Could a High-Fat diet tame Super-Refractory seizures?

NCT ID NCT07496749

Recruiting now Disease control Sponsor: Xuanwu Hospital, Beijing Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether a ketogenic diet (a high-fat, low-carbohydrate diet) can help stop super-refractory status epilepticus—a life-threatening condition where seizures continue despite standard medications. The diet is given via feeding tube or by mouth to 84 ICU patients aged 14–80. Researchers will measure how quickly seizures stop using brain wave monitoring.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ketogenic diet (a high-fat, low-carbohydrate diet given via feeding tube or by mouth)
What this could lead to: If it works, this could offer a new, drug-free option to stop prolonged seizures in the ICU, potentially reducing brain damage and time on life support.
What could go wrong: This is a relatively small trial (84 people) and the diet can cause side effects like digestive issues or nutrient imbalances. It may not work for everyone, and results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

encephalitis Status Epilepticus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SUPER-REFRACTORY STATUS EPILEPTICUS

Contacts and locations

Locations

Beijing Tongren Hospital, Capital Medical University
NOT_YET_RECRUITING

Beijing, 100730, China
Chifeng Municipal Hospital
RECRUITING

Chifeng, Neimenggu, 024000, China
Department of Neurology, Xuanwu Hospital Capital Medical University
RECRUITING

Beijing, Beijing Municipality, 100053, China
Fujian Medical University Union Hospital
RECRUITING

Fuzhou, Fujian, 350001, China
Guizhou Provincial People's Hospital
RECRUITING

Guiyang, Guizhou, 550002, China
Liaocheng People's Hospital
RECRUITING

Liaocheng, 252000, China
Qilu Hospital，Shandong University
NOT_YET_RECRUITING

Jinan, Shandong, 2500012, China
The First Affiliated Hospital of Anhui Medical University
RECRUITING

Hefei, Anhui, 230022, China
The First Affiliated Hospital of Guangxi Medical University
RECRUITING

Nanning, Guangxi, 530021, China
The First Affiliated Hospital of Harbin Medical University
RECRUITING

Harbin, Heilongjiang, 150001, China
The First Hospital of Hebei Medical University
RECRUITING

Shijiazhuang, Hebei, 050031, China
The First Hospital of Jilin University
RECRUITING

Jilin City, 130021, China
The Second Affiliated Hospital of Hainan Medical University
NOT_YET_RECRUITING

Haikou, Hainan, 570311, China
The Second Affiliated Hospital of Zhejiang University School of Medicine
RECRUITING

Hanzhou, Zhejiang, 310009, China

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