple tool to help family doctors better manage mental health problems after a mild traumatic brain injury (concussion). Over 500 adults who visited an emergency department were enrolled. Doctors received a letter with their patient's mental health screening …

This study tested a simple frailty score (TSFI) to see if it can predict complications and death in trauma patients aged 65 and older. Researchers enrolled 500 patients across multiple hospitals. The goal was to improve care by identifying high-risk patients early, not to provide…

This study tracked 69 older adults (age 40 and up) with traumatic brain injury to learn more about their health, frailty, and recovery. Researchers collected data on medications, injuries, and outcomes to find better ways to manage care. No new treatments were tested—the goal was…

This study looked at how obesity affects the hospital course and outcomes of trauma patients aged 60 and older. Researchers compared obese and non-obese patients to see if obesity leads to longer stays, more complications, or higher costs. The goal was to clarify conflicting repo…

This study observed how breathing machines (mechanical ventilation) are used in 2,299 brain-injured patients in intensive care units worldwide. Researchers collected data on different ventilation strategies and their link to patient recovery. No new treatments were tested; the go…

This study tested two types of robot-assisted training for people recovering from a severe brain injury. Ten participants were randomly assigned to either five days of robot-assisted walking training or five days of robot-assisted stepping training, then switched to the other. Th…

This study tested a program called TEaM to improve how doctors and schools support children after a mild traumatic brain injury (concussion). The program included training for doctors and tools to help them communicate with schools and families. Researchers enrolled 101 children …

This study looked at whether a structured regional health system, where trauma centers are organized by level of care, reduces deaths within 28 days after severe injury. Researchers compared outcomes for 2193 severely injured patients treated in a structured system versus a non-s…

This study checked how well the Trauma and Injury Severity Score (TRISS) predicts survival and the need for intensive care or surgery in 204 trauma patients at one hospital in Iraq. Researchers measured the score within 6 hours of arrival and tracked outcomes. The goal is to see …

This study looked at how different amounts of numbing medicine given around the collarbone affect pain relief and side effects during arm surgery. Researchers also used ultrasound to measure the nerve behind the eye to see if it relates to brain pressure. 64 patients aged 18 to 5…

This small pilot study looked at whether aerobic exercise can improve memory, attention, and fatigue in people who had a stroke or traumatic brain injury. Twelve participants were split into two groups: one did 30 minutes of aerobic exercise 3-4 times a week for 8 weeks, while th…

This study looked at swallowing problems in 34 patients with severe traumatic brain injury who are minimally conscious. Researchers used a special X-ray test called videofluoroscopy to see how swallowing works. The goal was to better understand these swallowing disorders, which c…

This study tested whether the sedative dexmedetomidine can lower C-reactive protein (CRP), a marker of inflammation, in 25 adults with traumatic brain injury undergoing emergency or planned skull surgery. Patients received either dexmedetomidine or a standard sedative during surg…

This study tested whether brief sessions of breathing low-oxygen air are safe for people who have had a traumatic brain injury (TBI). Twelve adults with mild to moderate TBI received up to four sessions of acute intermittent hypoxia, where oxygen levels were briefly lowered. Rese…

Researchers studied 407 children under 18 who had whole-body CT scans after trauma. They looked at injury details, physical exams, and lab results to create a scoring system called WHOLE. The goal is to help emergency doctors decide when a full-body scan is truly needed, reducing…

This small pilot study looked at whether a ketogenic diet (a high-fat, low-carb diet) is safe and possible for children who have had a moderate to severe traumatic brain injury. Seven children took part, and the main goal was to see if they could stay on the diet for 14 days with…

This study looked at 208 adults with severe brain injuries from bleeding or trauma. Researchers used a special monitor to track brain temperature and pressure together. The goal was to see if certain patterns could predict how well patients would recover 30 days later.

This study looked at 263 severely injured trauma patients to find out how often they develop early blood clotting problems (called trauma-induced coagulopathy) and excessive clot breakdown (hyperfibrinolysis) within the first hour of arriving at the emergency room. Researchers us…

This study looked at how the brain controls eye movements in people aged 11 to 35 who had a concussion 1 to 6 months ago and still have trouble focusing their eyes (convergence insufficiency). Researchers compared these participants to others with eye focusing problems not caused…

This study looked at whether planning, reminders, and small rewards can help older adults who had a mild or moderate traumatic brain injury (TBI) walk more. 57 participants wore a Fitbit and received weekly calls for 12 weeks. The goal was to see if these simple tools could incre…

This study tested a phone app called MEMI designed to help adults with chronic traumatic brain injury improve their memory. Forty participants used the app to practice remembering words through spaced retrieval exercises. The main goal was to see if the app was easy to use and ac…

This study looked at 68 adults with traumatic brain injury who also have fatigue and trouble thinking. Researchers used machine learning to search for specific genetic markers linked to these symptoms. The goal was to better understand why some people develop these problems after…

This study looked at whether special electrodes placed on the brain or scalp can detect abnormal brain waves called spreading depolarizations in people with traumatic brain injury. Researchers monitored 147 adults in intensive care to see if these methods could work without major…

This study tested whether using ultrasound to guide the placement of catheters in the femoral artery and vein (in the groin) reduces complications in severely injured patients in the intensive care unit. The trial involved 136 adults with severe trauma who needed these catheters.…

This study followed 88 adults with moderate to severe traumatic brain injury for up to 18 months. Researchers used MRI scans and hormone tests to see if hormone deficiencies after injury are linked to lower quality of life. The goal was to better understand these connections, not…

This study tested whether implanting special electrodes on the brain's surface can safely detect spreading depolarizations—electrical waves that may signal new damage after severe head trauma or brain hemorrhage. Twenty patients in intensive care received these electrodes alongsi…

This study looked back at data from 50 patients with severe brain injuries (from trauma or bleeding) who were treated in the ICU. Researchers analyzed brain blood flow, oxygen levels, and scans to understand how treatments affect the brain and body. The goal is to develop more pe…

This study uses MRI to measure how the brain moves inside the skull during gentle head motions, like turning your head while swimming. Researchers will scan 90 healthy adults aged 18-65 as they perform small, repeated head movements. The goal is to develop a fast imaging method t…

This study tested whether a virtual reality (VR) program could help children who had a traumatic brain injury (TBI) improve their thinking and problem-solving skills. Fourteen children took part in the trial. Researchers measured their executive functions (like memory and attenti…

This study looked at 15,000 trauma patients treated at a Swedish hospital over 10 years. Researchers focused on those with serious neck or face injuries to understand what causes deadly bleeding and how it is managed. The goal is to improve care for future patients with these inj…

This study gathered brain monitoring data from 162 patients with serious brain injuries, such as traumatic brain injury or stroke. Using a noninvasive ultrasound device, researchers recorded blood flow signals to build a database. The goal is to develop algorithms that could one …

This study tested whether it is safe to get patients with severe brain injuries out of bed early in the intensive care unit. 22 patients were moved using a special device called the Sara Combilizer, and researchers measured brain oxygen levels and other vital signs. The goal was …

This study looked at 126 children and young adults (up to age 25) with serious, non-progressive neurological diseases like cerebral palsy or brain injury. Researchers wanted to understand the best time to introduce a pediatric palliative care team. They reviewed medical records f…

This study looked at two community-based wellness programs for adults with disabilities like spina bifida, cerebral palsy, spinal cord injury, and traumatic brain injury. Researchers measured changes in health, mood, quality of life, and healthcare costs over up to 24 months. The…

This study tested a decision aid designed to help adolescents, parents, and clinicians make shared decisions about returning to contact sports after a concussion. Researchers enrolled 110 participants, including teens aged 11-17, their parents, and healthcare providers. The tool …

This study looked at whether a single session of moderate cycling, done in a lab, with a non-immersive virtual reality screen, or with a full immersive virtual reality headset, could improve thinking speed and multitasking in 24 adults with traumatic brain injury. Participants co…