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One operation, two lungs: talc procedure tested for fluid around both lungs

NCT ID NCT07810049

Symptom relief Sponsor: European Institute of Oncology Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 09, 2026 · Last updated Sep 10, 2026 · Updated 1 time

Summary

Researchers are studying whether they can safely perform talc pleurodesis on both lungs at the same time in people with malignant pleural effusions, which is fluid that builds up around the lungs because of cancer. The procedure uses medical-grade talc to seal the space around the lungs and stop fluid from collecting. The trial includes 31 adults who had this bilateral procedure, and researchers track complications and deaths after surgery to see if the approach is feasible.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
talc pleurodesis, a procedure that uses medical-grade talc to seal the space around the lungs
What this could lead to
If it works, doctors could treat both lungs in one operation, which may mean fewer procedures and shorter hospital stays for people with fluid around both lungs.
What could go wrong
This is a small study of 31 people, so the results may not apply to everyone. Treating both lungs at once carries risks of complications, and the approach may not prove safe or practical enough for routine use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

31 people

The number who actually took part.

Started

Jan 1998

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

patient diagnosed with malignant pleural bilateral effusion

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 year-old * Patients undergoing synchronous bilateral talc pleurodesis * Diagnosis of malignant bilateral pleural effusions * Surgical resection between 1998 and September 2025 Exclusion Criteria: * Other type of surgery * Lack of consent to research * Other type of diagnosis (e.g. viral disease)

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Conditions

The condition(s) this trial relates to.

lung neoplasm Pleural Effusion, Malignant

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bilateral pleural effusion Pleurodesis

Contacts and locations

Locations

  • Istituto Europeo di Oncologia

    Milan, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.