New brain surgery sealant tested to stop leaks

NCT ID NCT06406790

First seen Nov 06, 2025 · Last updated May 09, 2026 · Updated 24 times

Summary

This study tests whether a new sealant called CraniSeal works as well as the current sealant DuraSeal for preventing cerebrospinal fluid leaks after planned brain surgery. About 224 adults having elective cranial surgery will be randomly assigned to receive one of the two sealants. The main goal is to see if CraniSeal is no worse than DuraSeal at stopping leaks, while also checking for infections and other side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Augusta University

    RECRUITING

    Augusta, Georgia, 30912, United States

  • Brigham and Women's Hospital

    RECRUITING

    Boston, Massachusetts, 02115, United States

    Contact Phone: •••-•••-••••

  • Jacobs Institute

    RECRUITING

    Buffalo, New York, 14203, United States

    Contact Phone: •••-•••-••••

  • Keck Medical Center at USC

    COMPLETED

    Los Angeles, California, 90033, United States

  • Mayo Clinic

    RECRUITING

    Jacksonville, Florida, 32224, United States

  • Mayo Clinic

    RECRUITING

    Rochester, Minnesota, 55905, United States

  • Prisma Health

    RECRUITING

    Greenville, South Carolina, 29605, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Tampa General Hospital

    RECRUITING

    Tampa, Florida, 33606, United States

Conditions

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