Experimental T-Cell therapy takes on deadly brain virus

NCT ID NCT06990087

Recruiting now Disease control Sponsor: Hannover Medical School Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new treatment for progressive multifocal leukoencephalopathy (PML), a rare brain infection with no approved therapy. Researchers will give 23 patients donor immune cells that target the virus causing PML. The goal is to see if the treatment is safe, improves neurological function, and helps patients live longer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: allogeneic HPyV-2-specific T-cells (donor immune cells targeting the virus)
What this could lead to: If successful, this could provide a new treatment option for PML, a rare and often fatal brain infection, potentially improving survival and quality of life.
What could go wrong: This is an early Phase 2 trial with only 23 participants, so results may not apply to all PML patients. There are risks of immune reactions like graft-versus-host disease or allergic responses.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

progressive multifocal leukoencephalopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PROGRESSIVE MULTIFOCAL LEUCOENCEPHALOPATHY (PML)

Contacts and locations

Locations

Hannover Medical School
RECRUITING

Hanover, Lower Saxony, 30625, Germany
LMU Klinikum Campus Großhadern
NOT_YET_RECRUITING

München, Bavaria, 81377, Germany
Universitätsklinikum Düsseldorf
NOT_YET_RECRUITING

Düsseldorf, North Rhine-Westphalia, 40225, Germany
Universitätsklinikum Essen
NOT_YET_RECRUITING

Essen, North Rhine-Westphalia, 45147, Germany
Universitätsklinikum Marburg
NOT_YET_RECRUITING

Marburg, Hesse, Germany
Universitätsklinikum Schleswig-Holstein
NOT_YET_RECRUITING

Kiel, Schleswig-Holstein, 24105, Germany