Immunodeficiency disease

This study tests whether the HPV vaccine Gardasil 9 can trigger an immune response in people with idiopathic CD4 T cell lymphocytopenia (ICL), a rare condition that weakens the immune system. About 54 adults with ICL and some healthy volunteers will receive three doses of the vac…

This early-phase trial tests a new HIV vaccine strategy in 36 healthy adults without HIV. The vaccine uses ferritin nanoparticles to display HIV envelope proteins, followed by an mRNA boost. The goal is to safely trigger broadly neutralizing antibodies that could protect against …

This study tests whether a simpler two-drug pill (dolutegravir/lamivudine) works as well as a standard three-drug pill (bictegravir/emtricitabine/tenofovir alafenamide) for adults with HIV who have never been treated. About 473 participants will take one of the two pills daily fo…

This study tests a new approach for people receiving a stem cell transplant from a partially matched family donor. The donor's immune cells (T cells) are modified in the lab to include a 'suicide gene' that can be activated by a drug if the cells attack the patient's body, causin…

This trial tests whether specially modified T cells from a partially matched donor can help patients recover their immune system faster after a stem cell transplant. The T cells are engineered with a 'suicide gene' that allows doctors to destroy them if they cause graft-versus-ho…

This study tests whether a stem cell transplant from a matched sibling, unrelated donor, or half-matched parent can fix the immune system in people with DOCK8 deficiency, a genetic condition that causes severe infections and cancer. Participants aged 4 to 35 receive chemotherapy …

This early-stage study tests a new lab-made antibody called VH4527079 in healthy adults and people with HIV. The goal is to check if it is safe and how the body processes it when given as a single shot or multiple infusions. About 102 participants aged 18-55 will take part. This …

This phase 2 trial tests whether the supplement fisetin can improve lung disease in people with common variable immunodeficiency (CVID). Twenty participants will receive either fisetin or a placebo on four days over a month. The study measures changes in immune cells and lung fun…

This phase II trial tests whether a new drug called Briquilimab can make stem cell transplants safer for people with GATA2 deficiency, a rare genetic condition that weakens the immune system and raises the risk of infections and blood cancers. The study involves 13 participants a…

This Phase 2 trial tests whether N-Acetylcysteine (NAC), an antioxidant, can help people with ME/CFS (chronic fatigue syndrome). Researchers will give 95 participants different doses of NAC or a placebo for four weeks, then measure brain glutathione levels and markers of oxidativ…

This study tests a donor stem cell transplant for people with severe immune system problems, like SCID and Wiskott-Aldrich syndrome. The goal is to help the body make healthy blood cells and fight infections. Participants receive donated stem cells to rebuild their immune system.…

This study tests a drug called leniolisib in children aged 1 to 6 years who have a rare genetic immune disorder called APDS. The drug aims to control the overactive immune system and reduce swollen lymph nodes. Researchers will monitor safety and how well the drug works over time…

This study tests a program called Healthy Choices, which uses text messages and telehealth sessions to help young people with HIV (ages 18-29) in Florida manage their alcohol use and take their HIV medication every day. The goal is to improve daily medication adherence and viral …

This study is for adult women living with HIV who have experienced intimate partner violence. It tests a program that combines trauma-informed counseling with a safety planning app to improve mental health, HIV management, and safety. The goal is to see if this approach can reduc…

This study tests whether giving a guaranteed income of $6,750—either as a lump sum or monthly payments—helps people with HIV who have recently been in jail stay connected to care and keep the virus under control. Thirty-three participants will be randomly assigned to receive the …

This study tests whether a smoking cessation medication (varenicline) combined with tools to help people stick with treatment can improve quit rates for smokers living with HIV. About 340 participants will be followed for 6 months to see if they stop smoking, confirmed by breath …

This study planned to test a blend of plant extracts and vitamin C, called Ahah, in people with HIV/AIDS. The goal was to see if it could protect and increase CD4+ T cells and B cells. However, the trial was withdrawn before enrolling any participants, so no results are available…

This early-phase trial tested whether combining two anti-cancer drugs, pomalidomide (taken as a pill) and liposomal doxorubicin (given through an IV), is safe and tolerable for people with advanced or hard-to-treat Kaposi sarcoma. The study enrolled 62 adults, including those wit…

This study gives children with HIV-1 who previously benefited from rilpivirine continued access to the drug along with other antiretrovirals. About 48 kids are taking part to monitor long-term safety and side effects. The goal is to keep their virus under control while checking f…

This study tests a new gene therapy for X-linked severe combined immunodeficiency (X-SCID), a rare immune disorder. Doctors take a person's own stem cells, fix a faulty gene using a technique called base editing, and return the cells to the body. The goal is to rebuild the immune…

This study tests a medicine called Kedrion IVIG 10% in 30 children with primary immunodeficiency, a condition where the immune system doesn't work properly. The treatment is made from donated antibodies and is given through a vein to help prevent serious bacterial infections. Res…

This study compares two methods of rolling out a program called Bridges, which gives financial literacy training and one-on-one mentors to 1,440 teens aged 11-17 who lost parents to AIDS in Uganda. The goal is to see which approach works better at reducing HIV risk and improving …

This study follows about 50 people with a rare immune disorder called ADA-SCID who have received a gene therapy treatment called Strimvelis. The goal is to track their health for many years to see if the treatment remains safe and effective. Researchers will monitor for side effe…

This study tests a mobile app called HealthMPowerment (HMP) designed to help young gay and bisexual men (ages 15-24) either start HIV prevention (PrEP) or stay on HIV treatment. About 1500 participants will get the app right away or after a delay. Researchers will see if the app …

This study tests a new drug called bepirovirsen in 153 people who have both HIV and chronic hepatitis B and are already on HIV treatment. The goal is to see if bepirovirsen can clear the hepatitis B virus from the body better than a placebo. Participants will continue their regul…

This phase 2 study tests a drug called MAS825 in 17 people with rare genetic conditions that cause severe inflammation. The goal is to see if the drug can prevent disease flares better than a placebo. Participants will be monitored for safety and effectiveness over several period…

This study tests whether a combination of weekly video-counseling sessions and a mobile app can help young adults (18-29) living with HIV achieve viral suppression. Participants who are not virally suppressed will be randomly assigned to receive the intervention or standard care.…

This study looks at whether giving Cutaquig® (a medicine that helps fight infections) by a faster manual push method is safe and easy for adults with primary or secondary immunodeficiency. About 36 participants will use the rapid push method at home. The goal is to see if this ap…

This study tests a program called Khanya, where trained peers (people with lived substance use experience) help HIV patients stick to their medication and reduce drug or alcohol use. The program is offered in steps: a basic version first, then a more intensive one if needed. Rese…

This study was designed to test whether adding an experimental drug and special immune cells to standard care could help critically ill adults with severe pneumonia, especially those with sepsis or lung failure. The trial was withdrawn before enrolling any participants, so no res…

This study tests whether a telemedicine program that combines brief counseling with cognitive-behavioral therapy can help people with HIV reduce unhealthy alcohol use and improve their overall health. About 308 participants in Alabama will receive either the combined program or b…

This study is testing a special kiosk placed in rural Appalachian Kentucky that provides clean syringes and harm reduction supplies to people who inject drugs. The goal is to see if the kiosk helps reduce the spread of HIV and hepatitis C, and lowers the risk of drug overdose. Ab…

This study tests a drug called leniolisib in children aged 4 to 11 with APDS, a rare genetic condition that causes a faulty immune system. The goal is to see if the drug is safe and can control the disease by blocking an overactive immune signal. About 15 children will take the d…

This study tests whether semaglutide, a drug used for diabetes, can reduce harmful belly fat and improve heart health in people with HIV who have excess fat around the midsection (lipohypertrophy). About 108 participants will receive either semaglutide or a placebo for 32 weeks. …

This study tests a milder chemotherapy and immune-suppressing regimen before a stem cell transplant for children and young adults with non-malignant blood disorders like sickle cell disease or immune deficiencies. The goal is to safely achieve donor cell engraftment with fewer si…

This study looks at how safe and effective certain HIV medicines are for children and teens (ages 4 weeks to under 18 years) who already have the virus under control. Participants take a combination of drugs (atazanavir or darunavir boosted with cobicistat, plus emtricitabine/ten…

This study tests a new medicine called crovalimab for people with a rare disease called atypical hemolytic uremic syndrome (aHUS), which causes blood clots and kidney damage. The trial includes 83 adults and teens who receive the drug to see if it can control the disease and impr…

This trial tests a video-based counseling program for adolescents living with HIV in Malawi. About 1,800 teens and their treatment supporters will either receive the video intervention or standard care. The goal is to see if the videos help teens take their medication regularly a…

This pilot study tests whether giving the smoking-cessation drug varenicline to people with HIV who also have alcohol use disorder is practical and safe. Thirty participants will receive the medication along with support from a pharmacist and psychiatrist. The goal is to see if t…

This phase 3 trial tests crovalimab in 41 children with atypical hemolytic uremic syndrome (aHUS), a rare disease that causes blood clots and kidney damage. The drug is given first through a vein, then as a shot under the skin every four weeks. The goal is to see if it can stop d…

This study compares a shortened steroid regimen (8 days for moderate, 14 days for severe pneumonia) against the standard 21-day course in 196 HIV patients with Pneumocystis pneumonia. The goal is to see if the shorter treatment is non-inferior in preventing death and complication…

This early-stage study tests whether adding an experimental drug (VH3810109) with or without another drug (fostemsavir) to standard HIV therapy can reduce the hidden viral reservoir in people living with HIV. About 107 adults, either new to treatment or already on stable therapy,…

This study tests whether a stem cell transplant from a healthy donor can safely treat people with severe T-cell problems. Participants receive chemotherapy and antibody therapy before the transplant, followed by donor stem cells. The goal is to see if the new immune system can co…

This study tests a 'data-to-suppression' approach to help people with HIV who are not virally suppressed. It uses reports to guide support services for about 1,500 low-income individuals in New York City. The goal is to improve viral suppression rates and reduce health disparitie…

This study tests a lotion called QRX003 in 30 people with Netherton Syndrome, a rare genetic skin condition. The lotion contains a drug that blocks certain enzymes thought to cause skin problems. Researchers are checking if it reduces redness, scaling, and itching compared to a p…

This study tests whether virtual or in-person support helps teens with HIV stay in care and keep the virus under control. About 570 teens aged 15-19 in South Africa will receive either standard care or extra support to prepare for moving to adult clinics. The goal is to see which…

This early-phase trial tests whether a combination of two experimental vaccines, an immune booster, and two powerful antibodies can help people with HIV control the virus after stopping their daily antiretroviral therapy. Eleven participants will receive the regimen while on ART,…

This study looks at whether giving HIV treatment to babies within the first week of life can reduce the amount of virus hiding in their bodies. Researchers want to see if this early start helps the immune system fight HIV better, possibly allowing children to stop medication for …

This study tests a stem cell transplant using a milder chemotherapy-like regimen to treat children and young adults (up to age 28) with various immune system disorders. The goal is to help the donor stem cells settle in the body with fewer side effects. The study involves 20 part…

This study tests whether giving people with HIV same-day results from a simple urine test and a viral load test can help them stick to their medication and keep the virus under control. About 539 people starting HIV treatment in South Africa will take part. The goal is to see if …

This phase 2 trial studies whether lower doses of the chemotherapy drug busulfan can help infants with severe combined immunodeficiency (SCID) achieve good immune function after a stem cell transplant, while reducing short- and long-term risks. The trial includes 56 babies receiv…

This study tests a drug called leniolisib in 12 people aged 12 to 75 with certain primary immunodeficiency disorders. The goal is to see if the drug is safe and can help control immune system problems. Participants will receive three different doses of the drug, and researchers w…

This study tests a drug called leniolisib in 20 people with common variable immunodeficiency (CVID), a condition that weakens the immune system. All participants will receive the drug for 6 months, starting at a low dose and increasing. The main goal is to check safety and tolera…

This study tests whether text messages and counseling can help women living with HIV make better decisions about contraception and pregnancy. About 3,310 women in Kenya will receive either standard care or the mobile health program. The goal is to reduce unplanned pregnancies and…

This study tests a pharmacist-led program to help women with HIV who also face social challenges like housing or food insecurity. The program supports switching from daily pills to a long-acting injectable medication (cabotegravir/rilpivirine) given every two months. The goal is …

This study tests a smartphone app and a tablet dashboard for community health workers to support people with both tuberculosis (TB) and HIV in South Africa. The app helps patients stay on track with their medications, while the dashboard alerts health workers if someone needs ext…

This study tests a program to help people living with HIV in Botswana stop smoking. It combines counseling with a medication called varenicline. The goal is to see if this approach helps them quit and improves their health. The study involves 750 participants who are daily smoker…

This Phase 3 trial tests whether switching from daily HIV pills to monthly injections of cabotegravir and rilpivirine can keep the virus suppressed in adults with HIV. About 618 participants who are already virally suppressed will either stay on their current pills or switch to t…

This study tests a program for couples to help adolescent girls and young women (ages 15-24) living with HIV in Uganda stay engaged in their HIV care. The approach works with male partners to reduce heavy drinking and intimate partner violence, which often interfere with women ta…

This study tests a new approach for people aged 5 to 45 with primary immune deficiencies and end-stage lung disease. Participants receive a double lung transplant followed by a stem cell transplant from the same donor. The goal is to see if this combined procedure is safe and can…

This study aimed to see if lower doses of chemotherapy drugs, with or without radiation, could safely prepare children and adults with SCID for a stem cell transplant. The goal was to help the donor cells take hold while avoiding severe side effects. However, the trial was withdr…

This Phase II trial tests a stem cell transplant from unrelated or partially matched family donors for children and young adults with severe immune deficiencies. The stem cells are specially processed to remove certain immune cells, aiming to reduce complications. The goal is to …

This study tests a gene therapy for infants with X-linked severe combined immunodeficiency (SCID-X1), a life-threatening condition where babies lack a working immune system. Researchers take the baby's own bone marrow stem cells, add a normal copy of the faulty gene using a lenti…

This study tests an experimental drug called Ampligen (rintatolimod) in people with severe chronic fatigue syndrome (CFS). Participants receive twice-weekly IV infusions over several months. The goal is to see if the drug can ease symptoms and improve quality of life for those wh…

This study tests a new combination pill (islatravir + ulonivirine) taken just once a week to control HIV. Researchers want to see if it works as well as the daily medication Biktarvy in keeping the virus suppressed. The trial involves 150 adults whose HIV is already well-controll…

This study tests whether giving HIV patients their own genetically modified stem cells is safe and feasible. The cells are changed to resist HIV, and patients receive a mild chemotherapy drug before infusion. The goal is to see if the modified cells can help control the virus, bu…

This early-phase trial tests a combination of HIV GP160 protein and BCG vaccine (used for tuberculosis) in 20 HIV-positive people without AIDS symptoms. The goal is to see if the mix can activate the immune system to recognize and kill HIV. It is a small proof-of-concept study, n…

This trial tests a gene therapy called OTL-103 for people with Wiskott-Aldrich syndrome, a rare genetic disorder that weakens the immune system and causes bleeding. The therapy uses the patient's own blood stem cells, modified in a lab to carry a working copy of the faulty gene, …

This early-stage trial tests the safety and tolerability of two experimental injectable drugs (capsid inhibitors) in 85 healthy adults. Participants receive a single dose or multiple doses of the drug or a placebo. The goal is to see if these drugs are safe enough to study furthe…

This early-stage study tests a new approach to HIV treatment. Researchers take a person's own T-cells, modify them to better recognize and attack HIV, and infuse them back. The main goal is to check safety in 12 stable HIV patients, while also seeing if the modified cells can hel…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study looks at how to keep a youth-friendly HIV self-testing program called 4YBY running in Nigeria. It will involve over 1,200 young people aged 14-24 who are at risk for HIV. Researchers will compare standard program delivery with an enhanced version that includes extra su…

This study tests whether trained peer navigators, connecting with students through a mobile health app, can increase the use of HIV prevention pills (PrEP) and contraception among sexually active female university students aged 18-24 in Zambia. 324 participants will be randomly a…

This study tests whether offering lottery-based rewards for saving money can help Kenyan men reduce behaviors that raise their risk for HIV and other STIs. About 1,500 men aged 18-39 who drink alcohol and have paid for sex in the past will be split into two groups. One group gets…

This study tests a program to help HIV-positive adults get the HPV vaccine, which can prevent HPV-related cancers. The program gives clinics and staff tools to encourage vaccination. Researchers will track how many people start and finish the vaccine series over two years.

This study tests whether nurse-navigators can help adolescent girls and young women in Kenya start and continue taking PrEP, a daily medication that prevents HIV. About 1,900 participants will get PrEP at local pharmacies after buying birth control, and half will also receive ext…

This study tests whether adding trauma-coping lessons to a relationship skills program helps teens aged 13-19 in Miami avoid unprotected sex and pregnancy. Nearly 1,000 youth will be split into three groups: one gets the combined program, one gets relationship skills only, and a …

This study tests a program called Tu'Washindi, designed by and for young women in Kenya. It combines support clubs and community sessions to help girls ages 15-24 reduce intimate partner violence and consistently use HIV prevention pills (PrEP). About 1,562 participants will be f…

This study tests whether sending HIV self-test kits to men who have sex with men on a subscription basis encourages them to test more regularly. 240 participants in Hong Kong will receive reminders to test during a control period, then receive actual test kits during an intervent…

This study tests a 45-60 minute online program called PATHS that teaches parents how to talk to their gay or bisexual sons about sexual health. About 393 parent-teen pairs join, with teens aged 14-19. The goal is to see if the program improves teens' condom use, PrEP awareness, a…

This study is testing a package of tools—training for healthcare workers, quality improvement methods, and a community of practice—to help clinics in Kenya offer HIV prevention pills (PrEP) to pregnant and postpartum women. The goal is to screen more women and start them on PrEP …

This study compares two ways to provide HIV prevention pills (PrEP) to young people in South Africa: the usual clinic-based approach versus a community-based model where pills are delivered and monitored outside clinics. Researchers will enroll 2,500 participants aged 16-30 to se…

This study tests whether a single dose of the HPV vaccine (Gardasil 9) can prevent persistent HPV infection in women living with HIV who have already been vaccinated. About 778 women will receive either the HPV vaccine or a meningitis vaccine (placebo) and be monitored for safety…

This study looks at how to best help HIV clinics in Vietnam offer a short alcohol counseling program to patients who drink heavily. The goal is to reduce risky drinking and lower the chance of spreading HIV. Over 3,200 people living with HIV and clinic staff are taking part to se…

This study follows 100 cisgender women in the southern U.S. who are already prescribed long-acting cabotegravir injections (Apretude) for HIV prevention. Over two years, researchers will track how many women stick with the shots, how satisfied they are, and rates of other sexuall…

This study tests a program to help pregnant and breastfeeding women in South Africa take a daily pill called PrEP that prevents HIV. The program includes extra counseling and community delivery of the pills for those who struggle to take them regularly. The goal is to see if this…

This study tests a program called PRISM that teaches teens with HIV how to manage stress, set goals, and build resilience. It involves three one-on-one sessions with a nurse. The goal is to see if the program is feasible and acceptable, and whether it reduces psychological distre…

This study compares two types of talk therapy—Acceptance and Commitment Therapy (ACT) and Cognitive Behavioral Therapy (CBT)—for HIV/AIDS patients experiencing psychological distress. 72 adults on antiretroviral therapy will receive 8 weekly sessions of either therapy or standard…

This study tests a pill called deucrictibant for quickly treating swelling attacks in people with hereditary angioedema (HAE), including life-threatening throat swelling. About 150 adults who have had HAE attacks before will take the drug as needed and be monitored for safety and…

This study tests ORCHID, an online skills-building program designed to improve mental health and reduce the risk of dropping out of care for aging women with HIV who also have HPV. The program includes 8 online sessions and optional meetings with a navigator. The study aims to se…

This study looks at whether low-dose rapamycin can reduce symptoms and improve quality of life in people with ME/CFS or Long-COVID. About 150 participants will take the drug as prescribed by their doctor and complete surveys and blood tests over time. The goal is to see if the dr…

This study compares a 12-week tele-rehabilitation program using mindful and conscious movement (like adapted yoga and breathing exercises) to conventional low-intensity exercise and usual care for people with chronic fatigue syndrome or post-COVID syndrome. The goal is to see if …

This study tests whether the drug vericiguat, already approved for heart failure, can improve physical function and reduce fatigue in people aged 18-50 with post-COVID syndrome. About 104 participants will receive either vericiguat or a placebo for 10 weeks, then be followed for …

This study tests whether a traditional Chinese herbal paste called Yiqi Fuyuan Paste can reduce fatigue in adults with Chronic Fatigue Syndrome (CFS). Eighty participants will take either the paste or a placebo daily for two months. Researchers will measure fatigue levels and che…

This study tests a new, team-based rehabilitation program for 125 working-age adults with persistent physical symptoms and chronic fatigue. The program includes doctors, therapists, and counselors who work together to help patients manage their symptoms and improve daily function…

This study tests whether adding methadone to usual morphine-based pain medicine reduces severe mouth pain in children aged 6–18 who are getting a stem cell transplant for leukemia, aplastic anemia, or similar conditions. The mouth pain is a common side effect of the chemotherapy …

This study tests whether a gentle electrical brain stimulation device, used at home under remote supervision, can help reduce fatigue in people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Twenty participants will use the device for 20 minutes each weekday ov…

This study collects small skin samples from people with primary immunodeficiency or immune regulation disorders, as well as from healthy volunteers. Researchers will use these cells to create cell lines for laboratory research. The goal is to better understand immune diseases and…

This study aims to better understand fatigue by comparing people who have felt tired for more than a month with those who are not fatigued. Researchers will use questionnaires, physical tests, and optional brain scans to identify different types of fatigue. The goal is to gather …

This study looks at how HIV infection and aging impact the body's response to the Prevnar 13 vaccine, which protects against pneumococcal bacteria. Researchers will measure antibody levels in the lungs, nasal passages, and blood of participants aged 21-45 or 55-75, comparing thos…

This study looks at HIV patients over 40 (or those on HIV therapy for over 10 years) who switched to either a three-drug or a two-drug antiretroviral regimen. Researchers will measure markers of inflammation in the blood and track how many patients develop other health conditions…

This Johns Hopkins study looks at whether a leaky blood-brain barrier and immune changes contribute to cognitive problems in people with ME/CFS (chronic fatigue syndrome), both those who got sick before the pandemic and those who developed it after COVID-19. Researchers will use …

This study adapts an existing stigma-reduction program specifically for pregnant and postpartum women living with HIV in Ghana. Researchers will interview 30 women and 20 providers to understand their experiences, then work with stakeholders to tailor the program. Finally, 90 pre…

This study tests a new imaging method to see if white blood cells enter the brain in people with multiple sclerosis, fibromyalgia, or chronic fatigue syndrome. Participants receive their own white blood cells tagged with a radioactive tracer, then undergo a brain PET/MRI scan. Th…

This study looks at why people with HIV and certain cancers caused by KSHV (Kaposi sarcoma herpesvirus) may lose bone density faster. Researchers will review past CT scans and health records from 40 adults treated at the NIH between 2005 and 2020. The goal is to find factors link…

This study looks at how well the HPV vaccine works in women living with HIV and whether self-collected HPV tests can improve cervical cancer screening. About 650 women will use a self-swab kit at home or in the clinic. Those with positive results will get follow-up exams. The goa…

This study looks at skin and blood samples from 200 people with ichthyosis (a genetic condition causing dry, scaly skin) and healthy volunteers. Researchers want to find specific markers that could help them understand the disease better and develop new treatments. No treatment i…

This study was designed to test a new system that uses tiny silica particles on HIV medication (Biktarvy) and a smartphone app to help people track whether they have taken their pills. The goal was to see if the system is easy to use and accurate over 90 days. However, the study …

This study observes 367 Chinese patients with atypical hemolytic uremic syndrome (aHUS), a rare condition that causes blood clots and kidney damage. Researchers will track how patients are treated in routine care and monitor their health for up to 12-24 months. The goal is to bet…

This study tests a program called LIFT to help people who inject drugs in Kyrgyzstan face less stigma and lower their risk of HIV. About 80 participants will join peer-led group sessions to build support and learn how to use HIV prevention services. The goal is to see if the prog…

This study looks at medical records and follow-up data from 10 people living with HIV in four cities in southern Sichuan, China. The goal is to see how well HIV treatment is working by checking virus levels after 12 months. This is an observational study that does not test a new …

This study tests a program called ENHANCE-TTS that trains pharmacists at HIV clinics to provide tobacco treatment. Researchers will see if the program helps pharmacists offer more smoking cessation services and if it helps patients quit. About 172 people from six clinics will tak…

This pilot study looks at whether light, self-paced swimming is a tolerable activity for people with ME/CFS and related conditions like Long COVID and fibromyalgia. Participants will swim for 15-30 minutes at their own pace and track symptoms and heart rate variability using an a…

This study collects health information and test results from 317 people at high risk for pancreatic cancer, including those with cysts, genetic syndromes, or other risk factors. Researchers aim to build a database to find better ways to detect the disease early or prevent it. No …

This observational study will follow 384 patients in Brazil who are using cannabis-based products (like CBD or THC oils) prescribed by their own doctors for chronic pain, anxiety, or depression. Researchers will not provide the medication but will track patients' quality of life,…

This study looks at how opioid use affects the immune system's response to the flu vaccine in people with and without HIV. Researchers will analyze blood samples from 400 participants to measure antibody levels and immune cell activity. The goal is to understand why opioid users …

This study aims to develop better lab tests to diagnose and monitor two rare kidney diseases: atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G). Researchers will analyze blood, cells, and kidney tissue from 180 patients and healthy volunteers to find markers t…

This study looks at how the complement system, a part of the immune system, may contribute to kidney damage in people with diabetes. Researchers will measure complement proteins in blood and urine from 90 participants to see if they are linked to kidney disease severity and blood…

This study looks at how HIV might disrupt the body's internal clock, which could lead to health problems like diabetes and heart disease. Researchers will track gene activity at different times of day in 80 people with and without HIV. The goal is to understand why these issues a…

This study aimed to understand how patients and clinic staff feel about using long-acting injectable medications to treat both HIV and opioid use disorder together. Researchers planned to enroll 30 patients and 5-10 staff, giving patients the combined injections and following up …

This study aimed to see if adding patient questionnaires, staff training, and telemedicine could improve mental health and substance use disorder care for people living with HIV. It was planned for five clinics in Alabama, but the trial was withdrawn before enrolling any particip…

This study was designed to test a holistic education program for stress management in people from colonized English-speaking countries. It aimed to help with conditions like stress, PTSD, anxiety, and fatigue using pastoral counseling and self-care activities. However, the study …

This study tests a computer program that predicts which HIV patients are most likely to need emergency care in the next two weeks. Care managers use this list to reach out and offer support, compared to usual care where they rely on schedules and judgment. The goal is to see if t…

This study looks at how often fatty liver disease occurs in people living with HIV. Researchers will measure liver fat in 1,250 adults with HIV who are on stable treatment. The goal is to understand the true scale of this liver condition in this group, which has been largely over…

This study follows 400 adults with HIV to learn how nonalcoholic fatty liver disease (NAFLD) develops and progresses in this group. Researchers will use a non-invasive scan to measure liver stiffness and fat content over one year. The goal is to fill major knowledge gaps, since p…

This study tests whether machine learning can predict which HIV patients are likely to miss clinic visits or have treatment failure. Researchers will give clinic workers risk alerts to help them reach out to high-risk patients. The goal is to improve retention in care and viral s…

This study tests a program called Potlako+ that combines community education, support for healthcare providers, and patient navigation to help people with cancer symptoms get diagnosed and treated faster. About 874 participants in Botswana will be split into two groups: one recei…

This study tests whether a rapid PCR test can help doctors choose the right antibiotics within 24 hours for immunocompromised ICU patients with pneumonia. Standard lab tests take days, which can lead to incorrect or overly broad antibiotics. The trial involves 31 adults with weak…

This study follows 70 people who previously received gene therapy for a rare immune disorder called ADA-SCID. Researchers want to see how well the treatment worked over time and check for any long-term side effects. No new treatment is given—just regular health checkups.

This pilot study is testing a new tool called PATH that helps doctors assess the unique health needs of people aged 50 and older living with HIV. Participants will answer questions about their health through a patient portal or with a research coordinator before a routine HIV app…

This study is for people with Long COVID, Lyme disease, or ME/CFS (chronic fatigue syndrome). Researchers want to see if a special blood test can find problems with T-cells, which are part of the immune system. Participants will give blood samples and fill out symptom questionnai…

This study tests a program called CHIMES designed to help young Black gay and bisexual men living with HIV get better mental health care. The program includes posters, provider training, mental health screening, and case management. Researchers will track whether it leads to more…

This study looks at immune cells from people with autoimmune diseases (like lupus), people with infections, and healthy volunteers. Researchers want to understand how these cells differ and what makes them attack the body in autoimmune conditions. The study involves blood and bon…

This study planned to test whether changing the layout and systems of HIV clinics in Uganda could make them feel more private and welcoming, reducing stigma and improving patient retention. Researchers intended to survey patients and staff before and after renovations. However, t…

This study follows 830 women in Alabama who are at risk for HIV and sexually transmitted infections (STIs). Researchers will use a smartphone app to provide information and resources, and track how many women start using PrEP, a medication that prevents HIV. The goal is to learn …

This study examines how the COVID-19 pandemic affected syphilis cases and their interaction with HIV. Researchers will review medical records of 240 adults diagnosed with syphilis in Italy between 2017 and 2025. The goal is to see if pandemic restrictions led to delayed diagnoses…