Parkinson disease

This phase 2 trial tests whether ENERGI-F705 tablets, taken twice daily alongside standard Parkinson's medications, can improve motor function and safety in people aged 40–75 with idiopathic Parkinson's disease. Participants are randomly assigned to receive a high dose, low dose,…

This study tests a new, faster method to deliver the drug AB-1005 into the brain of people with advanced Parkinson's disease. The goal is to see if the new approach can consistently reach the target area while being safer and quicker. 18 participants will be enrolled to assess th…

This study compares two types of cognitive-based balance training for people with Parkinson's disease: one using virtual reality (VR) and the other combining balance exercises with mental tasks like counting. Thirty-four participants aged 40-80 will do 16 sessions over 8 weeks. R…

This study investigates whether upper extremity exercise training delivered via tele-rehabilitation (synchronous or asynchronous) can improve motor symptoms, hand dexterity, and daily living activities in people with Parkinson's disease. Participants will receive either remote or…

This study tests a single injection of AB-1005 gene therapy directly into the brain for Japanese adults with moderate Parkinson's disease. The goal is to see if it is safe and can improve daily movement. Eight participants will be followed for 18 months.

This early-stage study will test a new way of using deep brain stimulation (DBS) for Parkinson's disease. Instead of the usual constant high-frequency pulses, this 'Coordinated Reset' approach uses lower-power, patterned stimulation. Researchers want to see if it's safe and can i…

This study tests whether fecal microbiota transplantation (FMT) from healthy donors can improve motor and non-motor symptoms in people with Parkinson's disease. 58 participants will receive either FMT or a control, and their movement scores will be compared after 6 months. The go…

This early-phase trial will test whether a special form of resveratrol (JOTROL) is safe and tolerable for people with Parkinson's disease. About 30 participants will receive either a low dose, high dose, or placebo daily for three months. The study will also measure how the drug …

This pilot study will test whether a virtual reality (VR) rehab program done at home can help people recover movement and thinking skills after a stroke or with Parkinson's disease. Sixty participants will either use a VR headset for daily exercises or receive standard rehab. The…

This phase 2 trial tests an injectable drug called GM1 in 276 people with Parkinson's disease who experience motor fluctuations (times when medication wears off). Participants are randomly assigned to receive GM1 or a placebo for about 12 weeks, while continuing their usual Parki…

This early-phase trial tests a gene therapy called VGN-R08b in 17 people with Parkinson's disease who have a GBA1 gene mutation. The therapy is injected directly into the brain's fluid spaces to try to improve symptoms. The main goals are to check safety and see if it works.

This study tests whether an 8-week plant-based diet, rich in fiber and low in processed foods, can improve gut bacteria and reduce inflammation in people with Parkinson's disease. Researchers will track 75 participants to see if the diet leads to healthier gut microbes and better…

This early-stage study tests a single injection of special brain cells (NouvNeu001) in 10 people with moderate-to-advanced Parkinson's who have already had deep brain stimulation surgery. The main goal is to check safety, but researchers will also track movement and daily functio…

This early-phase trial tests a new gene therapy for Parkinson's disease. Six participants will receive a virus-based treatment injected into a specific brain area during surgery. Afterward, they take a drug to control abnormal brain activity and improve movement. The main goal is…

This study tests whether lecanemab, a drug that clears amyloid plaques in Alzheimer's disease, can also help people with Parkinson's disease who have amyloid buildup in their brains. About 60 adults aged 50-90 with mild cognitive impairment or early dementia will receive lecanema…

This study tests a new adaptive brain stimulation system that adjusts in real time, compared to standard constant stimulation, for people with Parkinson's disease. About 104 participants will try both modes for three months each to see which gives them more good-quality ON time w…

This early-stage trial will test the safety and tolerability of a new oral drug called Lu AF28996 in 10 Chinese adults with Parkinson's disease. Participants will take the drug and be monitored for side effects and how the body processes it. The study is not yet recruiting and do…

This Phase 2 trial tests whether terazosin, a drug already used for high blood pressure, can improve energy production in the brains of people with Parkinson's disease. Researchers will measure changes in a key energy molecule (ATP) in 120 participants over 1.5 years. If it works…

This study tests two types of stem cell treatments for people with Parkinsonism, a condition that causes movement and non-movement problems. The goal is to see if these treatments are safe and can improve symptoms like tremors, stiffness, and mood changes. About 120 adults aged 4…

This study will screen 600 adults aged 55 and older in U.S. communities to find early signs of mild cognitive impairment (MCI). Participants will receive a combination of stem cell therapy, a wearable brain-computer interface device, and wellness coaching to see if these treatmen…

This study tests a new way to use deep brain stimulation (DBS) in people with early-stage Parkinson's disease. The goal is to see if targeting a specific brain area can safely slow or stop worsening of motor symptoms. About 40 participants will receive DBS plus standard medicatio…

This study looks at how well the drug Foslevodopa/Foscarbidopa works for people with advanced Parkinson's disease who are still in the earlier phases of that stage. About 100 adults will receive the drug as a continuous infusion under the skin for up to 6 months. Researchers will…

This study tests a home-based dual-task training program for people with Parkinson's disease who have mild cognitive impairment and are at high risk for dementia. Participants will cycle on a stationary bike while playing brain-training games on a tablet, three times a week for 3…

This early-stage trial tests a single injection of lab-grown dopamine-producing cells into the brains of 12 people with advanced Parkinson's disease. The goal is to see if the procedure is safe and if it can improve motor function and quality of life. Participants must be between…

This study tests whether using brain imaging and electrical signals to program deep brain stimulation (DBS) works better than the usual method for people with Parkinson's disease. Twenty adults aged 30 to 70 who are getting DBS will be randomly assigned to either standard program…

This study tests if a gentle electrical stimulation of the ear (called taVNS) combined with treadmill training can improve walking and brain function in people recently diagnosed with Parkinson's disease. Sixty participants will receive either real or fake stimulation during 12 t…

This study tests whether spinal cord stimulation can help people with Parkinson's disease who experience sudden drops in blood pressure when standing up. Forty participants will receive either an implanted stimulator or a non-invasive version. The goal is to see if the treatment …

This study tests whether terazosin, a drug currently used for an enlarged prostate, can boost energy production in brain cells of people with early Parkinson's disease. One hundred participants will receive either terazosin or a placebo for 6 months. Researchers will measure chan…

This study tests an oral drug called GT-02287 in 111 people with early Parkinson's disease. Participants will receive either a low dose, high dose, or placebo for 48 weeks. The goal is to see if the drug improves daily movement and motor symptoms, and to check its safety and effe…

This early-stage trial tests a gene therapy called AAV2-hAADC in 9 adults with young-onset Parkinson's disease. The therapy delivers a gene directly to two brain regions (putamen and caudate) to help convert levodopa into dopamine more efficiently. The main goal is to check safet…

This study compares two brain areas for deep brain stimulation (DBS) in 86 people with Parkinson's disease. The goal is to see which target—the subthalamic nucleus (STN) or the globus pallidus internus (GPi)—better improves movement symptoms 90 days after surgery. Participants wi…

This early-stage study tests whether stem cells from umbilical cords are safe for people with Parkinson's disease. About 20 adults will receive either the cells or a placebo, and researchers will monitor side effects and any changes in movement. The goal is to see if this approac…

This phase 2 trial is testing whether FHL-301 (gemfibrozil, a drug usually used for cholesterol) can help control motor symptoms in people with early-stage Parkinson's disease. Thirty-two adults aged 40 to 75 will receive either the drug or a placebo for up to 48 weeks. The main …

This early-phase trial tests a new radioactive tracer called [11C]MODAG-005 that binds to abnormal protein clumps in the brain linked to Parkinson's disease and multiple system atrophy. Nine participants (patients with Parkinson's, MSA, and healthy volunteers) will receive the tr…

This early-phase trial will test a new radioactive tracer called 18F-FCOB04 in 40 people with neurodegenerative diseases like Alzheimer's or Parkinson's. The tracer targets a brain protein called MAO-B and is used with PET scans to see if it can help diagnose these conditions. Th…

This study will test a new intelligent diagnostic system for orthostatic hypotension (a sudden drop in blood pressure when standing up). The system continuously monitors blood pressure, brain blood flow, and heart signals to classify the condition more precisely. Researchers plan…

This study explores painless ways to diagnose Parkinson's disease using advanced eye imaging, memory tests, and voice analysis. Researchers will compare results from 60 people with and without Parkinson's to see if these methods can accurately identify the disease. The goal is to…

This study tests whether a smartphone app, called ICD-Shield, can help doctors adjust Parkinson's medications to prevent impulse control disorders (like compulsive gambling or shopping). About 528 people with early-stage Parkinson's will be randomly assigned to use the app or rec…

This study tests whether a 6-month program combining exercise, Mediterranean diet, sleep counseling, and cognitive training can help people with early Parkinson's or a sleep disorder (RBD) stick to healthy habits. Researchers will track how well 99 participants follow the program…

This study tests whether a small device that gently stimulates a nerve in the ear can help reduce depression in people with Parkinson's disease. Participants use the device at home twice a day for 14 days. The trial measures changes in mood and brain activity to see if this simpl…

This study tests whether a wearable device called cueStim can shorten the duration of freezing of gait—a sudden inability to move—in people with Parkinson's disease. About 60 participants, aged 60 to 90, will wear the device for four weeks during daily life and be assigned to one…

This phase 2 trial tests whether a single dose of psilocybin, the active ingredient in magic mushrooms, can improve depression in people with Parkinson's disease. Forty participants will receive a low to high dose with psychological support. The study measures changes in depressi…

This study will test whether a gentle, non-invasive brain stimulation technique called tDCS can improve verbal fluency, thinking, and motor control in people with Parkinson's disease. Twenty participants aged 50-90 with Parkinson's and a verbal fluency deficit will receive the st…

This pilot study will test whether active music therapy (with a therapist) or passive music therapy (just listening to music) can improve exercise ability and motivation in 28 people with Parkinson's disease. Participants will do sit-to-stand and walking tests while receiving mus…

This study tests whether a non-invasive device that gently stimulates a nerve on the forehead (external trigeminal nerve stimulation, or eTNS) can immediately improve walking and other movement problems in people with Parkinson's disease. Thirty participants will each try two dif…

This study tests whether combining a painless brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) with balance exercises can improve walking and balance in people with Parkinson's disease. Twenty participants aged 40-80 will receive the combined…

This study will test whether a special exercise program called LSVT BIG, done via video calls at home, works as well as the same program done in a clinic. Forty people with mild-to-moderate Parkinson's disease will be randomly assigned to either remote or in-person therapy for 4 …

This study tests whether the sleep medication lemborexant can improve both sleep and motor symptoms in people with Parkinson's disease. Forty-four participants will take either lemborexant or a placebo nightly for 28 days. Researchers will measure changes in sleep quality and mov…

This study tests whether a non-invasive brain stimulation technique called temporal interference stimulation can improve tremor and walking difficulties in people with Parkinson's disease. Fifty participants will be randomly assigned to receive either real or sham stimulation dai…

This study will test a comfortable, soft elbow brace that helps bend and straighten the arm, along with a vibrating forearm bracelet that gives touch cues. About 45 people with stroke or Parkinson's disease will try these devices during arm exercises. The goal is to see if the de…

This study tests a robotic device designed to help people with stroke, Parkinson's disease, ALS, or mild cognitive impairment improve their arm and hand function. Thirty adults will receive standard rehabilitation, and half will also use the robot for up to 30 minutes per session…

This trial investigates whether doing enjoyable, meaningful activities—like cooking, gardening, or painting—can improve thinking skills and daily function in older adults with Parkinson's disease who have mild to moderate memory or thinking problems. Participants are randomly ass…

This study tests a 16-week home-based exercise program for people with Parkinson's disease. Fifty participants will either do aerobic and resistance training or just stretching. The goal is to see if the program increases daily physical activity, improves thinking, and enhances q…

This study tests whether using a virtual reality (VR) system during cycling exercise makes rehabilitation more motivating for adults with conditions like stroke, Parkinson's, multiple sclerosis, or frailty. About 70 participants will try cycling with and without VR over 4 weeks. …

This study tests a smartphone app called CuePD that uses a person's favorite music to help retrain their walking. The goal is to improve gait and reduce fall risk in people with Parkinson's disease. Forty participants who can walk without help will use the app at home and while o…

This pilot study tests whether a special shoe that vibrates can safely help people with Parkinson's disease who experience freezing of gait — a sudden inability to move their feet while walking. Twenty participants will wear the smartshoes and researchers will measure how well th…

This study tests whether immersive virtual reality (VR) therapy can improve balance, reduce fall risk, and boost cardiorespiratory fitness in people with Parkinson's disease. Fifty participants aged 55–75 with mild to moderate Parkinson's will be randomly assigned to either VR-ba…

This study tests an automated programming method for deep brain stimulation (DBS) in people with Parkinson's disease. Fifteen participants who recently had DBS surgery will try the new algorithm and perform motor tasks like walking and finger tapping. The goal is to see if the au…

This trial tests the ParkinSense system, a body-worn device that detects freezing of gait in Parkinson's disease and delivers personalized cues to help patients start walking again. Sixty participants will first use the device in a lab, then at home for two weeks. The main goal i…

This study will test whether people with Parkinson's disease can safely follow a home-based exercise program using video instructions and real-time feedback from a camera. Fifteen participants will do exercises like stretching, strength training, and balance work at home for 6 we…

This study will test a special moving platform combined with virtual reality to help people with neurological disorders like Parkinson's disease, stroke, ALS, or mild cognitive impairment improve their balance and movement. The platform moves in three directions and adapts exerci…

This study tests two treatments—mirabegron (a drug) and exercise-based behavioral therapy—for overactive bladder in people with Parkinson's disease. Researchers want to see if combining treatments helps those who don't respond to one alone. The trial will involve 146 participants…

This Phase 2 trial tests whether adding Lu AF28996 to standard Parkinson's medications can extend the time patients feel their movement symptoms are well-controlled (called 'good ON time'). About 150 adults with Parkinson's who still experience motor fluctuations despite optimize…

This study tests a 6-week exercise program called SwallowFit designed to improve swallowing fitness in people with Parkinson's disease. Researchers will compare the exercise group to those receiving standard care. The goal is to see if the exercises lead to safer swallowing and b…

This study tests a new, non-invasive brain stimulation technique called temporal interference stimulation (TIS) for people with Parkinson's disease. The device uses electrodes on the scalp to send electrical currents deep into the brain, aiming to improve movement problems withou…

This study will compare two types of physical therapy—strategy training (using mental cues and visual guides) and proprioceptive neuromuscular facilitation (a stretching and movement technique)—to see which one improves balance, walking, and daily independence in people with Park…

This study tests whether adding whole-body vibration (standing on a vibrating platform) to a home exercise program helps people with Parkinson's disease improve balance, mobility, and fall risk more than exercise alone. About 68 adults aged 50-75 with mild to moderate Parkinson's…

This pilot study tests whether 10 sessions of low-fidelity driving simulator training can improve driving performance, confidence, and thinking skills in people with Parkinson's disease. 36 participants will be randomly assigned to either the simulator training or a waitlist grou…

This early study will test whether low-intensity focused ultrasound (LIFU) can safely stimulate a brain region in people with Parkinson's disease. Fifteen participants will receive a single session of LIFU. The main goal is to check for side effects, with a secondary look at whet…

This study tests whether repeated sessions of a gentle brain stimulation technique called tDCS can improve motor function in people with Parkinson's disease. Thirty adults with moderate-stage Parkinson's will receive stimulation over several days. The goal is to see if this safe,…

This study will test whether virtual reality therapy combined with proprioceptive neuromuscular facilitation (a type of hands-on exercise) can improve arm movement, reduce tremors, and enhance body awareness in people with Parkinson's disease. Twenty-eight participants will recei…

This study is testing whether virtual reality (VR) and augmented reality (AR) games can be a safe and easy-to-use tool for rehab in people with Parkinson's disease. Thirty healthy volunteers aged 50 to 70 will try the game system for four sessions over two weeks. Researchers will…

This study will test a robotic device called BackHug that delivers deep back massages to 30 adults with mild-to-moderate Parkinson's disease. The goal is to see if it improves walking, balance, back pain, and sleep quality. Participants will receive 40-minute sessions over a set …

This study tests whether a mild electrical stimulation applied to the ear (taVNS) can improve walking, balance, and movement in people with Parkinson's disease when combined with physical therapy. Thirty participants will receive either real or sham stimulation during therapy ses…

This study tests a new, non-invasive brain stimulation technique called transcranial temporal interference stimulation (TIS) to see if it can improve movement problems in people with Parkinson's disease. Twenty participants will be randomly assigned to receive either real TIS or …

This study tests whether a custom foot wedge combined with balance exercises can improve walking and stability in people with Parkinson's disease. Thirty participants with moderate Parkinson's will either get standard physical therapy or the same therapy plus the wedge and specia…

This study tests whether applying menthol to the skin can improve motor symptoms and sleep quality in people with early-stage Parkinson's disease. Researchers will enroll 80 adults aged 30-80 who have had Parkinson's for less than 3 years and report poor sleep. Participants will …

This study tests a new type of cycling called eccentric cycling for people with multiple sclerosis. Researchers want to see if it improves muscle strength, walking ability, fatigue, and quality of life better than standard cycling. Sixty adults with MS who can walk independently …

This study tests whether a special 40 Hz flickering light, used for 30 minutes each night for a week, can improve insomnia in people with Parkinson's disease. Thirty participants will be randomly assigned to receive either the 40 Hz light or a control light. The main goal is to s…

This study tests whether wearable body sensors can help doctors better adjust medication for people with Parkinson's disease who experience motor fluctuations. 218 participants will wear the sensors for 7 days before each visit, and only the experimental group's data will guide t…

This study tests whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can improve walking in people with Parkinson's disease. 81 participants with mild to moderate Parkinson's who have trouble starting to walk will receive …

This study tests a non-invasive treatment called remote ischemic conditioning (RIC) for sleep problems in people with Parkinson's disease. For 7 days, 48 participants will receive either active RIC (using a blood pressure cuff to briefly restrict arm blood flow) or a sham version…

This study tests a non-invasive device called Temporal Interference Stimulation (TIS) to see if it can improve movement in people with Parkinson's disease. The device uses electrical fields to stimulate deep brain areas without surgery. Twenty-four adults with mild to moderate Pa…

This study tests whether a gamification program—using game-like rewards and challenges—can help veterans with Parkinson's disease become more physically active. About 110 veterans will either use the gamification program or continue their usual routine. The goal is to see if incr…

This study tests two types of exercise in people with Parkinson's disease: one focuses on balance exercises (vestibular rehab), the other combines thinking tasks with movement (dual-task training). Forty-five participants will do supervised exercises twice a week for eight weeks.…

This study tests whether a 10-week balance-focused exercise program can improve how the calf muscle activates when starting to walk in people with Parkinson's disease. Researchers in Kuwait will enroll 80 participants who can walk independently. The goal is to see if these exerci…

This study tests whether an AI-powered smart electric vehicle can help people with Parkinson's disease or dementia improve their walking and reduce falls. The vehicle monitors gait, gives real-time feedback, and adapts to the user. Researchers will enroll 120 participants aged 50…

This pilot study tests whether a breathing exercise program (expiratory muscle strength training) can improve cough, swallowing, and drooling in people with Parkinson's disease who also have a forward-bent posture. About 28 adults with Parkinson's will participate. The goal is to…

This study will test a smartphone app that uses artificial intelligence to create personalized lifestyle plans for people with Parkinson's disease. The app combines diet, exercise, sleep, and other habits to help manage symptoms and possibly slow the disease. Researchers will enr…

This study tests a new, high-dose form of non-invasive brain stimulation (called accelerated theta burst stimulation) to see if it can improve walking problems, like freezing, in people with Parkinson's disease. The study will enroll 20 adults with early-stage Parkinson's who hav…

This study tests two types of deep brain stimulation (DBS) in 30 people with Parkinson's disease who already have a DBS implant. One type uses fixed settings, while the other adapts in real time to brain signals. Each participant tries both settings at home for up to a week and t…

This study aims to find unique biological and clinical markers for a specific genetic form of Parkinson's disease linked to the LRRK2 gene. Researchers will compare 10 people with LRRK2-related Parkinson's to 10 people with sporadic Parkinson's using blood tests, brain MRI scans,…

This study investigates how stimulating the vagus nerve through the ear affects stomach function and brain activity in people with Parkinson's disease. Participants receive non-invasive electrical stimulation via a device placed on the ear, and researchers measure stomach respons…

This study investigates whether deep brain stimulation (DBS) of the subthalamic nucleus alters inflammation in people with Parkinson's disease. Researchers will measure inflammatory and neurodegenerative markers in the blood of 90 participants before and after DBS surgery, compar…

This study follows 70 people with PRKN- or PINK1-linked Parkinson's disease, as well as those with typical Parkinson's and healthy volunteers, over 5 years. Researchers will track movement, thinking, and mood symptoms, and collect blood, urine, and optional spinal fluid or muscle…

This study looks at how dopamine levels affect the ability to keep a steady beat in people with early-stage Parkinson's disease. 34 participants will do simple tapping tasks both on their usual levodopa medication and after skipping it for 12 hours. The goal is to understand whet…

This study looks at how a brain region called the subthalamic nucleus (STN) is involved in sleep and wakefulness in people with Parkinson's disease. Researchers will record brain activity during sleep using special electrodes already implanted for deep brain stimulation. The goal…

This study looks at how Parkinson's disease affects arm and hand skills, trunk control, and body awareness. Researchers will compare 118 people with Parkinson's (ages 50-80) to healthy adults using tests like pegboard, grip strength, and reaction time. The goal is to understand t…

This study will measure how common and severe depression, anxiety, and sleep disorders are in 100 people with idiopathic Parkinson's disease. Researchers will use standard rating scales to assess these symptoms and see how they relate to the disease. The goal is to help doctors r…

This study looks at brain activity recorded from deep brain stimulation (DBS) devices in 20 people with Parkinson's disease. Researchers want to see if certain brain signals are linked to symptoms like sudden anxiety, impulse control problems, and hallucinations. Participants wil…

This study looks at whether slowly reducing or stopping a type of bladder medication (antimuscarinics) can improve thinking and quality of life in people with Parkinson's disease. Twenty participants will go through periods of taking their usual dose and periods of tapering off, …

This study explores whether dual-task training—doing two things at once, like walking while solving a puzzle—can improve self-efficacy (confidence) and physical function in people with Parkinson's disease. Researchers will compare different training types (motor-cognitive vs moto…

This observational study will enroll 200 people—100 with Parkinson's disease, 50 with related conditions, and 50 healthy controls—to find molecular markers in blood, urine, and stool that can distinguish Parkinson's from atypical parkinsonism. Participants provide samples and und…

This natural history study will follow 3,000 people with Parkinson's disease over 10 years to understand how the disease progresses and to find early diagnostic markers. Participants will undergo regular check-ups, imaging scans, and lab tests, but no experimental treatments will…

This pilot study will test a flexible, home-based care pathway for 100 people newly diagnosed with Parkinson's disease and their caregivers. The program includes questionnaires and educational tools to help patients and families better understand the disease and manage their care…

This study looks at how the nerves connecting the gut and brain affect Parkinson's disease. Researchers will compare people with Parkinson's, those at risk, and healthy volunteers. Participants will give blood, stool, and saliva samples, have X-rays and colon exams, and answer qu…

This study uses advanced PET/MRI scanning to examine the noradrenaline system in the brains of 165 healthy adults and people with Parkinson's disease. Participants receive a radioactive tracer that binds to specific receptors, allowing researchers to see how this system changes w…

This study looks at how abnormal proteins, like alpha-synuclein and tau, build up and affect brain function in people with Parkinson's disease. Researchers will use brain scans, blood tests, and skin biopsies to track these changes. The goal is to find better ways to diagnose and…

This study looks at how doing mental tasks—like naming objects or remembering words—changes the way people with Parkinson's disease walk. Researchers will compare 30 people with Parkinson's to healthy adults of the same age and sex. The goal is to find out which type of thinking …

This study tests a driving simulator designed to help people with neurological conditions like stroke, Parkinson's, ALS, or mild cognitive impairment improve their motor and thinking skills. About 60 participants (including healthy volunteers) will use the simulator to see if it …

This observational study looks at whether a specific brain function called inhibitory control — the ability to stop or change actions — is linked to how people with Parkinson's disease adjust their walking to step over obstacles. Researchers will measure brain activity with EEG a…

This study will check if a Turkish version of a questionnaire about thinking confidence (cognitive self-efficacy) works well for people with Parkinson's disease. Around 100 participants will fill out the questionnaire, and researchers will see if it is reliable and accurate. This…

This study looks at how self-compassion (being kind to yourself) and self-efficacy (believing you can manage your health) relate to Parkinson's symptoms, daily function, and quality of life. About 100 adults with mild-to-moderate Parkinson's will fill out questionnaires and do a …

This study looks at how people with Parkinson's disease imagine movements, sense their own bodies, and fear physical activity, and how these factors relate to their symptoms and frailty. Researchers will assess 100 participants using questionnaires and physical tests. The goal is…

This study looks at people with advanced Parkinson's disease who already have a brain device (deep brain stimulation). Researchers want to understand how aerobic exercise—specifically cycling—changes movement, thinking, and brain activity. Thirty-six participants will do an eight…

This observational study will examine whether prior expectations increase false perceptions in Parkinson's patients who experience visual hallucinations. About 60 participants, including patients with and without hallucinations and healthy volunteers, will complete a computer-bas…

This study looks at gut changes in people with untreated Parkinson's disease compared to healthy adults. Researchers will measure gut permeability, microbiome, and transit time using stool samples, X-rays, and optional endoscopy. The goal is to better understand early gut involve…

This study will test an artificial intelligence system that uses smartphone video to rate motor symptoms in people with Parkinson's disease. Researchers aim to make assessments more objective and less time-consuming than current methods. The trial will enroll 500 participants in …

This study looks at how different amounts of oral THC (the main psychoactive ingredient in cannabis) affect mood, heart rate, and drug feelings in healthy adults who have used cannabis before. Participants will take either a low, medium, or high dose of THC or a placebo during fo…

This study looks at how deep brain stimulation (DBS) can be adjusted to help people with Parkinson's disease who have trouble with eye alignment and focusing. Researchers will use eye-tracking and brain models to find the best stimulation settings. The goal is to improve vision w…

This observational study will follow 100 medically fragile adults with conditions like stroke, multiple sclerosis, Parkinson's disease, or certain fractures. The goal is to see if remote check-ins via video calls can reliably spot declines in mobility and thinking, compared to in…

This study follows 6 people with Parkinson's disease who already received an experimental injection called RGL-193. Researchers will check their safety and brain enzyme activity over 5 years. No new treatment is given—this is just observation to see how the injection holds up lon…

This study will use PET-MRI brain scans to compare the reward system in 44 Parkinson's patients, some of whom have a sleep disorder called RBD. The goal is to understand why some patients develop impulse control problems, like gambling or compulsive behaviors, as a side effect of…

This study will test if a smartphone app can accurately measure fall risk in people with Parkinson's disease. Researchers will compare app results before and after adjusting medication in 100 participants. The goal is to see if the app can help doctors better manage fall risk.

This study will test whether artificial intelligence (AI) can predict how Parkinson's disease will progress and how patients will respond to medication. One hundred people with Parkinson's will wear a smartwatch and use a mobile app for one year. The AI models will analyze data f…

This study brings together 30 Italian experts to agree on the best ways to use deep brain stimulation (DBS) for Parkinson's disease. DBS uses electrical pulses to improve movement problems, but practices vary widely. Through a series of surveys, the experts will develop clear gui…