Encephalomyelitis

This study tests a new oral polio vaccine (nOPV3) in healthy young children, infants, and newborns in Panama. The goal is to see if it is safe and triggers a strong immune response compared to the current vaccine. About 1,500 participants will receive either the new or existing v…

This study tests two types of inactivated polio vaccine (Sabin strain and wild strain) given in different orders to 480 infants aged 2 months. The goal is to see which sequence triggers the best immune response and causes the fewest side effects. Participants will receive three d…

This phase 4 study compares a single dose of an inactivated polio vaccine (sIPV) in people aged 7 to 50 years with the standard three-dose series given to infants. Researchers want to see if one shot can produce a similar immune response. The trial is recruiting 180 healthy parti…

This study tests a new oral polio vaccine (nOPV1) in over 2,200 healthy young children, infants, and newborns in Bangladesh. Researchers will compare it to the current Sabin vaccine to see if it is safe and triggers a strong immune response. The goal is to find a more stable vacc…

This study tests whether giving two new oral polio vaccines (types 1 and 2) together is safe and works as well as giving them separately in healthy 16-week-old infants. About 675 babies in Panama will receive either the combo or single vaccines. The goal is to see if the combo ap…

This early-stage trial is testing a new vaccine that combines protection against several serious childhood diseases: diphtheria, tetanus, whooping cough, meningitis, and Hib. The study involves 260 children aged 2 months to 6 years to check the vaccine's safety and immune respons…

This study tests two new mRNA vaccines (GBP560) against Japanese encephalitis, a virus that can cause brain swelling. About 402 healthy adults will receive different doses of the vaccine or a comparison vaccine. Researchers will monitor safety and measure immune responses to find…

This Phase 3 trial tests whether privosegtor, a neuroprotective drug, can improve vision recovery in people having their first episode of optic neuritis. About 210 adults aged 18 to 50 will receive either privosegtor or a placebo, both alongside standard steroid treatment. The ma…

This phase 2 trial tests the safety of brincidofovir, an antiviral drug, in 24 adults with progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by the JC virus. Participants receive the drug intravenously twice a week for up to 12 weeks, with follow-up …

This study tests whether giving patients special donor immune cells (called CD45RA-depleted DLI) can treat viral infections that persist after a stem cell transplant. The trial involves 30 participants who have not improved with standard antiviral drugs. Researchers will measure …

This Phase III trial in sub-Saharan Africa tests whether giving higher doses of rifampicin plus linezolid, along with aspirin, can reduce deaths from tuberculous meningitis (TBM) in both HIV-positive and HIV-negative people. About 768 adolescents and adults will receive either th…

This large platform trial is testing new antifungal drug combinations for cryptococcal meningitis, a severe brain infection that is fatal without treatment and common in people with HIV. The study will enroll 2,000 participants across multiple sites to compare a newer oral drug, …

This study tests a daily pill called vibegron to see if it safely improves bladder control in children aged 2 to 18 with neurogenic detrusor overactivity (NDO), a condition where the bladder contracts too often due to nerve damage. Participants must already use a catheter to empt…

This early-phase study tests whether specially trained immune cells from healthy donors can safely treat viral infections (EBV, CMV, adenovirus, BK virus) in patients who have had a stem cell transplant or certain CAR-T therapy. These infections can be life-threatening when the i…

This study tests whether specially grown donor immune cells (called cytotoxic T lymphocytes) can safely and effectively control BK and JC virus infections in people with weakened immune systems, such as those with cancer, HIV, or organ transplants. About 100 participants will rec…

This study tests whether combining two drugs—ofatumumab and daratumumab—can safely and effectively treat people with severe anti-NMDAR autoimmune encephalitis, a condition where the immune system attacks the brain. The drugs aim to eliminate the harmful immune cells producing the…

This Phase 3 trial tests satralizumab, an injected drug, in 120 people with NMDAR or LGI1 encephalitis—rare conditions where the immune system attacks the brain. The goal is to see if the drug improves disability and reduces the need for rescue treatments. Participants receive ei…

This phase 2 trial tests whether adding the antibiotic doxycycline to standard treatment can reduce deaths and severe brain damage in adults with tuberculosis of the brain or its lining. About 200 participants will receive either doxycycline or a placebo for 8 weeks, alongside us…

This study compares a 6-month treatment using high doses of four antibiotics against the standard 9-month therapy for tuberculous meningitis, a serious brain infection. About 330 adults and teens without HIV will take part. The goal is to see if the shorter regimen is as safe and…

This study is testing whether a ketogenic diet (a high-fat, low-carbohydrate diet) can help stop super-refractory status epilepticus—a life-threatening condition where seizures continue despite standard medications. The diet is given via feeding tube or by mouth to 84 ICU patient…

This study tests a new treatment called Modified Zipper Therapy for people with a rare disease called NMOSD. It combines standard treatments with a drug called eculizumab to help patients recover better from sudden attacks. About 198 adults will take part to see if this approach …

This early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a small dose of radiation to help …

This study tests whether the steroid dexamethasone can reduce brain damage in adults hospitalized with tick-borne encephalitis. Researchers will compare disability outcomes in 200 patients who receive either dexamethasone or a placebo. The goal is to see if this treatment lowers …

This Phase 2a trial tests a drug called ART5803 in 30 adults with anti-NMDAR encephalitis or related psychiatric disease. The drug is a lab-made antibody designed to block harmful autoantibodies from attacking brain receptors. The study focuses on safety and tolerability, with ea…

This early-phase study tests a new treatment called RD06-05, which uses specially engineered immune cells (CAR-T cells) to target and calm the immune system in people with neurological autoimmune diseases like multiple sclerosis, myasthenia gravis, chronic inflammatory demyelinat…

This early-phase trial is testing a new cell therapy called QH103 for people with severe autoimmune diseases like multiple sclerosis and myasthenia gravis that haven't responded to standard treatments. The therapy uses specially engineered immune cells to target and attack the fa…

This study tests whether starting plasma exchange early, rather than waiting, leads to better vision in severe optic neuritis and less disability in severe transverse myelitis. About 382 adults with these inflammatory nerve conditions will be randomly assigned to early or rescue …

This study tests whether adding one dose of a stronger antifungal drug (liposomal amphotericin) to the standard treatment (fluconazole) can prevent cryptococcal meningitis in HIV-positive adults who test positive for the fungus but have no symptoms. About 356 participants in Ugan…

This early-stage trial is testing whether genetically modified T-cells can safely control viral infections in cancer patients with weakened immune systems. The T-cells are designed to target specific viruses like CMV, BK virus, or COVID-19. The study involves 30 participants and …

This study is testing whether immune checkpoint inhibitors, drugs that help the immune system fight infections, can improve outcomes for people with progressive multifocal leukoencephalopathy (PML), a rare brain virus. Researchers will follow 66 patients over a year, measuring di…

This study tests whether clemastine fumarate, a drug originally approved for allergies, can help repair nerve damage in people with acute optic neuritis (inflammation of the optic nerve). About 90 participants will receive either clemastine or a placebo for 9 months. Researchers …

This study tests a new treatment using a patient's own immune cells, modified to target and attack faulty immune cells that cause autoimmune diseases. It is for people with severe, hard-to-treat conditions like lupus. The goal is to see if this therapy is safe and can control the…

This early-stage study tests a new cell therapy called CNCT19 in 18 adults with relapsed or treatment-resistant autoimmune neurological diseases like neuromyelitis optica. The goal is to see if it is safe and can help control the disease by targeting certain immune cells. Partici…

This study compares two common procedures—CSF shunting and dural venous sinus stenting—to see which better preserves vision in adults with idiopathic intracranial hypertension (IIH) who are at risk of permanent sight loss. About 80 participants will be randomly assigned to one of…

This study tests a new treatment for progressive multifocal leukoencephalopathy (PML), a rare brain infection with no approved therapy. Researchers will give 23 patients donor immune cells that target the virus causing PML. The goal is to see if the treatment is safe, improves ne…

This study tests whether specially grown immune cells from an unrelated donor can safely treat viral infections in people with weakened immune systems, such as after a stem cell transplant. About 750 participants will receive these cells and be monitored for side effects like inf…

This study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…

This phase 2 trial tests whether adding adalimumab (an arthritis drug) to standard tuberculosis meningitis treatment can reduce deaths in HIV-positive adults. About 130 participants in Brazil, Mozambique, and Zambia will receive adalimumab injections every two weeks for 10 weeks …

This early-stage study tests a new treatment using specially engineered immune cells (CAR T-cells) that target two proteins, CD19 and BCMA, to calm overactive immune attacks in people with severe autoimmune diseases like multiple sclerosis, myasthenia gravis, and neuromyelitis op…

This pilot study tests efgartigimod alfa (Vyvgart Hytrulo) against placebo in 20 adults having their first episode of moderate to severe optic neuritis, an inflammation of the optic nerve that can cause vision loss. Participants get two injections over a week, plus standard stero…

This phase 2 trial tests whether bortezomib, a drug that targets antibody-producing cells, can help people with severe autoimmune encephalitis. In this condition, the body's own antibodies attack the brain. The study will enroll 50 adults who have already tried another treatment …

This study looks at whether a new set of international criteria can accurately diagnose optic neuritis—a condition that causes sudden vision loss—in Chinese patients. Researchers will enroll 500 people with acute or subacute vision loss and compare the criteria's results against …

This study tests whether a smartphone app that analyzes voice patterns can help diagnose and monitor myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Researchers will compare voice samples from 40 people with ME/CFS and those without to find unique voice signatures. T…

This early-stage study tests a new imaging agent called 18F-4FN for PET scans to safely detect inflammation in the body. It involves 55 adults with cancer who are on immunotherapy or have suspected inflammation. The goal is to see if this agent can highlight areas of inflammation…

This study tests whether a special PET scan tracer called [18F]-DPA-714 can detect brain inflammation in people with autoimmune encephalitis (AE). Researchers will compare scans from 40 newly diagnosed AE patients to healthy volunteers. If the tracer works well, it could become a…

This study looks at whether a special brain scan called FDG-PET can help doctors diagnose autoimmune encephalitis, a condition where the immune system attacks the brain. Researchers will compare scans from 90 patients with the disease to scans from healthy people and those with A…

This study is testing whether a simple ultrasound of the optic nerve can quickly detect brain swelling and inflammation in ICU patients with conditions like meningitis, encephalitis, or stroke. Researchers will measure the optic nerve sheath diameter in 200 adults and compare it …

This study looks at whether measuring a substance called D-lactate in spinal fluid can help doctors diagnose meningitis (a brain infection) in patients who have a brain drain (ventriculostomy). About 185 adults with suspected meningitis will have their spinal fluid tested. The go…

This study tests whether dialectical behavior therapy (DBT), a type of talk therapy, can help people with acquired brain injury manage emotional distress and challenging behaviors. 77 participants will receive standard care for 5 months, then DBT for 5 months, then follow-up. Res…

This study tests whether using ultrasound to guide the needle during a lumbar puncture (spinal tap) helps doctors get a clean sample of spinal fluid from infants under 12 months. The goal is to reduce failed attempts and avoid repeat procedures. Eighty infants who need a lumbar p…

This study tests a powered leg brace called the Nomad in 36 people who have trouble walking due to conditions like stroke, multiple sclerosis, or spinal cord injury. Participants will use the brace at home for three months to see if it improves their walking speed, balance, and q…

This study tests whether whole-body electrical muscle stimulation (WB-EMS) can help adults with neuromuscular diseases like ALS, SMA, and muscular dystrophy exercise safely. Because these conditions weaken the nerves that control muscles, traditional exercise is often too hard. W…

This study tests whether injecting a numbing medication (bupivacaine) near a nerve cluster in the nose can reduce pain after minimally invasive pituitary tumor removal. About 108 adults will be randomly assigned to receive the nerve block, a placebo (saline), or no extra injectio…

This study tests whether a 10-week online expressive writing program can help adults with spinal cord injury work through feelings of grief and loss. Participants will write about their emotions with guidance from a coach and share reflections with others. The goal is to see if t…

This study follows 700 people with progressive multifocal leukoencephalopathy (PML), a rare brain infection caused by the JC virus. Researchers will collect blood, spinal fluid, and brain scans over time to understand how the disease progresses. No treatment is given; the goal is…

This study follows 500 people with neurocysticercosis, a brain infection caused by the pork tapeworm. Participants receive standard antiparasitic drugs and anti-inflammatories. Researchers will track their health over many years to understand what factors lead to better or worse …

This study follows 100 women with neuroimmune diseases (like multiple sclerosis or myasthenia gravis) through pregnancy and up to five years after. Researchers will track disease activity, pregnancy complications, and baby health to learn how these conditions affect fertility and…

This study looks at 800 healthy adults who have cryptococcosis, a fungal infection that usually only harms people with weak immune systems. Researchers want to learn why these otherwise healthy people get sick, how their immune system responds, and how the disease progresses over…

This study follows 950 people with idiopathic CD4+ lymphocytopenia (ICL), a rare condition where low CD4+ white blood cells raise infection risk. Researchers will track participants for up to 10 years, collecting medical history, blood samples, and infection data. The goal is to …

The CLUE study is a research project that follows 1,000 people with neuroinflammatory diseases like multiple sclerosis and neuromyelitis optica. Participants undergo detailed MRI and PET scans at the start and after one year to see how their brain, spinal cord, and optic nerves c…

This pilot study tests whether a radioactive tracer called 89Zr-Df-crefmirlimab can help PET scans detect certain immune cells (CD8+ T cells) in the brain and spinal cord of people with multiple sclerosis (MS) or progressive multifocal leukoencephalopathy (PML). About 15 adults w…

This study follows 2000 adults who are in a coma or have disorders of consciousness after serious brain injuries like stroke, cardiac arrest, or trauma. Researchers collect medical records and later interview survivors or their caregivers about physical and emotional recovery. No…

This study collects blood, spinal fluid, and brain tissue from 400 people with severe seizures (status epilepticus) or epilepsy linked to brain inflammation (dysimmune encephalitis), plus control patients. Researchers aim to find antibodies and markers of nerve cell death that co…

This study is tracking how adults with meningitis are treated in about 30 hospitals across Brazil. Researchers will follow 624 patients during their hospital stay and after discharge to see what treatments work best and how patients recover. The goal is to gather real-world evide…

This study is creating a registry of 600 children under 18 with meningitis treated at hospitals across Brazil. Researchers will collect data during and after hospitalization to see how well current treatments work and what long-term problems, like hearing loss, occur. The goal is…

This study is testing a new, non-invasive brain monitor (Neurosteer) in 100 ICU patients who are on breathing machines and sedatives. The monitor is a small device placed on the forehead that measures brain activity. Researchers want to see if it can accurately track levels of se…

This study is a national observatory that will follow 10,000 children and newborns with bacterial meningitis. Researchers aim to understand which bacteria are causing infections, how often treatments fail, and how well vaccines are working. The goal is to improve future treatment…

This study aims to find blood-based biomarkers that can predict whether a child with acute disseminated encephalomyelitis (ADEM) will experience relapses. Researchers will analyze immune cells from blood samples of 20 children aged 1-18 with a first demyelinating event. The goal …

This study tests a new, lightweight ultrasound device called NeoDoppler that can be gently placed on a newborn's soft spot (fontanelle) to continuously measure blood flow in the brain. Researchers will enroll 180 preterm and full-term infants, including those with conditions like…

This study aims to find genetic mutations in the brain that cause drug-resistant epilepsy in children. Researchers will compare DNA from blood and brain tissue, including samples from special electrodes placed in the brain. The goal is to better understand the root causes of thes…

This study looks at whether a new, simpler guideline can safely reduce the number of tests, antibiotics, and hospital stays for infants under 2 months old with a fever. Researchers will compare hospitals using the new guideline to those using standard care. The goal is to find ou…

This pilot study is measuring prednisolone levels in 120 people with inflammatory diseases like thyroid eye disease, vasculitis, COPD, asthma, and others. Participants take high-dose prednisolone as part of their routine care, and researchers take timed blood samples to see how t…

This study aims to better understand autoimmune encephalitis, a condition where the immune system attacks the brain. Researchers will analyze blood and spinal fluid from 20 patients to find new antibodies that may explain the disease in people who currently test negative. The goa…

This study aims to see if blood markers for Alzheimer's and brain injury can help predict death and hospital readmission in older patients. Researchers will follow 400 hospitalized seniors, including those with neurological issues or dementia. The goal is to develop a tool that u…

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Part…

This study looks at the long-term social and emotional challenges faced by people who have had NMDA receptor encephalitis, a rare brain inflammation. Researchers will ask 30 adults to complete questionnaires about fatigue, anxiety, depression, sleep, and quality of life. The goal…

This study looks at a condition called augmented renal clearance (ARC), where the kidneys work too fast and flush out medications before they can help. It involves 512 adults in intensive care with severe brain injuries, strokes, seizures, or meningitis. Researchers will measure …

This study looks at whether showing parents a video along with the usual talk helps them agree to a lumbar puncture (spinal tap) for their child with suspected meningitis. About 154 parents of children aged 0–12 years will take part. One group gets standard verbal counseling, the…

This study is testing a new device that aims to measure pressure inside the skull from the outside, avoiding the need for surgery. Currently, doctors must drill a hole in the skull to monitor intracranial pressure (ICP) in patients with conditions like traumatic brain injury or s…

This study is a registry that collects information from 520 patients diagnosed with central nervous system (CNS) infections, such as meningitis or encephalitis. Researchers will track how many patients survive to discharge. The goal is to better understand these rare but serious …

This research study collects health information from 10,000 people with brain inflammation conditions like Long COVID, ME/CFS, and autoimmune diseases. Participants use a smartphone app to share symptoms, health history, and wearable data. The goal is to find disease subtypes and…

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This study looks at how a person's sex and gender might change their immune system's reaction to the meningitis B vaccine. Researchers will compare immune responses in transgender and cisgender adults aged 18 to 50. The goal is to better understand why men and women often respond…

This study in northern Uganda will track 1,100 people with meningitis symptoms and screen 10,000 HIV-positive patients for a fungal infection that can lead to meningitis. Researchers will use modern diagnostic tests to understand the causes and outcomes of the disease. The goal i…

This study is testing whether a special type of MRI, called resting-state fMRI, can predict how well people with optic neuritis (inflammation of the optic nerve) will recover their vision. Researchers will scan 200 patients and track their vision over 6 months. The goal is to see…

This study follows 209 children and adults hospitalized with tick-borne encephalitis (TBE) in the Czech Republic for one year after discharge. Researchers track symptoms like fatigue, headaches, memory problems, and weakness to see how long they last and who needs extra support. …

This study is testing whether next-generation sequencing can identify the infectious germs causing severe brain (encephalitis) and spinal cord (myelitis) inflammation in 100 patients in Guadeloupe. Many cases currently have no known cause. By analyzing spinal fluid, researchers h…

This study looks at whether measuring certain proteins (free light chains) in spinal fluid can help predict how multiple sclerosis (MS) will progress. Researchers will follow 100 people with MS or optic neuritis, tracking their disability, relapses, and vision recovery. The goal …

This study surveys 100 doctors and trainees in France to assess their knowledge of tick-borne encephalitis, a rare but serious viral infection spread by ticks. The goal is to see if doctors in high-risk areas are more aware than those elsewhere, and to identify gaps that could im…

This study follows 3,000 childhood cancer survivors in Switzerland to learn about long-term health problems caused by cancer treatments. Participants undergo physical exams, lab tests, and questionnaires during regular follow-up visits. The goal is to better understand and manage…