Cardiovascular disorder

Researchers at Penn State University are testing whether a healthy diet that includes two eggs every day changes cholesterol and other heart-health markers compared with a healthy diet that includes three eggs a week. The study enrolls about 65 adults with mildly elevated LDL cho…

This phase II trial tests whether intensive blood pressure management (targeting systolic BP below 120 mmHg) is better than standard care (below 140 mmHg) for patients with advanced kidney or thyroid cancer starting anti-angiogenic TKI therapy. The study enrolls 61 participants a…

This study tests a device that uses radiofrequency energy to calm overactive kidney nerves, which can drive high blood pressure. About 1,900 adults with uncontrolled hypertension will receive the procedure and be followed for years. The goal is to see if this approach safely and …

This study tests a new device called the Navitor TAVI system to replace a stiff, narrowed heart valve without open-heart surgery. It includes 1,500 people with severe aortic stenosis who are at low or intermediate risk for surgery. The goal is to see if the device is safe and eff…

Researchers are testing whether a structured primary care program can help adults aged 40 to 90 with higher heart or diabetes risk reach recommended prevention targets. The program trains doctors and nurses, uses routine data to flag at-risk patients before visits, and provides d…

This study tests two approaches—lifestyle medicine consultations and cognitive behavioral therapy (CBT)—to reduce cardiovascular risk in autistic individuals aged 9 to 26 who have a high body mass index. Participants are randomly assigned to receive lifestyle coaching, CBT sessio…

This Phase 2 trial tests an inhaled medication called mosliciguat in 135 people who have both lung scarring (interstitial lung disease) and high blood pressure in the lungs. Participants are randomly assigned to receive either the drug or a placebo for 16 weeks. The study measure…

This study tests whether a newer type of dialysis filter (medium cut-off membrane) can reduce inflammation and improve heart function better than the standard filter in people with end-stage kidney disease. Thirty adults on maintenance hemodialysis will use each filter for three …

This study looks at how ketogenic diets impact heart health in adults with epilepsy. Researchers will measure cholesterol, blood pressure, weight, and artery thickness over 12 months. Participants are adults 18 or older who are already on a keto diet or starting the modified Atki…

This trial is testing a device called the Aventus Thrombectomy System, which suctions out blood clots from the lungs in people with acute pulmonary embolism. The study involves 130 participants aged 18 to 80. The goal is to see if the device is safe and effective at improving blo…

This first-in-human trial tests a small device called the FIRE1 System, which is implanted in a major vein to monitor fluid buildup in people with heart failure. The study enrolls up to 50 adults who have recently needed hospital care for heart failure. Researchers check whether …

This early study tests a new device called the NORM™ system in 25 adults with heart failure. The device is placed inside a large vein near the heart to send health information to doctors. The goal is to see if the implant is safe and can reliably transmit data, which may help man…

This study investigates whether omega-3 fatty acids, natural fats found in fish and flaxseed, can help manage blood sugar and reduce inflammation in people with type 2 diabetes and heart disease. Participants take omega-3 supplements or a placebo for 28 days, and researchers meas…

This study tests a clinic program called ActivityChoice that helps cancer survivors become more physically active to lower their risk of heart disease. About 114 adult cancer survivors will be offered a choice of group in-person, group virtual, or self-monitored digital exercise …

This study tests whether a weekly injection of CagriSema (a combination of two drugs) can reduce the risk of heart attacks, strokes, and other heart-related events in people with established cardiovascular disease. About 7,100 participants will receive either CagriSema or a place…

This study tests whether a procedure called pulsed field ablation (PFA) is safer and more effective than anti-arrhythmic drugs as a first treatment for people with persistent atrial fibrillation, a type of irregular heartbeat. About 484 participants will be randomly assigned to r…

This phase 3 trial tests whether colchicine, an anti-inflammatory drug, can slow the progression of aortic valve stenosis—a narrowing of the heart's aortic valve that currently has no drug treatment. The study enrolls 150 people with moderate, symptom-free valve disease. Particip…

This trial tests whether sparsentan, a tablet that blocks a chemical called endothelin and lowers blood pressure, can improve blood vessel function and reduce stiffness in people with ANCA-associated vasculitis. Vasculitis is an autoimmune disease that damages blood vessels and r…

This phase 3 trial is testing whether the drug retatrutide can lower the chance of serious heart problems (like heart attacks and strokes) and slow kidney disease in 10,000 overweight adults who already have heart or kidney disease. Participants receive either retatrutide or a pl…

This study follows 250 people with severe aortic stenosis who receive the SAPIEN 3 transcatheter heart valve as part of their standard care. The goal is to see how safe and effective the valve is over the long term in everyday clinical practice. Researchers will track how many pa…

This Phase 3 trial tests whether a daily pill called AZD0780 can safely lower LDL (bad) cholesterol in adults with heart disease or at high risk. About 3,100 participants will receive either AZD0780 or a placebo for 52 weeks, and neither they nor their doctors will know which the…

This phase 2 trial tests an injectable drug called DII235 in 233 adults with high lipoprotein(a), a genetic condition that raises heart disease and stroke risk. Participants have heart disease or type 2 diabetes. The study compares different doses of DII235 against a placebo to s…

This trial tests whether an insomnia treatment can improve markers of heart health in adults with insomnia and risk factors for cardiovascular disease. Participants receive either a cognitive-behavioral therapy program for insomnia or a sleep education control. The study measures…

This early-stage study tests a new drug called AZD1705 in adults with high cholesterol (dyslipidemia). The main goal is to check if the drug is safe and how the body processes it. About 98 participants will receive either the drug or a placebo. This research helps determine if th…

This study compares two community-based programs designed to reduce heart disease risk factors—like high blood pressure and obesity—in Black women after pregnancy. About 432 Black or African American women who are early in pregnancy and have obesity or high blood pressure will ta…

This study looks at whether a telehealth system can help people in rural areas get better heart care. It connects local emergency services and clinics with heart experts at a major medical center. About 215 adults with heart symptoms will take part. The goal is to see if this app…

This study tests whether using the Impella heart pump during a high-risk stenting procedure helps people with weak hearts and blocked arteries. About 1,250 participants will be randomly assigned to get either Impella-supported stenting or standard care. The goal is to see if the …

This study tests a small sensor implanted in the lung artery that sends daily pressure readings to doctors. It involves 81 adults with advanced heart failure (NYHA Class III). The goal is to see if the device is safe and accurate, helping patients avoid hospital stays by catching…

This study tested a small sensor placed in the lung artery to help doctors monitor heart failure patients remotely. 738 people with advanced (NYHA Class III) heart failure took part. The goal was to see if using the sensor could reduce hospitalizations and deaths compared to a ta…

This study tests a new device called Tendyne, which is a replacement heart valve placed through a tube in the blood vessels, avoiding open-heart surgery. It is for people with a leaky mitral valve (mitral regurgitation) who are too high-risk for traditional surgery. The trial com…

This early study tested a new device called the Millipede ring, which is delivered through a catheter to tighten the mitral valve in people with functional mitral regurgitation (a leaky valve). Only 4 participants were enrolled to see if the procedure is safe and technically poss…

This trial compares two group-based education programs for people with serious mental illness who also have chronic physical conditions like diabetes or heart disease. One program, Integrated Illness Management and Recovery (I-IMR), covers both mental and physical health self-man…

This trial tests a procedure called pulmonary arterial denervation (PADN) for people with heart failure who also have high blood pressure in the lungs. A special catheter delivers radiofrequency energy to nerves in the pulmonary artery, which may help lower pressure and improve h…

This study investigates whether long-acting parathyroid hormone (PTH) analogues can reduce signs of early heart and blood vessel damage in adults with chronic hypoparathyroidism. Researchers will compare artery stiffness and heart function in people taking the PTH analogue palope…

This study tests whether a 12-week telephone health coaching program, called Support Your Heart, is practical and helpful for young adults aged 18-39 who have at least two heart disease risk factors (like poor sleep, inactivity, or high blood pressure). Twenty participants in the…

This phase 2 trial tests whether a daily low dose of colchicine, an anti-inflammatory drug used for gout, can reduce inflammation and heart disease risk in adults with type 1 diabetes. 102 participants aged 35–80 will take either colchicine or a placebo for 26 weeks, with an opti…

This study follows about 3000 people with complex coronary artery disease who receive the Ultimaster Nagomi stent, a device that slowly releases a drug to keep arteries open. The goal is to see how often the stent fails—meaning heart-related death, heart attack, or need for anoth…

This study looks at how prostate cancer treatments, especially hormone therapy, affect heart health. It includes two parts: one that follows men over time to track heart problems, and another that tests whether a program of healthy eating, exercise, smoking cessation, and medicat…

This study tests whether showing people images of their own carotid arteries (the main arteries in the neck) can improve how they and their doctors manage heart disease risk. Participants are adults aged 40, 50, or 60 who are already part of a health program in Sweden. Some recei…

This study looks at how well Onyx drug-eluting stents work in everyday medical practice for people with coronary artery disease. Researchers will track 4,500 patients to see if these stents are safe and effective compared to other stents. The main focus is on preventing stent-rel…

This trial studies nearly 1,000 people with severe aortic stenosis and blocked coronary arteries who need both a valve replacement (TAVI) and artery stenting (PCI). Researchers want to see if doing the stenting before or after the valve replacement leads to fewer deaths, heart at…

This study tests whether adding a specially trained doula, along with home blood pressure and weight monitoring, can improve blood pressure in women who had high blood pressure during pregnancy. About 454 women will be randomly assigned to usual care or the doula program. The goa…

This study compares two types of weight-loss surgery (gastric bypass and gastric banding) with an intensive diet and exercise program for controlling type 2 diabetes in moderately obese adults aged 25 to 55. The goal is to see which approach works best for improving diabetes and …

This study tests a daily oral drug called nemtabrutinib (ARQ 531) in 190 people with blood cancers like lymphoma or leukemia that have come back or not responded to prior treatment. The goal is to find a safe dose and see if the drug can shrink tumors. It is an early-phase trial,…

This study tests whether a church-based program led by community health workers can help Black adults in Louisiana lower their risk of heart disease, high blood pressure, diabetes, and high cholesterol. About 812 participants from local churches will receive either a health worke…

This study compares two cholesterol-lowering strategies in adults aged 75 and older who have heart or blood vessel disease. One group aims for a very low LDL cholesterol target (below 55 mg/dL) using high-intensity statins, while the other receives standard moderate-intensity sta…

This study tests whether a drug-coated balloon is as safe and effective as a drug-eluting stent for people with large coronary artery disease. About 1,400 participants from multiple countries will be randomly assigned to one of the two treatments. The goal is to see which approac…

This study tests a health support program for 600 people with disabilities who also have chronic conditions like diabetes or obesity. The program includes weekly nutrition classes, three exercise sessions per week, and help managing chronic conditions. Researchers want to see if …

This large study compares two popular diabetes drugs, tirzepatide and semaglutide, in 26,000 people who have both type 2 diabetes and a type of heart failure. Researchers will track who ends up in the hospital for heart failure or dies, to see if one drug works better. The goal i…

This study tests a new device called the Cardiovalve TR system for people with a leaky tricuspid heart valve (tricuspid regurgitation). The goal is to see if the device is safe and can reduce the leak. The study involves 157 participants with moderate to severe symptoms. Research…

This study tests a 90-day fully virtual lifestyle program for adults aged 30-60 who are sedentary and at risk for heart disease. Participants exercise via Peloton, take daily supplements (Omega-3, Vitamin D3, Magnesium, fiber), and use wearable devices to track activity and sleep…

This study is testing a new device called the Edwards EVOQUE system, which replaces the tricuspid valve using a thin tube (catheter) instead of open-heart surgery. The trial includes 228 people with moderate or severe tricuspid regurgitation who still have symptoms despite medica…

This study is testing a new online app that helps people who have had a heart attack or stroke follow a Mediterranean lifestyle — including diet, sleep, exercise, and social habits. About 80 to 100 adults in Spain will use the app for 8 months to see if it improves their health a…

This study tests whether a 12-week home-based exercise program can improve heart health in kidney transplant recipients. Half of the 50 participants will follow the exercise plan, while the other half continues usual care. Researchers will use detailed MRI scans to measure change…

This study compares a new leadless pacemaker (Micra AV) to a standard dual-chamber pacemaker in 100 patients aged 70 and older with heart block. The goal is to see if the leadless version works just as well for exercise capacity. Participants are randomly assigned to receive one …

This study looks at how the timing of meals and sleep patterns influence blood sugar, heart health, and weight loss in adults with type 2 diabetes, obesity, or high blood pressure. Researchers will provide nutritional guidance and track changes in weight, lab results, and body me…

This study tests a newer drug-coated stent (Resolute Onyx) against an older one (Resolute Integrity) in 550 people with blocked heart arteries in China. The goal is to see if the new stent works better at keeping arteries open after angioplasty. Participants receive one of the tw…

This study tests a special stent coated with a drug called zotarolimus to treat people with blocked heart arteries. The stent is placed during a procedure to open the artery and slowly releases medication to prevent re-blockage. About 591 participants in China are being followed …

This study tests a device called Paradise™ that uses ultrasound to calm overactive nerves in the kidneys, which can drive high blood pressure. Researchers will compare the device to a sham (fake) procedure in 154 adults with hypertension who are already taking two blood pressure …

This study tests a proactive, culturally tailored outreach program to help BIPOC adults who smoke quit tobacco. Researchers will enroll 700 participants from two health systems and provide personalized materials and support to connect them with proven cessation treatments. The go…

This early study is testing a new balloon-expandable heart valve device (TAVI) in 8 people with severe aortic stenosis who are at increased surgical risk. The goal is to see if the device can be safely delivered and perform as intended. Because this is a first-in-human study with…

This study follows 116 people who received an experimental gene-editing therapy for heart disease or high cholesterol. Researchers will monitor them for 15 years to track any side effects and how well the treatment controls cholesterol levels. The goal is to understand the long-t…

This study tests a device called the Cleaner Pro Thrombectomy System, which is threaded through a blood vessel to suction out clots in the lungs of people with acute pulmonary embolism. The trial aims to see if the device safely reduces heart strain and avoids major complications…

This study tests whether giving stroke patients extra tests—like checking for hidden heart problems, artery stiffness, and leg circulation—can lower their chance of having another stroke or heart attack. About 600 people in Stockholm will get this expanded check-up and a personal…

This study is tracking 251 patients with symptomatic coronary heart disease who received the EucaLimus stent, a sirolimus-coated device designed to keep arteries open. The goal is to see how well the stent works and how safe it is over the long term in real-world use. Researchers…

This study tests whether a comprehensive program of lifestyle changes (diet, exercise, education) plus aggressive cholesterol-lowering drugs, guided by PET heart scans, can reduce heart attacks and deaths better than standard medical care. Over 1,000 adults with suspected or know…

This study was designed to test a special catheter that delivers clot-dissolving medicine directly into the lungs of people with blood clots. The trial was withdrawn before enrolling any participants, so no results are available. It would have included adults aged 18 to 80 with s…

This study tests whether a personalized program—including patient navigation, individual health benefits, and financial help—can reduce deaths from preventable causes like heart attacks, strokes, heavy drinking, and HIV in low-income adults aged 35–64. Researchers will track chan…

This study tests whether a daily dose of alpha lipoic acid, an antioxidant supplement, can lower the risk of heart problems in 50 children who are on regular hemodialysis. Participants will either take the supplement or a placebo pill for a period, and researchers will monitor fo…

This study compares two types of stents (small mesh tubes) used to open blocked heart arteries in people with severe three-vessel coronary artery disease. About 1,550 participants will receive either the SUPRAFLEX Cruz or SYNERGY stent. The goal is to see which stent is safer and…

This study tests a new device called EVOQUE that replaces the tricuspid valve in people with severe leakage (tricuspid regurgitation). The goal is to see if it is safe and can reduce leakage, improve symptoms, and enhance quality of life compared to standard medical therapy alone…

This study tests a program that combines a mobile health app, community health workers, and text message reminders to help people lower their risk of heart disease. About 968 adults in Argentina who are at high risk will take part. The goal is to see if this approach can improve …

This study tests a new way for cancer doctors and primary care doctors to work together to help cancer survivors manage other health problems like high blood pressure, diabetes, and high cholesterol. About 800 adults with certain cancers and at least one of these conditions will …

This study tracks 73 adults with homozygous familial hypercholesterolemia (HoFH), a rare genetic disorder causing extremely high cholesterol and early heart disease. Researchers will compare major cardiovascular events (like heart attacks and strokes) during the first three years…

This study looks at the long-term safety of the drug ralinepag in people with pulmonary arterial hypertension (PAH), a serious lung condition that makes it hard to breathe. About 1,000 adults who were in earlier ralinepag studies can join. The goal is to see if the drug remains s…

This study tests whether a specially designed app can help women who had high blood pressure or diabetes during pregnancy get the recommended heart check-ups after giving birth. About 400 women from Oslo University Hospital will either use the app or receive standard care. The go…

This trial tests whether trained village health workers, using a smartphone app, can effectively manage high blood pressure in rural Lesotho. About 1,350 participants with either uncontrolled or controlled hypertension will receive either community-based care (medication and moni…

This study is a registry that collects information on the AMDS stent, a device used to treat a life-threatening tear in the aorta (the main artery). The registry includes 301 adults aged 18-80 with acute DeBakey type I aortic dissection or intramural hematoma. The goal is to see …

This study looks at whether eating walnuts can improve cholesterol levels, reduce inflammation, and change gut bacteria in overweight adults aged 45-70 who are at risk for heart disease. Participants eat walnuts as part of their diet, and researchers measure blood lipids, blood p…

This study is tracking 282 patients with coronary artery disease who received a paclitaxel-coated balloon catheter (Support C DCB) during routine care. Researchers are monitoring for heart-related events like cardiac death, heart attack, or the need for repeat procedures over the…

This study looks at whether eating dark chocolate regularly can improve key heart health markers like blood pressure, blood flow, and cholesterol. Researchers at San Diego State University are comparing dark chocolate, bloomed dark chocolate, and white chocolate in 45 generally h…

This early study is testing a new balloon-expandable heart valve system from Abbott for people with severe, symptomatic aortic stenosis. The valve is delivered through a catheter, avoiding open-heart surgery. Only 11 participants are enrolled to check if the device is safe and wo…

This study tests two different ways to perform a heart ablation for a condition called PSVT (a fast heart rhythm) without using any X-ray radiation. About 70 adults who have PSVT and have not had this procedure before will take part. The goal is to see which workflow is faster an…

This study tests a new, less invasive heart valve (SAPIEN 3) for people with severe aortic stenosis who are at low risk for standard surgery. About 1,000 participants will be randomly assigned to get the new valve or traditional open-heart surgery. The goal is to see if the new v…

This study tests a program called Living Healthy for Moms, where doulas provide cognitive behavioral training and heart health coaching to new mothers. The goal is to reduce postpartum depression and lower the risk of heart problems. The trial includes 21 mothers who recently gav…

This study tests whether giving patients capsules containing gut bacteria (called Probacine) before and after heart surgery can reduce gut injury and organ failure. Researchers will enroll 500 adults undergoing cardiovascular surgery. The goal is to see if changing the gut microb…

This study tests whether a pharmacist-led program can help people reduce their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity are taking part. Pharmacists use a step-by-step guide to assess risk and support lifestyle change…

This study tests whether colchicine, a drug used for gout, can improve blood vessel stiffness and heart function in people with high blood pressure. About 150 adults with hypertension and additional risks like diabetes or high cholesterol will take colchicine or a placebo daily f…

This large trial tests whether a program led by village doctors can help control high blood pressure in rural China. Over 33,000 participants will receive training, discounted medications, and a simple treatment protocol. The study aims to see if this approach improves blood pres…

This study tests a less invasive way to replace a failing mitral valve in the heart. About 53 people who already have a surgical valve that is not working well will receive a new valve placed inside the old one using a thin tube. The goal is to see if this procedure is safe and h…

This study tests whether using an implantable heart monitor (or a wearable patch) to detect atrial fibrillation early after catheter ablation can reduce the total time spent in AF. About 120 people with paroxysmal or persistent AF will be monitored for 15 months. The goal is to s…

This study tests whether giving evolocumab, a powerful cholesterol-lowering drug, very early during a heart attack hospital stay can reduce the chance of another heart attack, stroke, or death. About 6,000 adults hospitalized for a heart attack are randomly assigned to receive ev…

This pilot study tests an 8-week program called REACH-SCI designed to help people with spinal cord injury (paraplegia) reduce the time they spend sitting. The program includes a wearable activity tracker, education, goal setting, one-on-one coaching, a peer support chat, and exer…

This study tests whether teaching families to have healthier, more frequent meals together can lower children's weight and improve their diet. Over 12 months, 500 families with children aged 5-10 will receive in-home coaching, video feedback of their meals, and text-message tips.…

This study tests whether having extra appointments with a heart specialist at a local GP practice helps people get better treatment for heart, kidney, metabolic, and lung conditions. 138 high-risk adults will either receive standard GP care or additional specialist reviews to opt…

This study tests whether ivabradine, a drug that slows heart rate, can prevent heart injury after noncardiac surgery. About 2,100 high-risk patients aged 45 and older will receive either ivabradine or a placebo before and after surgery. The goal is to see if the drug reduces hear…

Researchers are studying whether high levels of a blood protein called Galectin-3 can predict which patients will develop an irregular heartbeat after coronary artery bypass grafting. About 90 adults scheduled for this surgery will give a blood sample before the operation and be …

This early-phase trial tests a radioactive imaging agent called 18F-mFBG to see how well it can show the nerves in the heart. Researchers will give the agent to 10 adults—some with heart disease and some without—and take PET scans over time. The goal is to measure how the agent m…

This trial tests whether adding a polygenic risk score (a DNA-based estimate of heart disease risk) to standard risk assessment helps better identify who needs preventive measures like statins or lifestyle changes. About 205 adults aged 40–69 with intermediate cardiovascular risk…

This Italian study is testing whether heavy smokers can be screened for lung cancer just as effectively with a CT scan every two years instead of every year, and whether a simple blood test can help catch cancers early. Over 7,300 current or former heavy smokers are taking part a…

This study is testing whether a smart blood pressure cuff called the Withings BPM Core can accurately detect atrial fibrillation, a common heart rhythm problem. Researchers will compare the device's single-lead ECG readings to a standard 12-lead ECG in 160 adults. If it works wel…

This study explores whether fluid from the skin can be used to detect signs of heart disease. Researchers will collect skin fluid and blood samples from 30 volunteers, including older adults with heart failure and younger healthy adults. The goal is to see if certain biomarkers i…

This study tests whether a blood test for NT-proBNP can spot undiagnosed heart failure in 706 people with diabetes who are at high risk. Those with elevated levels get a heart ultrasound and exam. The goal is to see if this screening strategy leads to more early diagnoses and pro…

This study explores whether a simple, non-invasive leg movement test can measure blood vessel health in older adults. Researchers will use ultrasound to track blood flow changes after a passive leg movement, comparing young healthy people and older patients undergoing heart tests…

This study tests whether portable ultrasound and blood glucose monitors can help doctors catch chronic conditions like diabetes, heart disease, and kidney disease earlier than usual. About 200 adults will use these devices or receive standard care for 6 months. The goal is to see…

This study is testing whether a new risk score can help find people who have atrial fibrillation (an irregular heartbeat) but don't know it yet. About 1,955 adults at higher risk will use a remote ECG monitor at home. The goal is to see if the risk score correctly identifies who …

Antiphospholipid syndrome (APS) raises the risk of blood clots and strokes, and doctors often prescribe warfarin to prevent another stroke. Warfarin requires frequent blood tests and carries bleeding risks, especially for younger patients. This trial compares clopidogrel-based an…

This large Phase 3 study tests whether inclisiran, a twice-yearly injection, can prevent major heart problems like heart attacks, strokes, and heart-related death in people at high risk who have not yet had such an event. Over 14,000 participants are receiving either inclisiran o…

This trial tests whether routinely screening heart attack patients for H. pylori, a common stomach bacteria, can prevent upper gastrointestinal bleeding. The bacteria can cause ulcers that bleed, especially when patients take blood thinners after a heart attack. Researchers will …

This study tests a program called Mom♥Health to help mothers of young children reduce their risk of heart disease. About 40 moms with kids aged 5 or younger will receive support and resources through their child's daycare center. The goal is to see if this approach is practical a…

This study tests whether a dedicated care coordinator can help people with psoriasis or psoriatic arthritis reduce their risk of heart disease. About 520 adults aged 40-75 who do not already take cholesterol medication will receive support to manage risk factors like high cholest…

This large study tested whether taking daily vitamin D3 and omega-3 (fish oil) supplements can lower the risk of developing cancer, heart disease, or stroke. Over 25,000 healthy older adults (men 50+, women 55+) took the supplements or placebos for about 5 years. The goal is to s…

This study looks at whether helping communities switch to cleaner cookstoves can lower indoor air pollution and prevent high blood pressure. About 1,280 households in Nigeria will take part. Some families get extra support to use the new stoves, while others just receive informat…

This study tests whether using a smartphone app and a home blood pressure monitor can help prevent heart disease in women who had high blood pressure during pregnancy. 120 women who gave birth at Northwestern Memorial Hospital will use these digital tools for 12 months after deli…

This study tests whether giving a daily statin (rosuvastatin 20mg) to healthy people with a high genetic risk for heart disease can prevent major cardiovascular events like heart attacks and strokes. Over 2,700 men and women aged 45-80 with top 20% genetic risk scores are being f…

This study tests a program called Health for Hearts United, which trains church health leaders to run heart-health programs for their congregations. The goal is to help African Americans eat better, move more, and lower their risk of heart disease. About 225 African American adul…

This study tests whether personalized counseling, leaflets, and text messages can help 1,700 healthy adults living in Dhaka slums avoid high blood pressure. Participants receive 20 face-to-face sessions on diet, exercise, and tobacco use. The goal is to see if these lifestyle cha…

This study compares two ways to prevent heart attacks in people at risk: a CT scan of the heart arteries versus the usual risk score method. About 6,139 adults aged 40-70 with risk factors like high blood pressure, diabetes, or smoking are involved. The goal is to see if the CT-g…

This large, phase 4 trial is testing whether berberine, a natural compound, can prevent heart disease and diabetes in over 2,000 high-risk adults in China. Participants take berberine or a placebo twice daily, plus receive lifestyle advice. The study tracks blood sugar and heart …

This pilot study tests whether remote monitoring and guideline-directed therapy can prevent heart dysfunction in African American women who had preeclampsia. Twenty participants will use a tablet, blood pressure cuff, and scale at home for three months after delivery. The goal is…

This study tests whether a mobile health unit program can help Black adults in Detroit lower their blood pressure and prevent stage 2 hypertension. Participants receive personalized lifestyle coaching from community health workers. The goal is to address social barriers like food…

This study looks at whether taking daily vitamin D or fish oil supplements can lower the risk of developing atrial fibrillation (an irregular heartbeat) in healthy adults. Over 25,000 men and women without prior heart disease or stroke took part. Researchers are tracking who deve…

This study tests a nurse-led education program designed to help women in cardiac rehab address sexual concerns after a heart event. Sixty-six women will be randomly assigned to either the program or usual care. The goal is to see if the program improves sexual function, mood, and…

This study looks at whether different levels of exercise can improve heart health in young adults who survived childhood cancer and were treated with a type of chemotherapy called anthracyclines, which can weaken the heart. Twenty survivors aged 18 to 39 will do either high-inten…

This study tests whether a 9-month program that encourages people with heart failure to gradually increase their daily steps and walking speed can improve their physical function and symptoms. Two hundred participants will either receive standard care or the step-based program, w…

This study tests whether a 48-week exercise program can improve physical function and reduce disability in HIV-positive adults over 50 in Côte d'Ivoire. 180 participants will be split into three groups: supervised group exercise, home-based exercise with phone support, or health …

This study tests whether a simple educational guide can help postpartum patients who had high blood pressure during pregnancy become more active in their own care. Researchers will give the tool to some mothers shortly after delivery and compare their engagement scores with those…

This long-term study follows over 3,700 adults in Baltimore to understand why some people age healthier than others. Researchers are looking at how race, income, and neighborhood affect risks for diseases like diabetes, heart disease, and memory loss. Participants visit mobile he…

Researchers at the University of California, San Francisco, are studying whether the pace at which a woman's ovaries age can signal her future risk of heart disease. The trial follows 865 women who were already part of a long-running reproductive health study. Participants underg…

This study compared 50,000 living kidney donors to similar healthy non-donors to see if donating a kidney raises the long-term risk of heart attack, stroke, or death. Researchers looked at health records from 1992 to 2024 in three Canadian provinces. The goal is to help doctors a…

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. Researchers are testing two different support strategies at 20 VA sites to see which works better. The study does not involve patients…

Researchers at University Hospital Freiburg are studying how blood levels of hsCRP and Lp(a), two markers linked to heart disease, change over time in patients who have had these tests more than once. The study asks whether a high result on a first test often returns to normal la…

This study aims to understand how genes affect obesity, diabetes, and heart disease in people of African ancestry. Researchers will collect blood samples and health information from 1,100 adults, including African Americans, Afro-Caribbeans, and migrants from sub-Saharan Africa. …

Researchers in Finland are surveying about 2,000 adults who were treated for a stroke between 2020 and 2022 in two regions. The postal questionnaire asks about health, daily functioning, work and income, social inclusion, and experiences with social and health services. The goal …

This pilot study is testing whether it's possible to run a larger study that focuses on heart disease in women. Researchers will gather information from 176 women aged 25-55 in Ontario who have had certain female-specific health issues like pre-eclampsia, gestational diabetes, or…

This study follows 121 adults who have been cured of chronic hepatitis C to understand why some still develop liver complications like scarring or cancer. Participants are monitored for up to 10 years with regular tests, scans, and occasional liver biopsies. The goal is to learn …

This study tests whether a machine-learning model can predict serious heart events in children admitted to the hospital. The model alerts doctors when a child may need a palliative care consultation. Researchers will compare outcomes before and after the model is used, involving …

This study looks at how holding weights in the hands or arms changes the way people walk and how their trunk and hip muscles work. Researchers will ask adults aged 18 to 80 who are in cardiac rehabilitation to walk on a treadmill at different speeds, with and without extra weight…

This study looks at whether genetic differences affect how omega-3 supplements influence heart disease risk factors like cholesterol and blood pressure. Researchers are giving 200 healthy adults omega-3 capsules daily and measuring changes in blood lipids, blood pressure, and gen…

Researchers at Fudan University are testing whether sitting in a 16°C room for two hours changes heart rate, blood pressure, lung function, or thinking speed in healthy young adults. Each participant will also spend time in a comfortable 22°C room for comparison. The study measur…

Researchers in Shanghai are testing whether breathing traffic-related air pollution during a short walk affects heart and lung function. Healthy young adults will either walk along a busy road or in a traffic-free park for 4.5 hours, alternating walking and rest. The team will me…

Researchers at Fudan University are testing what happens to healthy young adults when they sit in a 32°C chamber for two hours. They will measure blood vessel stiffness, lung function, and mental speed, comparing these to a day spent at a comfortable 22°C. The study aims to revea…

This study looks at whether a special heart MRI can find problems in the small arteries of women who have chest pain but no major blockages. About 375 women will get both a standard angiogram and a cardiac MRI to compare results. The goal is to see if the MRI can detect hidden he…

This study follows 2,000 people in China who received the SYNERGY stent to open blocked heart arteries. Researchers are collecting real-world data on safety and major heart events after the procedure. The goal is to see how well the stent performs in everyday medical practice.

This study looks at whether having a heart doctor check patients during a COPD flare-up helps find and treat hidden heart problems. 150 hospitalized adults with COPD are randomly assigned to see only a lung doctor or also a heart doctor. Researchers then track changes in heart tr…

This study is testing whether a wearable ECG patch, combined with AI analysis, can help doctors identify a wide range of heart conditions and risks from a single recording. The Cor360 system looks at many aspects of heart health at once, such as heart failure, rhythm problems, an…

This study explores whether adults at low risk for heart disease can reliably measure their own physical activity, fitness, and body size at home using simple tools like pedometers and tape measures. Researchers will compare home-collected data to standard clinic measurements. Th…

This study looks at whether training doctors on quickly starting and adjusting heart failure medications (called GDMT) during a hospital stay leads to better treatment after discharge. About 438 adults with heart failure and reduced ejection fraction will be observed across multi…

This study follows over 4,800 Dutch heart attack survivors aged 60-80 to understand how diet, lifestyle, blood markers, and genetics relate to their long-term health. Researchers are tracking cardiovascular deaths, major heart events, and other conditions like diabetes and cognit…

People recently released from prison face twice the risk of dying from heart disease compared to the general population. This study investigates the barriers and facilitators to healthcare access for this group, following 508 adults released from state prison in the Denver/Aurora…

This study tests a new imaging device called OCT-NIRAF that takes detailed pictures inside heart arteries during a standard heart procedure. Researchers want to see if the images can predict which plaques (fatty buildups) will grow and become dangerous. Forty adults with heart di…

This study follows 800 adults who have had their first ischemic stroke in Central Norway for up to 10 years. Researchers will track how physical activity, medication use, and control of blood pressure and cholesterol affect the risk of death, another stroke, or severe disability.…

This study follows 2,000 adults aged 45-75 in Pennsylvania to better understand why some groups have higher heart disease risk. About 800 participants at higher risk will receive either usual care or a personalized program with nutrition, exercise, and stress management advice. T…

This study follows 347 heart surgery patients to understand why some develop swallowing problems (dysphagia). Researchers will use special camera tests to watch how patients swallow and look for risk factors. The goal is to create simple tools that doctors can use at the bedside …

This study is for women with breast cancer who are receiving a treatment that greatly lowers estrogen levels. Researchers want to see if this treatment changes how the heart works. They will use heart scans to measure blood flow in 90 women over two years. The goal is to learn mo…

This registry follows 500 people receiving a specific type of surgical aortic valve replacement (the INSPIRIS RESILIA valve) for up to five years. Researchers are tracking how pre-existing conditions like kidney disease, diabetes, and high blood pressure affect survival and valve…

This study combines data from over 2,500 people with treated and controlled high blood pressure to understand why some still die from heart attacks, strokes, or kidney failure. Researchers are looking beyond blood pressure numbers to find other factors that might predict these fa…

This study compares blood vessel function in healthy adults who have taken estrogen-based contraceptives for at least a year versus those who have not. Researchers will measure how small vessels in the skin and under the tongue respond to drugs that affect blood flow. The goal is…

This study looks at whether heart rate variability (small changes in heartbeat timing) and early signs of inflammation can help predict breathing or heart problems in children having their tonsils or adenoids removed. Researchers will monitor heart rhythms and measure immune mark…

This long-term study follows over 121,000 female nurses to explore how hormones, diet, lifestyle, and genetics affect the risk of heart disease and stroke. Researchers are analyzing blood samples to create a 'metabolomic risk score' that could help predict coronary heart disease.…

This study scans over 16,000 adults aged 18 to 70 without known heart disease to find hidden (silent) plaque in their arteries using ultrasound and CT scans. The goal is to measure how common silent atherosclerosis is and build a risk calculator that combines imaging, lifestyle, …

This study collects blood and tissue samples from up to 500,000 adults, including heart patients, their family members, and healthy individuals. Researchers will analyze these samples to find molecular and genetic markers linked to heart disease. The goal is to improve understand…

This study follows over 800 heart failure patients in Germany who are starting dapagliflozin, a drug recently approved for heart failure. Researchers will track how long patients stay on the drug, any side effects, and changes in symptoms and quality of life. The goal is to under…

This study follows 172 adults over two years to compare cardiovascular function among four groups: vapers who previously smoked, vapers who never smoked, people who both vape and smoke, and ex-smokers who do not vape. Researchers measure blood vessel health, lung function, and bl…

This study follows over 6,000 people over many years to see if feelings like hostility and other psychological factors are linked to heart disease. Researchers are tracking who develops heart problems and looking for patterns. The goal is to better understand how our minds and em…

This pilot study looks at how daily experiences like stress and discrimination, health behaviors like sleep and exercise, and neighborhood factors affect heart health in Black women. Researchers will monitor 80 Black women aged 18-49 using wearable devices, surveys, and lab tests…

This trial investigates whether kidney transplant candidates on dialysis can safely skip routine heart screening after being placed on the waiting list. Participants are randomly assigned to either no further screening or regular annual screening for hidden coronary artery diseas…

This study looks at whether a hormonal implant containing gestrinone affects blood vessel function and heart health in young women. Researchers will compare women who have used the implant in the last six months with those who have never used it. The goal is to understand any pot…

This study follows over 32,000 people who helped clean up the 2010 Deepwater Horizon oil spill in the Gulf of Mexico. Researchers want to see if exposure to crude oil and chemical dispersants leads to long-term health problems like heart disease, cancer, or lung issues. Participa…

This study follows over 4,000 women who were tracked during their first pregnancy to see how pregnancy complications like high blood pressure or diabetes relate to future heart disease. Researchers will check for conditions like high blood pressure, diabetes, and obesity over tim…

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This study is building a large gene bank by collecting blood samples and health information from nearly 10,000 people who have had heart catheterization or cardiac CT scans. The goal is to identify genetic and other factors that contribute to coronary artery disease. Participants…

This study tests a wearable device that continuously measures lactate levels in the fluid just under the skin. Researchers want to see if it matches standard blood tests in patients recovering from heart bypass or valve surgery. If it works, the device could make recovery more co…

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This study tracks 120 adults with heart disease and at least two other long-term illnesses to see how often dangerous drug interactions happen. Researchers check medications, including over-the-counter and herbal products, and follow participants for a year. The goal is to unders…

This study is following 964 people with type 2 diabetes to see if three blood markers (hs-cTnI, NT-proBNP, and sST2) can predict who will die or have heart problems. Participants gave blood samples and are being tracked for years. No treatment is being tested—the goal is to learn…

This study tests a nurse-led health program for adults in a secure forensic psychiatric clinic. Fifty participants will either get usual care or also take part in two personalized health coaching sessions. The goal is to see if the program is practical and acceptable, and whether…

This study looks at two ways to share important genetic findings with people who joined a biobank. Some participants will get their results through a website or chatbot, while others will speak with a genetic counselor by phone or video. The goal is to see if the digital method w…

This study follows 4,000 healthy adults aged 40 to 65 in the Miami area to find early, hidden signs of heart disease. Participants undergo advanced heart scans and blood tests at the start, then report their health yearly for years. The goal is to discover new ways to predict and…

This study looks at how serious combat injuries affect the long-term health of U.S. military members. Researchers will measure heart function, sleep quality, and stress-related body signals in 200 injured service members. The goal is to understand links between injury severity, s…

This study follows 500 people with peripheral artery disease (PAD) who undergo a procedure to open blocked leg arteries. Researchers check blood and heart ultrasound before and after the procedure to find hidden heart injury. The goal is to see if certain markers can predict futu…

This study is a medical registry that follows over 21,000 adults hospitalized in 2021 at a Russian hospital. Researchers will analyze their health records, including chronic conditions, COVID-19 history, and outcomes like heart attacks or strokes, over five years. The goal is to …

This study tracks over 1,700 heart patients who had hip or knee replacement surgery. Researchers want to see how often bleeding or blood clots happen in the months after surgery. The goal is to find better ways to prevent these complications.

This study looks at whether taking potassium supplements can reduce the negative effects of a high-sodium diet on blood vessel function and blood pressure. Researchers will compare three different diet conditions in 30 healthy adults aged 18 to 45. The goal is to understand how p…

This large real-world study will follow 10,000 Italian patients with COPD to see how their treatments, flare-ups, and other health conditions affect their risk of death. Researchers will collect data on medications, lung function, and heart problems over time. The goal is to bett…

This study will observe 200,000 Chinese adults with heart disease to see how their heart and lung function changes over 5 years. Participants will take a special exercise test to measure their fitness. Researchers hope to find better ways to predict future heart problems like hea…

This study aims to find new genes that cause very low cholesterol levels (a condition called FHBL). Researchers are recruiting 435 people with low cholesterol and their family members to analyze their DNA. The goal is to discover new targets for understanding and potentially mana…

This study is a large registry that collects medical data and tissue samples from 30,000 people with heart disease and healthy volunteers. Researchers will analyze this information to better understand risk factors, treatments, and outcomes for various heart conditions. The goal …

This study tests whether the PulsePoint app can increase the number of people who receive CPR or a defibrillator from bystanders before paramedics arrive. About 340 adults who suffer sudden cardiac arrest in public places will be included. Half of the 911 calls will trigger the a…

This study tracks 300 adults in the Bonton neighborhood to see how taking part in farm-based wellness activities (like healthy eating and exercise programs) affects their heart health and quality of life over one year. Participants choose which activities to join, and researchers…

This study is collecting data from 400 people with abdominal aortic aneurysms to improve how doctors predict aneurysm growth. The goal is to create more personalized monitoring plans. Participants will have regular check-ups and imaging tests to track changes over time.

This study examines whether a common gene variation (CYP2C19) influences the long-term risk of serious heart and blood vessel events, such as heart attacks, strokes, and limb problems, in people with vascular disease. Researchers will analyze genetic and health data from 13,000 p…

This study tests whether a 'toolbox' of educational materials—including report cards for doctors, patient handouts, and an online decision aid—can increase the use of cholesterol-lowering statins in communities with high rates of heart disease. Researchers will track prescription…

This study follows 2000 people with dilated cardiomyopathy (a weakened, enlarged heart) over several years to learn how genetics and heart scarring affect the disease. Participants give blood for genetic testing and have heart MRI scans. The goal is to improve diagnosis and pave …

This study follows 200 men with prostate cancer who are receiving hormone therapy (androgen deprivation therapy) for at least 6 months. Researchers want to understand how this treatment affects the heart over time, and how factors like medical history, race, income, and access to…

This study looks at data from 1 million adults worldwide to see if eating nuts is linked to a lower risk of diseases like diabetes, heart disease, cancer, and dementia. Researchers will combine information from many past studies to get clearer answers. The goal is to understand i…

This pilot study tests whether keeping blood pressure higher than usual during and after major surgery can reduce serious complications like heart attack, kidney injury, and confusion. About 80 adults aged 45 and older who take blood pressure medication and are having long surger…

This study checks how common high levels of lipoprotein(a) — a genetic risk factor for heart disease — are among hospital staff and their families. About 2800 participants will give blood samples and be followed over time to see if high levels lead to more heart problems. The goa…

This study is building a large biobank of health information and blood samples from 48,000 people with diabetes in Hong Kong. Researchers will analyze genetic and other markers to find better ways to predict serious complications like kidney failure, heart disease, and stroke. Th…

The ALOHA study is a community-based research project for adults aged 50 and older in the Washington, D.C., Maryland, and Virginia area. Over five years, participants receive annual health assessments—including physical and cognitive tests—and get a personalized 'Health Passport'…

This study examines the links between sleep bruxism (teeth grinding during sleep) and sleep quality, heart health, thyroid function, and mood. Researchers will give some participants opipramol, a drug that may reduce grinding activity, and monitor them with sleep tests. The goal …

This study is gathering health information from one million people across Africa to better understand noncommunicable diseases like heart disease, cancer, and diabetes. Researchers are looking at risk factors such as weight, blood pressure, and smoking. The goal is to produce rel…

This study tests a new sensor worn on the skin that measures lactate levels without needles. It involves 20 adults recovering from heart bypass or valve surgery. The goal is to see if the sensor works as well as standard blood tests, which could make monitoring more comfortable a…

This study aimed to learn more about using a CT scan to check for calcium buildup in the heart arteries of people with diabetes. The goal was to improve screening and treatment decisions. However, the study was withdrawn before enrolling any participants, so no new information wa…

This study reviews past clinical trials to see if different soy foods (like tofu, tempeh, and soy drinks) lower cholesterol as effectively as isolated soy protein. The goal is to help update dietary guidelines and health claims. No new participants are being enrolled; the researc…

This long-term study is following over 10,000 healthy adults aged 50-75 to understand how the body's natural regulation of heart rate and blood pressure relates to future heart disease, stroke, and sudden death. Participants undergo non-invasive tests like a special ECG and carot…

This study tests whether trained peer coaches can help people with limited health literacy discuss heart disease prevention with their doctors. Researchers will enroll 60 patients at one clinic and analyze whether coaching leads to better conversations about treatment options. Th…

This study looks at how breastfeeding changes cholesterol and heart disease risk in women with familial hypercholesterolemia (FH), a genetic condition causing high cholesterol. Researchers will follow 50 pregnant women with and without FH from late pregnancy to one year after bir…

This study follows over 5,000 Black and White men and women from age 18-30 for many years to see how their lifestyles and health habits affect their risk of heart disease later in life. Researchers measure things like blood pressure, weight, and cholesterol to understand why some…

This study will use advanced heart scans (coronary CT angiography) on 4,000 people with rheumatoid arthritis aged 50-75. The goal is to better understand why people with this condition have higher risks of heart attacks, strokes, and lung problems. Researchers will track particip…

This study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related health problems. Researchers aimed to identify risks and understand what leads to disability or death after a heart event. The study did not test a new treat…

This study follows over 5,000 people with stable heart disease who were previously treated with either an invasive strategy (like stents or bypass surgery) plus medication, or medication alone. Researchers want to see which approach leads to better survival over 10 years. The goa…

This study follows over 2,300 South Asian adults in the US to understand why they have high rates of heart disease and stroke, even without traditional risk factors. Participants are aged 40-84 and have no prior heart events. Researchers will track heart scans, diabetes, and othe…

This study looks at how being in a hospital intensive care unit (ICU) after heart surgery affects your body's natural sleep-wake cycle. Researchers will track sleep patterns and thinking ability in 15 adults to see if disrupted rhythms slow down recovery. The goal is to understan…

This study tests a new digital platform that helps doctors and nurses share important patient information when a person is moved from one hospital to another. About 1,000 adults being transferred to a major hospital will take part. The goal is to see if better information sharing…

This study followed over 6,800 adults from different racial and ethnic backgrounds to understand how heart disease develops over time. Participants were healthy at the start and were monitored for risk factors and heart-related events like heart attacks and strokes. The goal is t…

This early-phase study tests whether a single dose of modafinil, a drug that promotes wakefulness, can improve concentration and mental clarity in people with Postural Tachycardia Syndrome (POTS). About 20 adults diagnosed with POTS will take the drug and then complete computer-b…

This study follows 450 people starting or continuing gender-affirming hormone therapy to see how it affects their heart and blood vessels over time. Researchers will use advanced heart scans, blood tests, and surveys to track changes. The goal is to provide clear information abou…

This study looks at why some people have higher heart disease risk from red meat than others. It focuses on a gut bacteria gene called gbu that helps turn carnitine (found in red meat) into TMAO, a compound linked to heart problems. Researchers will test blood and stool samples f…

This study was designed to see if certain immune cells (T cells) contribute to age-related blood vessel problems that raise heart disease risk. It planned to give a single injection of abatacept to adults aged 55-75 and measure changes in artery function and inflammation. However…

This study looks at people with rare adrenal tumors (pheochromocytomas and paragangliomas) that do not produce excess hormones. Researchers want to see if these 'silent' tumors still cause heart problems, blood pressure changes, or metabolic issues like diabetes and high choleste…

This study tests different ways to reach and enroll women and Black/Latino adults in heart disease research. Participants receive educational text messages about heart health and research opportunities. The goal is to see if these methods increase diversity and trust in clinical …

This study aimed to see if using a special pad along with a standard closure device could help patients get out of bed sooner after a heart catheterization. It was planned for adults having the procedure through the groin. However, the study was withdrawn before any participants …

This study aims to improve exercise prescription in cardiac rehabilitation by using machine learning to analyze data from the autonomic nervous system. Researchers will enroll 90 patients with coronary artery disease or non-ischemic heart failure. They will measure nerve activity…

This study uses stem cells made from patients' own cells to understand why some people develop severe heart or lung side effects from certain chemotherapy drugs. Researchers will compare cells from patients who had extreme toxicity to those who did not. The goal is to uncover the…

This study was designed to test whether giving nitric oxide gas during heart surgery could help protect blood vessels in patients with pre-existing vessel problems. It was an add-on to a larger trial and planned to enroll adults having elective heart surgery with prolonged bypass…

This study was designed to measure how breathing nitric oxide gas affects oxidation levels in the blood of heart surgery patients. It was an add-on to a larger trial and planned to enroll adults having elective heart surgery with a bypass machine. However, the study was withdrawn…

This observational study is looking at 1,000 people with type 2 diabetes to understand why some develop serious complications like eye, kidney, or heart problems while others do not, even with similar blood sugar levels. Researchers will collect medical history and blood samples …

This study aims to see if a high-sensitivity troponin blood test can better sort people into low, moderate, or high risk for heart disease compared to standard checks. Researchers will enroll up to 300,000 adults in India who are already getting routine health screenings. The goa…

This study looks at how a gene called PDE3B affects fat tissue and the body's ability to handle sugar and fats. Researchers will compare two groups of people: those with a natural gene variant and those without. The goal is to understand if this gene could be a target for prevent…

This study tests a new camera-based system called HERO that uses artificial intelligence to measure heart rate, breathing, oxygen levels, and even detect pain or emotions in hospital patients. About 100 adults with heart conditions will be monitored with both the camera and stand…

This study looks at how the timing of meals changes the way your body uses energy, especially in overweight adults aged 30 to 75. Researchers will compare eating most calories early versus late in the day, and test how this affects insulin sensitivity and metabolism. The goal is …

This study at Vanderbilt University Medical Center is looking at whether people with postural tachycardia syndrome (POTS) have higher levels of certain immune proteins that might affect their symptoms. Researchers will measure these proteins in blood samples and test how the hear…

This study aimed to gather real-world health records to help build a computer tool that predicts a person's risk of a major heart event within 30 days. The tool would use one or two high-sensitivity troponin blood tests. The study was withdrawn before enrolling any participants, …

This study follows 200 women with breast cancer who are receiving doxorubicin and/or trastuzumab. Researchers want to learn how these drugs affect the heart over time and how factors like race, income, and access to healthcare play a role. Participants will have heart ultrasounds…

This study gives 300 new mothers a medical-grade smartwatch that tracks blood pressure multiple times daily for 6 weeks after delivery. Researchers want to see if daily blood pressure patterns differ between low-risk, intermediate-risk, and high-risk groups. The goal is to better…

This study follows 1,545 adults over many years to understand how sleep-disordered breathing and other sleep problems develop and affect health. Participants were Wisconsin state employees aged 30-60 when the study began. Researchers use overnight sleep tests, questionnaires, and…

This study looks at what causes dangerous blood clots in the legs (venous thrombosis) and lungs (pulmonary embolism) in over 21,000 African American and white adults. Researchers are using data from two long-running heart health studies to find patterns and risk factors. The goal…

This study looks at how two specific genes, SWAP70 and GMPR, may influence the risk of heart disease. Researchers will analyze blood samples and health data from 100 healthy volunteers who are part of a larger research resource. The goal is to better understand the biological mec…

This study is a review of many smaller trials that looked at what happens when people replace animal protein (like meat, dairy, eggs) with plant protein (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weight,…

This study aimed to see if thyroid surgery changes the thickness of the carotid artery, which is a sign of heart disease risk. It planned to measure artery thickness before and after surgery in adults with various thyroid conditions. However, the study was withdrawn before enroll…

This study tracks 221 people with stage II or III lung cancer to see how chemoradiation therapy affects their heart health. Participants undergo heart scans, blood tests, and quality-of-life surveys before, during, and for at least two years after treatment. The goal is to better…

This study is following 10,000 adults who are having a heart MRI for medical reasons. Researchers want to see if the MRI results can help predict who will have heart problems in the future, like heart attacks or heart failure. The goal is to better understand how MRI scans can gu…

This study follows 1,400 women who had a stroke with no known cause. Researchers use a small implantable heart monitor to check for hidden atrial fibrillation, an irregular heartbeat that can cause strokes. The goal is to see if detecting this condition and using blood thinners c…

This study was designed to see if a cholesterol-lowering drug called a PCSK9 inhibitor could also reduce inflammation in the arteries of people with heart disease. Researchers planned to use a special imaging scan to measure inflammation. The study was withdrawn before enrolling …

This study looks at millions of medical records to see if GLP-1 agonists (like Ozempic) and SGLT2 inhibitors (like Jardiance) affect heart, kidney, and metabolic health differently in men versus women. Participants are adults with early-stage cardiovascular-kidney-metabolic syndr…

This study looks at whether giving people a personalized genetic risk score for coronary artery disease helps doctors make better decisions about prevention. About 1,000 adults with moderate heart risk will be randomly assigned to receive their risk score or not. Researchers will…

This study follows nearly 1,000 testicular cancer survivors to understand why they have a higher risk of heart disease. Researchers are looking at how cancer treatments like chemotherapy may damage blood vessels or lead to risk factors like high blood pressure. The goal is to imp…

This study follows over 3,000 Black people with HIV in the UK to understand how genes and lifestyle affect their risk for kidney disease, heart disease, diabetes, and obesity. Researchers collect health data and blood/urine samples to find genetic markers that predict these condi…