PET scans may reveal hidden leukemia spots before CAR t treatment
NCT ID NCT05969002
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 28 times
Summary
This pilot study tested whether PET-CT scans can detect leukemia that has spread outside the bone marrow in patients with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia (ALL). Ten participants received a PET scan before and after CAR T-cell therapy. The goal was to see how common these hidden spots are and whether they affect treatment success.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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National Institutes of Health Clinical Center
Bethesda, Maryland, 20892, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
18F-FDG PET-CT imaging
What this could lead to
If successful, this imaging approach could help doctors better detect hidden leukemia before CAR T-cell therapy, potentially improving treatment outcomes.
What could go wrong
This is a very small pilot study with only 10 participants, so results may not apply to all patients. The imaging is for observation only and does not directly treat the disease.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.