Neoplasm

Researchers are testing a vaccine called BNT113 in people whose cancers are driven by HPV16, a common virus linked to head and neck, cervical, and anogenital tumors. The trial enrolls two groups: one with head and neck cancer that has been treated and shows no signs of disease, a…

This trial tests a treatment strategy for adults with acute myeloid leukemia (AML) that did not respond to standard induction chemotherapy. Participants receive clofarabine and intermediate-dose Ara-C chemotherapy, followed by a reduced-intensity allogeneic stem cell transplant u…

Researchers test a reduced-toxicity conditioning regimen before allogeneic stem cell transplant in children and young adults with blood cancers. The regimen combines fludarabine, full-dose busulfan, and anti-thymocyte globulin. The trial measures transplant-related mortality at o…

Researchers test a reduced-intensity conditioning regimen before allogeneic stem cell transplant in adults with high-risk AML, MDS, or ALL who cannot tolerate standard intensive treatment. The regimen combines clofarabine, busulfan, and thymoglobulin. The trial measures relapse r…

Researchers test a gentler conditioning regimen before allogeneic stem cell transplantation in adults with blood cancers. The goal is to see if this reduced-toxicity approach lowers the risk of death within the first year after transplant. Participants receive fludarabine, busulf…

Researchers are testing a treatment called TOOKAD Soluble vascular targeted photodynamic therapy in men with localized intermediate-risk prostate cancer. The approach uses a drug activated by light to destroy cancer tissue in the prostate. The trial follows 50 men for up to 60 mo…

This trial tests whether MR-guided focused ultrasound can safely and effectively treat early breast cancer. The procedure uses MRI images to target and heat tumors with ultrasound waves, destroying them without surgery. Participants are women with a single small breast tumor that…

This trial tests whether a combination of the immunotherapy drug pembrolizumab, chemotherapy, and radiation can control advanced larynx cancer while preserving the voice box. Adults with stage III or IV larynx cancer who are candidates for organ preservation receive three cycles …

Researchers are testing a vaccine called 3D189 in adults with blood cancers such as acute leukemia, multiple myeloma, non-Hodgkin lymphoma, and higher-risk myelodysplastic syndrome. Participants must be in remission after standard treatment and unable to receive a stem cell trans…

This study tests a vaccine designed to help the immune system fight HPV-positive throat cancer. It is for patients who have completed surgery or chemoradiation and show no signs of cancer remaining. The trial will enroll 24 adults to find the safest and most effective dose by mea…

Researchers are testing whether adding the immunotherapy drug tislelizumab to standard TAC chemotherapy helps shrink triple-negative breast cancer before surgery. The trial enrolls 36 women with newly diagnosed triple-negative breast cancer. Participants receive six cycles of tis…

This completed Phase 4 trial tested two different doses of chemotherapy (standard and low-dose) combined with the immunotherapy drug Sintilimab in 20 people with advanced squamous non-small cell lung cancer. The goal was to see if the lower-dose combination could shrink tumors an…

This Phase 3 study tests whether adding tiragolumab (an experimental immunotherapy) to the standard combination of atezolizumab plus chemotherapy can help people with untreated, widespread small cell lung cancer live longer without their disease worsening. About 123 participants …

This study tests a new drug combination for people with a specific type of advanced lung cancer (EGFR-mutant non-small cell lung cancer). The two drugs, LY3295668 and osimertinib, work by blocking enzymes that help cancer cells grow. The goal is to find the safest dose and see if…

This Phase 3 study tests whether a gel containing patidegib can lower the number of new basal cell carcinomas (a type of skin cancer) on the face of adults with Gorlin syndrome. Participants apply the gel or a placebo to their face twice daily for a year. The study will compare h…

Researchers are testing a combination of rituximab, acalabrutinib, and durvalumab in adults with primary central nervous system lymphoma, a rare cancer that starts in the brain or spinal cord. The trial enrolls people whose disease has returned or worsened after earlier treatment…

Researchers are testing whether lucitanib, an oral drug, can slow the growth of advanced thymic carcinoma that has worsened after at least one round of chemotherapy. The trial enrolls adults with recurrent or metastatic thymic carcinoma. In one part, participants receive lucitani…

Researchers are testing whether adding fruquintinib to standard chemotherapy (mFOLFOX6 or FOLFIRI) helps people with metastatic colorectal cancer who have not yet received treatment for advanced disease. The trial enrolls adults up to age 75 with confirmed metastatic colorectal c…

This study tested whether taking the drug abiraterone on an on-and-off schedule could help it work longer for men with advanced prostate cancer that no longer responds to hormone therapy. Nineteen men whose cancer had already responded to standard daily abiraterone were enrolled.…

This study looked at whether a special care plan led by a geriatrician and a nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

Researchers are testing sorafenib, a drug that blocks enzymes tumors need to grow and cuts off their blood supply, in people with angiosarcoma that is locally advanced, has spread, or cannot be removed by surgery. The trial enrolls about 88 participants and measures how many rema…

This study tested two treatments for people with advanced cancer who cannot have standard therapy. One group took a low-dose chemotherapy pill (cyclophosphamide) daily, and the other took a hormone pill (megestrol). The goal was to see which treatment could slow cancer growth for…

This phase 2 study tested the drug erdafitinib in 316 adults and children with advanced solid tumors that have specific FGFR gene mutations or fusions. The main goal was to see if the drug could shrink tumors. Participants took erdafitinib tablets daily. The study is now complete…

Researchers are testing whether combining cetuximab, a drug that blocks tumor growth, with stereotactic body radiation therapy can help patients whose head and neck cancer has returned after earlier radiation and cannot be removed by surgery. The trial enrolls about 45 people wit…

This study tests a combination of laser heat therapy (LITT) and the immunotherapy drug pembrolizumab in 32 adults with recurrent glioblastoma, an aggressive brain cancer. The laser heats and destroys hard-to-reach tumors, while pembrolizumab helps the immune system fight cancer c…

Researchers are testing whether adding vitamin B12 to standard chemotherapy helps people with pleural mesothelioma that cannot be removed by surgery. The trial gives participants pemetrexed and cisplatin, two chemotherapy drugs that block tumor cell growth in different ways, alon…

This early-phase trial tested two cancer drugs—imatinib mesylate and cyclophosphamide—given daily by mouth to 26 people with rare, advanced tumors that had no standard treatment. The main goal was to find the safest dose of imatinib when combined with a fixed dose of cyclophospha…

Researchers are testing a radiation technique called PULSAR in people with metastatic cervical cancer. PULSAR delivers radiation in short bursts to pelvic tumors, guided by imaging, alongside standard systemic therapy. The trial aims to see whether this approach improves overall …

This study tested whether adding the drug nintedanib to standard chemotherapy (docetaxel) helps people with advanced HER2-negative breast cancer live longer without their disease getting worse. Fifty-one adults who had already received some treatment took part. The goal was to se…

Researchers are testing an experimental immunotherapy called GNR-051 in adults with advanced lung cancer, kidney cancer, or melanoma that has returned or not responded to other treatments. The Phase 1 trial aims to find the highest dose people can tolerate and to track side effec…

This early-phase trial tested a new drug called TdCyd in 27 adults with advanced solid tumors that had stopped responding to standard treatments. The drug is designed to turn back on genes that may slow tumor growth. The main goal was to find a safe dose and check for side effect…

This study tests two experimental drugs, ERAS-007 and ERAS-601, in people with advanced solid tumors that have not responded to standard treatments. The drugs are taken orally and aim to block signals that help cancer grow. The trial will first find safe doses and then check if t…

This early-phase trial tested whether adding nilotinib (a pill) to paclitaxel (a chemotherapy) is safe and tolerable for people with advanced solid tumors that no longer respond to standard treatments. The study included 47 adults and children aged 12 and older. Researchers aimed…

This early-phase study tests a new drug called ERAS-601, alone or with other cancer treatments, in adults with advanced solid tumors that have not responded to standard therapies. The main goals are to find safe doses and check for side effects. About 90 participants will take pa…

This early-phase trial tested a combination of two chemotherapy drugs (gemcitabine and carboplatin) plus lenalidomide, a drug that blocks blood vessel growth in tumors, in 18 adults with advanced solid tumors, especially urothelial (bladder) cancer. The main goal was to find the …

This early-phase study tested a new approach for people whose B-cell cancers (like lymphoma or leukemia) came back after a donor stem cell transplant. Researchers took white blood cells from the original donor, genetically modified them to recognize and attack cancer cells, and g…

This study tests a mix of antibodies that help the immune system fight cancer, block tumor growth signals, and cut off the tumor's blood supply. It is for adults with head and neck cancer that did not respond to prior treatment or has no standard options. Participants receive inf…

This study tests whether adding the immunotherapy drug nivolumab (Opdivo) to standard radiation and hormone therapy is safe and effective for men with a very aggressive form of prostate cancer (Gleason grade group 5). About 44 men will receive the drug combination. The goal is to…

Researchers are testing whether adding simvastatin, a widely used cholesterol-lowering drug, to zoledronic acid helps women with breast cancer that has spread to bone. Thirty-five women who have already received chemotherapy receive either simvastatin or a placebo alongside zoled…

Researchers are testing a combination of L-DEP chemotherapy (aspargase, liposomal doxorubicin, etoposide, and methylprednisolone) and a PD-1 antibody as initial treatment for people with Epstein-Barr virus-positive lymphoma-associated hemophagocytic lymphohistiocytosis, a rare an…

Researchers are testing whether adding AGuIX, a gadolinium-based nanoparticle, to whole brain radiation therapy improves how well brain metastases shrink in adults whose cancer has spread to the brain. Participants receive standard whole brain radiation, and some also receive thr…

This study tests whether adding darolutamide to standard hormone therapy (ADT) can delay cancer worsening in men with metastatic hormone-sensitive prostate cancer. About 223 men will receive darolutamide plus ADT, and their results will be compared to men from an earlier study wh…

This study tested a radioactive drug called 177Lu-PSMA-617 in 62 Chinese men with advanced prostate cancer that had spread and stopped responding to hormone therapy and chemotherapy. The drug targets a protein on cancer cells and delivers radiation directly to them. Researchers m…

This early-phase trial tests a new approach for advanced head and neck cancer that has stopped responding to standard treatments. Doctors take a patient's own tumor-fighting immune cells (TILs), grow more of them in a lab, and give them back along with the immunotherapy drug Keyt…

Researchers test whether adding high-dose radiotherapy to standard chemoembolization slows tumor growth better than chemoembolization alone in adults with hepatocellular carcinoma. Participants have liver tumors up to 9 cm that cannot be removed by surgery or treated with percuta…

Adults with B-cell acute lymphoblastic leukemia that has come back or stopped responding to treatment have few options. This phase 2 trial tests whether adding epratuzumab, an antibody that attaches to the CD22 protein found on most of these leukemia cells, to standard chemothera…

This phase II trial is testing an oral drug called giredestrant in 30 people with grade 1 endometrial cancer. The goal is to see if the drug can shrink or control the cancer over 6 months. Participants take one pill daily for up to 24 cycles, and doctors monitor tumor changes and…

This study tests a radioactive drug called 177Lu-PSMA-617 in men with advanced prostate cancer that has stopped responding to hormone therapy. The drug seeks out and delivers radiation directly to cancer cells. The trial aims to find the safest effective dose and see if it can lo…

This study tests whether adding tiragolumab to atezolizumab can help control esophageal cancer that hasn't grown after standard chemoradiotherapy. About 760 adults with inoperable esophageal squamous cell carcinoma will receive either the drug combination, atezolizumab alone, or …

Lentigo maligna is an early form of melanoma that appears on sun-exposed skin, often on the face. Doctors usually remove it with surgery, but it can be hard to decide how much tissue to take. This trial tests whether applying imiquimod cream for four weeks before surgery can shri…

Researchers compare two three-drug combinations, VTD and VCD, as initial treatment for people newly diagnosed with multiple myeloma who are eligible for a stem cell transplant. Participants receive four cycles of either combination. The trial measures how well each combination re…

Researchers are testing whether adding tocilizumab, a drug that blocks an inflammation signal called IL-6, to standard chemotherapy helps adults with high-risk acute myeloid leukemia. Participants receive idarubicin and cytarabine, the usual induction chemotherapy, plus a single …

Researchers are testing a combination of three drugs, obinutuzumab, ibrutinib, and GDC-0199, in people with mantle cell lymphoma. The trial includes patients whose cancer has come back or stopped responding to treatment, as well as those who have not yet received treatment. The g…

Researchers are testing a two-step radioimmunotherapy for people with medullary thyroid cancer that has come back. Participants receive a bispecific antibody followed by a radioactive peptide. The goal is to see if this targeted radiation can shrink tumors and how safe it is.

Researchers are testing whether adding brain radiotherapy to PD-1/PD-L1 inhibitors and chemotherapy helps people with untreated stage IV non-small cell lung cancer that has spread to the brain. The trial enrolls about 40 adults whose tumors lack common driver mutations and whose …

This early-phase trial tests a new drug called AI-061, which combines two immune-boosting antibodies (anti-PD-1 and anti-CTLA-4) into one treatment. The study will enroll 18 adults with advanced solid tumors that have spread or cannot be removed. The main goals are to find a safe…

Researchers are testing a combination of carfilzomib, melphalan, and prednisone in adults over 65 with newly diagnosed multiple myeloma. The trial first aims to find the highest dose of carfilzomib that people can tolerate without severe side effects. Then it will measure how wel…

This study tests a combination of two drugs, abemaciclib and ramucirumab, in people with advanced esophageal or gastroesophageal junction cancer that has spread. The goal is to see if this treatment is safe and can help control tumor growth. About 8 participants are enrolled, and…

This study tests a new drug, Tuvusertib, combined with an immunotherapy called Cemiplimab in people with a specific type of advanced lung cancer (non-squamous non-small cell) that has worsened after prior treatments. The trial aims to see if the combination can shrink tumors and …

This Phase 2 trial tests two experimental drug combinations in 63 women with a specific type of ovarian cancer (BRCA-mutant or HRD-positive) that has worsened after prior PARP inhibitor treatment. Participants receive either tuvusertib plus niraparib or tuvusertib plus larteserti…

Researchers are testing whether adding the experimental drug MLN9708 to lenalidomide and dexamethasone can help adults under 66 with newly diagnosed multiple myeloma. Participants receive three cycles of the triplet, then a stem cell transplant, followed by more triplet and maint…

This early-stage trial is testing a new drug called tuvusertib, given together with either lartesertib or avelumab, in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety, find the best dose, and see how the body pr…

Researchers are testing whether regorafenib, a daily oral drug, works as well as standard combination chemotherapy for people with newly diagnosed metastatic colorectal cancer. The trial enrolls adults with good performance status who have not yet received treatment for metastati…

Researchers are testing a combination of the experimental antibody MEDI5752 and stereotactic body radiotherapy in people with metastatic soft tissue sarcoma that has spread to the lungs. MEDI5752 targets two immune checkpoints, PD-1 and CTLA-4, and the radiation is aimed at one l…

Researchers are testing lurbinectedin, an intravenous chemotherapy drug, in adults with advanced gastrointestinal cancers that carry mutations in DNA repair genes. The trial enrolls a small group of participants whose tumors are locally advanced or metastatic and who have specifi…

Researchers are testing whether giving radiation therapy before sipuleucel-T, a personalized immunotherapy vaccine, works better than the vaccine alone in men with hormone-resistant prostate cancer that has spread. The trial enrolls about 51 participants and randomly assigns them…

This study tested a new device that uses focused ultrasound (histotripsy) to break apart solid kidney tumors without making any cuts. Twenty adults with small, non-spreading kidney tumors were treated. The main goals were to see if the device could fully cover the tumor and if th…

Researchers are comparing two doses of chest radiation therapy, 45 Gy and 70 Gy, in people with limited-stage small cell lung cancer. All participants also receive chemotherapy with cisplatin or carboplatin plus etoposide. The trial measures overall survival to see whether the hi…

This study tested whether eating less fat and more fiber can reduce the chance of a repeat Clostridioides difficile infection in cancer patients. Eight participants with leukemia, lymphoma, or other cancers followed a specific diet. Researchers tracked diarrhea and measured C. di…

Researchers are studying whether an enhanced package of care helps people with advanced HIV in Malawi stay in treatment and keep the virus suppressed. The package adds CD4 and TB-LAM tests and starts patients on TB preventive therapy, delivered through a hub-and-spoke system of c…

Researchers are testing whether a liposomal chemotherapy drug called CPX-351 works better than standard chemotherapy before an allogeneic stem cell transplant in adults with higher-risk myelodysplastic syndromes (MDS) or oligoblastic acute myeloid leukemia (AML). The trial enroll…

This trial tests a treatment called Melphalan/HDS for people whose eye melanoma has spread to the liver. The approach delivers high-dose melphalan, a chemotherapy drug, straight into the liver through a device system while limiting exposure to the rest of the body. Researchers wa…

This study tests whether adding immunotherapy drugs (nivolumab, with or without BMS-986205) to standard chemotherapy before and after bladder cancer surgery helps more people achieve a complete response and live longer without the cancer returning. About 855 adults with muscle-in…

This study tests whether adding an immunotherapy drug (atezolizumab) to standard chemotherapy and targeted therapy (trastuzumab) can better shrink HER2-positive stomach or gastroesophageal junction cancer before surgery. About 42 adults with advanced but removable tumors will rec…

This early-phase trial tested a new drug called vilastobart, alone or with another drug (atezolizumab), in 125 people with advanced solid tumors that had stopped responding to standard treatments. The main goals were to check safety and find the right dose. Researchers also looke…

Researchers are studying a spinal implant called the EVOS Lumbar Interbody System, which uses PEEK-OPTIMA HA enhanced cages, in adults with degenerative disc disease or grade 1 spondylolisthesis in the lower back. The study follows participants who receive the device during spina…

This pilot study tested a new, non-invasive way to locate multiple small lung nodules (under 20 mm) before surgery, comparing it to the standard CT-guided needle method. Forty people with early-stage lung cancer took part. The goal was to see if the new method could help surgeons…

Researchers are testing an experimental drug called MRG003, both by itself and combined with the immunotherapy drug HX008, in people with head and neck squamous cell carcinoma that has come back or spread. Participants have already tried standard treatments like platinum chemothe…

This phase 2 trial tested a combination of an injected drug (LTX-315) and an intravenous immunotherapy (pembrolizumab) in 23 people with advanced melanoma that no longer responded to standard PD-1/PD-L1 inhibitors. The goal was to see if the combination could shrink tumors or slo…

Researchers are testing whether combining ibrutinib and venetoclax can help people with previously untreated chronic lymphocytic leukemia or small lymphocytic lymphoma. The trial assigns participants to either a fixed course of the two drugs or a course guided by a sensitive test…

This study tests a drug called apatinib combined with two chemotherapy drugs (irinotecan and temozolomide) in children aged 5 to 18 with neuroblastoma that has returned or not improved after standard treatment. The goal is to see if the combination can shrink tumors and help chil…

This study tests a drug called mogamulizumab in 23 Chinese adults with mycosis fungoides or Sézary syndrome, two types of skin lymphoma that have not responded to previous treatments. The drug is given as an IV infusion and aims to shrink or eliminate cancer in the skin, lymph no…

This early-phase study tests whether Mozobil, a drug already used to boost stem cells for transplants, can safely raise white blood cell counts in people with WHIMS. WHIMS is a rare genetic condition that traps infection-fighting cells in the bone marrow, leading to frequent infe…

Researchers are testing an experimental drug called MRG003 in adults with EGFR-positive advanced non-small cell lung cancer that has worsened after at least two standard treatments. The trial enrolls about 87 participants across multiple sites and gives MRG003 intravenously as a …

This phase III trial compares two consolidation treatments for people with relapsed or refractory follicular lymphoma whose cancer has shrunk after chemotherapy. Participants receive either a radioactive antibody called Zevalin or high-dose chemotherapy followed by an autologous …

Researchers are reviewing records from 200 adults who received CyberKnife stereotactic radiosurgery for vestibular schwannomas, benign tumors on the nerve that controls hearing and balance. The study compares MRI scans before and after treatment to see if the tumors shrink or sto…

This phase 2 trial is testing a drug called ado-trastuzumab emtansine (Kadcyla) in 131 adults with advanced solid tumors that have a specific HER2 gene change. The drug combines an antibody that targets HER2 with a chemotherapy agent, aiming to deliver treatment directly to cance…

This study tests whether gabapentin, an FDA-approved medication, can help restore the balance of key brain chemicals (GABA and glutamate) in people with bipolar disorder who also use cannabis. Participants are randomly assigned to receive either gabapentin or a placebo for 17 day…

Researchers are testing an experimental drug called MRG003 in adults with biliary tract cancer that is EGFR-positive and cannot be removed by surgery or has spread. The trial enrolls people whose cancer worsened after at least one standard treatment. Everyone receives MRG003 by i…

This study tests whether adding the immunotherapy drug nivolumab to standard chemotherapy (carboplatin) helps people with metastatic triple-negative breast cancer live longer without their disease getting worse. About 78 participants with advanced cancer that has spread will rece…

This trial tests whether patient-specific PEEK implants, custom-made plastic pieces, can rebuild the bone under the eye after surgery to remove part of the upper jaw due to tumors. The goal is to keep the eye in its natural position and avoid a sunken appearance or vision problem…

Researchers are testing whether a combination of venetoclax and a three-day course of decitabine works better than the standard pairing of venetoclax and azacitidine for older or unfit adults newly diagnosed with acute myeloid leukemia. The trial enrolls 154 participants and comp…

This phase 2 trial tests whether simvastatin, a widely used cholesterol-lowering drug, can prevent liver cancer in 52 adults with liver cirrhosis. Participants take simvastatin and are monitored with blood tests and imaging to see if cancer-related markers change. The goal is to …

Researchers are testing whether combining bevacizumab, a drug that blocks new blood vessel growth, with Optune, a device that delivers electric fields to the brain, can help people with recurrent high-grade meningioma. Participants wear the Optune device for at least 18 hours a d…

This early-phase study tests a new drug called AB680, combined with immunotherapy (zimberelimab) and two chemotherapy drugs (nab-paclitaxel and gemcitabine), in people with advanced pancreatic cancer that has spread. The main goals are to check safety and find the right dose. Abo…

This phase 2 trial tests a new COVID-19 booster vaccine (GEO-CM04S1) in 80 people with chronic lymphocytic leukemia (CLL). The goal is to see if this vaccine triggers a stronger immune response than standard mRNA boosters. Participants will receive either the new vaccine or a sta…

This phase 1 trial is testing whether a diet that severely limits arginine—an amino acid some tumors depend on—is safe and might help control solid tumors. About 25 adults with solid tumors will follow a specially designed low-arginine liquid diet for two 3-week cycles while cont…

This study tests a device that delivers specific light and sound patterns to the brain, aiming to slow the progression of mild-to-moderate Alzheimer's disease. About 670 participants will use the device at home for an hour daily over a year, with half receiving a sham (inactive) …

This trial tests whether removing lung nodules with non-intubated video-assisted thoracic surgery, which avoids a breathing tube and ventilator, helps patients recover faster and feel better than traditional intubated surgery. Researchers will compare symptom burden, quality of l…

This phase 2 trial tests whether adding an experimental drug called pixatimod to the immunotherapy nivolumab can shrink tumors in people with advanced melanoma, non-small cell lung cancer, or colorectal cancer that has stopped responding to prior treatment. One group with colorec…

This early-stage trial tested a combination of two oral drugs, tipifarnib and alpelisib, in 45 adults with recurrent or metastatic head and neck squamous cell carcinoma that has specific genetic changes (HRAS overexpression or PIK3CA mutations). The goal was to find a safe dose a…

This phase II trial tests whether giving a combination of inetetamab, pyrotinib, and nab-paclitaxel before surgery can eliminate cancer in women with HER2-positive early or locally advanced breast cancer. Participants receive four cycles of the drugs, then undergo surgery. The ma…

This phase 3 trial tests whether giving recombinant human thyrotropin (rhTSH) injections before radioactive iodine can effectively destroy leftover thyroid tissue after surgery for differentiated thyroid cancer. Normally, patients must stop thyroid hormone medication to raise TSH…

This study tested two new treatments for people with small cell lung cancer that came back after initial chemotherapy. The experimental drugs, lurbinectedin alone or with irinotecan, were compared to standard treatments (topotecan or irinotecan). The goal was to see if the new op…

This phase 3 trial tested whether a combination of sitravatinib (a targeted drug) and nivolumab (an immunotherapy) works better than docetaxel (standard chemo) for people with advanced non-squamous non-small cell lung cancer that got worse after platinum chemo and checkpoint inhi…

This study tests a chemotherapy drug called CPX-351 in people under 60 with secondary acute myeloid leukemia (AML), a type of leukemia that develops after other blood disorders or cancer treatments. The goal is to see how well the drug can make the cancer disappear or improve blo…

This trial tests whether a steam-based treatment called Rezūm can work as well as standard surgery (TURP) for men with an enlarged prostate who need a catheter to urinate. Men aged 50 to 80 with this condition will be randomly assigned to receive either Rezūm or TURP. The main go…

Researchers are testing whether a device called ExAblate MRgFUS can safely and completely destroy small breast cancers using focused ultrasound waves guided by MRI. The trial enrolls women with a single invasive breast tumor smaller than 2 centimeters who are already scheduled fo…

This early-phase trial tests a new drug, SG1827, in people with advanced solid tumors that have stopped responding to standard treatments or have no standard therapy available. The main goals are to check the drug's safety, find the best dose, and get a first look at whether it c…

This trial studies people with advanced non-small cell lung cancer who have already tried platinum-based chemotherapy. Researchers compare those who receive immunotherapy with those who receive standard chemotherapy as a second-line treatment. The goal is to see which approach he…

This pilot study tested a wearable device that delivers low-intensity electric fields (TTFields) together with immunotherapy (atezolizumab) and two chemotherapy drugs (gemcitabine and nab-paclitaxel) in 84 people with metastatic pancreatic cancer who had not received prior treatm…

This early-stage trial tests an experimental drug called SG2918 in 17 people with advanced cancers that no longer respond to standard treatments. The main goal is to check safety and find the right dose, not yet to prove it works. Participants receive the drug by IV every three w…

This phase 2 trial tests whether giving recombinant human thyroid stimulating hormone (rhTSH) before radioactive iodine can improve the destruction of leftover thyroid tissue after surgery in people with differentiated thyroid cancer. Participants receive either rhTSH injections …

This phase II trial tests whether giving chemotherapy and proton beam radiation before surgery can help people with borderline-resectable pancreatic cancer. The goal is to shrink the tumor enough so that surgeons can remove it completely, with no cancer cells left at the edges. P…

This study tests a decision model that aims to predict whether a person with unresectable hepatocellular carcinoma, a type of liver cancer, will benefit more from transarterial chemoembolization (TACE) alone or TACE combined with atezolizumab plus bevacizumab. Researchers will de…

This study tests whether tailored vitamin and mineral supplements can correct nutrient deficiencies that often follow surgery for esophageal or gastric cancer. Researchers will enroll 107 adults who had either an esophagectomy or a (sub-)total gastrectomy for cancer and show no s…

This phase 2 trial tests whether adding triamcinolone 0.1% ointment to Valchlor gel reduces contact dermatitis, a common skin reaction, in people with early-stage cutaneous T-cell lymphoma. Participants apply Valchlor nightly, with or without the steroid up to three times daily, …

This study tests whether giving higher doses of radiation, guided by MRI, can help people with pancreatic cancer that cannot be removed by surgery. Participants must have already had several months of chemotherapy without the cancer spreading. The goal is to see if this approach …

This phase 3 study tests whether a new combination of two immunotherapy drugs (domvanalimab and zimberelimab) plus chemotherapy works better than the current standard (nivolumab plus chemotherapy) for people with advanced stomach, gastroesophageal junction, or esophageal cancer t…

This Phase 3 trial tests an oral drug called QLG1080 in men with hormone-sensitive advanced prostate cancer. The goal is to see if the drug can safely lower testosterone to castration levels, which helps slow cancer growth. Participants must be eligible for endocrine therapy and …

This early-stage trial is testing whether a pill made from freeze-dried healthy donor stool (MTP-101P) is safe and can restore good bacteria in people having part of their colon removed. Forty adults aged 18-75 with colon polyps, early-stage cancer, or diverticulitis will take th…

This study tested three flavors of Supportan® drink (Tropical Fruits, Cappuccino, and Pineapple-Coconut) in 123 cancer patients undergoing chemotherapy, radiotherapy, immunotherapy, or targeted therapy. Patients drank two bottles daily for four weeks alongside their normal diet. …

This study tested whether adding a Chinese herbal formula (QingyiHuaji) to standard chemotherapy helps people with stage IV pancreatic cancer live longer. About 305 adults with advanced pancreatic cancer were randomly assigned to receive either the herbal formula plus chemo or a …

This phase 1 trial tests a genetically engineered virus called C134, made from a herpes simplex virus, in people with recurrent malignant glioma, a type of brain cancer. The virus is injected directly into the tumor, where it aims to infect and kill cancer cells while also trigge…

This trial tests an experimental drug called FLX475, given alone or with the immunotherapy pembrolizumab, in people with advanced cancers that have not responded to standard treatments. The study aims to find the safest dose and to see whether the combination can shrink tumors. P…

This early-phase trial tested the drug enasidenib in 17 people with low-risk myelodysplastic syndrome or a related leukemia who had anemia and did not have a specific gene mutation. The goal was to see if the drug could safely improve red blood cell counts and reduce the need for…

This study looks at how well different immunochemotherapy combinations, such as RCHOP, BR, and RCVP, work for people with small B-cell non-Hodgkin lymphoma. Researchers will track 206 adults with this type of lymphoma to see how many respond to treatment and how long they stay fr…

This pilot study tests whether injecting a corticosteroid called dexamethasone directly into the salivary glands can prevent dry mouth in people receiving radiation therapy for head and neck cancer. Researchers will enroll 10 adults with certain types of throat cancer who are sch…

This phase II trial tests whether combining niraparib and dostarlimab can control metastatic pancreatic cancer in people who carry BRCA1/2 or PALB2 gene mutations. Niraparib blocks enzymes that cancer cells need to grow, while dostarlimab helps the immune system attack the tumor.…

This study looks at whether eating a high-fiber diet (over 21 grams per day) can change gut bacteria and improve the immune system's ability to fight solid tumors like colorectal cancer. About 25 adults with solid tumors will follow this diet to see if it is safe and helps with t…

This phase III trial compares two radiation schedules for women with high-risk breast cancer who have had a mastectomy. One group receives hypofractionated radiation, which uses fewer but larger daily doses over a shorter period. The other receives conventional radiation, with sm…

This trial tests an experimental drug called zanidatamab, which targets HER2, a protein that fuels certain breast and stomach cancers. Researchers give zanidatamab alongside chemotherapy, and sometimes with the immunotherapy tislelizumab, to people with advanced HER2-positive bre…

This trial tests whether adding a Braun anastomosis, an extra connection between two parts of the small intestine, during standard pancreatic surgery helps prevent delayed gastric emptying. Delayed gastric emptying is a common complication where the stomach is slow to empty food,…

This early-phase trial tests a combination of two immunotherapy drugs (nivolumab and ipilimumab), a vaccine targeting TGFβ-15, and targeted radiation for pancreatic cancer that has not responded to standard treatments. The goal is to see if this mix can safely boost the immune sy…

This trial asks whether women with early breast cancer who have lumpectomy and whole-breast radiation can safely skip the sentinel lymph node procedure, a biopsy of the first lymph node under the arm. The procedure helps check if cancer has spread, but it can cause arm swelling a…

This phase 2 trial tests a personalized cell therapy called Lete-Cel in 7 people with advanced synovial sarcoma or myxoid/round cell liposarcoma that has not been treated before. Participants receive their own immune cells that have been engineered to recognize and attack their c…

This trial tests whether applying tranexamic acid directly to the wound during a mastectomy reduces the amount and duration of fluid drainage afterward. Researchers will compare 30 patients who receive the topical drug with 30 who get standard postoperative care. The goal is to s…

This pilot study tested a drug called BGJ398 in 4 people with a type of bladder cancer that stays in the bladder lining but keeps coming back after standard treatment. The drug targets tumors with a specific genetic change (FGFR3 mutation or fusion). The main goal was to see if t…

This study tested whether adding the immunotherapy drug pembrolizumab to standard hormone therapy (enzalutamide plus ADT) could help men with metastatic hormone-sensitive prostate cancer live longer or delay cancer growth. The trial enrolled 186 Chinese men and was stopped early …

This trial tests whether giving a combination of two chemotherapy drugs, gemcitabine and cisplatin, before surgery can shrink high-grade tumors in the upper urinary tract, a type of kidney cancer. Participants receive four cycles of the drugs over about 12 weeks, followed by surg…

This phase III trial compares two chemotherapy approaches for children and young adults with previously untreated low grade glioma, a type of brain or spinal cord tumor. One group receives the standard combination of carboplatin and vincristine, while the other receives carboplat…

This phase 2 study tested two drugs—durvalumab and cetuximab—together in 35 people with head and neck cancer that had come back or spread and was no longer responding to standard treatments. The goal was to see if the combination could shrink tumors. The study is complete, and re…

This trial tests whether adding Lonsurf (trifluridine/tipiracil) to standard chemotherapy can help control metastatic colorectal cancer. Researchers will enroll about 97 adults in Taiwan whose cancer has progressed after prior treatments, including anti-VEGF therapy. Participants…

This trial tests whether adding venetoclax to a standard chemotherapy pair (cytarabine and mitoxantrone) can help adults with acute myeloid leukemia that has relapsed or not responded to initial treatment. In the first phase, researchers find the highest safe dose of cytarabine w…

This trial tests two drugs, degarelix and triptorelin, in premenopausal women with hormone-sensitive breast cancer. Both drugs temporarily stop the ovaries from making estrogen, which can fuel tumor growth. Women receive one of the drugs along with the hormone therapy letrozole f…

This trial tests three different schedules of the chemotherapy drug nab-paclitaxel (Abraxane) in women with HER2-negative metastatic breast cancer. The goal is to find a schedule that allows patients to stay on treatment longer, potentially improving progression-free survival, wh…

This phase 2 trial tests a combination of four drugs, selinexor, bortezomib, lenalidomide, and dexamethasone (SVRd), in people newly diagnosed with multiple myeloma whose disease has spread outside the bone marrow, called extramedullary disease. The study aims to see how well thi…

This trial tests an experimental drug called SNS-101, which targets a protein called VISTA that may help tumors evade the immune system. Researchers give SNS-101 alone or with another immunotherapy, cemiplimab, to adults with advanced solid tumors that have not responded to stand…

This Phase 3 trial tested whether adding the immunotherapy drug retifanlimab to standard chemotherapy (carboplatin and paclitaxel) helps people with advanced anal cancer that cannot be removed by surgery. The study enrolled 308 adults who had not received chemotherapy for their a…

This trial tests whether combining the immunotherapy drug atezolizumab with precise, high-dose radiation (SABR) can better control metastatic cancers, including colorectal, lung, kidney, and sarcoma. The idea is that radiation may make tumors more visible to the immune system, wh…

This trial tests whether giving the chemotherapy drug mitomycin C into the bladder just before tumor removal works better than giving it right after. The goal is to reduce the chance that non-muscle-invasive bladder tumors come back. Adults with one or two bladder tumors will be …

This study tests whether eating wild blueberry powder every day can lower blood pressure and improve blood vessel health in middle-aged and older men and postmenopausal women with slightly high blood pressure. Researchers will measure artery function and stiffness over time. The …

This trial tests whether combining two DNA-based immunotherapies with the drug atezolizumab can help people with advanced urothelial carcinoma, a type of cancer of the bladder and urinary tract. The DNA therapies are injected into muscle and followed by a brief electric pulse to …

This trial tests whether combining cabozantinib, a drug that blocks tumor blood vessel growth, with avelumab, an immunotherapy that boosts the immune system, can control advanced neuroendocrine neoplasia G3 (NEN G3). The study enrolls adults whose cancer has progressed after at l…

This phase III trial tests whether taking letrozole continuously for five years is better than taking it in cycles with breaks, for postmenopausal women who have already had 4 to 6 years of hormone therapy for early-stage, hormone-receptor-positive breast cancer. Letrozole works …

This phase II trial tested the drug alisertib, alone or combined with fulvestrant, in 96 postmenopausal women with advanced breast cancer that no longer responds to hormone therapy. Alisertib blocks enzymes that help cancer cells grow, while fulvestrant blocks estrogen. The goal …

This early-phase trial tests a new therapy for Hodgkin and non-Hodgkin lymphoma that has returned or not responded to standard treatment. Researchers take a patient's own immune cells, train them in the lab to recognize five cancer-specific proteins (tumor-associated antigens), a…

This study tested two different treatment plans for people with a specific type of pancreatic cancer that is on the edge of being removable by surgery. 130 patients received either chemotherapy alone or chemotherapy plus radiation before surgery. The goal was to see which approac…

This trial tests whether giving a higher radiation dose during brachytherapy, a type of internal radiation, can improve local control in patients with locally advanced cervical cancer. Participants receive standard external beam radiation and chemotherapy, plus a boosted brachyth…

This early-phase trial tested whether giving activated natural killer (NK) cells, with or without a protein called rhIL15, is safe and feasible for children and young adults with solid tumors that didn't respond to other treatments. Sixteen participants received chemotherapy to l…

This trial is testing whether combining the immunotherapy drug pembrolizumab with other experimental agents can help people with advanced melanoma whose cancer has stopped responding to standard anti-PD-1 treatment. The study includes several treatment arms, each pairing pembroli…

This phase 2 trial tests a new drug combination called MK-4280A (favezelimab plus pembrolizumab) against standard chemotherapy in people with classical Hodgkin lymphoma that has come back or stopped responding to treatment. About 200 participants will be randomly assigned to rece…

This trial compares two types of radiation therapy for prostate cancer: proton therapy and standard photon therapy. The main question is whether proton therapy reduces moderate to severe urinary or intestinal side effects. Researchers will also track quality of life, cancer recur…

This study tested a daily medication called acalabrutinib in 552 adults with chronic lymphocytic leukemia (CLL), a type of blood cancer. Participants included those newly diagnosed, those whose cancer returned, and those who had previously taken a similar drug. The goal was to se…

This phase 2 trial is testing whether combining the immunotherapy drug tislelizumab with other experimental drugs (surzebiclimab or alcestobart) can shrink tumors or slow cancer growth in people with advanced head and neck cancer that has come back or spread. About 160 participan…

This phase 2 study is testing a combination of three drugs—paclitaxel (a chemotherapy), pembrolizumab (an immunotherapy), and olaparib (a targeted therapy)—in 36 adults with advanced gastric or gastroesophageal cancer that has worsened after one prior treatment. The goal is to se…

This early-phase trial is testing whether combining two drugs—pembrolizumab (Keytruda) and ibrutinib (Imbruvica)—can safely treat advanced melanoma that cannot be removed by surgery. Pembrolizumab helps the immune system fight cancer, while ibrutinib blocks enzymes that help canc…

This trial tests a structured diet and exercise program for overweight Chinese cancer survivors. The program, led by a dietitian and a cancer exercise specialist, teaches weight loss strategies, healthy eating, and physical activity. Researchers want to see if the program is prac…

This trial tests two ways of delivering Cyberknife radiation to people with acoustic neuromas, benign tumors on the hearing nerve. One group receives a single radiation session, while the other receives three sessions. The goal is to see which approach better preserves useful hea…

This study tests whether dietary nitrate from beetroot juice can disrupt the altered metabolism of breast cancer cells. Researchers will give a concentrated beetroot juice drink for five days to patients scheduled for breast cancer surgery. Using advanced MRI scans, they will mea…

This trial tests whether stereotactic ablative body radiation (SAbR), a precise form of high-dose radiation, can delay the need for systemic therapy in people with oligometastatic renal cell carcinoma, meaning kidney cancer that has spread to a few limited sites. Researchers will…

This Phase 2 trial tests a new way of delivering radiation therapy (SIB-IMRT) together with standard chemotherapy (5-FU and Mitomycin-C) for people with locally advanced anal cancer. The goal is to see if this approach can improve tumor control and reduce the severe side effects …

This early-stage trial is testing whether combining the immunotherapy drug pembrolizumab with a personalized vaccine made from a patient's own tumor cells can help the immune system attack recurrent glioblastoma, a type of brain cancer that has returned after initial treatment. T…

This phase 1 trial tested the combination of dasatinib (a pill) and bevacizumab (an infusion) in 50 adults with advanced solid tumors that no longer respond to standard treatments. The goal was to find the safest dose and see how well the two drugs work together to slow cancer gr…

This study looks at whether it's possible to increase fiber intake in people with colorectal cancer before they have surgery. Researchers will compare personalized digital dietary advice, a dried vegetable product, and usual diet in 54 participants. The goal is to see if fiber in…

This trial tests whether multisession radiosurgery, a type of focused radiation delivered in several sessions using the Cyberknife system, can safely control atypical meningiomas that remain or come back after surgery. The study enrolls adults with grade II meningiomas who have r…

This study tests whether giving 6 months of hormone therapy before surgery helps remove all cancer cells in women with early-stage, estrogen-positive breast cancer. It involves 8 postmenopausal women with low-risk, node-negative tumors. The goal is to see if this approach leads t…

This phase II trial tests whether combining two immunotherapy drugs, nivolumab and relatlimab, can shrink tumors in people with metastatic melanoma who have not yet received immunotherapy. Nivolumab helps immune cells attack cancer, while relatlimab blocks a different brake on th…

This trial follows 178 adults with benign meningiomas that are large, medium-sized, or located near critical brain areas. Researchers use a robotic system called CyberKnife to deliver radiation in multiple sessions, aiming to control tumor growth while limiting damage to nearby h…

This phase 1 trial tests an experimental drug called MRG003 in people with advanced solid tumors, including colorectal cancer, head and neck squamous cell carcinoma, and nasopharyngeal carcinoma. The study aims to find a safe dose and to see whether the drug can shrink tumors. Pa…

This pilot study tests whether a drug called trastuzumab, given with an immune booster (GM-CSF), can safely reach and treat recurrent ependymoma in children. Ten children with this rare brain tumor will receive the drugs to see if the treatment is safe and can be detected in the …

This study tests whether avatrombopag, a pill that boosts platelet production, can help people with gastrointestinal cancer who develop low platelets from chemotherapy. About 60 participants will receive either avatrombopag or a placebo. The goal is to see if the drug can raise p…

This trial tests whether combining two drugs, brentuximab vedotin (Adcetris) and bendamustine (Levact), can safely and effectively treat Hodgkin lymphoma in people aged 60 to 80 who have not had prior treatment. The standard therapy, ABVD, often causes lung damage in older adults…

This study tests whether multisession radiosurgery, a precise form of radiation delivered in several doses, can control optic nerve sheath meningiomas, benign tumors that grow around the nerve connecting the eye to the brain. Researchers will enroll about 50 adults with a single …

This trial tests whether a 12-week program of aerobic and resistance exercises can help people with gastrointestinal cancer and cachexia, a condition marked by severe weight and muscle loss. Researchers will compare an exercise group with a standard-care group, measuring changes …

This trial investigates whether combining two targeted drugs—erlotinib and bevacizumab—can help people with advanced non-small cell lung cancer that has specific EGFR mutations. The goal is to see if the combination extends the time before the cancer grows or spreads. Participant…

This phase 2 trial investigates whether afatinib, an oral targeted therapy, can control advanced non-small cell lung cancer (NSCLC) that carries a specific HER2 exon 20 mutation. Participants have already received prior chemotherapy and have stage IIIB or IV disease. The study me…

This trial is testing whether a blood test called VeriStrat can help choose between two drugs for people with advanced squamous non-small cell lung cancer that has progressed after initial chemotherapy. Participants are grouped by their VeriStrat result (good or poor) and then ra…

This trial is testing whether combining palbociclib and fulvestrant can help postmenopausal women with a specific type of advanced breast cancer (ER+/HER2-) that has stopped responding to prior treatments. The study aims to see how long the cancer stays under control and to look …

Researchers are studying whether features from pretreatment 18F-FDG PET/CT scans can predict how well people with metastatic kidney cancer respond to first-line targeted therapy plus immunotherapy. The study reviews medical records and imaging data from 228 patients treated at a …

Researchers are testing whether a combination of PET scans with a radioactive tracer called [18F]PSMA-1007, sodium MRI, and multiparametric MRI can accurately predict where prostate cancer is and how aggressive it is. The study enrolls men who are scheduled to have their prostate…

Researchers are studying whether PET scans help doctors plan radiation more precisely for people with locally advanced head and neck cancer. Participants receive 3-dimensional conformal radiation therapy and intensity-modulated radiation therapy, which shape beams to the tumor. T…

This Phase 3 trial tests a radioactive imaging agent called 18F-mFBG to see if it can accurately detect neuroblastoma, a type of childhood cancer. The study involves 43 participants who either have or are suspected of having neuroblastoma. Researchers will compare the new PET sca…

Researchers at Hanoi Medical University are studying whether two blood markers, AFP-L3 and PIVKA-II, can accurately detect hepatocellular carcinoma, the most common form of liver cancer. The trial enrolls 200 adults, including people with liver cancer and people with benign liver…

This study tests whether contrast-enhanced mammography (CEM) can safely reduce the number of breast biopsies for women with breast findings that are suspicious but not highly suspicious (BI-RADS 4A or 4B). About 2,100 women scheduled for a biopsy will first get a CEM. The goal is…

Researchers in Cameroon are comparing a new smart speculum with a standard speculum to see which gives better comfort for women and clearer views of the cervix. Each participant receives both exams in random order, and clinicians use the smart speculum's images to make remote dia…

Researchers are testing whether a fluorescent dye called cRGD-ZW800-1 can help surgeons see oral cancer tumors more clearly during surgery. The trial enrolls adults with squamous cell carcinoma of the mouth who are scheduled for tumor removal. Participants receive an injection of…

When a general practitioner spots a skin lesion that might be melanoma, the patient is referred to a dermatologist, but some never go and others wait too long. This trial tests whether the GP calling the dermatologist directly and emailing a smartphone photo of the lesion shorten…

Researchers are studying whether a blood test can detect the BRAF V600E mutation in people with melanoma. The trial enrolls patients with advanced melanoma and those with earlier-stage disease after surgery. By comparing blood samples to standard tumor tissue tests, they aim to s…

Researchers test a two-step PET scan to find colorectal cancer that has spread to the liver or other organs. The scan uses an antibody that sticks to a protein called CEA on cancer cells, then a radioactive peptide that lights up those cells. Adults with colorectal cancer that ma…

Researchers compare PET scans and MRI to see which imaging method detects more myeloma lesions in adults under 65 with newly diagnosed multiple myeloma. Participants receive both scans at diagnosis, after three cycles of chemotherapy, and at the end of treatment. The study also t…

Researchers at Washington State University are testing whether tailored digital messages can increase colorectal cancer screening among American Indian and Alaska Native adults aged 50 to 75. The trial compares screening rates between people who receive the messages and those who…

This study tests Cellvizio, a device that provides real-time, high-resolution views of tissues during gynecological surgery. Researchers want to see if it can help diagnose lesions and check surgical margins more accurately. The study will enroll 80 women undergoing laparoscopic …

This completed trial tested whether a 3D imaging device helps doctors more accurately classify colon polyps and adenomas during colonoscopy compared to standard 2D imaging. 460 adults with colorectal polyps were randomly assigned to either 3D or 2D imaging before polyp removal. T…

This study looked at whether a new at-home stool DNA test (Cologuard) can help more Alaska Native people get screened for colorectal cancer, which is very common in this group. About 2,000 Alaska Native adults who were due for screening took part. The test was offered in differen…

This study is testing whether an artificial intelligence program called Mirai can better identify women at high risk for breast cancer compared to traditional risk models. Researchers will invite 200 women flagged as high-risk by Mirai to receive an additional breast MRI. The goa…

This trial tests a blood-based test designed to detect multiple cancers early in people aged 40 to 74 who have no cancer symptoms. The study will enroll about 2,500 participants and will check how well the test identifies lung, colorectal, liver, gastric, and esophageal cancers. …

This study looked at whether a special PET scan (18FDG dual-point) can tell the difference between real tumor growth and harmless inflammation caused by immunotherapy. Researchers studied 100 people with advanced lung cancer or melanoma who were being treated with drugs like nivo…

This study investigates whether blood samples can reveal early warning signs of severe dry mouth in patients receiving radiation for head and neck cancer. Researchers will collect blood before and after treatment and use advanced molecular techniques to search for biomarkers that…

Researchers are testing whether a handheld device that shines a special light on the inside of the mouth can help clinicians spot suspicious areas that might be precancerous or cancerous. The study will have three dentists with different levels of experience examine 200 adults, i…

This study is testing whether a set of memory and thinking tests, usually done in person, can be given remotely over a video call. Researchers will compare results from in-person and remote versions to see if they match. If it works, it could make dementia assessments easier for …

This study tests whether a combination of serial C-reactive protein blood tests and targeted CT scans can safely identify which rectal cancer patients can skip a temporary ileostomy after laparoscopic low anterior resection. Anastomotic leakage is a serious complication, and a pr…

This study tests whether a blood test can help doctors tell apart uveitis caused by lymphoma from other types of uveitis. Uveitis is an eye inflammation that can lead to vision loss, and in some cases it is a sign of a rare eye lymphoma that may spread to the brain. The researche…

This study tests a special microscope that lets doctors check if all cancer cells have been removed during surgery for common skin cancers. About 42 adults with head, neck, or skin cancer will take part. The goal is to see if this quick method is as accurate as the standard lab t…

This trial tests whether indocyanine green, a dye injected before surgery, can find sentinel lymph nodes as reliably as the standard technetium-99 radioactive tracer. About 744 adults with various cancers will receive both agents, and surgeons will compare detection rates using a…

This trial investigates whether a blood test can detect circulating tumor cells (CTCs) in patients with advanced head and neck cancer. Researchers will take blood samples before, during, and after surgery, and use two different methods to count these cells. The goal is to see if …

Researchers are testing whether a standard MRI scanner can be used to create detailed 3D maps of fat molecules in the breast. The idea is that changes in fat composition may appear before cancer develops, so this could help detect very early breast cancers. The study will compare…

Researchers at Lund University Hospital are testing a new MRI technique called DIVIDE to see if it can measure how sensitive brain metastases are to radiation. Today, doctors only see whether radiation worked by watching tumor size change on scans weeks or months later. This tria…

This trial tests a device that uses a laser to scan the inside of the mouth and help detect pre-cancer and cancer. Currently, doctors rely on their eyes to decide where to take a biopsy, which can miss early signs. The device collects molecular information from the tissue, and th…

This study tests whether a dental assistant can help patients with head and neck cancer keep their mouths clean during and after radiotherapy. Patients receive oral hygiene education and a written guide before treatment starts. Researchers measure plaque levels at the beginning a…

Researchers are testing whether pirfenidone, a drug that reduces inflammation and scarring, can prevent radiation pneumonitis in people with advanced lung cancer. Participants have already received immune checkpoint inhibitors and need chest radiation. The trial gives pirfenidone…

Researchers are testing three ways to deliver the same breast cancer and early-detection education to adult women: a private Instagram account, a dedicated website, and an electronic brochure sent through WhatsApp. A fourth group receives no education. The study measures whether …

Researchers are testing whether giving azacitidine, a chemotherapy drug, together with donor lymphocyte infusions after a stem cell transplant can prevent relapse in people with high-risk acute myeloid leukemia or myelodysplastic syndrome. About 30 patients will receive the combi…

This phase III trial tests whether the immunotherapy drug durvalumab (MEDI4736) can prevent non-small cell lung cancer from returning after patients have surgery and possibly chemotherapy. Participants have completely resected stage IB, II, or IIIA lung cancer and are randomly as…

Researchers are testing whether low-dose tamoxifen or a 5:2 intermittent fasting diet can raise levels of a protein called sex hormone binding globulin (SHBG) in women at high risk of breast cancer. Higher SHBG levels have been linked to lower breast cancer risk. The trial enroll…

Researchers are testing whether a supplement made from nine fungal extracts, called MICODIGEST 2.0, can reduce complications after surgery for colorectal cancer. The trial enrolls 48 adults scheduled for curative-intent surgery. Half receive the supplement and half receive a plac…

Radiation for head and neck cancer often causes painful mouth sores called oral mucositis. Researchers are testing whether a probiotic, Lactobacillus rhamnosus GG, can prevent severe cases. The trial enrolls 160 adults with head and neck cancer who are scheduled for radiation. Ha…

This trial tests whether a software tool called the hypotension prediction index (HPI) can help prevent acute kidney injury after robotic-assisted urologic surgery. The tool uses arterial pressure data to forecast drops in blood pressure during the operation, allowing doctors to …

This trial tests whether using a technique called hybrid argon plasma coagulation (h-APC) on the edges of the removal site can prevent colon polyps from growing back after endoscopic mucosal resection (EMR). EMR is a standard procedure for removing large polyps, but when polyps a…

This study tested a program to increase colorectal cancer screening among adults aged 50-74 in 12 counties in Appalachian Kentucky and Ohio. The program included efforts targeting clinics, doctors, patients, and the community. Researchers measured screening rates using clinic rec…

This trial tests whether a structured education program can improve colorectal cancer knowledge, health beliefs, and screening uptake in adults aged 50-70. Participants are randomly assigned to receive the program—combining face-to-face teaching, a video, and a brochure—or to a c…

Researchers are testing whether a brief educational session helps Latina women who are overdue for cervical cancer screening use a mailed HPV self-sampling kit. Half of the participants receive the kit alone, and the other half also join a small-group session with a bilingual hea…

This trial tests whether a single high dose of vitamin A, given before a donor stem cell transplant, can prevent gastrointestinal graft-versus-host disease (GVHD), a condition where donor cells attack the gut. Vitamin A deficiency is linked to a higher risk of this complication, …

Researchers are testing whether a drug called eflornithine can reduce DNA damage in stomach cells that have precancerous changes. The trial enrolls adults aged 30 to 60 with atrophic gastritis or intestinal metaplasia, conditions that raise stomach cancer risk. Participants take …

This trial tests whether a one-hour group discussion helps Latino men aged 50 to 70 make informed decisions about PSA screening for prostate cancer. Participants receive either a printed pamphlet or an interactive session covering the benefits, risks, and controversy around PSA t…

This study tests whether women in Kazakhstan will accept self-sampling kits for HPV detection, a key step in preventing cervical cancer. Researchers will distribute three different self-sampling devices to 1,000 women and survey their willingness to use them. The goal is to see i…

This trial tests whether sending a colorectal cancer screening kit directly to people's homes, along with the invitation letter, increases the number of people who get screened. It compares this approach to the standard practice of asking people to visit their doctor to receive t…

Researchers compare two chest drain sizes, 20-Fr and 24-Fr, in people having part of a lung removed for early-stage lung cancer. After surgery, each participant receives one of the two drains to clear fluid and air from the chest. The trial tracks complications such as collapsed …

Researchers at Hanoi Medical University are testing whether personalized meals and diet coaching help stomach and colon cancer patients who are starting chemotherapy. About 120 adults receive tailored menus in the hospital, then learn to prepare high-energy, high-protein diets at…

This study tests whether remimazolam, a newer anesthetic, can reduce the risk of postoperative delirium (sudden confusion) in elderly patients undergoing laparoscopic stomach cancer surgery. Researchers will compare remimazolam to standard anesthesia in 170 patients aged 65 and o…

Researchers are testing whether the 4-7-8 breathing technique can reduce anxiety, ease symptom burden, and improve sleep quality in people receiving chemotherapy. The trial enrolls 64 adults undergoing their third treatment cycle, splitting them into a group that practices the br…

Researchers are testing an 8-session mindfulness-based self-compassion program for women diagnosed with breast cancer. The program combines meditation, yoga, and homework to help participants focus on the present moment. The trial measures changes in self-esteem and spiritual wel…

This trial tests whether immersive virtual reality or relaxing nature videos can reduce symptom severity, distress, and improve quality of life in people with lung cancer who are starting chemotherapy. Participants will be randomly assigned to one of three groups: virtual reality…

Researchers test a 10-week lifestyle program for people who have finished cancer treatment. The program combines structured exercise, nutrition counseling, and behavioral therapy. They compare it with a waitlist group to see how it affects cardiorespiratory fitness and body weigh…

Researchers test a guided exercise program for people aged 60 and older recovering from lung cancer surgery. The program combines breathing exercises, shoulder training, and strength work, taught through videos and a manual. The trial measures how far participants can walk in six…

This study tests whether a personalized 4-week exercise program can improve quality of life and physical function in men with metastatic prostate cancer who are receiving radiation therapy. Eighty participants will either exercise or not, and researchers will track changes in wel…

This study follows 500 breast cancer patients who receive targeted radiation therapy after surgery to remove their tumor. The goal is to track side effects and quality of life over time. Researchers want to understand how well patients tolerate this treatment and how it affects t…

Parents of children with complex medical conditions often feel unsure about managing their child's symptoms at home. This trial tests whether a mobile app with nurse support can help. Ninety-six parents receive either the app, which offers health checks, monitoring, education, an…

This study looked at two oral chemotherapy drugs, Xeloda and UFT with folinic acid, in 89 people with advanced or metastatic colorectal cancer. The main goal was to see which treatment patients preferred after trying both. The study also checked how safe each drug was. Results he…

This study tests whether a program combining resistance training and a Mediterranean diet is practical and helpful for people with head and neck cancer undergoing radiation. Forty participants will receive supervised exercise sessions and pre-made meals, plus dietary coaching. Th…

This study looked at whether giving a specific type of numbing medicine (called PECS) during mastectomy surgery can lower the chance of having chronic pain 6 months later. It included 194 women having a breast removed, with or without lymph node removal or reconstruction. The goa…

Researchers compare two ultrasound-guided nerve blocks to see which one better controls pain after video-assisted thoracoscopic surgery (VATS), a minimally invasive lung operation. The trial enrolls 46 adults scheduled for VATS. Participants receive either a serratus posterior su…

Researchers at the University of Oklahoma are testing a mobile health program designed to help adults receiving chemotherapy for metastatic breast or gynecologic cancer stay physically active. The program combines a wearable activity tracker, behavior change techniques, acceptanc…

This trial tests whether an 8-week behavioral activation program can reduce cancer-related fatigue in women who have had surgery for stage I-III breast cancer. Participants are randomly assigned to receive the program plus usual care, or usual care alone. The study measures fatig…

This study tests a new way to give radiotherapy for men with intermediate-risk prostate cancer. The goal is to lower the dose to healthy parts of the prostate while boosting the dose to the tumor, using a special MRI-guided machine (MR-linac). Twenty men will take part to see if …

This study tested whether a 12-week physical activity program could improve memory and attention in children who had radiation for brain tumors. Thirty-six kids aged 8–17 who finished radiation at least a year ago took part. Half started the program right away, while the other ha…

Researchers are studying whether a stoma self-care app, accessed through the LINE messaging platform, can help people with an enterostomy improve their self-care and quality of life. The study enrolls 50 adults who have a colostomy and can use a smartphone. It combines two models…

This trial compares two ultrasound-guided pain-relief techniques for children aged 1 to 12 undergoing surgery on the front or side of the thigh. One group receives a fascia iliaca nerve block, while the other gets caudal analgesia, both given after general anesthesia. The goal is…

Researchers at Jagiellonian University are studying whether a supplement made from freeze-dried black raspberries and strawberries affects inflammation in people over 65 receiving treatment for colorectal cancer. About 70 participants take the anthocyanin-rich supplement for 21 d…

Researchers compare two surgical techniques for rebuilding the tongue after cancer removal: the submental island pedicled flap, taken from under the chin, and the radial forearm free flap, taken from the arm. Twenty-eight adults with tongue cancer that requires partial or total r…

Researchers compare two ultrasound-guided nerve block techniques to see which controls pain better after modified radical mastectomy, a common breast cancer operation. The study enrolls 86 adults scheduled for the surgery. One group receives an erector spinae plane block, the oth…

This study tested whether a web-based exercise program could reduce nerve pain and improve quality of life in breast cancer patients receiving chemotherapy. 90 patients with stage II-III breast cancer and neuropathy symptoms took part. The program was guided by a physiotherapist …

Researchers are testing whether an ultrasound-guided paravertebral nerve block, given before general anesthesia, reduces the amount of opioid painkiller needed during a mastectomy. The study enrolls 40 women with breast cancer who are scheduled for unilateral mastectomy, with or …

Researchers are testing three non-drug approaches for nerve pain caused by paclitaxel, a common chemotherapy for breast cancer. The trial enrolls 140 women receiving weekly paclitaxel who develop mild nerve symptoms. Participants are assigned to TENS, compression, cryotherapy, or…

This study is testing a mobile health app designed to help cancer survivors manage pain and other symptoms after treatment. Twenty-five survivors who have finished cancer treatment but still have pain will use the app for one week, receiving helpful messages and completing daily …

This study tests whether adding a special yoga and physiotherapy program to standard care can lower stress in women receiving brachytherapy for cervical cancer. About 98 women will take part. The program includes gentle movement and breathing exercises designed to be safe during …

This study tests whether giving dexmedetomidine—either as a nasal spray or through an IV—before thyroid surgery can improve sleep quality afterward. 120 adults undergoing thyroid removal will be randomly assigned to one of two drug groups or a placebo. The goal is to see if this …

This study tested a new care plan that gets people eating and moving sooner after lung surgery. 232 adults took part. The goal was to see if this approach, based on the ERAS protocol, improves recovery quality, reduces complications, and shortens hospital stays compared to standa…

This study tests whether a program of specific shoulder exercises can improve muscle function and reduce pain in women who have had a mastectomy. Sixty women aged 35-55 with shoulder problems will be enrolled. The exercises focus on strengthening and stabilizing the shoulder blad…

Boys with hemophilia often miss out on games and activities because of concerns about bleeding and joint damage. Researchers developed a 12-week muscle-strengthening exercise programme with input from children, parents, and physiotherapists. The DOLPHIN-II trial compares this pro…

Whole-brain radiotherapy is a common treatment for cancer that has spread to the brain, but it often harms memory and thinking. This phase III trial tests whether adding the drug memantine and using a radiation technique that avoids the hippocampus, a brain area key to memory, ca…

This study tests a pre-surgical toolkit (OPTI-Surg) designed to help older cancer patients recover more quickly after major surgery. The toolkit provides recommendations before surgery to improve physical function and reduce complications. About 325 participants with various canc…

This study looked at 2,000 adults with solid tumors to find the best dose of olanzapine for preventing nausea and vomiting caused by strong chemotherapy. Researchers compared 2.5 mg, 5 mg, and 10 mg doses to see which works best with the fewest side effects like daytime sleepines…

This study tested whether electrostimulation and compression can reduce nerve pain and improve quality of life in people with gastrointestinal cancer who developed peripheral neuropathy from oxaliplatin chemotherapy. 140 patients were split into four groups: control, electrostimu…

This study tests whether custom-made 3D-printed masks fit children better than standard commercial masks for non-invasive ventilation (NIV). Fifteen children aged 8-12 who already use NIV but have poor adherence will try a custom mask made from a 3D facial scan. Researchers will …

Researchers are studying whether they can safely perform talc pleurodesis on both lungs at the same time in people with malignant pleural effusions, which is fluid that builds up around the lungs because of cancer. The procedure uses medical-grade talc to seal the space around th…

This study compared two methods of pain control after open stomach surgery: a nerve block (rectus sheath block) using bupivacaine versus standard epidural pain relief. Sixty adults scheduled for elective open gastrectomy were randomly assigned to one of the two groups. The resear…

Researchers at Rigshospitalet in Denmark are testing whether adults newly diagnosed with acute myeloid leukemia can safely measure their own blood counts and give themselves blood and platelet transfusions at home. The study trains and certifies 22 participants to use a home bloo…

Researchers are testing a digital picture-based tool that lets children with cancer report symptoms and distress during high-dose methotrexate treatment. The study includes children aged 5 to 17, their guardians, and healthcare professionals. Children use the tool to rate distres…

This trial compares two ultrasound-guided pain relief techniques for women undergoing breast-conserving surgery for cancer: a serratus anterior plane block and a thoracic epidural. Both use the local anesthetic bupivacaine to numb nerves and reduce post-operative pain. The study …

This study tested three different nerve block methods to manage pain after a double mastectomy with immediate reconstruction. Over 1,500 women received either a paravertebral block, a serratus+PECS-1 block, or a combination. The goal was to see which approach reduces the need for…

This trial tests whether a single 600 mg dose of gabapentin, taken one hour before breast cancer surgery, reduces the amount of morphine needed for pain afterward. Sixty women scheduled for elective breast surgery will be randomly assigned to receive either gabapentin or a placeb…

This study tests whether adding a nerve block (numbing medicine) before Mohs surgery for skin cancer on the face or scalp can lower pain and anxiety during the procedure. About 150 adults will be randomly assigned to receive either a real nerve block or a placebo (salt water) inj…

This trial tests two types of nerve blocks for pain after breast cancer surgery. One method targets a deeper layer of muscle, while the other combines both superficial and deep layers. The goal is to see which approach better reduces pain, cuts down on opioid use, and improves co…

This trial tests whether applying a phenytoin-loaded hydrogel to surgical wounds can improve healing after oral cancer surgery. Adults with locally advanced oral squamous cell carcinoma who are having surgery to remove the tumor will receive either standard wound care or standard…

This trial tests whether a self-management program can reduce lymphedema symptoms and improve quality of life in women with breast cancer who have developed arm swelling after mastectomy. Participants will learn exercises and receive education on lymphedema care, such as skin pro…

This study tests whether a 5-minute educational video about uterine fibroids and their treatments can help patients feel less conflicted when deciding on a treatment plan. About 154 women with fibroids will be randomly assigned to watch the video before their appointment or recei…

This trial compares two anesthesia approaches for women having a mastectomy for breast cancer. One group receives opioid-free anesthesia with a pectoral nerve block, while the other receives standard opioid-based anesthesia with fentanyl. Researchers measure CD4+ T-cell counts be…

This completed Phase 2 trial tested whether formal hypnosis, alongside standard care, could reduce anxiety and pain in 68 cancer patients undergoing brachytherapy. Patients received either standard care with Kalinox or standard care plus formal hypnosis. The study measured anxiet…

This study tested an experimental oral drug called Trichomylin® in 11 adults with advanced cancer who had moderate to severe pain despite taking strong opioids. The goal was to see if the drug is safe and can provide additional pain relief. Participants took the drug twice daily,…

This study tested whether a device that gently stimulates the vagus nerve through the ear could reduce delayed stomach emptying after a major pancreatic surgery (pancreaticoduodenectomy). 84 patients were randomly assigned to receive the stimulation during surgery or not. The goa…

This Phase 3 trial tests whether wearing a hydrogel bandage on the skin of the head and neck during radiation therapy can reduce pain and skin irritation in people with head and neck cancer. About 130 participants will either wear the bandage for at least 5 hours a day during tre…

This study tests an internet-based self-help program called eConquerFear-HK for Chinese cancer survivors who have mild to moderate fear of their cancer coming back. About 48 people who finished treatment for early-stage breast or colorectal cancer will try the program. The goal i…

This study tests a program that helps caregivers of teens and young adults (ages 15-26) with cancer find resources for financial and social needs. About 60 caregiver-patient pairs will take part. The goal is to see if this support reduces stress and improves well-being.

This trial tests whether a structured patient education program can lower the risk of severe immune-related side effects in people receiving immunotherapy for certain cancers, including melanoma, lung, kidney, and head and neck cancers. Participants either attend five educational…

This trial tests whether an AI emotional companion app can improve depression, anxiety, and demoralization in adults with advanced cancer. Participants use a mobile app where a virtual character holds conversations, reads emotional cues, and offers a link to a human hotline if di…

This trial tests whether art therapy can reduce physical and psychological symptoms in cancer patients receiving chemotherapy or immunotherapy. Over six treatment sessions, participants engage in artistic activities like painting, drawing, or clay work, guided by an art therapist…

This trial tests whether regular electronic questionnaires after prostate cancer surgery can improve recovery. Men who have their prostate removed will report symptoms like incontinence and mood through an app or computer. If scores hit certain levels, a nurse calls to offer a ur…

This study gives questionnaires to patients, interpreters, and healthcare professionals to understand how language and cultural differences impact care for women with gynecologic cancer. The goal is to identify barriers and improve the patient experience. About 45 people will tak…

This study looked at whether being more physically active, measured by daily steps, helps rectal cancer patients respond better to chemotherapy and radiation before surgery. About 120 participants wore smartwatches to track their steps, heart rate, and sleep. The goal was to see …

Researchers are studying a technique to remove fewer lymph nodes in women with breast cancer that has spread to the lymph nodes and who receive chemotherapy before surgery. The approach uses a clip placed in the affected node to guide surgeons during a selective axillary dissecti…

Researchers are studying whether daily step counts and other smartwatch measurements can predict which cancer patients will be readmitted to the hospital after discharge. Adults who have just left an oncology ward wear a Huawei smartwatch for 30 days to track steps, heart rate, a…

This study is collecting blood, urine, and stool samples from 500 children with autoimmune diseases and healthy controls. Researchers will analyze these samples to find molecular patterns that could help diagnose these conditions and guide treatment decisions. The goal is to crea…

Researchers are studying whether delays in follow-up colonoscopies after certain polyp findings raise the risk of advanced growths or colorectal cancer. The study looks at medical records of adults aged 45 to 80 who had serrated lesions or high-grade dysplasia found during a colo…

Researchers want to understand what patients with early oesophageal cancer value most when deciding whether to have major surgery. The study uses interviews and a choice experiment with about 118 people under care for Barrett's, dysplasia, or oesophageal cancer. Participants answ…

This study looked at whether a special PET scan (FDG-PET) can detect early whether breast cancer is responding to chemotherapy. 63 women with breast cancer had a PET scan before and after their first chemo cycle. The goal was to see if the scan could tell responders from non-resp…

This study checks for muscle loss (sarcopenia) in 25 women with advanced ovarian cancer before they start chemotherapy. Using CT scans, researchers want to see how common this condition is and if it affects treatment timing. The goal is to better understand how muscle health rela…

This study collects videos and images from 1,650 adults having a camera test of their stomach or bowel (endoscopy). Researchers will use these recordings to see how well artificial intelligence (AI) can spot early signs of cancer. The goal is to improve detection and help doctors…

This study followed 76 children with brain tumors to learn how radiation therapy affects their quality of life, thinking, and body functions over time. Researchers collected blood, urine, and MRI scans before and after treatment, along with tests of memory, behavior, vision, and …

This study looked at the emotional and practical challenges faced by patients with incurable cancer and their caregivers when planning to return home for end-of-life care. Researchers measured how each person perceived the burden, using surveys and statistical analysis to find fa…

Researchers are studying whether protein patterns in the blood can predict which people with esophageal cancer will respond completely to combined chemotherapy and radiation. The trial enrolls about 50 adults with invasive esophageal cancer who receive standard radiochemotherapy.…

Researchers are studying blood and tumor tissue from people with squamous cell cancer of the larynx, pharynx, or oral cavity who have no history of smoking, heavy drinking, or workplace exposure to substances like asbestos or wood dust. The goal is to learn how DNA changes and bi…

This completed Phase 2 trial looked at whether the sentinel lymph node technique—a less invasive way to check if cancer has spread—works for women with multifocal breast cancer (more than one tumor in the same breast). 216 women with early-stage, node-negative multifocal breast c…

This study tests a new way to find the first lymph node (sentinel node) during breast cancer surgery. Instead of using the usual armpit hairline as a guide, doctors will use ultrasound to mark the exact spot. The goal is to see if this leads to a smaller cut, less tissue damage, …

This study followed 150 people with solid tumors who were starting immunotherapy (immune checkpoint inhibitors) as part of their regular care. Researchers collected data on side effects and asked patients to fill out questionnaires before each treatment. The goal was to better un…

This completed study looked at blood and tumor samples from 66 women with breast cancer who were about to receive chemotherapy before surgery. Researchers searched for unique protein patterns that might show whether the tumor would shrink with treatment. The goal was to find a wa…

This study looked at 629 children in California to see if exposure to pesticides at home or from nearby farms is linked to childhood leukemia. Researchers collected dust from carpets and vacuum cleaners and mapped crops near homes. The goal was to measure chemical levels and see …

This completed study enrolled 377 individuals and families with a high risk of breast or ovarian cancer due to known or suspected genetic factors. Researchers collected medical records, questionnaires, and biological samples to better understand the disease's natural history and …

This study aims to understand why testicular cancer sometimes runs in families. Researchers will collect DNA samples and medical information from about 750 people in families with multiple cases of testicular cancer. No treatment is given; the goal is to find genes that increase …

This study tests a new way to choose treatments for people with multiple myeloma or plasma cell leukemia that has returned or stopped responding to standard therapy. Researchers use a lab test that checks many drugs at once, along with genetic information, to find which drug or d…

This study looked at whether standard radiation treatment for cancer that has spread to the brain causes changes in thinking skills like memory and attention. 35 adults with brain metastases received radiation and took tests and surveys before and after treatment. The goal was to…

This study tested new screening methods like MRI, duct lavage, and PET scans in 200 women with BRCA gene mutations who are at high risk for breast cancer. The goal was to see if these tools can find cancer earlier than standard mammograms. Participants were followed for three yea…

This completed study looked at how to best find and manage tumors in people with Zollinger-Ellison syndrome, a rare condition that causes too much stomach acid. Researchers used imaging tests and tissue samples to locate tumors and check for a related genetic condition called MEN…

Researchers at Centre Oscar Lambret are studying how immune cells get inside breast and colon tumors. They will analyze stored tumor samples from about 70 patients treated between 2005 and 2007, looking at genes and proteins on blood vessel cells that may control this process. Th…

Researchers are testing two ways to train VA primary care clinicians to hold goals of care conversations with veterans who have serious illnesses such as cancer, heart failure, or dementia. One approach gives clinicians written materials and online training. The other adds team f…

This study follows up on over 32,900 people from Linxian, China, who took part in a nutritional trial between 1985 and 1991. Researchers are tracking cancer cases and deaths to see if earlier vitamin and mineral supplements had lasting effects. They are also collecting blood samp…

This completed study analyzed genetic material from 1,340 patients with lymphoma, leukemia, or multiple myeloma. Researchers used DNA microarrays and other tools to find new molecular subtypes that could explain why some patients respond better to treatment than others. The goal …

This completed study looked at genetic factors that might increase the risk of esophageal and stomach cancers. Researchers collected DNA samples from over 7,700 people, including patients with cancer and healthy individuals from high- and low-risk areas in China. The goal was to …

This study looks at whether closely following a standard enhanced recovery after surgery (ERAS) protocol affects nutritional status in 120 adults undergoing lung cancer surgery. Researchers will measure nutritional risk and a nutritional index before surgery and two days after, a…

This completed study analyzed leftover tissue samples from 130 people with lymphoma or related conditions. Researchers measured levels of histone and other proteins to find patterns linked to different lymphoma types. The goal was to better understand the biology of these cancers…

Researchers want to know how common a BRCA2 gene mutation is among people diagnosed with breast cancer on Reunion Island. Earlier work found that more than half of patients there with a BRCA mutation carry a variant specific to the island's population. This study collects blood s…

This completed study enrolled over 50,000 adults aged 40-75 in Iran's Golestan Province to understand why esophageal cancer is so common there. Participants filled out lifestyle and diet questionnaires and provided blood, urine, hair, and nail samples. Researchers are analyzing f…

This study collected information from 733 people with a personal or family history of hereditary stomach cancer. The goal was to better understand how these cancers develop and what genes are involved. Participants provided medical history, blood samples, and genetic testing. The…

This study followed 17 adults with neurofibromatosis type 1 (NF1) over two years to learn how their skin tumors (dermal neurofibromas) grow and change. Researchers used special cameras and skin biopsies to measure tumor growth and look for genes that might influence it. The goal …

This study looked at whether offering genetic testing to all young adults with cancer (ages 18-39) is better than only testing those who meet certain guidelines. About 749 participants were randomly assigned to either universal testing with a broad gene panel or standard testing …

Researchers at a large hospital in Seoul reviewed records from nearly 33,000 adults who had curative-intent surgery for one of seven cancers in the abdomen or pelvis: pancreatic, gastric, rectal, cervical, endometrial, kidney, or prostate. They grouped patients by whether they re…

This study gathered information from 326 adults with rare central nervous system tumors, such as medulloblastoma and ependymoma. Participants completed surveys about their symptoms, treatments, and lifestyle, and provided a saliva sample for genetic analysis. The goal was to lear…

This study looked at people with three rare genetic conditions—xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD)—that affect the body's ability to repair DNA. Researchers examined 709 participants to understand how these defects relate to cancer ri…

This study collected and stored biological samples from nearly 10,000 tin miners in China who are at high risk for lung cancer due to workplace exposures. The goal is to use these samples to discover early markers of the disease, which could lead to better screening and preventio…

This completed study looked at why some women reject personalized breast cancer risk estimates. Researchers gave 781 Black or African American women aged 39-74 a personal risk score based on the Gail Model and asked if they agreed with it. The goal was to understand risk rejectio…

Researchers in Taiwan are building a nationwide registry of people diagnosed with gastrointestinal stromal tumors, a rare cancer of the digestive tract. The study collects details on how the tumors are found, their stage, the treatments patients receive, and how they fare over ti…

This study looks at how Spanish-speaking Latiné men cope after prostate cancer treatment, especially with issues like erectile dysfunction and urinary problems. Researchers will survey and interview 55 survivors to understand their needs and cultural barriers. The goal is to crea…

This phase 3 trial compares a less invasive sentinel node biopsy approach to standard staging methods in 262 women with early-stage endometrial cancer at intermediate or high risk of recurrence. The goal is to see if the sentinel node policy reduces surgical complications while s…

This study followed over 46,000 women in the Netherlands who tested positive for HPV and had mild abnormal Pap results. Researchers tracked how many developed cervical cancer within five years. The goal was to see if these women could safely have fewer follow-up tests, making scr…

Researchers want to learn which molecules on cancer cells the immune system attacks when checkpoint inhibitor drugs work well. They collect tumor and blood samples from adults with solid tumors who respond to these drugs, either during treatment or after surgery. The team then se…

Researchers are pooling data from 3,648 women with early triple-negative breast cancer who received dose-dense sequential chemotherapy in seven studies. They will analyze tumor tissue and germline DNA to see how genetic and clinical features relate to long-term overall survival. …

Researchers compare children with cancer and healthy children to see how pain sensitivity, body composition, and physical activity differ. The study also looks at how parents respond to their child's pain. About 60 children aged 8 to 18 and their parents take part. The goal is to…

This study reviews medical records of 350 adults who had surgery for esophageal cancer in France between 2017 and 2024. Researchers want to understand how often infections happen after surgery, what causes them, and how they affect recovery. The goal is to find ways to prevent th…

This study is testing whether a green dye called ICG can help surgeons see tumors more clearly during surgery in children and teens with solid tumors. The dye is injected before surgery and makes tumor tissue glow under a special camera. The goal is to see if this technique helps…

This study follows people treated for anal cancer with radiotherapy to see how their sexual quality of life changes over time. Participants complete questionnaires during treatment, three months later, and two years after diagnosis. The goal is to understand the long-term impact …

Researchers are studying natural killer (NK) cells in people who receive stem cell transplants for leukemia. The study follows 92 patients and their donors, looking at genes called KIR and HLA that control how NK cells work. By tracking NK cells during immune recovery, researcher…

Researchers want to learn what causes myeloproliferative neoplasms, a group of rare blood cancers. They are testing whether small incentives like pens, trolley tokens, or a £10 reimbursement encourage more people to join a case-control study. The trial includes about 100 patients…

Researchers in seven European and Latin American countries ask bereaved relatives to complete the CODE questionnaire about two months after a family member died of cancer in hospital. The survey asks whether patients were treated with dignity and respect and whether relatives fel…

Researchers survey 260 cancer surgeons in France to understand what gets in the way of evaluating and adopting new surgical methods. The study looks at personal background, workplace culture, and psychological factors that may shape a surgeon's openness to innovation. Surgeons an…

This registry study follows 400 patients with a specific type of leukemia (non-high-risk APL) who are 70 or younger. It compares two standard treatments: ATRA plus chemotherapy versus ATRA plus arsenic trioxide. The goal is to see which approach leads to better long-term outcomes…

This study asks over 1,600 African American women aged 23-35 about their experiences during the COVID-19 pandemic. Participants fill out a short online or paper survey covering infection, vaccination, childcare, job loss, and emotional stress. The goal is to understand how the pa…

This large observational study looks at whether getting an mRNA COVID-19 vaccine shortly before or after starting immune checkpoint inhibitor therapy is linked to longer survival in adults with cancer. Using data from nearly 100,000 patients in France, researchers are comparing t…

Researchers at Fudan University are studying how three strengths of the local anesthetic ropivacaine affect lung ventilation when used for intercostal nerve blocks during breast quadrantectomy. The trial enrolls 67 adults scheduled for this surgery and randomly assigns them to re…

This pilot study tested whether PET-CT scans can detect leukemia that has spread outside the bone marrow in patients with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia (ALL). Ten participants received a PET scan before and after CAR T-cell therapy. The goal was to…

This trial tests whether an AI-supported chatbot can boost nursing students' knowledge of gynecologic cancers and their clinical decision-making skills. Third-year nursing students who have completed their obstetrics and gynecology course will be randomly assigned to either use t…

This study tests whether a training program for pediatric oncology nurses improves their knowledge and infection prevention behaviors when caring for central venous catheters (CVCs). Thirty nurses will receive education including a presentation, video, and hands-on practice. Thei…

This study tests a digital platform called ConnectedNest that helps cancer patients find and connect with social services like housing assistance, food aid, and financial help. About 400 adults with cancer in Minnesota will use the platform for 90 days. Researchers will measure i…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

Breast cancer surgery often involves removing lymph nodes from the armpit, which can lead to lasting arm swelling and reduced arm function. This study follows 258 breast cancer patients who have this node removal and compares two groups: those whose surgeons preserve small vein b…

This study looks at how giving fluids during robotic prostatectomy affects patient outcomes. It compares two approaches: one guided by a special monitor (LiDCO) that tracks blood flow in real time, and the other using standard clinical judgment. The researchers will measure the t…

This study asks whether measuring circulating endothelial cells (CECs), cells shed from blood vessel walls, can predict how well ovarian cancer patients respond to standard chemotherapy with or without bevacizumab. Researchers will use a standardized flow cytometry method to coun…

This study looks at how a protein called AXL in head and neck tumors responds to a combination of two drugs, imatinib and cetuximab, given before standard treatment. About 15 adults with head and neck cancer will receive the drugs for a short time between diagnosis and surgery or…

This trial tests whether a single dose of the antipsychotic drugs olanzapine or ziprasidone changes how the body responds to insulin, compared with a placebo. The study enrolls healthy young men who are overweight or have early signs of insulin resistance, but who have never take…

This study looked at how common BRCA1 and BRCA2 gene mutations are in Hispanic/Latino women with breast cancer. Researchers collected saliva samples and medical history from 266 participants to better understand these mutations in this group. No treatment was given; the goal was …

This study looks at how doctors currently diagnose lung and breast cancer using tissue samples. It will also test whether artificial intelligence (AI) can help analyze these samples faster and more accurately. Researchers will review records from 600 patients to measure diagnosis…

This study looks at whether providing cancer care at home is a good option for Black men with advanced prostate cancer. Researchers want to see if this approach can reduce healthcare disparities and improve quality of life. Participants will fill out questionnaires about their pr…

This study looks at medical records from 584 men in Brazil with castration-resistant metastatic prostate cancer, a form of the disease that no longer responds to hormone therapy. Researchers aim to describe how long these patients survive and to identify their individual characte…

This study looks back at the medical records of 150 adults in Brazil diagnosed with adrenocortical carcinoma, a rare cancer of the adrenal glands. Researchers will collect details on age, gender, location, tumor stage, hormone activity, and treatments received since the year 2000…

This study examines whether a routine blood test called Mean Platelet Volume (MPV), taken when a cancer patient is admitted to the intensive care unit (ICU), can help predict their risk of dying. Researchers will review the medical records of 425 adult cancer patients who stayed …

This study follows children born moderately or late preterm (32-36 weeks) to age 9, measuring their thinking, movement, language, behavior, and growth. Researchers compare these kids to full-term peers to understand long-term effects. The goal is to learn how early development pr…

This study looks at proteins in the blood of women with ovarian, peritoneal, or fallopian tube cancer who are in remission. The goal is to find a protein pattern, or 'fingerprint,' that signals when the cancer might come back. Researchers followed 119 women with stage III or IV c…

This study compares bowel function and quality of life in adults who had a sigmoidectomy, a surgery to remove the sigmoid colon, for either diverticulitis or sigmoid cancer. Researchers will measure incontinence using a standard score and track stool form with the Bristol stool c…

This study looks at whether starting to eat within 24 hours after a colon polyp removal procedure (called ESD) is safe and better than waiting longer. About 204 patients will be randomly assigned to either early feeding (water after 2 hours, then liquid diet) or delayed feeding (…

Researchers are investigating whether a patient's age influences the outcomes of BCG therapy for a high-risk form of bladder cancer called pT1 high-grade. This study reviews medical records from 64 patients who received standard BCG treatment after tumor removal. The goal is to c…

This study tested a document called Voicing My CHOiCES, designed to help young adults (ages 18-39) with serious illnesses like cancer or HIV discuss their care preferences. Participants filled out questionnaires about anxiety, social support, and communication, then reviewed the …

This study looks at whether analyzing the genes of a tumor (from a tissue sample or a blood test) can help doctors pick a more effective treatment for people with advanced solid cancers that have stopped responding to standard therapies. About 235 participants will have their tum…

This study explores whether men with early prostate cancer on active surveillance would be willing to take dietary fibre supplements, such as inulin or psyllium. Previous research hints these fibres may reduce inflammation and slow tumour growth, but no one has asked patients abo…

This study looks at whether the amount of radiation reaching a small brainstem region, the dorsal vagal complex, is linked to nausea in people receiving radiation for benign brain tumors. Researchers will track nausea scores and radiation doses in 100 adults. The goal is to find …

This study looks back at the medical records of about 266 adults who received CAR T-cell therapy for blood cancers. The goal is to describe lung complications that happen within 30 days or up to 2 years after treatment. Researchers will also look for patient characteristics that …

This study looked at adrenal gland tumors to understand why they form, why some release extra hormones, and why some are cancerous. Researchers studied 690 people with known or suspected adrenal tumors. Participants underwent tests like blood draws, imaging scans, and urine colle…

Researchers are using wearable sensors and smartphone check-ins to track fatigue as it happens in people with myeloma, long COVID, heart failure, and healthy controls. Participants wear an ECG patch and a wrist sensor that measure heart rate, activity, and posture, and they rate …

This study looks at people with neurofibromatosis type 1 (NF1) and their families to find out why some have more severe symptoms than others. Researchers will collect medical history, blood samples, and images to study genes and physical traits. The goal is to identify genes that…

This pilot study tests a program to help young female cancer survivors in rural Imperial County, California, get reproductive health care that matches their personal goals. The program includes a quick needs assessment during oncology visits, followed by a session with a social w…

This study examined how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Mexican-American households in Houston to understand how culture and family history influence health communic…

This study aims to identify which of four French-validated questionnaires is most suitable for assessing sexual function in women who have had surgery for rectal or recto-sigmoid cancer. Researchers will ask 50 women to complete all four questionnaires and rank their preferences.…

This completed study looked at how women ages 39-49 make decisions about breast cancer screening. Participants read a decision aid explaining the pros and cons of mammograms and then answered surveys about their reactions, knowledge, and screening plans. The goal was to understan…

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This study explores whether magnetic resonance spectroscopy (MRS) can be used to safely evaluate spinal cord lesions. Researchers will test the technique in healthy volunteers and patients with leptomeningeal disease who are receiving radiation. The main goal is to see if MRS is …

This study tests whether a novel MRI technique called Fast Field Cycling imaging and the bacteria in the mouth and bowel can predict how well rectal cancer responds to chemoradiotherapy given before surgery. Researchers will scan 15 patients three times and collect saliva and sto…

This study looks back at the medical records of 88 adults with neuroendocrine tumors that have spread or cannot be removed. Researchers will examine how different patient characteristics and treatments relate to overall survival and other outcomes. The goal is to identify factors…

This study builds a global registry of adults with anal squamous cell carcinoma, both with and without HIV infection. Researchers will collect real-world data on treatments, lab results, and outcomes to compare how the disease progresses in each group. The goal is to identify fac…

This study looks back at the records of 461 women in Brazil who received a short, high-dose radiation schedule after breast cancer surgery. The schedule, called extreme hypofractionation, delivers 5 doses of 5.2 Gy instead of many smaller doses. Researchers want to see how well t…

This trial tests whether an early PET scan can help doctors choose the right treatment for people with locally advanced oesophago-gastric cancer. Patients receive one round of standard chemotherapy, then a second PET scan. If the tumor shows a strong response, they continue chemo…

This observational study will examine the molecular and epidemiological characteristics of endometrial cancer in Brazil, focusing on women diagnosed between 2016 and 2019. Researchers will analyze tumor samples for genetic mutations and biomarkers, and collect data on demographic…

This study looks at whether men and women with a certain type of advanced thyroid cancer (radioiodine-refractory differentiated thyroid cancer) experience different side effects and outcomes when treated with the drug lenvatinib. Researchers will compare dose reductions, side eff…