Brain disorder
MONDO:0005560A disease affecting the brain or part of the brain.
Also known as: brain disease, brain disease or disorder, disease of brain, disease or disorder of brain, disorder of brain, encephalopathy
16683 clinical trials for this condition and its sub-types, 137 tagged with Brain disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Brain disorder
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Mental disorder 250 trials · 7,381 incl. sub-types
14 sub-types
- Anxiety disorder 2,032 trials · 3,117 incl. sub-types Sub-types →
- Mood disorder 184 trials · 2,669 incl. sub-types Sub-types →
- Developmental disorder of mental health 1 trial · 1,588 incl. sub-types Sub-types →
- Psychotic disorder 201 trials · 767 incl. sub-types Sub-types →
- Pain agnosia 146 trials
- Psychosexual disorder 4 trials · 47 incl. sub-types Sub-types →
- Adjustment disorder 34 trials
- Disruptive behavior disorder 34 trials
- Alcohol-induced mental disorder 0 trials · 24 incl. sub-types Sub-types →
- Drug-induced mental disorder 1 trial · 8 incl. sub-types Sub-types →
- Visual agnosia 0 trials · 2 incl. sub-types Sub-types →
- Akinetopsia 0 trials
- Cortical deafness 0 trials
- Tactile agnosia 0 trials
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Cerebrovascular disorder 108 trials · 3,287 incl. sub-types
24 sub-types
- Stroke disorder 2,034 trials · 2,851 incl. sub-types Sub-types →
- Brain ischemia 55 trials · 281 incl. sub-types Sub-types →
- Intracranial arterial disease 26 trials · 206 incl. sub-types Sub-types →
- Brain infarction 26 trials · 151 incl. sub-types Sub-types →
- Carotid artery disorder 41 trials · 114 incl. sub-types Sub-types →
- Vascular dementia 72 trials Sub-types →
- Cerebral artery stenosis 23 trials · 71 incl. sub-types Sub-types →
- Occlusion precerebral artery 0 trials · 25 incl. sub-types Sub-types →
- Pseudotumor cerebri 22 trials
- Cerebral amyloid angiopathy 16 trials · 17 incl. sub-types Sub-types →
- Cerebral sinovenous thrombosis 16 trials
- Intracranial thrombosis 12 trials · 13 incl. sub-types Sub-types →
- Intracranial vasospasm 13 trials
- APP-related brain and vascular amyloidosis 0 trials · 5 incl. sub-types Sub-types →
- Basal ganglia cerebrovascular disorder 5 trials
- Internal carotid artery stenosis 5 trials
- Familial porencephaly 0 trials · 3 incl. sub-types Sub-types →
- Vascular brain injury 3 trials
- HTRA1-related autosomal dominant cerebral small vessel disease 2 trials
- Subclavian steal syndrome 1 trial
- Cathepsin a-related arteriopathy-strokes-leukoencephalopathy 0 trials
- Cerebral arteritis 0 trials
- Microangiopathy and leukoencephalopathy, pontine, autosomal dominant 0 trials
- Precerebral artery stenosis 0 trials
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Basal ganglia disorder 9 trials · 1,319 incl. sub-types
4 sub-types
- Parkinsonian disorder 67 trials · 1,312 incl. sub-types Sub-types →
- Basal ganglia cerebrovascular disorder 5 trials
- Bilateral striopallidodentate calcinosis 1 trial Sub-types →
- Biotin-responsive basal ganglia disease 1 trial
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Brain neoplasm 247 trials · 1,078 incl. sub-types
17 sub-types
- Brain cancer 681 trials · 901 incl. sub-types Sub-types →
- Cerebellar neoplasm 3 trials · 114 incl. sub-types Sub-types →
- Infratentorial neoplasm 6 trials · 114 incl. sub-types Sub-types →
- Brainstem neoplasm 0 trials · 101 incl. sub-types Sub-types →
- Primary brain neoplasm 87 trials · 92 incl. sub-types Sub-types →
- Hypothalamic neoplasm 3 trials · 85 incl. sub-types Sub-types →
- Pineal body neoplasm 4 trials · 22 incl. sub-types Sub-types →
- Benign neoplasm of brain 16 trials · 21 incl. sub-types Sub-types →
- Choroid plexus neoplasm 5 trials · 18 incl. sub-types Sub-types →
- Neoplasm of cerebral hemisphere 3 trials · 14 incl. sub-types Sub-types →
- Optic pathway glioma 11 trials Sub-types →
- Olfactory nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Cerebellopontine angle tumor 1 trial Sub-types →
- Dysembryoplastic neuroepithelial tumor 1 trial
- Childhood brain meningioma 0 trials
- Olfactory groove meningioma 0 trials
- Optic tract meningioma 0 trials Sub-types →
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Multiple sclerosis 766 trials · 854 incl. sub-types
4 sub-types
- Relapsing-remitting multiple sclerosis 263 trials
- Chronic progressive multiple sclerosis 82 trials · 114 incl. sub-types Sub-types →
- Pediatric multiple sclerosis 5 trials
- Marburg acute multiple sclerosis 0 trials
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Insomnia 822 trials · 826 incl. sub-types
1 sub-type
- Fatal familial insomnia 4 trials
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Cerebral cortex disorder 0 trials · 721 incl. sub-types
6 sub-types
- Cerebral palsy 441 trials · 497 incl. sub-types Sub-types →
- Visual cortex disorder 0 trials · 187 incl. sub-types Sub-types →
- Pick disease 35 trials
- Hippocampal sclerosis of aging 3 trials
- Occipital lobe neoplasm 0 trials
- Primary motor cortex epilepsy 0 trials
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Brain injury 220 trials · 692 incl. sub-types
2 sub-types
- Traumatic brain injury 557 trials
- Vascular brain injury 3 trials
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Epilepsy 461 trials · 645 incl. sub-types
13 sub-types
- Epilepsy syndrome 2 trials · 181 incl. sub-types Sub-types →
- Reflex epilepsy 1 trial · 155 incl. sub-types Sub-types →
- Focal epilepsy 101 trials · 135 incl. sub-types Sub-types →
- Developmental and epileptic encephalopathy 29 trials · 98 incl. sub-types Sub-types →
- Generalized epilepsy 9 trials · 39 incl. sub-types Sub-types →
- Monogenic epilepsy 0 trials · 12 incl. sub-types Sub-types →
- Metabolic epilepsy 0 trials · 8 incl. sub-types Sub-types →
- Post-traumatic epilepsy 6 trials
- Structural epilepsy 5 trials
- Immune epilepsy 0 trials · 1 incl. sub-types Sub-types →
- Infantile-onset epilepsy 1 trial Sub-types →
- Epilepsy, unknown whether focal or generalized 0 trials
- Extratemporal epilepsy 0 trials
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Migraine disorder 391 trials · 412 incl. sub-types
2 sub-types
- Migraine with aura 30 trials · 44 incl. sub-types Sub-types →
- Migraine without aura 42 trials
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Cerebellar disorder 9 trials · 270 incl. sub-types
5 sub-types
- Cerebellar degeneration 6 trials · 150 incl. sub-types Sub-types →
- Cerebellar neoplasm 3 trials · 114 incl. sub-types Sub-types →
- Dandy-Walker syndrome 1 trial Sub-types →
- Behrens Baumann dust syndrome 0 trials
- Miller Fisher syndrome 0 trials
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Visual pathway disorder 1 trial · 201 incl. sub-types
5 sub-types
- Visual cortex disorder 0 trials · 187 incl. sub-types Sub-types →
- Optic pathway glioma 11 trials Sub-types →
- Coloboma of optic nerve 1 trial Sub-types →
- Retinal nerve fiber layer disorder 1 trial Sub-types →
- Optic tract meningioma 0 trials Sub-types →
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Pituitary gland disorder 18 trials · 175 incl. sub-types
9 sub-types
- Pituitary tumor 23 trials · 83 incl. sub-types Sub-types →
- Anterior pituitary gland disorder 1 trial · 60 incl. sub-types Sub-types →
- Hypopituitarism 5 trials · 46 incl. sub-types Sub-types →
- Neurohypophyseal diabetes insipidus 9 trials
- Inappropriate ADH syndrome 5 trials
- Hypophysitis 2 trials Sub-types →
- Necrosis of pituitary 0 trials · 1 incl. sub-types Sub-types →
- Empty sella syndrome 0 trials
- Pituitary hypoplasia 0 trials
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Thalamic disorder 0 trials · 110 incl. sub-types
3 sub-types
- Hypothalamic disorder 3 trials · 88 incl. sub-types Sub-types →
- Thalamic cancer 1 trial · 24 incl. sub-types Sub-types →
- Pineal body neoplasm 4 trials · 22 incl. sub-types Sub-types →
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Intracranial hypertension 51 trials · 97 incl. sub-types
2 sub-types
- Hypertensive encephalopathy 1 trial · 28 incl. sub-types Sub-types →
- Pseudotumor cerebri 22 trials
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Encephalitis 26 trials · 96 incl. sub-types
7 sub-types
- Infectious encephalitis 3 trials · 50 incl. sub-types Sub-types →
- Autoimmune encephalitis 32 trials · 33 incl. sub-types Sub-types →
- Anti-NMDA receptor encephalitis 9 trials
- Meningoencephalitis 6 trials
- Limbic encephalitis 1 trial · 2 incl. sub-types Sub-types →
- Paraneoplastic isolated brainstem encephalitis 0 trials
- Post-vaccinal encephalitis 0 trials
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Hydrocephalus 52 trials · 79 incl. sub-types
7 sub-types
- Communicating hydrocephalus 3 trials · 38 incl. sub-types Sub-types →
- Obstructive hydrocephalus 6 trials
- Congenital hydrocephalus 1 trial · 3 incl. sub-types Sub-types →
- Baker Vinters syndrome 0 trials
- Craniosynostosis-Dandy-Walker malformation-hydrocephalus syndrome 0 trials
- Megalencephaly-polymicrogyria-postaxial polydactyly-hydrocephalus syndrome 0 trials Sub-types →
- Palmer pagon syndrome 0 trials
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Cerebral degeneration 0 trials · 61 incl. sub-types
2 sub-types
- Pick disease 35 trials
- Corticobasal degeneration disorder 28 trials
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Hepatic encephalopathy 44 trials
1 sub-type
- Hepatic coma 0 trials
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Narcolepsy-cataplexy syndrome 42 trials · 44 incl. sub-types
3 sub-types
- Narcolepsy 1 5 trials
- Narcolepsy 3 0 trials
- Narcolepsy 7 0 trials
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Cerebral lipidosis with dementia 0 trials · 38 incl. sub-types
8 sub-types
- Sandhoff disease 13 trials Sub-types →
- Tay-Sachs disease 13 trials Sub-types →
- Gaucher disease type I 12 trials
- Cerebrotendinous xanthomatosis 6 trials
- Juvenile neuronal ceroid lipofuscinosis 6 trials Sub-types →
- Adult Krabbe disease 0 trials
- Adult neuronal ceroid lipofuscinosis 0 trials Sub-types →
- Infantile neuronal ceroid lipofuscinosis 0 trials Sub-types →
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Intracranial hypotension 32 trials
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Cluster headache syndrome 26 trials
1 sub-type
- Cluster headache, familial 0 trials
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Brain edema 23 trials
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Narcolepsy without cataplexy 22 trials
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Encephalomalacia 1 trial · 13 incl. sub-types
1 sub-type
- Periventricular leukomalacia 12 trials
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Olfactory nerve disorder 8 trials · 12 incl. sub-types
1 sub-type
- Olfactory nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
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Traumatic encephalopathy 11 trials
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Prion disease 5 trials · 11 incl. sub-types
10 sub-types
- Creutzfeldt Jacob disease 4 trials · 7 incl. sub-types Sub-types →
- Fatal familial insomnia 4 trials
- Gerstmann-Straussler-Scheinker syndrome 1 trial
- Huntington disease-like 1 0 trials
- PrP systemic amyloidosis 0 trials
- Familial Alzheimer-like prion disease 0 trials
- Kuru 0 trials
- Scrapie 0 trials
- Spongiform encephalopathy with neuropsychiatric features 0 trials
- Sporadic fatal insomnia 0 trials
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Cerebral cortical dysplasia 2 trials · 7 incl. sub-types
2 sub-types
- Isolated focal cortical dysplasia 5 trials · 6 incl. sub-types Sub-types →
- Central bilateral macrogyria 0 trials
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Progressive bulbar palsy 5 trials
1 sub-type
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Akinetic mutism 3 trials
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Bilirubin encephalopathy 3 trials
1 sub-type
- Kernicterus due to isoimmunization 0 trials
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Central nervous system cyst 3 trials
1 sub-type
- Choroid plexus cyst 0 trials
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Megalencephaly 3 trials
4 sub-types
- Bagatelle Cassidy syndrome 0 trials
- Isolated megalencephaly 0 trials
- Macrocephaly/megalencephaly syndrome, autosomal recessive 0 trials
- Megalencephaly, autosomal dominant 0 trials
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Encephalopathy, acute, infection-induced 2 trials · 3 incl. sub-types
1 sub-type
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Encephaloclastic disorder 0 trials · 3 incl. sub-types
3 sub-types
- Porencephaly 0 trials · 3 incl. sub-types Sub-types →
- Hydranencephaly 0 trials Sub-types →
- Schizencephaly 0 trials Sub-types →
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Cerebral malaria 2 trials
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Leukoencephalopathy, megalencephalic 0 trials · 2 incl. sub-types
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Wernicke encephalopathy 1 trial
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Brain compression 1 trial
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Cerebral sarcoidosis 1 trial
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Reye syndrome 0 trials
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XK aprosencephaly 0 trials
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Acute bilirubin encephalopathy 0 trials
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Aprosencephaly 0 trials
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Atelencephaly 0 trials
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Bulbar polio 0 trials
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Cerebritis 0 trials
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Chronic bilirubin encephalopathy 0 trials
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Colpocephaly 0 trials
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12 sub-types
- Complex cortical dysplasia with other brain malformations 1 0 trials
- Complex cortical dysplasia with other brain malformations 2 0 trials
- Complex cortical dysplasia with other brain malformations 3 0 trials
- Complex cortical dysplasia with other brain malformations 4 0 trials
- Complex cortical dysplasia with other brain malformations 5 0 trials
- Complex cortical dysplasia with other brain malformations 6 0 trials
- Complex cortical dysplasia with other brain malformations 7 0 trials
- Cortical dysplasia, complex, with other brain malformations 10 0 trials
- Cortical dysplasia, complex, with other brain malformations 11 0 trials
- Cortical dysplasia, complex, with other brain malformations 12 0 trials
- Cortical dysplasia, complex, with other brain malformations 9 0 trials
- Polymicrogyria with optic nerve hypoplasia 0 trials
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Diabetic encephalopathy 0 trials
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Disorder of optic chiasm 0 trials
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Encephalopathy, acute transient 0 trials
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Glycine encephalopathy 0 trials
5 sub-types
- Atypical glycine encephalopathy 0 trials
- Glycine encephalopathy 1 0 trials
- Glycine encephalopathy 2 0 trials
- Infantile glycine encephalopathy 0 trials
- Neonatal glycine encephalopathy 0 trials
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Meningoencephalocele 0 trials
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Midbrain disorder 0 trials
Most studied deeper sub-types
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Can Lab-Grown brain cells replace what Parkinson's destroys?
Cure Recruiting nowThis early-stage trial tests whether transplanting lab-grown dopamine-producing cells into the brains of people with Parkinson's disease is safe and might help replace the cells lost to the disease. About 7 adults with Parkinson's who have not responded well to standard medicatio…
Phase 1 • Sponsor: University of California, San Diego • Aim: Cure
Last updated Aug 19, 2026 00:00 UTC
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Can donated plasma shield newborns from chikungunya brain damage?
Disease control Recruiting nowThis study tests whether giving newborns plasma from people who recently recovered from chikungunya can prevent brain swelling or damage. The trial will include 60 newborns whose mothers were infected around the time of birth. Half will receive the plasma transfusion, and their o…
Sponsor: Centre Hospitalier Universitaire de la Réunion • Aim: Disease control
Last updated Sep 17, 2026 00:00 UTC
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Can a Two-Drug combo quiet the tremors Parkinson's patients still feel?
Disease control Recruiting nowThis phase 2 trial tests an experimental drug called VIM0423 in adults with Parkinson's disease whose tremor does not respond well to standard dopaminergic therapy. Researchers want to see if VIM0423 can reduce tremor severity, improve daily function and quality of life, and be s…
Phase 2 • Sponsor: Vima Therapeutics • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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New minimally invasive procedure could change outcomes for bleeding stroke patients
Disease control Recruiting nowThis study compares standard medical care to a new, less invasive surgery for people with a severe bleeding stroke. The surgery uses a small tube to drain the blood clot and delivers clot-busting medicine directly into the brain. Researchers want to see if this approach helps pat…
Sponsor: Xuanwu Hospital, Beijing • Aim: Disease control
Last updated Sep 11, 2026 00:00 UTC
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New hope for breast cancer patients with brain tumors: drug combo trial underway
Disease control Recruiting nowThis study tests a combination of two drugs, elacestrant and abemaciclib, in people with a specific type of breast cancer (ER-positive, HER2-negative) that has spread to the brain. The goal is to see if the combination can shrink or control brain tumors. The trial involves about …
Phase 1/2 • Sponsor: Stemline Therapeutics, Inc. • Aim: Disease control
Last updated Sep 11, 2026 00:00 UTC
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Could a new drug slow lewy body dementia? phase 2 trial begins
Disease control Recruiting nowThis phase 2 trial tests whether donanemab, an antibody given by IV, can slow worsening of thinking and daily function in people with early cognitive decline and Lewy body dementia. The study enrolls 350 participants who also have signs of two brain proteins (amyloid and alpha-sy…
Phase 2 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Sep 10, 2026 00:00 UTC
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Killer virus turned against childhood brain cancer
Disease control Recruiting nowThis early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a small dose of radiation to help …
Phase 1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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New schizophrenia drug shows promise in Long-Term safety trial
Disease control Recruiting nowThis study is testing a new drug called ML-007C-MA for adults with schizophrenia. The goal is to see if it is safe and works well over a full year. About 500 people who have recently been in a related study or are new to the trial will take the drug twice daily. Researchers will …
Phase 2 • Sponsor: MapLight Therapeutics • Aim: Disease control
Last updated Sep 03, 2026 00:00 UTC
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New Alzheimer's drug injected into spine shows promise in early safety trial
Disease control Recruiting nowThis early-stage study tests a new drug called LY3954068 in 48 people with mild Alzheimer's symptoms. The drug is given directly into the spinal fluid, either once or twice, to see if it is safe and how it affects Alzheimer's markers. The study lasts up to 100 weeks and includes …
Phase 1 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Aug 26, 2026 00:00 UTC
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Light and magnets: a new weapon against Alzheimer's?
Disease control Recruiting nowThis trial tests whether a wearable device called RGn600 can slow cognitive decline in people with mild-to-moderate Alzheimer's disease. The device, worn as a helmet and abdominal belt, delivers red-to-near-infrared light and static magnetic fields, aiming to reduce inflammation …
Sponsor: REGEnLIFE SAS • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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Gene therapy trial offers hope for babies with rare, deadly metabolic disease
Disease control Recruiting nowThis study tests a one-time gene therapy called ECUR-506 in baby boys under 9 months old with a severe form of OTC deficiency, a genetic disorder that prevents the body from breaking down ammonia. The goal is to see if the treatment is safe and can reduce dangerous ammonia levels…
Phase 3 • Sponsor: iECURE, Inc. • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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Could a pill shield the brain and kidneys during heart surgery?
Disease control Recruiting nowThis trial tests whether vericiguat, a drug that relaxes blood vessels, can protect the body during heart surgery. About 170 adults scheduled for open-heart surgery will receive either vericiguat or a placebo starting two days before the operation. Researchers will measure blood …
Phase 4 • Sponsor: Vanderbilt University Medical Center • Aim: Disease control
Last updated Aug 08, 2026 00:03 UTC
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Can a tiny mesh device defuse brain aneurysms? a registry investigates
Disease control Recruiting nowThis study is a registry that will follow about 200 people with brain aneurysms who are treated with a flow diverter device (p64, p64 MW, or p48 MW). The goal is to see how safe and effective these devices are in real-world practice across France. Participants will be monitored f…
Sponsor: Phenox GmbH • Aim: Disease control
Last updated Aug 07, 2026 00:00 UTC
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Experimental Alzheimer's vaccine aims to clear brain plaques
Disease control Recruiting nowThis study tests an experimental vaccine called ACI-24.060 in people with early Alzheimer's and non-demented adults with Down syndrome. The vaccine is designed to help the immune system clear amyloid plaques from the brain, which are linked to Alzheimer's. Researchers will check …
Phase 1/2 • Sponsor: AC Immune SA • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
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Lifeline for kids with severe epilepsy: drug access extended
Disease control Expanded accessThis program offers continued access to rufinamide for children with Lennox-Gastaut syndrome, a severe form of epilepsy, who completed a previous study. The goal is to keep providing the medication until it becomes commercially available in Poland. Only children who were already …
Sponsor: Eisai Inc. • Aim: Disease control
Last updated Jul 10, 2026 00:00 UTC
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Could a simple ear clip tame brain swelling after a stroke?
Disease control Recruiting nowThis study tests whether a non-invasive device that gently stimulates the vagus nerve through the ear can reduce inflammation and brain swelling after a hemorrhagic stroke (intracerebral hemorrhage). The trial enrolls adults with a specific type of brain bleed and compares the ac…
Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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Could a second drug boost stroke recovery?
Disease control Recruiting nowThis study tests whether giving a clot-busting drug called tenecteplase directly into the brain artery after mechanical clot removal helps people recover better from a severe stroke. About 462 adults with a large vessel blockage in the front part of the brain will be randomly ass…
Phase 2/3 • Sponsor: University of Melbourne • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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Could a simple neck device help stroke patients survive?
Disease control Recruiting nowThis study is testing a non-invasive device that stimulates the vagus nerve (a major nerve in the neck) to see if it is safe and helpful for people who have had a severe bleeding stroke called aneurysmal subarachnoid hemorrhage. About 25 adults in the intensive care unit will rec…
Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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New drug could extend window for treating deadly stroke
Disease control Recruiting nowThis trial is testing a drug called tenecteplase for people with a severe stroke caused by a blockage in the basilar artery at the back of the brain. About 688 participants will receive either tenecteplase or standard care within 24 hours of symptoms starting, followed by a clot-…
Phase 2/3 • Sponsor: University of Melbourne • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Smart glove could bring arm rehab home for brain injury patients
Disease control Recruiting nowThis study tests whether a smart glove can help people with brain disorders (like stroke or brain injury) improve arm and hand function from home. Forty adults with lasting arm weakness will either use the smart glove for guided exercises or do standard home therapy. The goal is …
Sponsor: Samsung Medical Center • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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New hope for medium vessel stroke? trial tests direct Clot-Busting drug
Disease control Recruiting nowThis study is testing whether giving a clot-busting drug (tenecteplase) directly into the blocked brain artery can improve outcomes for people having a stroke caused by a medium-sized vessel blockage. About 282 participants will be randomly assigned to receive either the intra-ar…
Sponsor: The Second Hospital of Anhui Medical University • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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New hope for early Alzheimer's? drug GSK4527226 tested for Long-Term safety
Disease control Recruiting nowThis study is an extension of an earlier trial, testing the long-term safety and effectiveness of the drug GSK4527226 in people with early Alzheimer's disease (mild cognitive impairment or mild dementia). All 220 participants will receive the drug, and researchers will monitor fo…
Phase 2 • Sponsor: GlaxoSmithKline • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Sound waves open brain barrier to attack deadly childhood tumors
Disease control Recruiting nowThis early study tests whether focused ultrasound can safely open the blood-brain barrier in children with progressive diffuse midline glioma (DMG), a rare and aggressive brain tumor. Ten children aged 4–21 will receive oral etoposide chemotherapy after ultrasound treatment to al…
Phase 1 • Sponsor: Columbia University • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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New stent aims to prevent stroke in patients with clogged brain arteries
Disease control Recruiting nowThis study is testing a special stent coated with the drug rapamycin to treat narrowed brain arteries in people who haven't gotten better with medication alone. About 300 participants will receive the stent and be monitored for up to a year to see if it reduces the risk of stroke…
Sponsor: The Affiliated Hospital of Qingdao University • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Ear zap may cut ICU stays and costs for brain injury patients
Disease control Recruiting nowThis study tests a non-invasive device that gently stimulates a nerve in the ear to help patients with serious brain or spinal cord injuries recover in the intensive care unit. Researchers want to see if it reduces complications like infections, the need for a breathing tube, and…
Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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Could a blood pressure cuff boost brain recovery after aneurysm surgery?
Disease control Recruiting nowThis study tests whether a non-invasive treatment called remote ischemic conditioning (RIC) can help people recover after surgery for a ruptured brain aneurysm. RIC involves using a blood pressure cuff on the leg to create brief, harmless blood flow interruptions, which may trigg…
Sponsor: Beijing Tiantan Hospital • Aim: Disease control
Last updated Jun 26, 2026 15:12 UTC
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Portable MRI could speed up stroke treatment
Diagnosis Recruiting nowResearchers test whether a portable low-field MRI scanner in the emergency department can help diagnose ischemic stroke faster and guide treatment. The trial enrolls 60 adults who arrive within 6 hours of stroke symptoms and are eligible for clot-busting drugs or clot removal. By…
Sponsor: Chinese University of Hong Kong • Aim: Diagnosis
Last updated Sep 12, 2026 00:00 UTC
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Blood test may unmask Alzheimer's during hospital stays
Diagnosis Recruiting nowThis study is testing whether a blood test (Quest AD-Detect) can help doctors identify Alzheimer's disease earlier in patients aged 60-90 who are hospitalized with confusion or delirium. The test looks for a protein linked to Alzheimer's. Patients with positive results will get f…
Sponsor: Covenant Health, US • Aim: Diagnosis
Last updated Jun 27, 2026 07:55 UTC
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Ambulance EEG could cut stroke treatment delays by an hour
Diagnosis Recruiting nowThis study tests a portable EEG device called StrokePointer that ambulance crews can use to detect severe strokes caused by large vessel blockages. Currently, over half of these patients are taken to hospitals that cannot perform the needed clot-removal procedure, causing an aver…
Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) • Aim: Diagnosis
Last updated Jun 27, 2026 07:53 UTC
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Can a phone app nudge people toward exercise and slow Parkinson's?
Prevention Recruiting nowThis trial tests whether a smartphone app can help people with REM sleep behavior disorder, a condition that often precedes Parkinson's, become more physically active over two years. Participants receive personalized activity goals through the app and track their steps and exerci…
Sponsor: Radboud University Medical Center • Aim: Prevention
Last updated Aug 29, 2026 00:00 UTC
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Could a phone app nudge people to exercise and slow Parkinson's before symptoms appear?
Prevention Recruiting nowThis trial tests whether a smartphone app can help 600 people with Parkinson's-related gene mutations increase their daily physical activity over two years. Participants set their own exercise goals and get feedback through the app. Researchers will measure changes in step counts…
Sponsor: Radboud University Medical Center • Aim: Prevention
Last updated Aug 29, 2026 00:00 UTC
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Step toward prevention: app-based exercise may protect the brain in Parkinson's risk group
Prevention Recruiting nowThis study tests whether increasing physical activity through a motivational smartphone app can slow cognitive decline in people with isolated REM sleep behavior disorder (iRBD), an early sign of Parkinson's disease and related disorders. Researchers will enroll 130 participants …
Sponsor: University Hospital, Bonn • Aim: Prevention
Last updated Jun 27, 2026 08:11 UTC
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Brain pacemaker tweak could help stroke and tremor patients speak and swallow better
Symptom relief Recruiting nowThis study looks at whether adjusting deep brain stimulation (DBS) can improve movement, speech, and swallowing in people already implanted with DBS for conditions like tremor, stroke, or traumatic brain injury. Researchers will test hand dexterity, grip strength, facial movement…
Sponsor: Jorge Gonzalez-Martinez • Aim: Symptom relief
Last updated Sep 20, 2026 00:00 UTC
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New pill aims to quiet Alzheimer's psychosis
Symptom relief Recruiting nowThis Phase 2 study tests an experimental drug, ML-007C-MA, to see if it can safely reduce hallucinations and delusions in people with Alzheimer's disease. About 300 participants aged 55 to 90 will receive either the drug or a placebo. The main goal is to measure changes in psycho…
Phase 2 • Sponsor: MapLight Therapeutics • Aim: Symptom relief
Last updated Aug 29, 2026 00:00 UTC
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Music before bed may ease Alzheimer's agitation, new study hopes
Symptom relief Recruiting nowThis pilot study tests whether listening to music in the evening can help people with Alzheimer's disease or related disorders fall asleep faster and behave more calmly. Researchers will compare music therapy to audiobooks in 48 adults living in secure care units. The goal is to …
Sponsor: Centre Hospitalier Universitaire de Saint Etienne • Aim: Symptom relief
Last updated Aug 05, 2026 00:00 UTC
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Gentle brain zaps may restore arm function in chronic stroke survivors
Symptom relief Recruiting nowThis study tests a low-intensity brain stimulation method called kTMP to help people who had a stroke at least 12 months ago improve arm and hand movement. About 12 adults aged 18-80 with moderate arm weakness will receive kTMP alongside motor rehabilitation. The goal is to see i…
Sponsor: Magnetic Tides • Aim: Symptom relief
Last updated Jul 24, 2026 00:00 UTC
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Smart board could bring arm rehab home for brain injury patients
Symptom relief Recruiting nowThis study tests whether a smart board device can help people with arm weakness from brain disorders (like stroke or brain injury) do rehab at home. Forty adults will either use the smart board or a workbook for 4 weeks. The goal is to see if the smart board improves arm function…
Sponsor: Samsung Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Could a magnetic helmet boost memory in Alzheimer's?
Symptom relief Recruiting nowThis study tests a device that combines magnetic brain stimulation with cognitive exercises to see if it can improve thinking and memory in people with mild Alzheimer's disease. About 180 participants aged 60-85 will receive either real or sham stimulation along with real cogniti…
Sponsor: Advanced Technology & Communications • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Magnetic pulses to the brain may curb suicidal thoughts in veterans
Symptom relief Recruiting nowThis study tests a magnetic brain stimulation technique called iTBS in 55 veterans aged 22-65 who have had a mild traumatic brain injury and struggle with impulsivity or suicidal thoughts. The treatment involves applying magnetic pulses to the front of the head over several sessi…
Phase 1 • Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
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Your phone could help beat depression: new app trial launches
Symptom relief Recruiting nowThis study tests whether a smartphone app that tracks daily mood and symptoms can help doctors treat depression more effectively. 200 adults with depression will use the app for 6 weeks, while a comparison group receives standard care. The goal is to see if the app improves treat…
Sponsor: Centre Hospitalier Charles Perrens, Bordeaux • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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New combo therapy aims to restore hand function after stroke
Symptom relief Recruiting nowThis study tests whether combining virtual reality training with a gentle brain stimulation technique can improve arm and hand movement in people who had a stroke at least three months ago. Researchers will enroll 100 adults to compare the effects of this combination on motor ski…
Sponsor: King Saud University • Aim: Symptom relief
Last updated Jun 27, 2026 08:07 UTC
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Scientists zap brain during surgery to uncover movement secrets
Knowledge-focused Recruiting nowThis study looks at how deep brain stimulation (DBS) changes movement in people with conditions like Parkinson's disease or essential tremor. About 60 people scheduled for DBS surgery will have extra temporary electrodes placed on the brain to measure muscle activity during stimu…
Sponsor: Jorge Gonzalez-Martinez • Aim: Knowledge-focused
Last updated Sep 20, 2026 00:00 UTC
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Can your education and background protect your brain after a stroke?
Knowledge-focused Recruiting nowThis study looks at how social and lifestyle factors—like education, race, and income—affect a person's thinking and memory after a stroke. Researchers will interview 450 adults who had a stroke and review their brain scans and medical records. The goal is to understand why some …
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Sep 19, 2026 00:00 UTC
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Brain pressure monitor could eliminate need for drilling into skull
Knowledge-focused Recruiting nowThis study is testing a new device that aims to measure pressure inside the skull from the outside, avoiding the need for surgery. Currently, doctors must drill a hole in the skull to monitor intracranial pressure (ICP) in patients with conditions like traumatic brain injury or s…
Sponsor: CoMind Technologies Limited • Aim: Knowledge-focused
Last updated Sep 06, 2026 00:00 UTC
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Can a single gene therapy dose keep working for 14 years?
Knowledge-focused Recruiting nowThis study follows people who received an investigational gene therapy in an earlier iECURE trial for a urea cycle disorder, a condition that can cause dangerous ammonia buildup. Researchers will track safety, side effects, and whether the therapy's effects last over up to 14.5 y…
Sponsor: iECURE, Inc. • Aim: Knowledge-focused
Last updated Sep 02, 2026 00:00 UTC
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Brain chemical may unlock migraine mystery
Knowledge-focused Recruiting nowThis study gives a natural brain chemical called adrenomedullin to 26 people with migraines to see if it triggers an attack. Participants first receive a migraine-preventing drug (erenumab) to block related receptors. The goal is to understand how migraines start, not to test a n…
Sponsor: Danish Headache Center • Aim: Knowledge-focused
Last updated Aug 30, 2026 00:00 UTC
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Major stroke study aims to unlock secrets of brain attacks
Knowledge-focused Recruiting nowThis study is for adults 18 and older who have had a stroke or a transient ischemic attack (TIA), often called a mini-stroke. The goal is to collect information from standard medical tests and some extra research tests, like blood draws and brain scans, to better understand how t…
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Aug 29, 2026 00:00 UTC
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Scientists watch brain diseases unfold to find better ways to diagnose and treat
Knowledge-focused Recruiting nowThis study aims to learn more about how infections and inflammation harm the brain and nerves. Researchers will collect samples and perform tests on people aged 2 and older who have or may have these conditions. The goal is to better understand these diseases so that better tests…
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Aug 22, 2026 00:00 UTC
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New blood test could reveal stroke damage in real time
Knowledge-focused Recruiting nowThis study will measure a protein called BD-tau in the blood of 100 people who have had an acute ischemic stroke. Researchers will take blood samples every hour for 48 hours to see how the protein levels change over time. The goal is to better understand brain injury patterns and…
Sponsor: Ludwig-Maximilians - University of Munich • Aim: Knowledge-focused
Last updated Aug 22, 2026 00:00 UTC
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Can genes explain brain malformations?
Knowledge-focused Recruiting nowThis study aims to understand the genetic causes of brain development disorders, including Aicardi syndrome, polymicrogyria, and Dandy-Walker malformation. Researchers will analyze genetic data from 2000 participants with these conditions, all confirmed by MRI. The goal is to use…
Sponsor: University of California, San Francisco • Aim: Knowledge-focused
Last updated Aug 19, 2026 00:00 UTC
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Can a simple test predict Alzheimer's before symptoms worsen?
Knowledge-focused Recruiting nowThis study aims to understand brain changes in people with mild cognitive impairment (MCI) and Alzheimer's disease. Researchers will use MRI, EEG, cognitive tests, and blood and stool samples to find differences between healthy individuals and those with cognitive impairment. The…
Sponsor: Norwegian University of Science and Technology • Aim: Knowledge-focused
Last updated Aug 15, 2026 00:00 UTC
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Could tailored blood thinner dosing prevent strokes in chinese patients?
Knowledge-focused Recruiting nowThis study looks at how blood levels of common blood thinners (apixaban, dabigatran, edoxaban, and rivaroxaban) change over time in Chinese patients with atrial fibrillation. Researchers will take blood samples before and after stopping the medication for medical procedures. The …
Sponsor: Chinese University of Hong Kong • Aim: Knowledge-focused
Last updated Aug 01, 2026 00:00 UTC
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AI camera watches newborns' brains—no wires, no touch
Knowledge-focused Recruiting nowThis study tests whether a video camera with artificial intelligence can track newborn brain health by analyzing their movements. About 200 babies in the NICU will be recorded continuously from admission to discharge. The AI's findings are kept from doctors for now, to see if the…
Sponsor: Artemis AI Labs • Aim: Knowledge-focused
Last updated Jul 17, 2026 00:00 UTC
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Sleep and seizures: new study probes why stroke triggers epilepsy in some patients
Knowledge-focused Recruiting nowThis observational study investigates why some people develop epilepsy after a stroke, while others do not. Researchers will compare first-time stroke patients with healthy volunteers using brain imaging (MRI), electrical brain recordings (EEG), and overnight sleep studies. The g…
Sponsor: Norwegian University of Science and Technology • Aim: Knowledge-focused
Last updated Jul 09, 2026 00:00 UTC
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New brain scan study aims to uncover Tau's role in memory loss
Knowledge-focused Recruiting nowThis study uses a special PET scan to look at tau protein buildup in the brain and see if it relates to memory and thinking problems. Researchers will study 900 adults, some with normal memory and some with mild dementia. The goal is to better understand Alzheimer's disease, not …
Sponsor: Tammie L. S. Benzinger, MD, PhD • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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Brain scans may reveal Alzheimer's before symptoms start
Knowledge-focused Recruiting nowThis study uses brain scans (PET and MRI) to find early signs of Alzheimer's disease in 650 adults with normal cognition or early-stage symptoms. Participants receive special tracers that highlight amyloid and tau proteins in the brain. The goal is to understand how these biomark…
Sponsor: Tammie L. S. Benzinger, MD, PhD • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:04 UTC
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Spinal circuit secrets: new study probes Stroke's hidden effects
Knowledge-focused Recruiting nowThis study looks at how stroke changes the way the spinal cord handles sensory signals. Researchers will stimulate nerve roots in the neck during surgery and measure muscle and brain responses in 15 people (some with stroke, some healthy). The goal is to better understand spinal …
Sponsor: Peter C. Gerszten, MD • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:03 UTC
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Brain surgery gets a High-Tech helper: first human test of CIPHER system begins
Knowledge-focused Recruiting nowThis early-stage trial tests a new device called the CIPHER System, which records brain activity during surgery to remove a type of brain tumor called glioma. Ten adults with newly diagnosed glioma will have the device placed on their brain surface during standard tumor removal. …
Sponsor: Coherence Neuro Australia Pty Limited • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Scientists map Brain's reaching circuits after stroke
Knowledge-focused Recruiting nowThis study uses a robotic arm and brain stimulation to learn how different brain areas control reaching movements in people who have had a stroke and those who haven't. Researchers will measure movement paths, speeds, and accuracy. The goal is to understand brain changes after st…
Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Baby eye exams may reveal hidden brain injury
Knowledge-focused Recruiting nowThis study looks at whether simple, non-invasive eye tests can help predict brain development in newborns with hypoxic-ischemic encephalopathy (HIE), a type of brain injury caused by lack of oxygen. Researchers will measure eye function using visual evoked potential (VEP) and ele…
Sponsor: University of Wisconsin, Madison • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:34 UTC
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Video link in ambulance could speed up stroke care
Knowledge-focused Recruiting nowThis study tests whether a live video call between a neurologist and emergency medical technicians (EMTs) can improve the accuracy of stroke detection in the ambulance. About 512 adults with suspected stroke will take part. The goal is to see if video assistance helps diagnose st…
Sponsor: University of Southern Denmark • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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Thin air for thicker brains? study tests hypoxia against aging
Knowledge-focused Recruiting nowThis study explores whether mild low-oxygen (hypoxic) conditioning, alone or combined with exercise, can improve blood vessel function in the brains of inactive adults aged 60-80. Researchers will measure changes in brain blood flow and other health markers in 64 participants. Th…
Sponsor: University Hospital, Grenoble • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Brain zaps may restore speech and hand movement in stroke survivors
Knowledge-focused Recruiting nowThis study tests whether temporarily stimulating a specific part of the brain can improve hand, arm, and speech abilities in people who had a stroke at least 6 months ago. Ten participants will have a thin wire placed deep in the brain for less than 30 days to deliver mild electr…
Sponsor: Jorge Gonzalez-Martinez • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Scientists hunt for the gene behind rare brain disorder
Knowledge-focused Recruiting nowThis study aims to find the specific gene that causes Aicardi syndrome, a rare brain disorder. Researchers will collect blood and skin samples from up to 500 patients and their parents to analyze their DNA. The goal is to identify genetic changes unique to people with Aicardi syn…
Sponsor: Baylor College of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC
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Parkinson's puzzle: does it start in the brain or the body?
Knowledge-focused Recruiting nowThis study follows 150 people with early-stage Parkinson's disease to see if the condition starts in the brain or the body first. Researchers will track symptoms like walking problems and thinking changes over 5 years using tests, scans, and questionnaires. The goal is to better …
Sponsor: Azienda USL Reggio Emilia - IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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AI cameras could spot delirium severity in ICU patients
Knowledge-focused Recruiting nowThis study tests whether a video camera and artificial intelligence can accurately measure delirium severity in ICU patients over 50. Researchers will compare the camera data with standard bedside assessments. The goal is to create a passive digital marker that works automaticall…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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Massive stroke study aims to bridge gap between clinical trials and Real-World care
Knowledge-focused Recruiting nowThis study tracks 350 stroke patients across the Asia-Pacific to see how well a proven clot-removal procedure (endovascular thrombectomy) works in everyday hospitals, not just in controlled trials. Researchers will analyze patient outcomes, imaging, and even the removed clots to …
Sponsor: Chinese University of Hong Kong • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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5,000 volunteers join hunt for brain disease clues
Knowledge-focused Recruiting nowThis long-term study is tracking 5,000 adults in Hong Kong who either have a brain disease (like stroke or dementia) or are at high risk due to family history or early signs. Researchers will collect medical records and questionnaires every 6 months to find what factors lead to b…
Sponsor: Chinese University of Hong Kong • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC
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Emergency intubation showdown: which method saves more oxygen?
Knowledge-focused Recruiting nowThis study compares two ways to place a breathing tube in emergency patients who are still breathing on their own but need help. The methods are Rapid Sequence Intubation (RSI) and Delayed Sequence Intubation (DSI). Researchers will measure oxygen levels, complications, and survi…
Sponsor: Kanuni Sultan Suleyman Training and Research Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Scientists launch massive mitochondrial disease registry to unlock secrets of rare disorders
Knowledge-focused Recruiting nowThis study is creating a large registry and tissue bank for people with mitochondrial disorders. Researchers will collect medical information and samples from up to 1,000 participants, including those diagnosed with or suspected to have a mitochondrial disease. The goal is to gat…
Sponsor: Columbia University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Brain tumor tissue bank aims to unlock future cures
Knowledge-focused Recruiting nowThis study collects brain tumor tissue samples from 4,000 children and adults undergoing brain surgery. The samples are stored in a tissue bank at the University of Florida for future research. The goal is to help scientists find better treatments and cures for brain tumors.
Sponsor: University of Florida • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC
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Brain zap test may spot dementia early in Parkinson's
Knowledge-focused Recruiting nowThis study uses a non-invasive brain stimulation technique called TMS to measure brain activity in 52 people with Parkinson's disease. The goal is to see if these measurements can tell the difference between normal thinking, mild cognitive impairment, and dementia, and predict fu…
Sponsor: Azienda Sanitaria Universitaria Integrata del Trentino • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC
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Stroke rehab showdown: does more therapy mean better recovery?
Knowledge-focused Recruiting nowThis study follows 213 adults recovering from a first ischemic stroke to see if the intensity of inpatient rehabilitation (high vs. moderate) affects their functional recovery at six months. It also compares people whose stroke was linked to atrial fibrillation with those whose s…
Sponsor: Parc de Salut Mar • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:04 UTC
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New study aims to solve the mystery of 'breakthrough' strokes in heart patients
Knowledge-focused Recruiting nowThis study will follow 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). Some were taking blood thinners when they had their stroke, others were not. Researchers want to understand why blood thinners fail in some patients, by looking at …
Sponsor: Insel Gruppe AG, University Hospital Bern • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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New ultrasound protocols aim to map normal blood vessel sizes
Knowledge-focused Recruiting nowThis study uses an advanced ultrasound machine to test new ways of measuring blood vessels in the arm and neck. Researchers will scan 60 healthy adults aged 18 to 75 to set normal ranges and check if the measurements are repeatable. The goal is to improve future diagnosis of kidn…
Sponsor: Mario Negri Institute for Pharmacological Research • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:14 UTC