Peripheral vascular disease

This study explores whether combining a high-protein Mediterranean diet with resistance exercise can help people with heart disease build muscle and lower their risk of future heart problems. The trial enrolls adults who have completed cardiac rehab and may have low muscle mass w…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tested a coaching program called MACRO-I for adults aged 70 and older who had a heart event. The program used coaches to guide patients through starting cardiac rehab, either at a center, at home, or a mix of both. 416 participants were split into the coaching group or…

This large study tested whether evolocumab (Repatha), a cholesterol-lowering injection, could reduce major cardiovascular events like heart attacks, strokes, or death in over 12,000 adults at high risk but without a prior heart attack or stroke. Participants received either evolo…

This study tested a device called the PQ Bypass System in 78 people with severe peripheral artery disease (blocked leg arteries). The device is designed to create a bypass inside the artery using small tubes (stent grafts) placed through a needle puncture, avoiding the need for t…

This study tested whether a newer stent (Supera) works better than a standard stent for people with blocked arteries in the leg. About 300 patients received one of the two stents. The goal was to see which stent kept the artery open longer and reduced the need for another procedu…

This study tested a new device that uses sound waves to break up calcium deposits in leg arteries of people with peripheral artery disease. Thirty-five participants received the treatment to see if it was safe and could open blocked arteries. The goal was to improve blood flow wi…

This study tested a surgical technique called femoral tripod eversion for people with blocked leg arteries. 37 patients were followed for two years to check safety and effectiveness. The procedure aims to clear blockages without using synthetic materials. Early results suggest it…

This early study tested whether injections of cells from donated placentas are safe for people with blocked leg arteries and diabetic foot ulcers. Fifteen adults with diabetes received one of several doses. The main goal was to check for side effects and find the safest dose. Thi…

This small pilot study tested the safety and effectiveness of the oral drug sirolimus for reducing nosebleeds in people with hereditary hemorrhagic telangiectasia (HHT). Ten adults with moderate to severe nosebleeds took 2 mg of sirolimus daily for 3 months. Researchers tracked b…

This study tested a temporary stent designed to open blocked arteries below the knee in people with peripheral artery disease or critical limb ischemia. The goal was to improve blood flow and prevent serious complications like amputation. The trial involved 130 participants and m…

This Phase 3 trial tested whether adding cilostazol to rosuvastatin helps people with peripheral artery disease (PAD) more than rosuvastatin alone. PAD narrows leg arteries, causing pain and trouble walking. The study enrolled 260 adults who took either the combo or a placebo for…

This study tested whether a drug called GM-CSF can improve symptoms and blood flow in people with peripheral artery disease (PAD), a condition where plaque narrows leg arteries, causing pain and limiting walking. 151 participants received either GM-CSF or a placebo for two 3-week…

This study looked at how well the AURYON atherectomy device works for people with peripheral artery disease (PAD), where leg arteries become blocked. The device uses a laser to vaporize plaque and restore blood flow. Researchers followed 102 patients to see if the procedure was s…

This study tested whether a physical activity program delivered by mail and website could improve the health of nearly 50,000 older women already in the Women's Health Initiative. The program included aerobic, balance, strength, and flexibility exercises, and encouraged reducing …

This study tested a device that uses sound waves to break up calcium buildup in the arteries below the knee in 250 people with peripheral artery disease (PAD). The goal was to safely restore blood flow and avoid serious complications like amputation. Results showed the procedure …

This pilot study tested a hybrid rehabilitation program for people with peripheral arterial disease (PAD), a condition that causes leg pain and limits walking. The program combines a few on-site supervised sessions with a home-based walking plan to make it easier for patients to …

This study tested two ways to treat blocked leg arteries in 47 people with leg pain when walking. One group had a special device to remove plaque (atherectomy) followed by a drug-coated balloon, while the other had standard balloon angioplasty followed by the same drug-coated bal…

This completed study tested a two-step treatment for severely calcified leg artery disease in 50 patients. First, a shockwave device cracks the hard calcium deposits, then a drug-coated stent is placed to keep the artery open. The goal was to see if this approach is safe and effe…

This study tested a once-daily pill called orforglipron against insulin glargine in nearly 2,750 adults with type 2 diabetes, obesity or overweight, and increased cardiovascular risk. The main goal was to see if orforglipron could reduce major heart events like heart attacks or s…

This completed Phase 4 trial tested the drug inclisiran (given as a shot under the skin) against a placebo in 1770 adults with high cholesterol who were already on cholesterol-lowering therapy. The goal was to see if inclisiran helps more people reach their LDL cholesterol target…

This study tested whether taking metformin daily for six months can improve how far people with peripheral artery disease can walk in six minutes. 203 participants were randomly assigned to receive metformin or a placebo. The goal was to see if this common diabetes drug could eas…

This completed Phase 4 trial studied 60 people with peripheral artery disease (PAD) to see if adding low-dose rivaroxaban to aspirin improves blood vessel function and reduces clotting. Participants took either rivaroxaban plus aspirin or a placebo plus aspirin. The study measure…

This pilot study tested whether delivering the drug paclitaxel directly to the leg artery during angioplasty could reduce the chance of the artery narrowing again. 27 adults with leg pain from blocked arteries took part. The main goal was to see if the drug helped keep the artery…

This pilot study tested whether taking a daily supplement called nicotinamide riboside (a form of vitamin B3) for 4 weeks could improve blood vessel function and thinking skills in 8 older adults with peripheral artery disease. Researchers measured changes in blood flow in the ar…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the leg arteries of people with peripheral artery disease (PAD). Twenty-four adults with PAD received either colchicine or a placebo. Researchers used special scans and blood tests to measure c…

This study tested whether using intravascular ultrasound (a tiny camera inside the artery) to guide stent placement in the leg is better than the usual X-ray guidance. One hundred people with blocked leg arteries were randomly assigned to one of the two methods. The goal was to s…

This study looked at how well the ELUVIA drug-coated stent works in real-world patients with blocked arteries in the thigh or knee area. A total of 291 adults received the stent and were followed for two years. The main goal was to see if their quality of life and walking ability…

This study looked at different treatments for people whose leg artery stents had become completely blocked. It included 322 adults with severe leg pain or wounds. The goal was to see how well the treatments restored blood flow and how long it lasted without needing another proced…

This study looked at 50 people who had a procedure to clear hardened blockages in their leg arteries using a special device (Jetstream) followed by a drug-coated balloon (Ranger). Researchers checked how many patients avoided needing another procedure on the same spot after 3 yea…

This completed study tested the LifeStream stent graft in 70 people with severe blockages in the iliac arteries (the main arteries in the pelvis). The device is a mesh tube that props open the artery and lines it to keep it clear. Researchers measured how well the artery stayed o…

This study tested whether intensive dental cleaning and oral hygiene advice can improve gum health and also affect markers of heart disease and type 2 diabetes. About 200 adults with gum disease and either heart disease or diabetes (or prediabetes) took part. Researchers measured…

This study tested a new tool called the AngioSafe Peripheral CTO Crossing System in 79 people with blocked leg arteries (peripheral artery disease). The goal was to see if the device could safely help doctors place a guidewire through the blockage. The study measured how often th…

This small completed study looked at a blood filtering procedure called double-filtration plasmapheresis (DFPP) in 5 kidney dialysis patients with very high levels of lipoprotein(a), a fatty substance linked to heart disease and blood clots. The goal was to see if DFPP could lowe…

This study tested the INDIGO Aspiration System, a device that uses a vacuum to remove blood clots from arteries and veins. It included 500 patients in Japan with acute limb ischemia, mesenteric artery occlusion, or severe deep vein thrombosis. The goal was to confirm the device's…

This study tested a special wound dressing called Symphony™ against standard care for people with diabetic foot ulcers that won't heal. 143 adults with mild to moderate ulcers took part. The goal was to see if Symphony™ helps more ulcers close completely within 12 weeks and how q…

This pilot study tested a staged application of two wound dressings (Endoform and Symphony) on 44 adults with chronic diabetic foot ulcers. The goal was to see if the treatment could fully close the wound within 12 weeks. Researchers measured healing rates, wound size reduction, …

This study tested whether a new stent (Dynetic-35) can safely open blocked arteries in the leg when inserted through the wrist instead of the groin. Twenty-five people with peripheral artery disease took part, and the main goal was to see if the procedure was safe and feasible. T…

This study tested a drug called crizanlizumab in 36 men with sickle cell disease who suffer from priapism—painful erections lasting an hour or more. The goal was to see if the drug could reduce how often these events happen. Participants received the drug by IV and reported their…

This study tested whether a drug called alirocumab, which lowers cholesterol, can reduce heart disease risk in people with HIV. The trial involved 118 adults aged 40 and older with well-controlled HIV and high heart disease risk. Participants received either alirocumab or a place…

This completed trial looked at whether taking two cholesterol-lowering drugs (rosuvastatin and ezetimibe) is more effective and safer than taking just one (rosuvastatin) for people with heart disease. 66 adults with high cholesterol were randomly assigned to one of the two treatm…

This study tested a special balloon coated with sirolimus, a drug that helps keep arteries open, in 34 people with peripheral artery disease (narrowed leg arteries). The goal was to see if the balloon is safe and works well at improving blood flow and symptoms like leg pain. Part…

This study tested a drug called bevacizumab in 25 adults with hereditary hemorrhagic telangiectasia (HHT) who had severe liver issues and high heart output. The goal was to see if the drug could improve heart function and reduce the need for a liver transplant, which requires lif…

This study tested whether a daily 30-minute foot exercise program could improve blood flow in the legs of 44 adults with type 2 diabetes. After 3 months, those who did the exercises had better circulation, measured by ankle-brachial index, compared to a control group. The exercis…

This study looked at 1,424 veterans at high risk for heart problems who had major surgery. It compared two approaches to blood transfusion: a liberal strategy (transfusing when hemoglobin drops below 10) versus a restrictive strategy (transfusing only when hemoglobin drops below …

This study tested a special balloon coated with a drug to open blocked arteries in the leg. 123 people with leg pain from poor blood flow were treated. The goal was to see if the balloon is safe and keeps arteries open for at least a year.

This study tested a special device called the Orbital Atherectomy System in 81 Japanese adults with hardened blockages in their leg arteries. The device was used to safely remove calcium buildup and improve blood flow. The goal was to see if the device works well enough to be app…

This study tested a device called the PQ Bypass Stent Graft System in 60 people with peripheral artery disease who had long blockages in their leg arteries. The goal was to see if the device could safely open the artery and improve blood flow. Participants received the stent graf…

This early-stage study tested the safety of a gene therapy called VM202 in 12 people with critical limb ischemia, a severe form of leg artery disease causing pain and ulcers. Participants received injections into their leg muscles and were monitored for side effects and pain reli…

This study tested whether injecting donor stem cells into the leg muscles before amputation could prevent wound problems and reduce the need for more amputations. 81 people scheduled for leg amputation due to poor blood flow took part. The main goal was to check safety, not yet t…

This completed study tested a handheld device called the Kaitoh Atherectomy System in 9 people with peripheral artery disease (PAD). The device uses a rotating blade to shave away plaque buildup in leg arteries, aiming to restore blood flow. Researchers checked for safety and how…

This study looked at whether a special eye scan (SS-OCTA) can detect signs of cardiovascular disease. Researchers compared retinal blood vessel changes to results from a standard carotid ultrasound in 42 adults. The goal was to see if the eye scan could predict the presence or se…

This study measures oxygen pressure in the skin of the upper arm to help diagnose chronic limb ischemia, a condition where blood flow is severely reduced. Researchers will test 30 healthy volunteers and at least 30 patients with known arm artery disease to find normal values and …

This study tested a new ultra-low-dose chest CT technique in 3 children (ages 1-17) with hereditary hemorrhagic telangiectasia (HHT) to see if it could detect abnormal blood vessels in the lungs (PAVMs) using much less radiation than standard CT. The goal was to find the lowest p…

This study tested two MRI methods for finding narrowed or blocked arteries in the pelvis and legs of 119 people with peripheral arterial disease (PAD). One method uses a special dye called ferumoxytol to make blood vessels stand out, while the other relies on natural blood flow. …

This study tested whether an AI app (IVENUS) could correctly classify the severity of chronic vein disease from leg photos. Over 1,600 patients had their legs photographed, and the app's diagnosis was compared to that of experienced doctors. The goal was to see if the app could r…

This study looked at whether a 15-minute hand soak in warm water can help diagnose small fiber neuropathy, a condition that causes pain, numbness, and problems with automatic body functions. Researchers tested 38 adults and compared the wrinkling pattern of their fingertips to st…

This study tested whether an ultra-low dose chest CT scan can find lung blood vessel malformations in people with hereditary hemorrhagic telangiectasia (HHT) as well as the standard low-dose CT scan, but with much less radiation. 45 HHT patients received both scans, and radiologi…

This study explores whether a vascular ultrasound can help diagnose May-Thurner syndrome, a condition where a vein in the pelvis is compressed, causing left leg swelling. Researchers will measure the vein's diameter in 40 adults with unexplained swelling and compare results to he…

This study tested several simple bedside tests—like ankle and toe blood pressure measurements and handheld Dopplers—to see how well they detect poor leg circulation (peripheral arterial disease) in 604 people with diabetes. The results were compared to advanced imaging scans (CTA…

This study looked at how often older adults with heart disease risk factors should exercise to improve fitness and blood pressure. Twenty-two participants did combined training either twice or three times a week for 12 weeks. The goal was to see which frequency worked better for …

This study tested a device called Prevena, a sterile sponge that applies gentle suction to a closed surgical wound for 5-7 days after groin surgery. The goal was to see if it lowers the chance of wound infections, reopening, or fluid leaks compared to a standard dry gauze dressin…

This study tested an 8-week digital lifestyle program called MYCardio-PEER for low-income adults at risk of heart disease. Participants received weekly videos and infographics on healthy eating and exercise, plus group chats with peer leaders. The goal was to see if the program i…

This study looked at whether a home-based physical activity program and computer-based cognitive training could help prevent memory loss in older women with heart disease. 253 women aged 65 and older participated. The goal was to see if these lifestyle changes could improve memor…

This completed study tested whether sending behavioral nudges through Denmark's official electronic letter system could increase flu vaccination among adults aged 18-64 with chronic diseases. Over 300,000 participants were randomly assigned to receive different types of letters o…

This study tested whether listening to music during wound dressing changes can reduce pain in people with severe arteritis (stage 5 or 6). Twenty-five patients were asked to listen to music during their daily wound care. The main goal was to see if pain levels were lower on a 0-1…

This study tested whether semaglutide, a diabetes medicine, improves walking ability in people with type 2 diabetes and peripheral artery disease (narrowed leg arteries). About 792 adults received weekly injections of semaglutide or a placebo for 59 weeks. The main goal was to se…

This Phase 2 trial tested whether selexipag, a drug that opens blood vessels, can reduce the number of Raynaud's attacks in adults with systemic sclerosis. 74 participants took either selexipag or a placebo twice daily. The main goal was to see if the drug lowered weekly attack f…

This phase 2 trial tests whether daily injections of unacylated ghrelin, a natural hormone, can improve walking ability in people aged 55 and older with peripheral artery disease (PAD). Participants receive either the hormone or a placebo for four months. The study measures chang…

This study looked at two methods to reduce pain after heart surgery through a cut in the chest bone. 120 adults received either a nerve block near the breastbone, pain medicine injected into the wound, or standard painkillers. Researchers measured pain levels using a saliva test …

This completed trial tested an 8-week program called Healing Hearts Together (HHT) for couples where one partner has heart disease. 474 couples attended weekly group sessions focused on communication, emotional support, and heart health. The goal was to see if the program improve…

This study tested whether a 20-minute session of nurse-led spiritual care, including prayer and relaxation techniques, could help heart surgery patients feel less anxious and have more stable blood pressure and heart rate before their operation. 248 adults in Indonesia took part.…

This study tested a pulsed dye laser to reduce red veins (telangiectasias) on the face and neck in 21 people with scleroderma. Participants received four laser sessions, and the researchers checked how many veins disappeared, how patients felt about the results, and any side effe…

This study tested if a gentle electrical stimulation on the ear (transcutaneous vagal stimulation) could improve blood vessel function in 11 people with peripheral artery disease (PAD). The goal was to see if this non-invasive method could help blood vessels relax and work better…

This study tested whether guided deep breathing exercises can reduce pain and improve vital signs in 100 patients who had a procedure to open blocked leg arteries (angioplasty). Half the patients did slow, deep belly breathing after surgery, while the other half received standard…

This completed study tested a 4-week educational program for 184 people with critical limb ischemia, a severe form of peripheral artery disease that can lead to amputation. The program included group sessions, digital materials, and peer support to teach patients about their cond…

This study tested whether a 3-month yoga program could improve physical and mental health in adults over 65 who had recently finished cardiac rehab. Participants attended yoga twice a week. Researchers measured balance, muscle strength, anxiety, and mood. The goal was to see if y…

This study tested a gel containing brimonidine to see if it can reduce persistent facial redness in people with rosacea. In the first part, 45 adults applied the gel to one side of their face and a placebo to the other, measuring redness after a few hours. In the second part, the…

This study tested whether using nerve blocks and sedation instead of general anesthesia could make upper leg amputation surgery safer for high-risk patients, such as the elderly or those with diabetes or heart disease. Thirty participants received ultrasound-guided nerve blocks a…

This study tested a gentle laser (micropulse) on 30 people with dry eye from meibomian gland dysfunction. The laser targets tiny blood vessels on the eyelid edge to reduce inflammation and improve tear quality. Researchers measured tear stability and symptom scores to see if the …

This study tested whether reflexology or classical hand massage can reduce pain, anxiety, and improve vital signs in 70 patients who had coronary angiography. Participants received one of the two massage types, and their pain and anxiety levels were measured. The goal is to see i…

This study tested whether ramipril, a common blood pressure medicine, can improve walking distance in people with intermittent claudication (leg pain due to narrowed arteries). Researchers planned to enroll 78 adults with stable leg pain, giving half ramipril and half a placebo. …

This small Phase 2 trial tested whether taking creatine supplements combined with a muscle-stretching device could help people with peripheral artery disease (PAD) walk longer. Thirteen participants either received creatine plus stretching or a placebo (cellulose) plus stretching…

This study tested whether adding body awareness therapy—relaxation, breathing, and gentle movements—to standard physiotherapy helps people with peripheral artery disease (PAD). Fifty-one adults with PAD were split into two groups: one got standard exercises, the other added body …

This study tested a 9-week internet-based cognitive behavioral therapy (CBT) program designed to reduce stress, anxiety, and depression in people with stable heart disease. 215 adults with heart disease and elevated stress or mood symptoms took part. The program was personalized …

This study tested whether wearing virtual reality (VR) glasses during a leg artery procedure (angioplasty) can lower patients' pain and anxiety. 52 adults having elective angioplasty were randomly assigned to either use VR or standard care. Researchers measured pain and anxiety l…

This study tested whether specially designed shoes (carbon fiber or spring-loaded) could help people with peripheral artery disease (PAD) walk farther and with less pain. Ten veterans with PAD wore the shoes for three months. Researchers measured changes in walking distance and c…

This study tested whether a digital app called KardioPAC could help people in cardiac rehab stay more active and feel better. 43 heart patients used the app alongside standard rehab, or just standard rehab alone. The goal was to see if the app improved exercise habits, blood pres…

This study tested special exoskeleton footwear designed to assist walking in people aged 40 and older with peripheral artery disease (PAD). Researchers compared different levels of assistance to see which worked best for comfort and walking performance. The study included 47 part…

This study tested whether a small device called TENS, which sends mild electrical pulses to the skin, could reduce leg pain during walking in people with peripheral artery disease (PAD). It also looked at adding a patient education program to encourage more physical activity. The…

This study tested whether adding virtual reality (VR) driving simulations to standard cardiac rehabilitation helps heart surgery patients feel less anxious and depressed. Sixty adults recovering from heart surgery took part. The results suggest VR can improve emotional well-being…

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This study looks at how eating a high-fat meal changes levels of certain fats in the blood called ceramides, and whether those changes affect blood vessel function. Healthy adults aged 18 to 40 will eat either a meal rich in long-chain fatty acids (which raise ceramides) or mediu…

This study tested whether screening high-risk patients for hidden peripheral arterial disease using a simple ankle blood pressure test is cost-effective. Over 600 patients were involved, and researchers compared different screening and counseling strategies. The goal was to see i…

This pilot study tested whether giving inhaled nitric oxide gas during laparoscopic surgery could protect blood vessels and organs in 40 adults with heart disease. Half received the gas through their breathing tube during surgery, and half received standard care. Researchers meas…

This study looked at 150 Caribbean Hispanic adults with heart disease or stroke risk who take the blood thinner clopidogrel. Researchers wanted to see if certain gene variants affect how well the drug works. The goal is to understand why some people get less benefit and to pave t…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This study checked how well over 5,000 heart patients follow their prescribed medicine routine. Researchers asked patients about their medication habits and any side effects. The goal was to understand how many patients do not take their medicines as directed.

This study looked at whether measuring carbon dioxide in a patient's breath at rest (PETCO2) can help predict lung and heart complications after major vascular surgery. Researchers studied 91 older adults who were scheduled for aortobifemoral bypass surgery. The goal was to see i…

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This study looked at over 2,200 people with hereditary hemorrhagic telangiectasia (HHT), a rare condition that causes abnormal blood vessels. The goal was to find out what makes some people with HHT more likely to have a brain bleed. Researchers collected health information, bloo…

This study checked whether the Turkish version of the Cardiac Depression Scale (CDS) works well for people with heart disease. Researchers tested 360 Turkish adults with various heart conditions to see if the scale accurately measures depression. The goal is to give doctors a rel…

This study looked at 26 people with peripheral arterial disease (PAD) to see how arm exercise changes oxygen levels in their leg muscles. Participants used an arm ergometer while a sensor measured calf oxygen saturation. The goal was to understand why arm training can improve leg…

This completed study looked at 400 people with both heart disease and a mental health condition (like depression or anxiety). Researchers used questionnaires, blood tests, and imaging to find shared risk factors and biological markers. The goal was to better understand how these …

This study tested how different levels of leg compression affect blood circulation in 30 adults after surgery. Participants received three pressure levels (low, moderate, high) on their calves, and blood flow was measured non-invasively. The goal is to gather early evidence for m…

This study looked at the safety of the blood thinner rivaroxaban in 1500 Japanese patients with peripheral arterial disease (PAD) who had surgery to improve blood flow in their legs. Researchers used existing health records to track bleeding events and heart-related deaths. No ne…

This completed study looked at 26,000 patients who had outpatient procedures for blood vessel problems like peripheral artery disease, varicose veins, or dialysis access issues. The goal was to see how safe and effective these procedures are when done in an office-based angiosuit…

This study looked at whether wearing an activity monitor (like a Fitbit) after heart surgery helps patients get moving sooner and return to their normal activity levels faster. Researchers tracked motivation, length of hospital stay, and readmission rates in 12 adults who had car…

This completed study tested a special guidewire with a sensor that measures electrical properties of tissues in people with peripheral artery disease. The goal was to see if the sensor could tell the difference between various tissues, like the artery wall and surrounding areas. …

This completed observational study looked at 61 people with peripheral artery disease to see if their gum health was linked to levels of a substance called TMAO in their blood and saliva. Researchers compared TMAO levels among those with healthy gums, gum disease, or no teeth. Th…

This study tested whether special communication training for pharmacists and general practitioners helps them involve older patients in decisions to stop or lower medications for heart disease and diabetes. Researchers enrolled 310 patients aged 75 and older who were taking certa…

This study tested a special imaging method (SPECT/CT) to measure blood flow in the leg muscles of people with peripheral arterial disease (PAD) and diabetes. Researchers compared these images to those from healthy volunteers to see how treatment affects muscle blood flow. The goa…

This study looked at a molecule called microRNA-210 in 230 people with peripheral artery disease (PAD), a condition where leg arteries become blocked. Researchers measured its levels and linked them to oxidative stress and walking ability. The goal was to understand how this mole…

This study tested whether a theory-based motivational letter mailed six months in advance could increase attendance at a one-year post-cardiac rehabilitation check-up. Researchers compared 102 adults who received the letter to those who got usual care. The goal was to see if a si…

This study looked at how compression therapy changes oxygen levels in the skin of people with leg ulcers that involve both arteries and veins. Researchers measured oxygen before and during compression in 38 adults. The goal was to better understand how compression works and how w…

This study looks at how arm cranking exercise and warm water foot immersion change blood flow and shear stress in the leg arteries of people with peripheral artery disease (PAD). Fifteen participants with PAD and claudication symptoms will complete three sessions: arm exercise, w…

This study in 18 rats investigates whether alpha lipoic acid, a natural antioxidant, can protect penile tissue from damage caused by restoring blood flow after a prolonged painful erection (priapism). Researchers will measure various markers of oxidative stress and inflammation i…

This study combines data from nearly 1,000 patients who received a special stent-graft (the GORE VIABAHN with a heparin coating) for peripheral artery disease in the leg. Researchers want to see how well the device keeps arteries open over time and which patient factors affect su…

This study looked at how well a daily low-dose aspirin works in people who have both immune thrombocytopenia (low platelets) and heart disease. Only 4 adults took part. Researchers measured platelet function after aspirin to see if the standard dose is enough to prevent blood clo…

This study tested whether prosthetists—specialists who fit artificial limbs—can screen for common but often unnoticed health problems like depression, nerve damage, and poor blood flow in people who have had a leg amputation. Seventy participants were split into two groups: one r…

This study tested whether a systematic phone call from a medical student, supervised by a general practitioner, could reduce hospitalizations in patients with chronic heart or mental health conditions during the COVID-19 lockdown in France. Over 22,000 patients aged 70 and older …

This study looked at 320 adults who had heart surgery to see how well two different risk scores (EuroSCORE-II and POSPOM) predict the chance of dying in the hospital. Researchers calculated each patient's scores before surgery and compared them to what actually happened. The goal…

This study tested a tool called KomPas+ that helps therapists and patients with leg pain from blocked arteries (intermittent claudication) make shared decisions about treatment. Over 2,200 participants used the tool to see if it improved walking distance and quality of life. The …

This study looked at whether orienteering (a navigation-based walk) is as good as regular walking for heart rehab. 40 people with stable heart disease took part. Researchers measured heart rate and enjoyment during both activities. The goal was to see if orienteering could be a f…

This study looked at whether asking people to "opt in" or "opt out" of a clinical trial changes how many people with peripheral artery disease (PAD) actually join. Over 5,000 adults with PAD were contacted by email. The goal was to see which approach leads to more enrollment and …

This study tested a new sensor (CIMON) to see if it can accurately measure how well compression bandages reduce leg swelling in people with chronic edema (long-term fluid buildup). Fifty-two adults with leg swelling who needed compression bandages took part. The sensor was placed…

This completed pilot study looked at 47 adults with hereditary hemorrhagic telangiectasia (HHT) who also have liver involvement. Researchers used exercise echocardiography (heart ultrasound while pedaling) to measure lung artery pressure during exercise. The goal was to see if th…

This completed study looked at whether patients hospitalized for a heart attack, stroke, or other cardiovascular event received the right medications to prevent future problems. Researchers reviewed records of 129 patients to see if doctors prescribed cholesterol-lowering drugs a…

This completed study looked at whether children with neurodevelopmental disorders (like mitochondrial disease, cerebral palsy, or developmental delay) have fewer small nerve fibers in their skin, which could cause pain. Researchers took small skin biopsies from 203 children—some …

This completed study looked for new risk factors that might lead to peripheral arterial disease (PAD), especially in the lower leg arteries. Researchers studied 123 adults in Guadeloupe, measuring things like HbA1c (a blood sugar marker) and other novel factors. The goal was to b…

This study tested an indoor air pollution intervention called AIRWISE in 20 adults aged 55 and older with heart disease. Participants received personal air cleaners, a color-changing air quality monitor, and educational materials. The goal was to see if they would use these tools…

This study followed nearly 800 people with peripheral artery disease (PAD) for one year to see how different treatments affect their symptoms, daily function, and quality of life. Researchers measured health status using a special questionnaire and looked for differences based on…

This completed study tested whether healthcare claims data can predict the results of a major heart trial (SURPASS-CVOT) comparing two diabetes drugs, tirzepatide and dulaglutide. Researchers analyzed records from over 44,000 people with type 2 diabetes and heart disease to see i…

This study looked at whether shining a special light on the head (called transcranial photobiomodulation) can improve blood flow in the brain and boost thinking skills. 24 healthy adults aged 18 to 80 took part. The goal was to gather information, not to treat or cure any disease…

This study looked at how symptoms of hereditary hemorrhagic telangiectasia (HHT) affect patients' quality of life. Researchers used a special questionnaire developed with patient input to measure different aspects like physical limits, worry about bleeding, and social relationshi…

This study tested whether sitting in a warm bath (38-41°C) for up to 30 minutes could reduce blood pressure spikes during exercise in 33 people with peripheral artery disease (PAD). Participants walked on a treadmill, and researchers measured walking time, blood pressure, and hea…

This study looked at two ways to assign care coordinators to older adults (65+) with heart disease or risk factors. One method used patients' own reports of difficulty coordinating care, while the other used usual triggers like hospital discharge. The goal was to see which approa…

This study looked at whether using telemedicine (video or phone consultations) can help people in rural communities with leg wounds get specialist care more quickly. Researchers compared the time from when a wound was found to when a specialist saw the patient, either through tel…

This study looked at how a special balloon coated with a drug called sirolimus derivative releases medication into the blood after being used to open blocked leg arteries. Six people with peripheral artery disease took part. The goal was to measure drug levels over time, not to t…

This study collected umbilical cord blood and tissue from 16 newborns who have a parent with hereditary hemorrhagic telangiectasia (HHT), a genetic disorder causing abnormal blood vessels. Researchers aim to grow and compare endothelial cells from these babies with cells from hea…