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Diabetes mystery: why some patients escape complications while others suffer

NCT ID NCT07250607

Knowledge-focused Sponsor: Azienda Ospedaliero, Universitaria Pisana Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This observational study is looking at 1,000 people with type 2 diabetes to understand why some develop serious complications like eye, kidney, or heart problems while others do not, even with similar blood sugar levels. Researchers will collect medical history and blood samples to identify biological markers that might predict a person's risk. The goal is to create a simple scoring system to help doctors personalize care and prevent complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a tool that helps doctors identify which patients with type 2 diabetes are at higher risk for complications, allowing for earlier and more personalized care.
What could go wrong
This is an observational study, not a treatment trial. It may not find clear biomarkers or a reliable risk score, and any findings will need further validation before they can be used in practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1,000 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2024

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Either sex, age between 40 and 80 years old. Diagnosed Type 2 diabetes (proven of exclusion of other forms diabetes if required by the PI) followed up regularly for T2D and with a comprehensive screening for complications including data on coronary, cerevrovascular and peripheral artery disease, and informations about chronic kidney, retinopathy and neuropathy diseases related to diabetes.

Ages

40 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Type 2 Diabetes * Age 40-80 years old * Comprehensive screening for DRC within 24 months from the inclusion in the survey. Exclusion Criteria: Diagnosis of forms of diabetes other than T2D * Any chronic inflammatory diseases or active cancer * Significant liver disfunction (cirrhosis, AST/ALT \> 3-fold normality range, total bilirubin \> 1,5-fold normal range w/o Gilbert syndrome) * Any other life expectancy-changing systemic disease.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder Diabetes Complications type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Diabete type 2 Diabetes complications

Contacts and locations

Locations

  • Azienda Ospedaliero Universitaria Pisana

    Pisa, PI, 56120, Italy

  • Azienda Rilievo Nazionale Alta Specialità (ARNAS) Garibaldi

    Catania, CT, 95100, Italy

  • Policlinico Consorziale di Bari

    Bari, BA, 70100, Italy

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