Central nervous system disorder
MONDO:0002602A disease involving the central nervous system.
Also known as: CNS disorder, central nervous disease, central nervous system disease, central nervous system disease or disorder, central nervous system disorder, disease of central nervous system, disease of the central nervous system, disease or disorder of central nervous system
20455 clinical trials for this condition and its sub-types, 119 tagged with Central nervous system disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Central nervous system disorder
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Brain disorder 137 trials · 16,709 incl. sub-types
71 sub-types
- Mental disorder 250 trials · 7,390 incl. sub-types Sub-types →
- Cerebrovascular disorder 108 trials · 3,292 incl. sub-types Sub-types →
- Basal ganglia disorder 9 trials · 1,322 incl. sub-types Sub-types →
- Brain neoplasm 247 trials · 1,080 incl. sub-types Sub-types →
- Multiple sclerosis 770 trials · 858 incl. sub-types Sub-types →
- Insomnia 823 trials · 827 incl. sub-types Sub-types →
- Cerebral cortex disorder 0 trials · 723 incl. sub-types Sub-types →
- Brain injury 220 trials · 693 incl. sub-types Sub-types →
- Epilepsy 461 trials · 645 incl. sub-types Sub-types →
- Migraine disorder 393 trials · 414 incl. sub-types Sub-types →
- Cerebellar disorder 9 trials · 271 incl. sub-types Sub-types →
- Visual pathway disorder 1 trial · 201 incl. sub-types Sub-types →
- Pituitary gland disorder 18 trials · 175 incl. sub-types Sub-types →
- Thalamic disorder 0 trials · 110 incl. sub-types Sub-types →
- Intracranial hypertension 51 trials · 97 incl. sub-types Sub-types →
- Encephalitis 26 trials · 96 incl. sub-types Sub-types →
- Hydrocephalus 52 trials · 79 incl. sub-types Sub-types →
- Cerebral degeneration 0 trials · 61 incl. sub-types Sub-types →
- Hepatic encephalopathy 45 trials Sub-types →
- Narcolepsy-cataplexy syndrome 42 trials · 44 incl. sub-types Sub-types →
- Cerebral lipidosis with dementia 0 trials · 38 incl. sub-types Sub-types →
- Intracranial hypotension 32 trials
- Cluster headache syndrome 26 trials Sub-types →
- Brain edema 23 trials
- Narcolepsy without cataplexy 22 trials
- Encephalomalacia 1 trial · 13 incl. sub-types Sub-types →
- Olfactory nerve disorder 8 trials · 12 incl. sub-types Sub-types →
- Prion disease 5 trials · 11 incl. sub-types Sub-types →
- Traumatic encephalopathy 11 trials
- Cerebral cortical dysplasia 2 trials · 7 incl. sub-types Sub-types →
- Progressive bulbar palsy 5 trials Sub-types →
- Akinetic mutism 3 trials
- Bilirubin encephalopathy 3 trials Sub-types →
- Central nervous system cyst 3 trials Sub-types →
- Encephaloclastic disorder 0 trials · 3 incl. sub-types Sub-types →
- Encephalopathy, acute, infection-induced 2 trials · 3 incl. sub-types Sub-types →
- Megalencephaly 3 trials Sub-types →
- Cerebral malaria 2 trials
- Leukoencephalopathy, megalencephalic 0 trials · 2 incl. sub-types Sub-types →
- Wernicke encephalopathy 1 trial
- Brain compression 1 trial
- Carbon monoxide-induced delayed encephalopathy 1 trial
- Cerebral sarcoidosis 1 trial
- Reye syndrome 0 trials
- XK aprosencephaly 0 trials
- Acute bilirubin encephalopathy 0 trials
- Aprosencephaly 0 trials
- Atelencephaly 0 trials
- Autoimmune encephalopathy with parasomnia and obstructive sleep apnea 0 trials
- Autosomal recessive frontotemporal pachygyria 0 trials
- Brain malformations with or without urinary tract defects 0 trials
- Bulbar polio 0 trials
- Central nervous system origin vertigo 0 trials
- Cerebritis 0 trials
- Chronic bilirubin encephalopathy 0 trials
- Colpocephaly 0 trials
- Complex cortical dysplasia with other brain malformations 0 trials Sub-types →
- Corpus callosum agenesis of blepharophimosis robin type 0 trials
- Corpus callosum dysgenesis X-linked recessive 0 trials
- Corpus callosum dysgenesis cleft spasm 0 trials
- Corpus callosum dysgenesis hypopituitarism 0 trials
- Diabetic encephalopathy 0 trials
- Disorder of optic chiasm 0 trials
- Encephalopathy due to mitochondrial and peroxisomal fission defect 0 trials Sub-types →
- Encephalopathy, acute transient 0 trials
- Encephalopathy, recurrent, of childhood 0 trials
- Glycine encephalopathy 0 trials Sub-types →
- Hypothalamic hamartomas with gelastic seizures 0 trials
- Meningoencephalocele 0 trials
- Midbrain disorder 0 trials
- Occipital pachygyria and polymicrogyria 0 trials
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Neurodegenerative disease 187 trials · 3,289 incl. sub-types
22 sub-types
- Tauopathy 24 trials · 1,193 incl. sub-types Sub-types →
- Demyelinating disease 27 trials · 938 incl. sub-types Sub-types →
- Inherited neurodegenerative disorder 11 trials · 808 incl. sub-types Sub-types →
- Motor neuron disorder 70 trials · 510 incl. sub-types Sub-types →
- Synucleinopathy 18 trials · 237 incl. sub-types Sub-types →
- Cerebellar degeneration 6 trials · 150 incl. sub-types Sub-types →
- Primary progressive aphasia 42 trials · 71 incl. sub-types Sub-types →
- Cerebral degeneration 0 trials · 61 incl. sub-types Sub-types →
- Neuroaxonal dystrophy 1 trial · 9 incl. sub-types Sub-types →
- Secondary Parkinson disease 9 trials Sub-types →
- Primary progressive apraxia of speech 2 trials
- Marchiafava-Bignami disease 1 trial
- Human prion disease 1 trial Sub-types →
- Brachial amyotrophic diplegia 0 trials
- Choroidal sclerosis 0 trials Sub-types →
- Eyelid degenerative disorder 0 trials
- Hypertrophic olivary degeneration 0 trials
- Infantile bilateral striatal necrosis 0 trials Sub-types →
- Olivopontocerebellar atrophy 0 trials
- Primary progressive freezing gait 0 trials
- Senile degeneration of brain 0 trials
- Superficial siderosis 0 trials
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Central nervous system neoplasm 51 trials · 1,986 incl. sub-types
10 sub-types
- Central nervous system cancer 131 trials · 1,706 incl. sub-types Sub-types →
- Brain neoplasm 247 trials · 1,080 incl. sub-types Sub-types →
- Tumor of meninges 1 trial · 123 incl. sub-types Sub-types →
- Central nervous system hematopoietic neoplasm 0 trials · 107 incl. sub-types Sub-types →
- Spinal cord neoplasm 36 trials · 77 incl. sub-types Sub-types →
- Autonomic nervous system neoplasm 0 trials · 60 incl. sub-types Sub-types →
- Central nervous system organ benign neoplasm 1 trial · 57 incl. sub-types Sub-types →
- Central nervous system germ cell tumor 6 trials · 9 incl. sub-types Sub-types →
- Epidural abscess 5 trials
- Optic nerve neoplasm 1 trial · 4 incl. sub-types Sub-types →
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Spinal cord disorder 47 trials · 1,255 incl. sub-types
10 sub-types
- Spinal cord injury 650 trials
- Anterior horn disorder 0 trials · 485 incl. sub-types Sub-types →
- Spinal cord neoplasm 36 trials · 77 incl. sub-types Sub-types →
- Spina bifida 44 trials · 59 incl. sub-types Sub-types →
- Myelitis 4 trials · 52 incl. sub-types Sub-types →
- Syringomyelia 6 trials Sub-types →
- Tethered spinal cord syndrome 6 trials
- Radiation myelitis 0 trials
- Segmental spinal dysgenesis 0 trials
- Vascular myelopathy 0 trials
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Autoimmune disorder of central nervous system 2 trials · 881 incl. sub-types
8 sub-types
- Multiple sclerosis 770 trials · 858 incl. sub-types Sub-types →
- Autoimmune encephalitis 32 trials · 33 incl. sub-types Sub-types →
- Central nervous system lupus 3 trials
- Autoimmune epilepsy 1 trial
- Miller Fisher syndrome 0 trials
- Autoimmune encephalopathy with parasomnia and obstructive sleep apnea 0 trials
- Autoimmune optic neuritis 0 trials
- Primary hypophysitis 0 trials Sub-types →
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Palsy 36 trials · 846 incl. sub-types
10 sub-types
- Cerebral palsy 443 trials · 499 incl. sub-types Sub-types →
- Hemiplegia 176 trials · 179 incl. sub-types Sub-types →
- Quadriplegia 73 trials
- Paraplegia 47 trials · 68 incl. sub-types Sub-types →
- Facial paralysis 19 trials · 34 incl. sub-types Sub-types →
- Respiratory paralysis 20 trials
- Erb palsy 11 trials
- Ophthalmoplegia 0 trials · 11 incl. sub-types Sub-types →
- Progressive bulbar palsy 5 trials Sub-types →
- Klumpke's paralysis 0 trials
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Encephalomyelitis 3 trials · 227 incl. sub-types
7 sub-types
- Encephalitis 26 trials · 96 incl. sub-types Sub-types →
- Meningitis 42 trials · 73 incl. sub-types Sub-types →
- Myelitis 4 trials · 52 incl. sub-types Sub-types →
- Optic neuritis 21 trials · 25 incl. sub-types Sub-types →
- Hypophysitis 2 trials Sub-types →
- Venezuelan equine encephalitis 1 trial
- Cerebritis 0 trials
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Autonomic nervous system disorder 59 trials · 209 incl. sub-types
13 sub-types
- Dysautonomia 16 trials · 64 incl. sub-types Sub-types →
- Autonomic nervous system neoplasm 0 trials · 60 incl. sub-types Sub-types →
- Sympathetic nervous system disorder 8 trials · 28 incl. sub-types Sub-types →
- Pure autonomic failure 18 trials
- Autonomic dysreflexia 11 trials
- Autonomic neuropathy 7 trials · 10 incl. sub-types Sub-types →
- Central hypoventilation syndrome, congenital, 1, with or without Hirschsprung disease 5 trials
- Baroreflex failure 1 trial
- Frey syndrome 0 trials
- Chronic hiccup 0 trials
- Harlequin syndrome 0 trials
- Idiopathic peripheral autonomic neuropathy 0 trials
- Parasympathetic nervous system disorder 0 trials Sub-types →
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Central nervous system infectious disorder 10 trials · 163 incl. sub-types
12 sub-types
- Viral infection of central nervous system 3 trials · 58 incl. sub-types Sub-types →
- Infectious encephalitis 3 trials · 50 incl. sub-types Sub-types →
- Infectious meningitis 3 trials · 49 incl. sub-types Sub-types →
- Prion disease 5 trials · 11 incl. sub-types Sub-types →
- Central nervous system tuberculosis 1 trial · 7 incl. sub-types Sub-types →
- Epidural abscess 5 trials
- Intracranial abscess 3 trials
- Cerebral malaria 2 trials
- Congenital toxoplasmosis 2 trials
- Human prion disease 1 trial Sub-types →
- Subdural empyema 1 trial
- Neuroschistosomiasis 0 trials
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Optic nerve disorder 23 trials · 96 incl. sub-types
8 sub-types
- Optic atrophy 4 trials · 26 incl. sub-types Sub-types →
- Optic neuritis 21 trials · 25 incl. sub-types Sub-types →
- Low tension glaucoma 21 trials
- Anterior ischemic optic neuropathy 9 trials · 11 incl. sub-types Sub-types →
- Optic nerve neoplasm 1 trial · 4 incl. sub-types Sub-types →
- Optic disk drusen 1 trial
- Extensive peripapillary myelinated nerve fibers 0 trials
- Isolated optic nerve aplasia 0 trials
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Tinnitus 91 trials
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Central nervous system vasculitis 3 trials · 55 incl. sub-types
5 sub-types
- Temporal arteritis 52 trials Sub-types →
- Primary central nervous system vasculitis 2 trials Sub-types →
- Benign angiitis of the central nervous system 0 trials
- Central nervous system AIDS arteritis 0 trials
- Cerebral arteritis 0 trials
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Trigeminal neuralgia 37 trials
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Cerebrospinal fluid leak 16 trials · 17 incl. sub-types
1 sub-type
- Cerebrospinal fluid rhinorrhea 2 trials
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High pressure neurological syndrome 0 trials · 5 incl. sub-types
1 sub-type
- Decompression sickness 5 trials
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SPAST-related motor disorder 0 trials · 2 incl. sub-types
1 sub-type
- Hereditary spastic paraplegia 4 2 trials
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1 sub-type
- NDE1-related microhydranencephaly 0 trials
Most studied deeper sub-types
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Can Lab-Grown brain cells replace what Parkinson's destroys?
Cure Recruiting nowThis early-stage trial tests whether transplanting lab-grown dopamine-producing cells into the brains of people with Parkinson's disease is safe and might help replace the cells lost to the disease. About 7 adults with Parkinson's who have not responded well to standard medicatio…
Phase 1 • Sponsor: University of California, San Diego • Aim: Cure
Last updated Aug 19, 2026 00:00 UTC
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New hope for glioblastoma? drug combo trial targets aggressive brain tumors
Disease control Recruiting nowThis Phase 2 trial tests whether adding the experimental drug silevertinib to standard chemotherapy (temozolomide) helps people with a specific type of newly diagnosed glioblastoma live longer without their cancer worsening. The study includes 162 participants whose tumors have c…
Phase 2 • Sponsor: Black Diamond Therapeutics, Inc. • Aim: Disease control
Last updated Sep 18, 2026 00:00 UTC
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Can a Two-Drug combo quiet the tremors Parkinson's patients still feel?
Disease control Recruiting nowThis phase 2 trial tests an experimental drug called VIM0423 in adults with Parkinson's disease whose tremor does not respond well to standard dopaminergic therapy. Researchers want to see if VIM0423 can reduce tremor severity, improve daily function and quality of life, and be s…
Phase 2 • Sponsor: Vima Therapeutics • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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Spinal fluid antibody shots tested for fresh spinal cord injuries
Disease control Recruiting nowResearchers are testing an experimental human monoclonal antibody called NG004 in people who have recently sustained an acute incomplete cervical spinal cord injury. Participants receive repeated injections of NG004 directly into the spinal fluid. The trial's main goal is to chec…
Phase 1 • Sponsor: NovaGo Therapeutics AG • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
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New hope for breast cancer patients with brain tumors: drug combo trial underway
Disease control Recruiting nowThis study tests a combination of two drugs, elacestrant and abemaciclib, in people with a specific type of breast cancer (ER-positive, HER2-negative) that has spread to the brain. The goal is to see if the combination can shrink or control brain tumors. The trial involves about …
Phase 1/2 • Sponsor: Stemline Therapeutics, Inc. • Aim: Disease control
Last updated Sep 11, 2026 00:00 UTC
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Killer virus turned against childhood brain cancer
Disease control Recruiting nowThis early-stage trial tests whether a specially engineered herpes virus (G207) is safe to inject directly into the brain tumors of children whose cancer has returned. Up to 24 children aged 3 to 21 will receive the virus, and some will also get a small dose of radiation to help …
Phase 1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Sep 06, 2026 00:00 UTC
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New schizophrenia drug shows promise in Long-Term safety trial
Disease control Recruiting nowThis study is testing a new drug called ML-007C-MA for adults with schizophrenia. The goal is to see if it is safe and works well over a full year. About 500 people who have recently been in a related study or are new to the trial will take the drug twice daily. Researchers will …
Phase 2 • Sponsor: MapLight Therapeutics • Aim: Disease control
Last updated Sep 03, 2026 00:00 UTC
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Magnetic pulses to the brain may tame Parkinson's drug side effects
Disease control Recruiting nowThis trial tests whether repetitive transcranial magnetic stimulation (rTMS) can reduce or delay the involuntary movements, called dyskinesia, that many Parkinson's patients develop after taking levodopa. Researchers will apply targeted magnetic pulses to a brain region involved …
Sponsor: Danish Research Centre for Magnetic Resonance • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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New Alzheimer's drug injected into spine shows promise in early safety trial
Disease control Recruiting nowThis early-stage study tests a new drug called LY3954068 in 48 people with mild Alzheimer's symptoms. The drug is given directly into the spinal fluid, either once or twice, to see if it is safe and how it affects Alzheimer's markers. The study lasts up to 100 weeks and includes …
Phase 1 • Sponsor: Eli Lilly and Company • Aim: Disease control
Last updated Aug 26, 2026 00:00 UTC
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Light and magnets: a new weapon against Alzheimer's?
Disease control Recruiting nowThis trial tests whether a wearable device called RGn600 can slow cognitive decline in people with mild-to-moderate Alzheimer's disease. The device, worn as a helmet and abdominal belt, delivers red-to-near-infrared light and static magnetic fields, aiming to reduce inflammation …
Sponsor: REGEnLIFE SAS • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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Gene therapy trial offers hope for babies with rare, deadly metabolic disease
Disease control Recruiting nowThis study tests a one-time gene therapy called ECUR-506 in baby boys under 9 months old with a severe form of OTC deficiency, a genetic disorder that prevents the body from breaking down ammonia. The goal is to see if the treatment is safe and can reduce dangerous ammonia levels…
Phase 3 • Sponsor: iECURE, Inc. • Aim: Disease control
Last updated Aug 14, 2026 00:00 UTC
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Experimental Alzheimer's vaccine aims to clear brain plaques
Disease control Recruiting nowThis study tests an experimental vaccine called ACI-24.060 in people with early Alzheimer's and non-demented adults with Down syndrome. The vaccine is designed to help the immune system clear amyloid plaques from the brain, which are linked to Alzheimer's. Researchers will check …
Phase 1/2 • Sponsor: AC Immune SA • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
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Could a simple ear clip tame brain swelling after a stroke?
Disease control Recruiting nowThis study tests whether a non-invasive device that gently stimulates the vagus nerve through the ear can reduce inflammation and brain swelling after a hemorrhagic stroke (intracerebral hemorrhage). The trial enrolls adults with a specific type of brain bleed and compares the ac…
Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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Could a 6-Month drug cocktail beat 9 months for brain TB?
Disease control Recruiting nowThis study compares a 6-month treatment using high doses of four antibiotics against the standard 9-month therapy for tuberculous meningitis, a serious brain infection. About 330 adults and teens without HIV will take part. The goal is to see if the shorter regimen is as safe and…
Phase 2 • Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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Could a second drug boost stroke recovery?
Disease control Recruiting nowThis study tests whether giving a clot-busting drug called tenecteplase directly into the brain artery after mechanical clot removal helps people recover better from a severe stroke. About 462 adults with a large vessel blockage in the front part of the brain will be randomly ass…
Phase 2/3 • Sponsor: University of Melbourne • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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Could a simple neck device help stroke patients survive?
Disease control Recruiting nowThis study is testing a non-invasive device that stimulates the vagus nerve (a major nerve in the neck) to see if it is safe and helpful for people who have had a severe bleeding stroke called aneurysmal subarachnoid hemorrhage. About 25 adults in the intensive care unit will rec…
Sponsor: Massachusetts General Hospital • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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New drug could extend window for treating deadly stroke
Disease control Recruiting nowThis trial is testing a drug called tenecteplase for people with a severe stroke caused by a blockage in the basilar artery at the back of the brain. About 688 participants will receive either tenecteplase or standard care within 24 hours of symptoms starting, followed by a clot-…
Phase 2/3 • Sponsor: University of Melbourne • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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New hope for early Alzheimer's? drug GSK4527226 tested for Long-Term safety
Disease control Recruiting nowThis study is an extension of an earlier trial, testing the long-term safety and effectiveness of the drug GSK4527226 in people with early Alzheimer's disease (mild cognitive impairment or mild dementia). All 220 participants will receive the drug, and researchers will monitor fo…
Phase 2 • Sponsor: GlaxoSmithKline • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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Ear zap may cut ICU stays and costs for brain injury patients
Disease control Recruiting nowThis study tests a non-invasive device that gently stimulates a nerve in the ear to help patients with serious brain or spinal cord injuries recover in the intensive care unit. Researchers want to see if it reduces complications like infections, the need for a breathing tube, and…
Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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Could ozone up the backside save Kids' brains?
Disease control Recruiting nowThis study tests whether giving ozone gas through the rectum can help protect the brain in children who have suffered a brain injury. 120 children aged 1 month to 18 years will either receive up to 80 rectal ozone sessions plus standard rehab, or rehab alone. The main goal is to …
Sponsor: Al-Azhar University • Aim: Disease control
Last updated Jun 26, 2026 13:53 UTC
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Ear-Worn gadget aims to predict seizures before they start
Diagnosis Recruiting nowThis study is testing a wearable device that sits on the ears and uses sensors to detect and predict seizures in people with epilepsy. The device records brain, muscle, and eye activity, along with heart rate and skin signals. It will be compared to standard hospital EEG monitori…
Sponsor: Felicia Chu • Aim: Diagnosis
Last updated Jun 27, 2026 07:55 UTC
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Ambulance EEG could cut stroke treatment delays by an hour
Diagnosis Recruiting nowThis study tests a portable EEG device called StrokePointer that ambulance crews can use to detect severe strokes caused by large vessel blockages. Currently, over half of these patients are taken to hospitals that cannot perform the needed clot-removal procedure, causing an aver…
Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) • Aim: Diagnosis
Last updated Jun 27, 2026 07:53 UTC
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Can a phone app nudge people toward exercise and slow Parkinson's?
Prevention Recruiting nowThis trial tests whether a smartphone app can help people with REM sleep behavior disorder, a condition that often precedes Parkinson's, become more physically active over two years. Participants receive personalized activity goals through the app and track their steps and exerci…
Sponsor: Radboud University Medical Center • Aim: Prevention
Last updated Aug 29, 2026 00:00 UTC
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Could a phone app nudge people to exercise and slow Parkinson's before symptoms appear?
Prevention Recruiting nowThis trial tests whether a smartphone app can help 600 people with Parkinson's-related gene mutations increase their daily physical activity over two years. Participants set their own exercise goals and get feedback through the app. Researchers will measure changes in step counts…
Sponsor: Radboud University Medical Center • Aim: Prevention
Last updated Aug 29, 2026 00:00 UTC
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Step toward prevention: app-based exercise may protect the brain in Parkinson's risk group
Prevention Recruiting nowThis study tests whether increasing physical activity through a motivational smartphone app can slow cognitive decline in people with isolated REM sleep behavior disorder (iRBD), an early sign of Parkinson's disease and related disorders. Researchers will enroll 130 participants …
Sponsor: University Hospital, Bonn • Aim: Prevention
Last updated Jun 27, 2026 08:11 UTC
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Brain pacemaker tweak could help stroke and tremor patients speak and swallow better
Symptom relief Recruiting nowThis study looks at whether adjusting deep brain stimulation (DBS) can improve movement, speech, and swallowing in people already implanted with DBS for conditions like tremor, stroke, or traumatic brain injury. Researchers will test hand dexterity, grip strength, facial movement…
Sponsor: Jorge Gonzalez-Martinez • Aim: Symptom relief
Last updated Sep 20, 2026 00:00 UTC
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New pill aims to quiet Alzheimer's psychosis
Symptom relief Recruiting nowThis Phase 2 study tests an experimental drug, ML-007C-MA, to see if it can safely reduce hallucinations and delusions in people with Alzheimer's disease. About 300 participants aged 55 to 90 will receive either the drug or a placebo. The main goal is to measure changes in psycho…
Phase 2 • Sponsor: MapLight Therapeutics • Aim: Symptom relief
Last updated Aug 29, 2026 00:00 UTC
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Gentle brain zaps may restore arm function in chronic stroke survivors
Symptom relief Recruiting nowThis study tests a low-intensity brain stimulation method called kTMP to help people who had a stroke at least 12 months ago improve arm and hand movement. About 12 adults aged 18-80 with moderate arm weakness will receive kTMP alongside motor rehabilitation. The goal is to see i…
Sponsor: Magnetic Tides • Aim: Symptom relief
Last updated Jul 24, 2026 00:00 UTC
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Could a gentle brain ZAP help ALS patients breathe easier?
Symptom relief Recruiting nowThis study is testing if a non-invasive brain stimulation method called HD-tDCS can help people with ALS. The goal is to see if it can improve muscle control and breathing by calming overactive brain cells. The study will involve 80 adults with ALS and will measure changes in bra…
Phase 2/3 • Sponsor: Universidade Federal do Rio Grande do Norte • Aim: Symptom relief
Last updated Jul 22, 2026 00:00 UTC
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New drug trial aims to ease fragile x symptoms in men
Symptom relief Recruiting nowThis study tests a new medicine called CTH120 in 30 adult men with Fragile X syndrome. The main goal is to see if the drug is safe and tolerable, while also checking if it helps improve symptoms. Participants will receive the drug and be monitored closely for side effects and cha…
Phase 2 • Sponsor: Connecta Therapeutics, S.L. • Aim: Symptom relief
Last updated Jul 19, 2026 00:00 UTC
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Can virtual reality make stroke rehab more tolerable?
Symptom relief Recruiting nowThis study tests whether adding immersive virtual reality (VR) to robotic walking rehabilitation is tolerable for people who cannot walk after a stroke. Thirty non-walking stroke patients will try both standard robotic rehab and VR-enhanced sessions. Researchers will measure moti…
Sponsor: University Hospital, Limoges • Aim: Symptom relief
Last updated Jun 27, 2026 14:02 UTC
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Could a magnetic helmet boost memory in Alzheimer's?
Symptom relief Recruiting nowThis study tests a device that combines magnetic brain stimulation with cognitive exercises to see if it can improve thinking and memory in people with mild Alzheimer's disease. About 180 participants aged 60-85 will receive either real or sham stimulation along with real cogniti…
Sponsor: Advanced Technology & Communications • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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Can VR and mixed reality help stroke survivors move better?
Symptom relief Recruiting nowThis study tests two new therapy systems that use virtual reality (VR) or mixed reality (MR) to help stroke survivors improve arm function. Participants will perform movements while watching a mirrored hand in a headset. The trial aims to see if these high-tech approaches are fea…
Sponsor: Chang Gung Memorial Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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Your phone could help beat depression: new app trial launches
Symptom relief Recruiting nowThis study tests whether a smartphone app that tracks daily mood and symptoms can help doctors treat depression more effectively. 200 adults with depression will use the app for 6 weeks, while a comparison group receives standard care. The goal is to see if the app improves treat…
Sponsor: Centre Hospitalier Charles Perrens, Bordeaux • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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Zapping the brain to ease Parkinson's slowness
Symptom relief Recruiting nowThis study tests whether a non-invasive brain stimulation technique called patterned repetitive transcranial magnetic stimulation (prTMS) can reduce bradykinesia—slowness of movement—in people with Parkinson's disease. Researchers will apply the stimulation over a brain area invo…
Sponsor: Danish Research Centre for Magnetic Resonance • Aim: Symptom relief
Last updated Jun 27, 2026 09:03 UTC
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New combo therapy aims to restore hand function after stroke
Symptom relief Recruiting nowThis study tests whether combining virtual reality training with a gentle brain stimulation technique can improve arm and hand movement in people who had a stroke at least three months ago. Researchers will enroll 100 adults to compare the effects of this combination on motor ski…
Sponsor: King Saud University • Aim: Symptom relief
Last updated Jun 27, 2026 08:07 UTC
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Could freezing nerves beat botox for spasticity pain?
Symptom relief Recruiting nowThis pilot study compares a nerve-freezing technique called cryoneurolysis to standard Botox injections for treating pain and stiffness caused by spasticity in people with brain or spinal cord injuries, multiple sclerosis, or stroke. Fifty adults will be randomly assigned to rece…
Phase 4 • Sponsor: Oxford University Hospitals NHS Trust • Aim: Symptom relief
Last updated Jun 27, 2026 08:06 UTC
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Virtual walking therapy tested for spinal cord injury pain
Symptom relief Recruiting nowThis study tests whether playing a virtual reality walking game at home can reduce neuropathic pain in adults with incomplete spinal cord injury. Participants will use a headset to see virtual legs and walk in a virtual world for about 30 minutes twice daily over 10 days. The goa…
Sponsor: Texas A&M University • Aim: Symptom relief
Last updated Jun 27, 2026 08:04 UTC
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Spinal zaps could stop dizziness after injury
Symptom relief Recruiting nowThis study tests whether gentle electrical stimulation on the back can help stabilize blood pressure in people who recently had a spinal cord injury. Participants will undergo sit-up tests with and without stimulation to see if it prevents dizziness and keeps blood pressure in a …
Sponsor: Kessler Foundation • Aim: Symptom relief
Last updated Jun 26, 2026 13:20 UTC
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Spinal zaps could steady blood pressure in paralyzed patients
Symptom relief Recruiting nowThis study tests whether mild electrical stimulation on the back can help stabilize blood pressure in people with chronic spinal cord injury who experience dizziness or fainting when sitting up. Five participants will have their blood pressure measured while tilted on a table, wi…
Sponsor: Kessler Foundation • Aim: Symptom relief
Last updated Jun 26, 2026 12:34 UTC
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Massive study aims to unlock secrets of Brain's immune attacks
Knowledge-focused Recruiting nowThis observational study is recruiting 2400 people with immune-related central nervous system diseases, such as multiple sclerosis, along with healthy volunteers for comparison. Researchers will use MRI scans, lumbar punctures, blood tests, and neurological exams to track disease…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Can a single gene therapy dose keep working for 14 years?
Knowledge-focused Recruiting nowThis study follows people who received an investigational gene therapy in an earlier iECURE trial for a urea cycle disorder, a condition that can cause dangerous ammonia buildup. Researchers will track safety, side effects, and whether the therapy's effects last over up to 14.5 y…
Sponsor: iECURE, Inc. • Aim: Knowledge-focused
Last updated Sep 02, 2026 00:00 UTC
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Brain chemical may unlock migraine mystery
Knowledge-focused Recruiting nowThis study gives a natural brain chemical called adrenomedullin to 26 people with migraines to see if it triggers an attack. Participants first receive a migraine-preventing drug (erenumab) to block related receptors. The goal is to understand how migraines start, not to test a n…
Sponsor: Danish Headache Center • Aim: Knowledge-focused
Last updated Aug 30, 2026 00:00 UTC
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Can a questionnaire reveal the hidden burden of a rare genetic disease in women?
Knowledge-focused Recruiting nowThis study looks at women who carry the gene for X-linked adrenoleukodystrophy (X-ALD), a rare inherited condition that mainly affects the nervous system. Although the disease is linked to the X chromosome, up to 80% of female carriers may develop symptoms like leg weakness and b…
Sponsor: Leipzig University Medical Center • Aim: Knowledge-focused
Last updated Aug 29, 2026 00:00 UTC
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New blood test could reveal stroke damage in real time
Knowledge-focused Recruiting nowThis study will measure a protein called BD-tau in the blood of 100 people who have had an acute ischemic stroke. Researchers will take blood samples every hour for 48 hours to see how the protein levels change over time. The goal is to better understand brain injury patterns and…
Sponsor: Ludwig-Maximilians - University of Munich • Aim: Knowledge-focused
Last updated Aug 22, 2026 00:00 UTC
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Spinal tap could spot hidden brain cancers
Knowledge-focused Recruiting nowThis pilot study is exploring whether a one-time sample of spinal fluid (taken via a lumbar puncture) can detect cancer DNA in patients with solid tumors that have spread to the brain or spinal cord. Researchers will enroll 60 participants across three groups: those with leptomen…
Sponsor: Sunnybrook Health Sciences Centre • Aim: Knowledge-focused
Last updated Aug 02, 2026 00:00 UTC
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Sleep and seizures: new study probes why stroke triggers epilepsy in some patients
Knowledge-focused Recruiting nowThis observational study investigates why some people develop epilepsy after a stroke, while others do not. Researchers will compare first-time stroke patients with healthy volunteers using brain imaging (MRI), electrical brain recordings (EEG), and overnight sleep studies. The g…
Sponsor: Norwegian University of Science and Technology • Aim: Knowledge-focused
Last updated Jul 09, 2026 00:00 UTC
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New study hopes to find a simple test for MS diagnosis
Knowledge-focused Recruiting nowThis study is analyzing inflammatory markers in the blood and spinal fluid of 300 people who are being checked for multiple sclerosis (MS). The goal is to see if certain markers can help doctors tell MS apart from other autoimmune diseases that affect the brain and spinal cord. R…
Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Knowledge-focused
Last updated Jun 28, 2026 00:00 UTC
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New brain scan study aims to uncover Tau's role in memory loss
Knowledge-focused Recruiting nowThis study uses a special PET scan to look at tau protein buildup in the brain and see if it relates to memory and thinking problems. Researchers will study 900 adults, some with normal memory and some with mild dementia. The goal is to better understand Alzheimer's disease, not …
Sponsor: Tammie L. S. Benzinger, MD, PhD • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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Spinal circuit secrets: new study probes Stroke's hidden effects
Knowledge-focused Recruiting nowThis study looks at how stroke changes the way the spinal cord handles sensory signals. Researchers will stimulate nerve roots in the neck during surgery and measure muscle and brain responses in 15 people (some with stroke, some healthy). The goal is to better understand spinal …
Sponsor: Peter C. Gerszten, MD • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:03 UTC
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Scientists map Brain's reaching circuits after stroke
Knowledge-focused Recruiting nowThis study uses a robotic arm and brain stimulation to learn how different brain areas control reaching movements in people who have had a stroke and those who haven't. Researchers will measure movement paths, speeds, and accuracy. The goal is to understand brain changes after st…
Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Video link in ambulance could speed up stroke care
Knowledge-focused Recruiting nowThis study tests whether a live video call between a neurologist and emergency medical technicians (EMTs) can improve the accuracy of stroke detection in the ambulance. About 512 adults with suspected stroke will take part. The goal is to see if video assistance helps diagnose st…
Sponsor: University of Southern Denmark • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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Brain zaps may restore speech and hand movement in stroke survivors
Knowledge-focused Recruiting nowThis study tests whether temporarily stimulating a specific part of the brain can improve hand, arm, and speech abilities in people who had a stroke at least 6 months ago. Ten participants will have a thin wire placed deep in the brain for less than 30 days to deliver mild electr…
Sponsor: Jorge Gonzalez-Martinez • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Can proton radiation save Kids' brainpower? new study aims to find out
Knowledge-focused Recruiting nowThis study will test whether computer-based thinking assessments are practical for children aged 4 to 21 with brain tumors who are receiving proton beam radiation therapy. Researchers will measure thinking skills before, during, and after treatment to see how radiation affects me…
Sponsor: Washington University School of Medicine • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:26 UTC
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Could your nerves predict liver cancer? new study investigates
Knowledge-focused Recruiting nowThis study looks at how the autonomic nervous system (which controls automatic body functions) might be involved in liver cancer. Researchers will measure nerve activity and psychological traits in 100 adults with cirrhosis to find new ways to detect liver cancer earlier. The goa…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:24 UTC
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New study tracks pregnancy dangers in rare vascular conditions
Knowledge-focused Recruiting nowThis study follows 400 pregnant women with rare blood vessel diseases (like HHT, Marfan syndrome, or lymphedema) to learn about serious pregnancy complications. Researchers will ask participants about their health during pregnancy and for 12 months after birth. The goal is to gat…
Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Glowing dye could help surgeons spot hidden brain tumor cells
Knowledge-focused Recruiting nowThis study is testing whether a dye called sodium fluorescein can help surgeons better see and remove aggressive brain tumors during surgery. The dye is injected into the bloodstream and collects in tumors where the blood-brain barrier is broken, making them glow under a special …
Sponsor: Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Brain tumor tissue bank aims to unlock future cures
Knowledge-focused Recruiting nowThis study collects brain tumor tissue samples from 4,000 children and adults undergoing brain surgery. The samples are stored in a tissue bank at the University of Florida for future research. The goal is to help scientists find better treatments and cures for brain tumors.
Sponsor: University of Florida • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC
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New study aims to solve the mystery of 'breakthrough' strokes in heart patients
Knowledge-focused Recruiting nowThis study will follow 500 people who have had a stroke and also have atrial fibrillation (an irregular heartbeat). Some were taking blood thinners when they had their stroke, others were not. Researchers want to understand why blood thinners fail in some patients, by looking at …
Sponsor: Insel Gruppe AG, University Hospital Bern • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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Blood tests may unlock secrets of rare brain disorders
Knowledge-focused Recruiting nowThis study collects blood samples from 100 people with rare brain diseases like adrenoleukodystrophy and metachromatic leukodystrophy. Researchers will study immune cells called macrophages to see if they affect how the disease progresses. No treatment is given; the goal is to le…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC
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New ultrasound protocols aim to map normal blood vessel sizes
Knowledge-focused Recruiting nowThis study uses an advanced ultrasound machine to test new ways of measuring blood vessels in the arm and neck. Researchers will scan 60 healthy adults aged 18 to 75 to set normal ranges and check if the measurements are repeatable. The goal is to improve future diagnosis of kidn…
Sponsor: Mario Negri Institute for Pharmacological Research • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:14 UTC