New drug shows promise for stopping Life-Threatening seizures

NCT ID NCT02477618

Completed Disease control Sponsor: Supernus Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a drug called SAGE-547 in 132 people with super-refractory status epilepticus, a dangerous condition where seizures don't stop with standard treatments. The drug was given as a continuous IV infusion to see if it could help patients come off strong sedatives and stay seizure-free. The trial was double-blind and placebo-controlled, meaning neither patients nor doctors knew who got the real drug.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: SAGE-547 injection (a drug given intravenously to stop prolonged seizures)
What this could lead to: If it works, this could provide a new treatment to help people with life-threatening, drug-resistant seizures recover faster and reduce the need for heavy sedation.
What could go wrong: This is a completed Phase 3 trial, but results are not yet widely confirmed. The condition is rare and severe, so benefits may not apply to all patients, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SUPER-REFRACTORY STATUS EPILEPTICUS

Contacts and locations

Locations

Sage Investigational Site

Birmingham, Alabama, 35233, United States
Sage Investigational Site

Mobile, Alabama, 36667, United States
Sage Investigational Site

Phoenix, Arizona, 85006, United States
Sage Investigational Site

Phoenix, Arizona, 85013, United States
Sage Investigational Site

Little Rock, Arkansas, 27702, United States
Sage Investigational Site

Fresno, California, 93721, United States
Sage Investigational Site

Loma Linda, California, 92354, United States
Sage Investigational Site

Los Angeles, California, 90027, United States
Sage Investigational Site

Roseville, California, 95661, United States
Sage Investigational Site

Sacramento, California, 95317, United States
Sage Investigational Site

New Haven, Connecticut, 06510, United States
Sage Investigational Site

Wilmington, Delaware, 19803, United States
Sage Investigational Site

Washington D.C., District of Columbia, 20010, United States
Sage Investigational Site

Gainesville, Florida, 32611, United States
Sage Investigational Site

Jacksonville, Florida, 32209, United States
Sage Investigational Site

Miami, Florida, 33155, United States
Sage Investigational Site

Orlando, Florida, 32803, United States
Sage Investigational Site

Sarasota, Florida, 34239, United States
Sage Investigational Site

Tampa, Florida, 33613, United States
Sage Investigational Site

Weston, Florida, 33331, United States
Sage Investigational Site

Atlanta, Georgia, 30303, United States
Sage Investigational Site

Atlanta, Georgia, 30322, United States
Sage Investigational Site

Atlanta, Georgia, 30342, United States
Sage Investigational Site

Honolulu, Hawaii, 96813, United States
Sage Investigational Site

Honolulu, Hawaii, 96826, United States
Sage Investigational Site

Boise, Idaho, 83706, United States
Sage Investigational Site

Chicago, Illinois, 60611, United States
Sage Investigational Site

Chicago, Illinois, 60612, United States
Sage Investigational Site

Maywood, Illinois, 60153, United States
Sage Investigational Site

Peoria, Illinois, 61637, United States
Sage Investigational Site

Springfield, Illinois, 62702, United States
Sage Investigational Site

Urbana, Illinois, 61801, United States
Sage Investigational Site

Iowa City, Iowa, 52242, United States
Sage Investigational Site

Wichita, Kansas, 67214, United States
Sage Investigational Site

Lexington, Kentucky, 40536, United States
Sage Investigational Site

Louisville, Kentucky, 40202, United States
Sage Investigational Site

Baton Rouge, Louisiana, 70808, United States
Sage Investigational Site

New Orleans, Louisiana, 70115, United States
Sage Investigational Site

Portland, Maine, 04102, United States
Sage Investigational Site

Baltimore, Maryland, 21201, United States
Sage Investigational Site

Baltimore, Maryland, 21215, United States
Sage Investigational Site

Boston, Massachusetts, 02111, United States
Sage Investigational Site

Boston, Massachusetts, 02114, United States
Sage Investigational Site

Boston, Massachusetts, 02115, United States
Sage Investigational Site

Boston, Massachusetts, 02118, United States
Sage Investigational Site

Boston, Massachusetts, 02215, United States
Sage Investigational Site

Newton, Massachusetts, 02462, United States
Sage Investigational Site

Ann Arbor, Michigan, 48109, United States
Sage Investigational Site

Detroit, Michigan, 48201, United States
Sage Investigational Site

Detroit, Michigan, 48202, United States
Sage Investigational Site

East Lansing, Michigan, 48824, United States
Sage Investigational Site

Grand Rapids, Michigan, 49503, United States
Sage Investigational Site

Royal Oak, Michigan, 48073, United States
Sage Investigational Site

Minneapolis, Minnesota, 55414, United States
Sage Investigational Site

Rochester, Minnesota, 55905, United States
Sage Investigational Site

Jackson, Mississippi, 39216, United States
Sage Investigational Site

Kansas City, Missouri, 64108, United States
Sage Investigational Site

St Louis, Missouri, 63110, United States
Sage Investigational Site

Edison, New Jersey, 08818, United States
Sage Investigational Site

Morristown, New Jersey, 08827, United States
Sage Investigational Site

New Brunswick, New Jersey, 08901, United States
Sage Investigational Site

Summit, New Jersey, 07901, United States
Sage Investigational Site

Buffalo, New York, 14203, United States
Sage Investigational Site

New York, New York, 10016, United States
Sage Investigational Site

New York, New York, 10029, United States
Sage Investigational Site

New York, New York, 10032, United States
Sage Investigational Site

Port Jefferson, New York, 11777, United States
Sage Investigational Site

Rochester, New York, 14642, United States
Sage Investigational Site

Syracuse, New York, 13210, United States
Sage Investigational Site

Durham, North Carolina, 27710, United States
Sage Investigational Site

Winston-Salem, North Carolina, 27157, United States
Sage Investigational Site

Akron, Ohio, 44308, United States
Sage Investigational Site

Cincinnati, Ohio, 45229, United States
Sage Investigational Site

Cincinnati, Ohio, 45267, United States
Sage Investigational Site

Cleveland, Ohio, 44195, United States
Sage Investigational Site

Columbus, Ohio, 43210, United States
Sage Investigational Site

Toledo, Ohio, 43614, United States
Sage Investigational Site

Portland, Oregon, 97213, United States
Sage Investigational Site

Portland, Oregon, 97225, United States
Sage Investigational Site

Portland, Oregon, 97239, United States
Sage Investigational Site

Hershey, Pennsylvania, 17033, United States
Sage Investigational Site

Philadelphia, Pennsylvania, 19104, United States
Sage Investigational Site

Philadelphia, Pennsylvania, 19107, United States
Sage Investigational Site

Philadelphia, Pennsylvania, 19140, United States
Sage Investigational Site

Philadelphia, Pennsylvania, 19141, United States
Sage Investigational Site

Philadelphia, Pennsylvania, 19147, United States
Sage Investigational Site

Pittsburgh, Pennsylvania, 15212, United States
Sage Investigational Site

Charleston, South Carolina, 29425, United States
Sage Investigational Site

Memphis, Tennessee, 38105, United States
Sage Investigational Site

Nashville, Tennessee, 37232, United States
Sage Investigational Site

Austin, Texas, 78723, United States
Sage Investigational Site

Dallas, Texas, 75251, United States
Sage Investigational Site

Salt Lake City, Utah, 84108, United States
Sage Investigational Site

Salt Lake City, Utah, 84113, United States
Sage Investigational Site

Burlington, Vermont, 05401, United States
Sage Investigational Site

Seattle, Washington, 98105, United States
Sage Investigational Site

Huntington, West Virginia, 25705, United States
Sage Investigational Site

Morgantown, West Virginia, 26506, United States
Sage Investigational Site

Wauwatosa, Wisconsin, 53226, United States
Sage Investigational Site

Innsbruck, 6020, Austria
Sage Investigational Site

Salzburg, 5020, Austria
Sage Investigational Site

Vancouver, British Columbia, V6H3V4, Canada
Sage Investigational Site

Hamilton, Ontario, L8L 2X2, Canada
Sage Investigational Site

Kingston, Ontario, K7L3C9, Canada
Sage Investigational Site

London, Ontario, N6A5A5, Canada
Sage Investigational Site

Montreal, Quebec, H1T 2M4, Canada
Sage Investigational Site

Montreal, Quebec, H2L 4M1, Canada
Sage Investigational Site

Montreal, Quebec, H3A 2B4, Canada
Sage Investigational Site

Montreal, Quebec, H3T 1C5, Canada
Sage Investigational Site

Montreal, Quebec, H3T1C5, Canada
Sage Investigational Site

Copenhagen, 2100, Denmark
Sage Investigational Site

Tallinn, 10617, Estonia
Sage Investigational Site

Tallinn, 13419, Estonia
Sage Investigational Site

Tartu, 51014, Estonia
Sage Investigational Site

Helsinki, 00029, Finland
Sage Investigational Site

Kuopio, 70210, Finland
Sage Investigational Site

Bron, 69677, France
Sage Investigational Site

Dijon, 21079, France
Sage Investigational Site

Lille, 59037, France
Sage Investigational Site

Limoges, 87042, France
Sage Investigational Site

Lyon, 69677, France
Sage Investigational Site

Paris, 75851, France
Sage Investigational Site

Hamburg, 22337, Germany
Sage Investigational Site

Marburg, 35043, Germany
Sage Investigational Site

Osnabrück, 49076, Germany
Sage Investigational Site

Balassagyarmat, 2660, Hungary
Sage Investigational Site

Budapest, 01134, Hungary
Sage Investigational Site

Budapest, 1134, Hungary
Sage Investigational Site

Ashkelon, 7830604, Israel
Sage Investigational Site

Holon, 58100, Israel
Sage Investigational Site

Holon, Israel
Sage Investigational Site

Jerusalem, 91120, Israel
Sage Investigational Site

Petah Tikva, 49100, Israel
Sage Investigational Site

Tel Litwinsky, 52621, Israel
Sage Investigational Site

Tzrifin, 70300, Israel
Sage Investigational Site

Bologna, 40139, Italy
Sage Investigational Site

Florence, 50139, Italy
Sage Investigational Site

Milan, 20132, Italy
Sage Investigational Site

Milan, 20132, Italy
Sage Investigational Site

Milan, 20133, Italy
Sage Investigational Site

Modena, 41100, Italy
Sage Investigational Site

Modena, 41126, Italy
Sage Investigational Site

Monza, 20900, Italy
Sage Investigational Site

Perugia, 06129, Italy
Sage Investigational Site

Reggio Calabria, 89124, Italy
Sage Investigational Site

Rome, 00165, Italy
Sage Investigational Site

Rome, 165, Italy
Sage Investigational Site

Verona, 37126, Italy
Sage Investigational Site

Enschede, 7512KZ, Netherlands
Sage Investigational Site

Heerlen, 6419PC, Netherlands
Sage Investigational Site

Maastricht, 6202AZ, Netherlands
Sage Investigational Site

Nijmegen, 6525GA, Netherlands
Sage Investigational Site

Belgrade, 11000, Serbia
Sage Investigational Site

Belgrade, 11070, Serbia
Sage Investigational Site

Niš, 18000, Serbia
Sage Investigational Site

Novi Sad, 21000, Serbia
Sage Investigational Site

Badalona, 8916, Spain
Sage Investigational Site

Barakaldo, 48903, Spain
Sage Investigational Site

Barcelona, 08035, Spain
Sage Investigational Site

Barcelona, 08036, Spain
Sage Investigational Site

Córdoba, 14004, Spain
Sage Investigational Site

Granada, 18016, Spain
Sage Investigational Site

L'Hospitalet de Llobregat, 08907, Spain
Sage Investigational Site

Madrid, 28040, Spain
Sage Investigational Site

Gothenburg, 413 45, Sweden
Sage Investigational Site

Manchester, M6 8HD, United Kingdom
Sage Investigational Site

Norfolk, NR4 7UY, United Kingdom
Sage Investigational Site

Norwich, NR4 7UY, United Kingdom
Sage Investigational Site

Staffordshire, ST3 6QG, United Kingdom
Sage Investigational Site

Stoke-on-Trent, ST4 6QG, United Kingdom
Sage investigational Site

San Antonio, Texas, 78229, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.