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New pill could stop dangerous swelling attacks in hereditary angioedema

NCT ID NCT05396105

ENROLLING_BY_INVITATION Symptom relief Sponsor: Pharvaris Netherlands B.V. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 22, 2026 · Updated 2 times

Summary

This study tests a pill called deucrictibant for quickly treating swelling attacks in people with hereditary angioedema (HAE), including life-threatening throat swelling. About 150 adults who have had HAE attacks before will take the drug as needed and be monitored for safety and how fast symptoms improve. The goal is to see if this oral treatment can provide fast relief without the need for injections.

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Conditions

The condition(s) this trial relates to.

C1 inhibitor deficiency hereditary angioedema hereditary angioedema type 1 hereditary angioedema type 2 hereditary angioedema type 3 Hereditary Angioedema Types I and II hereditary angioedema with C1Inh deficiency hereditary angioedema with normal C1Inh

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

C1 ESTERASE INHIBITOR [C1-INH] DEFICIENCY C1 ESTERASE INHIBITOR DEFICIENCY C1 ESTERASE INHIBITOR, DEFICIENCY OF C1 INHIBITOR DEFICIENCY HAE WITH NORMAL C1 ESTERASE INHIBITOR HEREDITARY ANGIOEDEMA HEREDITARY ANGIOEDEMA (HAE) HEREDITARY ANGIOEDEMA - TYPE 1 HEREDITARY ANGIOEDEMA - TYPE 2 HEREDITARY ANGIOEDEMA - TYPE 3 HEREDITARY ANGIOEDEMA ATTACK HEREDITARY ANGIOEDEMA TYPE I HEREDITARY ANGIOEDEMA TYPE I AND II HEREDITARY ANGIOEDEMA TYPE II HEREDITARY ANGIOEDEMA TYPE III HEREDITARY ANGIOEDEMA TYPES I AND II HEREDITARY ANGIOEDEMA WITH C1 ESTERASE INHIBITOR DEFICIENCY

Contacts and locations

Locations

  • Study site

    Birmingham, Alabama, 35209, United States

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    Little Rock, Arkansas, 72205, United States

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    San Diego, California, 92122, United States

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    Santa Monica, California, 90404, United States

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    Walnut Creek, California, 94598, United States

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    Colorado Springs, Colorado, 80907, United States

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    Chevy Chase, Maryland, 20815, United States

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    Boston, Massachusetts, 02115, United States

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    Detroit, Michigan, 48202, United States

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    St Louis, Missouri, 63141, United States

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    Hershey, Pennsylvania, 17033, United States

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    Dallas, Texas, 75231, United States

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    Buenos Aires, B1629AHJ, Argentina

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    Salta, 4400, Argentina

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    Campbelltown, New South Wales, 2560, Australia

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    Graz, 8036, Austria

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    Vienna, 1090, Austria

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    Salvador, Estado de Bahia, 41950-640, Brazil

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    Ribeirão Preto, 14048-900, Brazil

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    Santo André, 09060-870, Brazil

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    São Paulo, 05403-000, Brazil

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    Sofia, 1431, Bulgaria

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    Sofia, 1680, Bulgaria

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    Edmonton, Alberta, T6G 1Z1, Canada

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    Montreal, Quebec, Canada

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    Brno, 602 00, Czechia

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    Grenoble, 38043, France

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    Paris, 75571, France

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    Berlin, 12203, Germany

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    Frankfurt am Main, 60590, Germany

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    Frankfurt am Main, 60596, Germany

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    Lübeck, 23538, Germany

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    Hong Kong, Hong Kong

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    Budapest, 1088, Hungary

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    Ashkelon, 78278, Israel

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    Catania, 95124, Italy

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    Milan, 20097, Italy

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    Milan, 20138, Italy

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    Naples, 80131, Italy

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    Padova, 35128, Italy

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    Palermo, 90146, Italy

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    Roma, 00133, Italy

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    Hiroshima, 730-8518, Japan

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    Kanagawa, 216-8511, Japan

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    Osaka, 569-8686, Japan

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    Tokyo, 113-8431, Japan

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    Tokyo, 133-8431, Japan

  • Study site

    Amsterdam, 1005 AZ, Netherlands

  • Study site

    Krakow, 31-503, Poland

  • Study site

    San Juan, 918, Puerto Rico

  • Study site

    San Juan, 927, Puerto Rico

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    Cape Town, 7700, South Africa

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    Daegu, 41944, South Korea

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    Seoul, 03080, South Korea

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    Barcelona, 08907, Spain

  • Study site

    Madrid, 28007, Spain

  • Study site

    Lund, 22185, Sweden

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    Ankara, 06230, Turkey (Türkiye)

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    Istanbul, 34093, Turkey (Türkiye)

  • Study site

    London, E1 2ES, United Kingdom

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