Can keeping blood pressure higher during surgery prevent organ damage?
NCT ID NCT04789733
First seen Mar 19, 2026 · Last updated Jun 23, 2026 · Updated 14 times
Summary
This pilot study tests whether keeping blood pressure higher than usual during and after major surgery can reduce serious complications like heart attack, kidney injury, and confusion. About 80 adults aged 45 and older who take blood pressure medication and are having long surgeries will be randomly assigned to either tight or routine blood pressure management. The goal is to see if this approach is feasible and safe before a larger trial.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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China Japan Union Hospital of Jilin University
Changchun, Jilin, China
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
norepinephrine or phenylephrine (medicines to raise blood pressure)
What this could lead to
If it works, this could point toward a standard way to manage blood pressure during surgery to lower the risk of serious complications.
What could go wrong
This is a very small pilot study with only 80 people, so results may not apply widely. The tight control approach could also cause side effects like too-high blood pressure.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.