Encephalomyelitis

This early-stage trial is testing a new vaccine called HydroVax-001B WNV to see if it is safe and triggers an immune response against West Nile virus, a mosquito-borne disease. About 30 healthy adults aged 18 to 49 will receive either the vaccine or a placebo. The study will comp…

This Phase 3 trial tests a new meningococcal conjugate vaccine in 660 healthy children aged 2-6 years. The vaccine targets four strains (A, C, Y, W135) that cause meningitis. Participants receive one shot and provide blood samples to compare immune response with a licensed vaccin…

This trial is testing an experimental vaccine made from virus-like particles (VLPs) that mimic polio viruses without causing disease. It aims to see if this vaccine is safe and triggers a strong immune response in healthy infants starting at 6 weeks old and toddlers aged 12-18 mo…

This study follows women who previously received the GBS-NN/NN2 vaccine during pregnancy to see how long their immune protection lasts. It also tests whether a booster dose given in a new pregnancy is safe and boosts immunity, aiming to protect newborns from group B strep infecti…

This study is testing a new vaccine called MenABCWY that aims to protect against five types of meningococcal bacteria, which can cause serious infections like meningitis. Around 312 healthy teenagers will receive two doses of the vaccine on different schedules to see how safe it …

This study tests the MenB+OMV NZ vaccine in 50 healthy infants starting at 2 months old in South Korea. The vaccine is given as three shots over about a year to see if it triggers a strong immune response against meningococcal group B bacteria, which can cause meningitis. Researc…

This study tests a vaccine designed to protect young children from four types of meningitis bacteria. Researchers gave the vaccine to 660 toddlers aged 6 to 23 months and will check their immune response over time. Some children will also receive a booster shot at age 3 to see if…

This Phase 2 trial tests a new vaccine called MVA-BN-WEV to prevent two types of equine encephalitis (Eastern and Venezuelan), which are rare but serious brain infections spread by mosquitoes. The study involves 411 healthy adults aged 18-50 and aims to find the best dose and dos…

This Phase 3 trial tests satralizumab, an injected drug, in 120 people with NMDAR or LGI1 encephalitis—rare conditions where the immune system attacks the brain. The goal is to see if the drug improves disability and reduces the need for rescue treatments. Participants receive ei…

This phase 2 trial tests whether a combination of intravenous immunoglobulin (IVIG) and rituximab can help people with psychosis caused by antibodies attacking the brain. 70 participants with acute psychosis and specific antibodies receive either the immunotherapy or a placebo. T…

This phase 2 trial tests whether high-dose chemotherapy followed by a stem cell transplant can stop the immune system from attacking the nervous system in people with autoimmune neurologic diseases like multiple sclerosis and stiff person syndrome. The treatment aims to weaken th…

This study tests a new way to treat viral infections that often occur after a solid organ transplant. Researchers create special immune cells, called viral-specific T-cells, from the patient's own blood to fight the virus. The goal is to reduce the need for strong anti-viral drug…

This study follows 76 people with autoimmune or post-infection brain inflammation who are receiving stem cell or exosome treatments. Researchers will track changes in symptoms, inflammation markers, and quality of life. The goal is to see if these experimental therapies can help …

This study checks how well a new test, the QIAstat-Dx ME Panel Plus, can detect meningitis and encephalitis from spinal fluid samples. Researchers will compare the test results to standard methods using leftover samples from 1500 patients. The goal is to see if the test works acc…

This study tests a new, team-based rehabilitation program for 125 working-age adults with persistent physical symptoms and chronic fatigue. The program includes doctors, therapists, and counselors who work together to help patients manage their symptoms and improve daily function…

This study looks at whether adding music to standard occupational therapy can help children aged 5-12 with conditions like cerebral palsy, encephalitis, or brain tumor recovery. Researchers will measure changes in walking, balance, and vital signs like heart rate and oxygen level…

This study looks back at medical records of 50 adults who had a shingles virus infection in their brain or spinal cord. Researchers want to find out what makes some people more likely to get these serious infections and what leads to long-term problems like memory loss or seizure…

This study uses a new, child-friendly brain imaging technique called OPM-MEG to understand how immune-related brain diseases (like autoimmune encephalitis and multiple sclerosis) and other brain conditions affect children aged 2 to 25. Standard scans often miss problems with memo…

This study looks at whether the immune system mistakenly makes antibodies that attack the body's own nerves and muscles in people with multiple sclerosis, myasthenia gravis, and similar conditions. Researchers will collect blood samples (and sometimes cheek swabs) from 120 adults…

This study follows 9 people with transverse myelitis who previously received an experimental cell therapy called Q-Cells®. Researchers will monitor them for 10 years to check for side effects and see if the treatment continues to have any effect. Participants will have regular ex…

This study follows 150 people with rare neuroimmunologic disorders like neuromyelitis optica and transverse myelitis. Researchers collect medical data and blood samples over time to learn what causes inflammation and why some patients respond to treatments while others do not. Th…

This study is creating a large, long-term collection of blood samples and health information from over 3,200 people with multiple sclerosis and related demyelinating diseases, as well as healthy volunteers. The goal is to provide scientists with a shared resource to better unders…

This study reviews medical records of 200 people hospitalized with unexplained meningitis or meningoencephalitis. Researchers want to see if adding a test for tick-borne encephalitis (TBE) helps find more cases. No new drug or treatment is being tested—only the impact of a change…