New drug targets Antibody-Producing cells in brain inflammation
NCT ID NCT03993262
First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether bortezomib, a drug that targets antibody-producing cells, can help people with severe autoimmune encephalitis. In this condition, the body's own antibodies attack the brain. The study will enroll 50 adults who have already tried another treatment (rituximab). Participants will receive either bortezomib or a placebo, along with dexamethasone, and be followed for 17 weeks to see if their symptoms improve.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
bortezomib
What this could lead to
If it works, this could provide a more targeted treatment for severe autoimmune encephalitis by directly attacking the cells that produce harmful antibodies.
What could go wrong
This is a small, early-phase trial with only 50 participants, so results may not apply to everyone. Bortezomib also has side effects like nerve damage and low blood cell counts.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Charité - Universitätsmedizin Berlin, Klinik für Neurologie mit Experimenteller Neurologie
RECRUITINGBerlin, 10117, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Klinik für Neurologie UKSH, Campus Kiel
RECRUITINGKiel, 24105, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ludwig-Maximilians-Universität München, Klinikum Großhadern
RECRUITINGMünchen, Bavaria, 81377, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Medizinische Hochschule Hannover
RECRUITINGHanover, Niedersachen, 30625, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ruhr-Universität Bochum, St. Josef Hospital, Klinik für Neurologie
RECRUITINGBochum, 44791, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Hospital Düsseldorf, Clinic for Neurology
RECRUITINGDüsseldorf, 40225, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University Hospital Frankfurt (Main), Clinic for Neurology
RECRUITINGFrankfurt, 60528, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitätsklinikum Erlangen, Neurologische Klinik
RECRUITINGErlangen, 91054, Germany
Contact Email: •••••@•••••
Contact Email: •••••@•••••
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Universitätsklinikum Essen (AöR), Klinik für Neurologie
RECRUITINGEssen, 45147, Germany
Contact Email: •••••@•••••
Contact Email: •••••@•••••
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Universitätsklinikum Jena, Sektion Translationale Neuroimmunologie, Klinik für Neurologie
RECRUITINGJena, Germany, 07747, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitätsklinikum Leipzig, Klinik und Poliklinik für Neurologie
RECRUITINGLeipzig, 04103, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitätsklinikum Münster Klinik für Neurologie
RECRUITINGMünster, 48149, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
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Universitätsklinikum Ulm, Klinik für Neurologie Neurologische Ambulanz
RECRUITINGUlm, 89081, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitätsklinikum Würzburg
RECRUITINGWürzburg, Bavaria, 97080, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitätsmedizin Greifswald, Klinik und Poliklinik für Neurologie
RECRUITINGGreifswald, 17475, Germany
Contact Email: •••••@•••••
Contact Email: •••••@•••••
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Universitätsmedizin Göttingen Georg-August-Universität, Klinik für Neurologie
RECRUITINGGöttingen, 37075, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Universitätsmedizin Mainz, Klinik und Poliklinik für Neurologie
RECRUITINGMainz, 55131, Germany
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••