New hope for kids with rare kidney disease: crovalimab trial underway

NCT ID NCT04958265

Ongoing Disease control Sponsor: Hoffmann-La Roche Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 3 trial tests crovalimab in 41 children with atypical hemolytic uremic syndrome (aHUS), a rare disease that causes blood clots and kidney damage. The drug is given first through a vein, then as a shot under the skin every four weeks. The goal is to see if it can stop disease flares and improve kidney function. Because aHUS is a chronic condition, treatment is expected to be lifelong.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Crovalimab (a drug given by IV and then by injection under the skin)
What this could lead to: If it works, this could offer a new treatment option for children with aHUS, helping control the disease and protect kidney function.
What could go wrong: This is a single-arm, open-label study with no comparison group, so results may be less certain. The drug requires lifelong use and carries infection risks, including meningitis.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atypical hemolytic-uremic syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATYPICAL HEMOLYTIC UREMIC SYNDROME

Contacts and locations

Locations

Aichi Children?s Health and Medical Center

Aichi, 474-8710, Japan
All India Institute Of Medical Sciences (AIIMS)

New Delhi, National Capital Territory of Delhi, 110029, India
Beijing Children's Hospital, Capital Medical University

Beijing, 100045, China
CHU Sainte-Justine

Montreal, Quebec, H3T 1C5, Canada
Chiba Children's Hospital

Chibashi, Chibaken, 266-0007, Japan
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Gh Necker Enfants Malades

Paris, 75743, France
Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States
Hospital de Especialidades Puerta de Hierro S.A de C.V.

Zapopan, 45116, Mexico
Hôpital Arnaud de Villeneuve

Montpellier, 34295, France
Inst. Da Criança- Faculdade de Medicina Usp

São Paulo, São Paulo, 05403-900, Brazil
Institute of Kidney Diseases and Research Centre

Ahmedabad, Gujarat, 380016, India
Instytut ?Centrum Zdrowia Matki Polki

Lodz, 93-338, Poland
Medanta-The Medicity

Gurgaon, Haryana, 122001, India
Peking University First Hospital

Beijing, 100034, China
The children's hospital , Zhejiang university school of medicine

Hangzhou, 310051, China
UZ Gent

Ghent, 9000, Belgium
UZ Leuven Gasthuisberg

Leuven, 3000, Belgium
University of Nebraska

Omaha, Nebraska, 68198, United States
Uniwersyteckie Centrum Kliniczne

Gdansk, 80-294, Poland

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