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Can a pre-surgery spray fix post-op sleep? new trial investigates

NCT ID NCT07622355

Symptom relief Sponsor: The Second People's Hospital of Huai'an Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Sep 11, 2026 · Updated 4 times

Summary

This study tests whether giving dexmedetomidine—either as a nasal spray or through an IV—before thyroid surgery can improve sleep quality afterward. 120 adults undergoing thyroid removal will be randomly assigned to one of two drug groups or a placebo. The goal is to see if this approach reduces sleep problems, pain, and side effects, helping patients recover better.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Dexmedetomidine
What this could lead to
If it works, this could point toward a simple way to improve sleep and recovery after thyroid surgery.
What could go wrong
This is an early-phase trial with only 120 participants, so results may not apply to everyone. The drug may not improve sleep significantly compared to placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1/2

Runs two stages together: safety and dose first, then whether the treatment works.

Participants

120 people

The number who actually took part.

Started

Jan 2026

Finished

Jun 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Aged 18-65 years; * ASA physical status classification I-II; * BMI ranging from 18 to 30 kg/m²; * Scheduled for general anesthesia thyroidectomy for benign or malignant thyroid lesions; * No history of sedative or hypnotic medication within one week before surgery. Exclusion Criteria: * History of sleep disturbance or psychiatric disorders; * Use of antidepressants, hypnotics or other sleep affecting medications; * Allergy to dexmedetomidine; * Nasal lesions or intolerance to intranasal spray administration; * Severe cardiac conduction block, bradycardia or hypotension; * Pregnant or lactating patients; * Complicated with severe dysfunction of heart, liver, brain, kidney or other organs; * Difficult airway encountered during anesthesia induction requiring modification of routine intubation strategy.o need to change the conventional intubation method

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Conditions

The condition(s) this trial relates to.

benign thyroid gland neoplasm thyroid cancer thyroid gland disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Thyroid diseases

Contacts and locations

Locations

  • The Affiliated Huaian Hospital of Xuzhou Medical University, Huai'an Second Hospital, Huaian

    Huai'an, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.