Traumatic brain injury

This study tests a 4-month in-home rehabilitation program called HOME for Us for people who have had a traumatic brain injury (TBI) at least one year ago and their family caregivers. The program involves eight sessions with an occupational therapist, focusing on adapting the home…

This study tests whether inhaling nitric oxide gas can improve blood flow in the brain after a traumatic brain injury (TBI). The trial enrolls adults aged 18 to 75 with moderate TBI or mild TBI with abnormal scans. Participants receive either inhaled nitric oxide or standard care…

This study tests whether naloxegol, a drug that blocks opioid effects in the gut, can prevent constipation and pneumonia in brain-injured patients in the ICU. These patients often receive opioids for sedation, which can slow digestion and lead to serious complications. The trial …

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This study tests whether an FDA-approved drug, used off-label, can improve recovery in adults with severe traumatic brain injury (TBI). 26 participants will receive either the drug or a placebo within 24 hours of injury. The main goal is to see if the drug leads to better functio…

This study compares two standard methods for treating severe traumatic brain injury in the ICU. One method monitors only brain pressure, while the other also tracks brain oxygen levels. About 1,094 patients will take part to see which approach leads to better recovery and surviva…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve daily functioning in 100 veterans who have both alcohol use disorder and a history of mild traumatic brain injury. Researchers will identify a specific brain target and then stimulate it w…

This study was designed to see if giving calcium right away to trauma patients who need large blood transfusions could help their blood clot better, reduce the need for more transfusions, and improve survival. The trial was withdrawn before enrolling any participants, so no resul…

This study tests a new heating device called Therm'Up to manage hypothermia in trauma patients. Hypothermia, when body temperature drops below 35°C, can worsen injuries and increase death risk. The trial will enroll 100 adults at risk of hypothermia due to trauma, cold exposure, …

This study tests whether certain FDA-approved drugs, used off-label, can help people recover better after a traumatic brain injury (TBI). About 672 adults with moderate to severe TBI will receive either an experimental drug or a placebo within 24 hours of their injury. The main g…

This pilot study tests whether a ketogenic diet—a high-fat, low-carbohydrate diet—is safe and feasible for children in the pediatric ICU with acute brain injuries like stroke or traumatic brain injury. The idea is that after injury, the brain may struggle to use sugar for energy,…

This early-stage trial tests whether a stimulant drug (methylphenidate, also known as Ritalin) given through an IV can safely help people with severe brain injuries regain consciousness. Ten adults in a coma or minimally conscious state will receive increasing doses to check for …

This study looks at whether giving platelets (cells that help blood clot) to people with severe traumatic brain injuries who are on antiplatelet medications (blood thinners) can improve clotting and stop bleeding in the brain. About 225 adults with certain types of head bleeds wi…

This study tests a weight-loss program designed for people with traumatic brain injury (TBI). About 57 adults with moderate to severe TBI and a BMI of 25 or higher will join. The program focuses on healthy eating and physical activity, tracking weight, step count, and blood press…

This study tests a weight-loss program delivered via telehealth, specifically designed for people with traumatic brain injury (TBI). The program is adapted from the Diabetes Prevention Program and addresses unique needs of TBI patients. Researchers aim to see if the program helps…

This study compares two types of brain surgery for people with a severe head injury that causes a blood clot (epidural hematoma) and brain herniation. One surgery removes the clot and a piece of skull to relieve pressure; the other removes the clot without removing skull bone. Th…

This study tests whether an AI tool can help radiologists read brain CT and MRI scans more accurately and quickly. Researchers will compare how well doctors, AI alone, and doctors using AI together can spot abnormalities, urgent findings, and classify diseases. The goal is to red…

This study compares how well AI and radiologists diagnose brain diseases using CT and MRI scans. Over 30,000 patients will be included, and the AI has been trained on more than 100,000 previous scans. The goal is to see if AI can match human experts and whether combining AI with …

This study tests a program designed to prevent opioid misuse in people hospitalized for a traumatic injury. Participants complete brief questionnaires about pain and opioid use risk, and receive enhanced care coordination based on their responses. The goal is to see if this adapt…

This study looks at whether a fall prevention discharge class can reduce repeat fall-related ER visits in adults aged 60 and older. Researchers will compare those who attended the class to those who did not. The goal is to see if this simple education step can help prevent future…

This study tests whether daily exposure to different scents can retrain the sense of smell in 250 adults with smell disorders, including those from traumatic brain injury. Participants will use scented inhaler sticks at home and take smell tests before and after 12 weeks. The goa…

This study tests whether high doses of branched chain amino acids (BCAAs), a type of supplement, can help people aged 11 to 23 recover from a concussion more quickly. Participants receive either a BCAA drink or a placebo for 28 days. The main goal is to see if more people in the …

This study tests a communication tool called Best Case/Worst Case-ICU for older adults (50+) with serious injuries in the ICU. The tool helps doctors, patients, and families discuss possible outcomes and treatment options using simple graphics. Researchers will measure if it impr…

This study tests whether a hormone called pregnenolone can improve mental health, thinking, and pain in veterans who had a mild traumatic brain injury (TBI) while serving after 9/11. About 108 veterans will take either pregnenolone or a placebo daily for 8 weeks. Researchers will…

This early-stage study tests whether a smartphone app and remote training can help military members and active young adults recover from a mild concussion. The goal is to improve symptoms and lower the risk of getting hurt again. About 88 people will participate.

This trial tests whether a Pain and Coordination Plan (PAC-plan) can reduce opioid use and improve quality of life in adults who have had surgery after an accidental injury. Participants receive the plan at hospital discharge, which includes an opioid management plan, a follow-up…

This small study tests whether a four-session program combining music and nature activities can improve wellbeing for people with acquired brain injuries and their care partners. Ten adult participants will complete surveys before and after the program. The goal is to see if this…

This study looks at why some people get persistent headaches after a mild concussion and tests a new treatment called repetitive transcranial magnetic stimulation (rTMS). Researchers will measure headache days and blood markers in 62 adults who had a mild brain injury 2-4 months …

This study tests a brief stepped care program for adults hospitalized after a traumatic injury who show signs of PTSD. The program starts in the hospital and aims to reduce PTSD symptoms and the number of emergency room visits over time. About 424 participants are involved, and t…

This study tests whether a 3-week outpatient rehab program can reduce long-lasting symptoms of traumatic brain injury (TBI) and related conditions like PTSD and depression in 416 veterans and first responders. Participants will complete surveys, and some will also give blood samp…

This study tests a type of talk therapy called graded exposure therapy for people who have had a concussion and are still having symptoms. The therapy, delivered by a psychologist over 12 video sessions, helps people gradually face activities they have been avoiding due to fear o…

This study tests a home-based program called HOBSCOTCH-PTE for people with epilepsy caused by a traumatic brain injury. The program aims to improve quality of life, memory, and thinking skills, and also helps support their caregivers. The study includes 160 adults with post-traum…

This study tests a set of virtual reality exergames in the Metaverse to help people with neurological conditions like multiple sclerosis, Parkinson's disease, stroke, and traumatic brain injury improve their cognitive skills. 25 participants will try games like virtual cooking an…

This study looks at whether a program called LearningRx can improve thinking skills, daily life function, and work confidence in adults who have had a traumatic or acquired brain injury, including from COVID-19. About 30 participants will complete cognitive exercises and be teste…

This small pilot study is testing whether walking on a treadmill with virtual reality feedback can help people with traumatic brain injury improve their balance, reduce fear of falling, and lower fall risk. The study involves 20 adults aged 18 to 90 who have had a TBI at least on…

This pilot study tests whether repetitive transcranial magnetic stimulation (rTMS) can reduce alcohol cravings in veterans who also have mild traumatic brain injury or PTSD. Twenty veterans will receive either real or placebo rTMS over 10 sessions in two weeks. The goal is to see…

This study looks at whether chiropractic care can help young athletes (ages 18-40) recover from sports-related concussions. Researchers will measure attention, balance, mood, and other functions before and after treatment. The goal is to see if this approach is practical and wort…

This pilot study aimed to test whether a virtual reality (VR) cooking simulation could improve arm movement and daily function in people with acquired brain injury. Participants would have used VR to practice reaching, grabbing, and stirring motions. However, the trial was withdr…

This study tests whether morning bright light therapy can improve sleep in 300 veterans who have had a traumatic brain injury. Participants use a special light box each morning, and researchers track changes in sleep quality, mood, thinking, and blood markers. The goal is to find…

This study tests a gentle brain stimulation method called tDCS in 41 veterans who had a mild traumatic brain injury over a year ago. Participants receive either real or fake stimulation while doing memory exercises. The goal is to see if tDCS can improve thinking skills and daily…

This study tests a new type of magnetic brain stimulation in 15 adults who have had a mild traumatic brain injury and still have symptoms like headaches or trouble thinking. Participants get 30 short treatment sessions and detailed MRI scans before and after. The goal is to see i…

This study tests whether 36 sessions of a computer-based brain training program, called PATH neurotraining, followed by digit memory exercises, can improve working memory, processing speed, and attention in people who have had a mild traumatic brain injury (concussion). The train…

This large observational study aims to collect medical data and biological samples from up to 5,000 people with chronic spinal cord injury or traumatic brain injury, as well as their family members and healthy volunteers. Researchers hope this information will help them better un…

This study tests a short, 6-session program for patients with a recent brain injury and their caregivers. The goal is to prevent long-term emotional distress and improve quality of life. About 388 pairs (patient and caregiver) will take part.

This study was designed to observe how patients with acute brain injury are taken off mechanical ventilation (breathing machines) in the ICU. It planned to include adults with brain injury who needed a ventilator for at least 24 hours, but the study was withdrawn before enrolling…

This study is trying to find ways to diagnose chronic traumatic encephalopathy (CTE) in living people. Right now, CTE can only be confirmed after death. Researchers will study 350 former college and professional football players, using memory tests and other biomarkers. The goal …

This study follows 300 people who had a traumatic brain injury (TBI) for at least two years after their injury. Researchers want to see how their recovery changes over time and test a blood marker that may show brain damage. The goal is to better understand the long-term effects …

This study follows 300 people who had a traumatic brain injury (TBI) to learn more about the long-term risk of developing epilepsy. Researchers will use interviews, brain scans, blood tests, and EEGs to track changes over time. The goal is to better understand how and why epileps…

This study looks at how different levels of traumatic brain injury (TBI) affect children's thinking, balance, and ability to do everyday tasks. Researchers will test 48 children aged 8 to 12 with mild to moderate TBI using standard assessments. The goal is to understand the links…

This study looks at how serious combat injuries affect the long-term health of U.S. military members. Researchers will measure heart function, sleep quality, and stress-related body signals in 200 injured service members. The goal is to understand links between injury severity, s…

This study was designed to test a program that helps caregivers of people with traumatic brain injury improve their problem-solving skills. It planned to enroll adults aged 19 and older, but was withdrawn before any participants joined, so no results are available.

This study aimed to compare three medicines (propofol, etomidate, and ketamine) given to adult trauma patients to help them breathe with a breathing tube. The goal was to see which drug leads to the best outcomes, like survival and fewer side effects. However, the study was withd…

This observational study looks at 300 adults with severe traumatic brain injury to see how low brain oxygen levels affect certain proteins in the blood, known as biomarkers. Researchers will measure these proteins to better understand brain damage and recovery. The study does not…

This study is working to create a prediction model specifically for children with moderate to severe traumatic brain injury (TBI). Currently, doctors use models designed for adults, which may not be accurate for kids. Researchers will analyze data from 2000 children to develop a …

This study follows 250 former NFL players and healthy volunteers aged 50-70 over 5 years. Researchers use brain scans, blood tests, and thinking/memory assessments to understand how concussions and repeated head impacts affect long-term brain health. The goal is to gather informa…

This study looks at whether a special computer tool can help doctors better care for children aged 5 to 18 with mild traumatic brain injury (concussion). The tool predicts which kids are at risk for long-lasting symptoms and suggests early referral to specialists. Researchers wil…

This study reviewed the medical records of 2500 people who received hyperbaric oxygen therapy (HBOT) for conditions like traumatic brain injury, stroke, fibromyalgia, or age-related decline. Researchers compared computerized thinking and memory tests taken before and after treatm…

This study tests a program called BETTER that helps adults with traumatic brain injury and their families after they leave the hospital. The program provides education, training, and therapy to support recovery at home. Researchers will compare the program to usual care in 500 pa…

This study looks at whether a computer-guided breathing machine (ventilator) protocol can help patients with serious brain injuries. The goal is to use low air volumes to protect the lungs while keeping carbon dioxide levels normal to protect the brain. About 728 adults on ventil…

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…

This study looks at how the body's natural response to severe injury or major surgery can sometimes go wrong, leading to complications. Researchers will collect blood samples from 320 trauma patients and elective surgery patients to measure markers of inflammation and blood clott…

This study looks at 30 people who have had a moderate to severe traumatic brain injury. Researchers use special PET scans to measure inflammation in the brain at two weeks and two months after the injury. The goal is to see if the amount of inflammation is linked to a higher risk…

This study was designed to test a wearable sensor system that tracks how people walk on different surfaces like grass, pavement, and stairs. It aimed to include healthy volunteers and people with conditions such as Parkinson's disease, dementia, stroke, multiple sclerosis, or low…

This study tracks 750 teens aged 13-18 with mild concussions to see if changes in their saliva can predict how long symptoms last. Researchers will check for persistent symptoms 30 days after injury. The goal is to find biological markers that help doctors personalize recovery pl…

This observational registry will follow 5,000 adults with various wounds—like diabetic foot ulcers, burns, or surgical wounds—to see how different treatments (e.g., hydrocolloid, foam, silver dressings) perform in everyday medical settings. Researchers will measure wound healing,…

This study looks at whether a simple ultrasound of the brain's blood flow can safely identify mild traumatic brain injury patients who can go home right away instead of staying in the hospital for observation. About 550 adults with mild head injuries will be randomly assigned to …

This study compares two treadmill tests—the Buffalo Concussion Treadmill Test and a modified dynamic exertion test—in teens aged 14-17 who had a sport-related concussion within the past 14 days. The goal is to see which test better measures symptoms like headache and dizziness, a…

This study aims to develop a new way to measure arm and hand function in people with brain disorders like stroke or Parkinson's disease. Researchers will use a smart board and smart glove to collect movement data and compare it with standard tests. The goal is to create a more pr…

This study planned to use high-frequency brain signals to locate important brain areas and understand conditions like epilepsy, migraine, and ADHD. It aimed to create a large database of brain activity in people aged 1 day to 69 years. However, the study was withdrawn before any …

This study is tracking over 600 people who received the GORE VIABAHN stent-graft as part of their normal medical care for conditions like peripheral artery disease or aneurysms. Researchers are monitoring how often serious device-related problems occur. The goal is to see how saf…

This study was designed to test a holistic education program for stress management in people from colonized English-speaking countries. It aimed to help with conditions like stress, PTSD, anxiety, and fatigue using pastoral counseling and self-care activities. However, the study …

This study looks at whether spontaneous eye blinking can help doctors understand the level of consciousness and attention in people with severe acquired brain injury. Researchers will record eye blinks using simple sensors while patients rest or listen to sounds. The goal is to d…

This study from Mayo Clinic will follow 4,000 athletes aged 12-30 to find better ways to diagnose concussions on the spot and set safe return-to-play rules. Researchers will also test if neck and vision training can help prevent brain injuries. The goal is to use simple tests and…

This study tests a new behavioral therapy designed to help veterans with traumatic brain injury (TBI) improve their storytelling and everyday communication. The therapy focuses on both story content and organization. The trial includes 34 veterans and aims to see if the treatment…

This study follows 52 elite junior ice hockey players over a season to understand how head impacts affect the brain and body. Players wear helmet sensors to record impacts, plus heart rate monitors and cognitive tests to detect subtle changes. The goal is to improve concussion de…

This study follows 432 adults who were in the ICU after a traumatic injury or burn. Researchers want to see if and why patients develop long-term problems with memory, thinking, and daily function. By tracking cognitive skills and inflammation over time, they hope to uncover link…

This study follows 1,500 older adults (65+) who come to the emergency department after a traumatic brain injury, along with matched controls. Researchers will track their recovery over 12 months using brain scans, blood tests, and health assessments. The goal is to develop age-ap…

This study will track 100 people with traumatic hand and wrist injuries at Sohag University Hospital in Egypt from October 2025 to April 2026. Researchers want to learn how these injuries happen and what the outcomes are. It is an observational study, meaning no new treatment is …

This study tests a program to help people with traumatic brain injury (TBI) who are leaving prison avoid returning to jail. 102 participants will be randomly assigned to either the new program or standard services. The program provides support and teaches coping skills to reduce …

This study looks at how common mild brain injuries are in Czech soldiers during tough training like parachute jumps and shooting. Researchers will test blood for injury markers and use wearable sensors to measure head impacts. The goal is to find risks and create ways to protect …

This study tests a 12-session teletherapy program called ICARE for people with traumatic brain injury (TBI) and their care partners. The program teaches emotion recognition from facial expressions and empathy skills through role-playing. Researchers want to see if it's practical …

This study follows 100 people with brain or spinal cord injuries to see how their ability to judge their own memory (metacognition) changes over time. Researchers want to know if better self-awareness helps people stick with rehabilitation. Participants complete computer memory t…

This study is looking at whether changes in RNA found in saliva can help predict how long concussion symptoms will last in children aged 5 to 21. Researchers will collect saliva samples and track symptoms like dizziness and balance problems. The goal is to better understand recov…

This study is testing whether a short educational video that gives positive reassurance can improve recovery in people with mild traumatic brain injury (mTBI). Researchers will enroll 229 participants aged 13-21 who were diagnosed with mTBI in the emergency department. The goal i…

This study looks at children aged 3 to 16 with severe head injuries to understand why some have poor outcomes. Researchers are testing extra monitors that track oxygen and chemical changes in the brain, which are already used safely in adults. The goal is to gather information th…

This study looks at 600 adults who take blood thinners and have a mild head injury but a normal first brain scan. Researchers want to know how often a delayed brain bleed happens within 24 hours and up to 4 weeks after the injury. They also track risks like blood clots or confusi…

This study gathers MRI, CT, and ultrasound images from 300 adults—some healthy, some with kidney or brain disease—to build a collection for future not-for-profit research. No new treatments are being tested; the goal is to make medical images available to scientists for advancing…