Peripheral vascular disease

This Europe-wide study will follow 400 people with severe leg artery disease (chronic limb-threatening ischemia) to see if a new dissolvable, drug-coated scaffold can keep leg arteries open better than standard treatments. The scaffold releases medication to prevent re-blockage a…

This study will follow 250 people with chronic limb-threatening ischemia (CLTI) across Europe to see how well orbital atherectomy works in real life. The procedure uses a tiny spinning tool to gently remove hard calcium from leg arteries, making it easier for balloons or stents t…

This study tests an experimental drug called ATV-1601 in people with moderate to severe HHT, a condition that causes frequent nosebleeds and anemia. The trial has two parts: first, participants receive either the drug or a placebo to check safety and effectiveness; then, all elig…

This trial tests a special balloon coated with a drug (paclitaxel) to treat blockages in the leg arteries caused by cholesterol buildup. The balloon is inflated to open the artery and release the drug to help keep it open. The study will include 200 people and check if the balloo…

This study tests whether a wearable monitoring system (ECG patch, temperature patch, and pulse oximeter) can reduce major heart complications in hospitalized patients with heart disease. About 1500 adults will be monitored either with standard care (vital signs every 4-8 hours) o…

This small pilot study will test a program where nurses and general practitioners help breast cancer survivors who also have heart disease make healthy lifestyle changes. The program includes exercise, diet changes, quitting smoking, and stress-reducing activities like yoga. The …

This study tests whether the drug vericiguat can prevent serious heart and organ problems in people undergoing heart surgery. About 600 high-risk patients will receive either vericiguat plus standard care or standard care alone. The goal is to see if vericiguat reduces early comp…

This early study tests a new device that combines a balloon with sound waves to treat blocked arteries in the legs, a condition called peripheral artery disease (PAD). The device is designed to crack hard plaque and widen the artery. The study will include 30 people with moderate…

This phase 1/2 trial tests whether a patient's own stem cells, taken from belly fat and grown in a lab, can heal leg ulcers caused by severe peripheral artery disease. 40 participants will either receive stem cell injections and a special cell-containing dressing, or standard hyd…

This study will test hyperbaric oxygen therapy (HBOT) — breathing pure oxygen in a pressurized chamber — for over 30 conditions, including long COVID, Crohn's disease, frostbite, and multiple sclerosis. Researchers will track 100 patients to see if HBOT improves their quality of …

This study tests whether a low-dose anti-inflammatory drug called colchicine can help people with severe leg artery disease (chronic limb-threatening ischemia) avoid amputation or death. About 200 adults who recently had a procedure to restore leg blood flow will take either colc…

This study compares two drug-coated balloons for treating narrowed or blocked arteries in the leg. The experimental balloon uses sirolimus, a drug that stops cells from growing and blocking the artery again, while the standard balloon uses paclitaxel. About 478 people with leg ar…

This study tests a new method for closing the breastbone after coronary artery bypass graft (CABG) surgery using special knotless barbed sutures and a skin adhesive. Researchers will compare 401 adults who receive this new closure to past patients who had standard closure. The go…

This pilot study tests a simple method to reduce wound complications after groin vascular surgery. Surgeons will inject a blue dye into the skin around the surgical wound to make any lymphatic leaks visible, then repair them immediately. The study will enroll 60 adults and track …

This trial tests whether using a laser device (Auryon Atherectomy System) along with standard balloon angioplasty is safer and more effective than balloon angioplasty alone for treating severe blockages in the lower leg arteries. The study will enroll 50 people with critical limb…

This study tests if a special balloon called the Chocolate PTA balloon prepares leg arteries better than a standard balloon before using a drug-coated balloon to treat blockages. About 242 adults with peripheral artery disease will take part. The goal is to see if the Chocolate b…

This study tests whether adding FoundationDRS Solo to usual wound care helps heal chronic foot ulcers in people with diabetes. About 124 adults with a nonhealing ulcer will get either the new treatment plus standard care or standard care alone for 12 weeks. The main goal is to se…

This study tests whether a special clinic where heart, kidney, diabetes, and liver doctors work together can help people with type 2 diabetes and heart disease get better control of their blood pressure and cholesterol. About 150 adults will be randomly assigned to either usual c…

This study will test a special balloon coated with the drug paclitaxel to treat long blockages in the leg arteries. About 300 people with severe leg pain or wounds will receive the balloon treatment during a standard angioplasty procedure. Researchers will track how well the arte…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This study tests whether taking vitamin B supplements before and after heart surgery can lower the chance of serious problems like heart attack, stroke, or irregular heartbeat. About 1,000 adults having heart surgery will take either vitamin B or a placebo daily for 6 months afte…

This study looks at whether a medical-grade smartwatch (CardioWatch 287-2) can improve a 13-week virtual cardiac rehab program for people with heart disease. About 216 participants will either use the watch or not, and researchers will compare their progress in areas like exercis…

This study compares two treatments for when a leg artery stent narrows again (in-stent restenosis). About 578 patients will receive either a drug-coated balloon or a drug-eluting stent, both of which release medication to keep the artery open. The goal is to see which approach re…

This study tests a new device that uses sound waves to break up hard calcium deposits in leg arteries of people with peripheral artery disease (PAD). About 110 adults will receive the minimally invasive procedure and be followed for 6 months. Researchers will check if the artery …

This study tests a drug-coated balloon to treat blockages in the leg's main artery. About 150 people with moderate to severe symptoms will receive the balloon treatment. The goal is to see if it keeps arteries open for at least 12 months and reduces the need for further procedure…

This Phase IIa trial tests the safety and tolerability of a new drug called etrinabdione in 30 adults with peripheral arterial disease (PAD). Participants take the drug twice daily for 12 months, starting with a low dose and possibly moving to a higher dose if safe. Researchers w…

This study tests Mobili®, a portable digital dispenser that automatically gives the right pills at the right time. Researchers will enroll 96 adults with diabetes or heart disease who take at least two daily medications. Participants use the device for a period, and the study mea…

This study tests a new radioactive tracer called 18F-FAPI-74 that may help detect scar tissue (fibrosis) in the heart and lungs earlier than current methods. Researchers will compare this new PET/CT scan to standard imaging in 210 adults with conditions like lung disease or heart…

This early-phase trial tests whether a fluorescent dye called LUMISIGHT (pegulicianine) can light up inflammation in artery plaques removed during surgery. Inflammation is a key driver of heart attacks, but current imaging can't see it clearly. Researchers will compare the dye to…

This study will check how common peripheral artery disease (PAD) is in people who need surgery for lumbar spinal stenosis (LSS). Both conditions can cause leg pain, making PAD hard to spot. Researchers will use a special CT scan to find PAD and compare it with simpler tests like …

This study tests whether a special camera that measures oxygen in leg tissues can help diagnose peripheral artery disease (PAD). About 200 adults with suspected or confirmed PAD will have their legs lifted while the camera takes images. The goal is to see if these oxygen patterns…

This study tests whether washing the surgical wound and the new prosthetic graft with a hypochlorous acid solution at the end of surgery can prevent infections. Participants are adults having open surgery to insert a synthetic bypass graft for narrowed or blocked arteries. The st…

This study tests whether adding a traditional Chinese medicine formula called Bu Yang Huanwu Decoction (in capsule form) to standard treatment can prevent leg pain at rest or foot ulcers in people with diabetic lower extremity vascular disease. About 300 adults aged 18 to 70 with…

This study tests whether a single dose of cold atmospheric plasma applied to the wound during groin surgery can prevent healing complications in 214 high-risk patients with peripheral artery disease. Half will get the real plasma device, half a sham device. Researchers will track…

This pilot study explores whether non-drug strategies like virtual reality or relaxing soundscapes can reduce anxiety and pain in adults undergoing scheduled coronary angiography or angioplasty. Participants will be assigned to listen to calming sounds, experience a virtual reali…

This study tests whether applying heat to the legs for 90 minutes each day at home can improve walking distance and leg function in adults over 50 with peripheral artery disease (PAD). Participants are randomly assigned to receive either active heat therapy or a sham (low-heat) v…

This study tests whether injecting botulinum toxin (Botox) into the hands or feet can help people with Buerger's disease, a rare condition that blocks blood flow and causes severe pain. Eight adults with critical limb ischemia will receive a single injection session and be follow…

This study tests whether using the Replexa+ device twice daily for 3 months can improve blood flow in the lower legs and feet of veterans with peripheral artery disease (PAD) and peripheral neuropathy. Ten participants will have their blood flow measured before and after treatmen…

This study tests whether low-intensity focused ultrasound (LIFU) applied to a nerve cluster in the neck can improve sleep quality and heart rate control in people recovering from heart surgery. 200 participants will receive either real or sham ultrasound daily for 3-7 days after …

This study tests whether a 24-week recreational team handball program can improve walking ability and overall health in 60 men aged 60-80 with peripheral artery disease (PAD) and leg pain when walking. Participants will be randomly assigned to either the handball program or usual…

This study tests a hybrid cardiac rehabilitation program for people with peripheral artery disease (PAD), a condition that reduces blood flow to the legs and causes pain while walking. The program combines in-person supervised exercise sessions with home-based telerehabilitation …

This study tests whether a special dermocosmetic cream can reduce facial redness and visible blood vessels in people with a common type of rosacea. Fifty adults will apply the cream to one side of their face and a placebo to the other, twice daily for two months, then continue wh…

This study looks at whether a supplement called Neurofast® can help people who have both anxiety and heart problems. 80 adults aged 18-70 will take the supplement or no extra treatment for 12 weeks. Researchers will measure changes in anxiety, heart rate, and blood pressure.

This early-phase study tests whether taking vitamin B6 for up to 31 days can reduce the sharp rise in blood pressure that happens during exercise after a temporary lack of blood flow (like a leg injury). Researchers will measure blood pressure, heart rate, nerve activity, and wal…

This study compares two drugs, gabapentin and oxcarbazepine, for treating chronic nerve pain in children aged 8 to 18. Sixty participants will receive one drug or the other in a blinded fashion, with the option to switch if pain doesn't improve. The goal is to see which drug redu…

This study tests whether adding epinephrine to a glycerin and lidocaine mixture improves the treatment of small leg veins (telangiectasias). Twenty adults will have one leg treated with the standard mixture and the other with the mixture plus epinephrine. Doctors will rate vein c…

This study tests whether taking daily supplements containing collagen, MSM, and vitamin C for 16 weeks can reduce facial redness and spider veins in healthy women aged 35–65. Ninety participants with stable facial redness will be randomly assigned to one of two supplement doses o…

This study tests whether adding a short, guided mindfulness meditation session to standard cardiac rehabilitation can help heart patients feel better and control their blood pressure. Eighty adults with heart disease will be split into two groups: one gets standard rehab plus med…

This study will compare cannabis, opioids, and two non-drug therapies (MIRE and TENS) in 1,000 people with chronic pain or circulatory disorders. The goal is to find safer, less addictive pain relief options. Researchers will measure changes in pain and nerve function using objec…

This study tests whether wearing a virtual reality headset with calming scenes and hypnotic speech can lower pain and anxiety during minimally invasive leg artery surgery done under local anesthesia. About 90 adults with peripheral artery disease will take part. The main goal is …

This study uses advanced 4D MRI scans to measure blood flow and heart function in adults with heart disease or cancer. Researchers aim to see if these detailed images can help predict how these diseases will progress. The study involves 1,000 participants who are already schedule…

This study will interview 15 people from ethnic minority backgrounds in the UK who have heart disease. The goal is to understand their views on the diet and lifestyle advice they get from doctors, and whether it fits their cultural and religious customs. Researchers hope to learn…

This study looks at whether a hospital rehab and prosthetic training program helps people who lost a leg due to diabetes or blood vessel disease use their artificial limb regularly. Researchers will review past patient records and follow new patients for up to 6 months after they…

This study tests whether it is possible to run a larger trial comparing two ways of using a breathing machine (ventilator) in critically ill heart patients who need help breathing. The two modes are volume-controlled (delivers a set amount of air each breath) and pressure-control…

This study surveys doctors who use Concerto Versa detachable coils to treat various blood vessel conditions like aneurysms and varicose veins. About 30 patients will be included, and doctors report how well the coils work and any problems within 72 hours. The goal is to collect e…

This observational study at a French hospital will ask 20 heart rehab patients and their care teams about what stops them from getting or offering psychological and social support. The goal is to understand these barriers so that hospitals can better help patients return to work …

This study aims to see if a quicker MRI scan can produce images of blood vessel walls that are just as good as the standard, longer scan. Researchers will enroll 15 adults who already need a vessel wall MRI as part of their care. The faster scan will be compared to the regular on…

This observational study will look at how exercise changes blood flow in the legs of people with or at risk for peripheral arterial disease (PAD). About 85 participants will walk for 6 minutes and have their ankle-brachial index (ABI) measured before and after. The goal is to see…

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …

This study looks at whether people with peripheral vascular disease (narrowed leg arteries) might also be at high risk for lung cancer because of shared smoking history. Researchers will check if these patients qualify for lung cancer screening and refer them for a low-dose CT sc…

This study compares two methods of accessing the brachial artery in the arm for treating blocked leg arteries: a needle poke through the skin (percutaneous) versus a small cut (open). About 246 adults will be randomly assigned to one method. The goal is to see which approach caus…

This pilot study will test whether a women-focused education program, called Cardiac College for Women, helps women with heart disease learn more about their condition and feel better. About 50 women in cardiac rehab across Canada will either get the program plus usual care or us…

This study will look at how consistently nearly 6,000 adults in Italy take three newer cholesterol-lowering drugs (inclisiran, evolocumab, and alirocumab) over the long term. Researchers will analyze prescription records to measure adherence and persistence in everyday medical pr…

This study will test new MRI methods to find early signs of heart disease in 1000 adults. Researchers want to see if these scans can detect tiny changes in heart muscle before standard tests do. Participants will have MRI scans and blood work, but no treatment is given. The goal …

This study looks at how hereditary hemorrhagic telangiectasia (HHT) affects the quality of life of children and young adults aged 2 to 25. Participants will fill out questionnaires about their physical, emotional, and social well-being. Researchers will also review medical record…

This study looks at whether a CT scan already done for routine care can predict which patients with leg artery disease will improve with supervised exercise therapy. About 40% of patients don't get enough benefit from exercise and need a procedure to open blocked arteries. Resear…

This large registry study will follow over 2,700 postmenopausal women aged 45-75 who use newer forms of hormone replacement therapy (creams, gels, sprays). The goal is to see if these modern delivery methods lower the risk of heart attacks, strokes, and other cardiovascular event…

This study will follow 4,000 intensive care patients aged 80 and older to see how chronic and acute heart conditions impact their survival, daily function, and quality of life. Researchers will use simple tests to measure frailty and independence. The goal is to help doctors bett…

This study will follow 500 Beijing residents aged 60 and older to see how urinary function (like bladder and kidney health) relates to the development of multiple chronic conditions such as diabetes, heart disease, and Alzheimer's. Participants will have regular health checks, bl…

This study tests a new, non-invasive imaging method (multispectral optoacoustic tomography) to measure oxygen levels in leg muscles during exercise. Researchers will compare results from endurance athletes, strength athletes, healthy controls, and people with peripheral arterial …

This observational study will examine whether a protein called the GLP-1 receptor is more active in patients with severe leg artery disease compared to those with milder symptoms. Researchers will take one extra blood sample from 50 adults with peripheral artery disease to measur…

This study will ask 380 heart patients and healthcare workers at Assiut University Heart Hospital to fill out questionnaires about depression, anxiety, stress, and burnout. No treatments or changes are given—the goal is simply to find out how common these mental health problems a…

This study looks back at medical records of 300 adults who had a minor amputation (at or below the ankle) to see if the type of anesthesia used affects their recovery. Early data suggests that using a nerve block instead of general anesthesia may lead to fewer complications and a…

This study will test 16 people with peripheral arterial disease (PAD) to see how different types of exercise—walking on a treadmill, traditional strength training, and circuit training—affect blood flow, oxygen levels, and leg pain. Participants will try each exercise type in ran…

This study tests a computer tool that helps doctors and cancer survivors decide together on the best heart-protective medications and tests. Researchers will enroll 60 cancer survivors at risk for heart problems. The goal is to see if the tool is easy to use and helps people foll…

This study will test whether an artificial intelligence (AI) system can detect pulmonary hypertension and other heart diseases using a smart stethoscope. Researchers will collect heart sound and ECG recordings from 1,000 adults already scheduled for routine echocardiography. The …

This study looks at how sleep disorders and problems with the body's automatic functions (like heart rate control) are linked in elderly people with heart disease. Researchers will study 210 patients aged 65 and older to find out how common sleep issues are and how they affect he…

This study will collect data from 1100 people with peripheral artery disease or abdominal aortic aneurysm across six European centers. Researchers will use artificial intelligence to analyze clinical data, blood samples, imaging, and wearable device information to build tools tha…

This study tests whether two widely used anti-platelet drugs, aspirin and clopidogrel, can reduce inflammatory markers in people with silent atherosclerosis (hardening of the arteries without symptoms). Researchers will measure changes in monocyte-platelet aggregates, a sign of i…