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New pill could stop dangerous swelling attacks in hereditary angioedema

NCT ID NCT05396105

ENROLLING_BY_INVITATION Symptom relief Sponsor: Pharvaris Netherlands B.V. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a pill called deucrictibant for quickly treating swelling attacks in people with hereditary angioedema (HAE), including life-threatening throat swelling. About 150 adults who have had HAE attacks before will take the drug as needed and be monitored for safety and how fast symptoms improve. The goal is to see if this oral treatment can provide fast relief without the need for injections.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

C1 inhibitor deficiency hereditary angioedema hereditary angioedema type 1 hereditary angioedema type 2 hereditary angioedema type 3 Hereditary Angioedema Types I and II hereditary angioedema with C1Inh deficiency hereditary angioedema with normal C1Inh

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

C1 ESTERASE INHIBITOR [C1-INH] DEFICIENCY C1 ESTERASE INHIBITOR DEFICIENCY C1 ESTERASE INHIBITOR, DEFICIENCY OF C1 INHIBITOR DEFICIENCY HAE WITH NORMAL C1 ESTERASE INHIBITOR HEREDITARY ANGIOEDEMA HEREDITARY ANGIOEDEMA (HAE) HEREDITARY ANGIOEDEMA - TYPE 1 HEREDITARY ANGIOEDEMA - TYPE 2 HEREDITARY ANGIOEDEMA - TYPE 3 HEREDITARY ANGIOEDEMA ATTACK HEREDITARY ANGIOEDEMA TYPE I HEREDITARY ANGIOEDEMA TYPE I AND II HEREDITARY ANGIOEDEMA TYPE II HEREDITARY ANGIOEDEMA TYPE III HEREDITARY ANGIOEDEMA TYPES I AND II HEREDITARY ANGIOEDEMA WITH C1 ESTERASE INHIBITOR DEFICIENCY

Contacts and locations

Locations

  • Study site

    Birmingham, Alabama, 35209, United States

  • Study site

    Scottsdale, Arizona, 85258, United States

  • Study site

    Little Rock, Arkansas, 72205, United States

  • Study site

    San Diego, California, 92122, United States

  • Study site

    Santa Monica, California, 90404, United States

  • Study site

    Walnut Creek, California, 94598, United States

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    Colorado Springs, Colorado, 80907, United States

  • Study site

    Chevy Chase, Maryland, 20815, United States

  • Study site

    Boston, Massachusetts, 02115, United States

  • Study site

    Detroit, Michigan, 48202, United States

  • Study site

    St Louis, Missouri, 63141, United States

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    Hershey, Pennsylvania, 17033, United States

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    Dallas, Texas, 75231, United States

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    Buenos Aires, B1629AHJ, Argentina

  • Study site

    Salta, 4400, Argentina

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    Campbelltown, New South Wales, 2560, Australia

  • Study site

    Graz, 8036, Austria

  • Study site

    Vienna, 1090, Austria

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    Salvador, Estado de Bahia, 41950-640, Brazil

  • Study site

    Ribeirão Preto, 14048-900, Brazil

  • Study site

    Santo André, 09060-870, Brazil

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    São Paulo, 05403-000, Brazil

  • Study site

    Sofia, 1431, Bulgaria

  • Study site

    Sofia, 1680, Bulgaria

  • Study site

    Edmonton, Alberta, T6G 1Z1, Canada

  • Study site

    Montreal, Quebec, Canada

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    Brno, 602 00, Czechia

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    Grenoble, 38043, France

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    Paris, 75571, France

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    Berlin, 12203, Germany

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    Frankfurt am Main, 60590, Germany

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    Frankfurt am Main, 60596, Germany

  • Study site

    Lübeck, 23538, Germany

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    Hong Kong, Hong Kong

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    Budapest, 1088, Hungary

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    Ashkelon, 78278, Israel

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    Catania, 95124, Italy

  • Study site

    Milan, 20097, Italy

  • Study site

    Milan, 20138, Italy

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    Naples, 80131, Italy

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    Padova, 35128, Italy

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    Palermo, 90146, Italy

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    Roma, 00133, Italy

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    Hiroshima, 730-8518, Japan

  • Study site

    Kanagawa, 216-8511, Japan

  • Study site

    Osaka, 569-8686, Japan

  • Study site

    Tokyo, 113-8431, Japan

  • Study site

    Tokyo, 133-8431, Japan

  • Study site

    Amsterdam, 1005 AZ, Netherlands

  • Study site

    Krakow, 31-503, Poland

  • Study site

    San Juan, 918, Puerto Rico

  • Study site

    San Juan, 927, Puerto Rico

  • Study site

    Riyadh, 11471, Saudi Arabia

  • Study site

    Cape Town, 7700, South Africa

  • Study site

    Daegu, 41944, South Korea

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    Seoul, 03080, South Korea

  • Study site

    Barcelona, 08035, Spain

  • Study site

    Barcelona, 08907, Spain

  • Study site

    Madrid, 28007, Spain

  • Study site

    Lund, 22185, Sweden

  • Study site

    Ankara, 06230, Turkey (Türkiye)

  • Study site

    Istanbul, 34093, Turkey (Türkiye)

  • Study site

    London, E1 2ES, United Kingdom