Cerebrospinal fluid leak

This study tests a special sealant called Immiseal that is applied during brain or spine surgery to prevent leaks of cerebrospinal fluid. It is used along with standard repair methods to create a watertight seal. The study follows adults aged 18 to 75 who need dural repair after …

This study tests a new way to fix cerebrospinal fluid (CSF) leaks using a small plastic splint to support a tissue graft during nose surgery. It compares this method to the standard flap technique in 20 adults with leaks in both nostrils. The goal is to see if the splint helps th…

This study tests a special plate that dissolves over time, placed during nose surgery to remove pituitary tumors. The plate supports the skull base to prevent spinal fluid leaks, a common complication. About 126 people aged 1 to 80 with sellar tumors will be randomly assigned to …

This study tests whether a new sealant called CraniSeal is as safe and effective as the current standard, DuraSeal, at preventing cerebrospinal fluid leaks after elective brain surgery. About 224 adults undergoing cranial surgery will be randomly assigned to receive one of the tw…

This study compares two types of drainage after surgery for chronic subdural hematoma (a blood collection on the brain). 354 adults in Denmark will receive either active drainage under the scalp or passive drainage under the brain's outer layer for 24 hours. The goal is to see wh…

This study compares two types of surgical sealants (fibrin glue and a synthetic polymer) against no sealant in preventing cerebrospinal fluid leaks after nose-based skull base surgery. About 225 adults with low leak risk will be randomly assigned to one of three groups. The goal …

This study tests a special hydrogel (PuraGel) placed inside the nose after skull base surgery to see if it helps the surgical site heal faster and reduces pain. Thirty adults having this surgery will be randomly assigned to get either the hydrogel or a standard silicone splint. D…

This study looks at the best way to treat a fluid pocket (pseudomeningocele) that can form under the scalp after brain surgery. It compares doing nothing active (just watching and caring for the wound) with doing a procedure like draining the fluid or another surgery. The goal is…

This study watches 200 adults having brain tumor surgery to see how often cerebrospinal fluid leaks happen and what makes them more likely. The goal is to find ways to prevent leaks and help people recover faster. No new treatment is being tested—just careful observation.