Sound waves open brain barrier to attack deadly childhood tumors
NCT ID NCT05762419
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early study tests whether focused ultrasound can safely open the blood-brain barrier in children with progressive diffuse midline glioma (DMG), a rare and aggressive brain tumor. Ten children aged 4–21 will receive oral etoposide chemotherapy after ultrasound treatment to allow more drug to reach the tumor. The goal is to see if the procedure is safe and feasible, not yet to measure effectiveness.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Etoposide (oral chemotherapy) combined with focused ultrasound to open the blood-brain barrier
What this could lead to
If successful, this approach could improve drug delivery to brain tumors, potentially slowing disease progression in children with diffuse midline glioma.
What could go wrong
This is a very early, small feasibility study (10 children). It primarily tests safety and whether the blood-brain barrier can be opened—not yet whether it improves outcomes. Risks include side effects from etoposide and the ultrasound procedure.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Columbia University Irving Medical Center
RECRUITINGNew York, New York, 10032, United States
Contact Email: •••••@•••••
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