Lung neoplasm

This study tests a new drug combination for people with a specific type of advanced lung cancer (EGFR-mutant non-small cell lung cancer). The two drugs, LY3295668 and osimertinib, work by blocking enzymes that help cancer cells grow. The goal is to find the safest dose and see if…

This study looked at whether a special care plan led by a geriatrician and a nurse could improve survival and quality of life for older adults (70+) with advanced cancer. 792 patients with breast, colorectal, lung, prostate, bladder, ovarian cancer, or lymphoma took part. The app…

Researchers are testing an experimental immunotherapy called GNR-051 in adults with advanced lung cancer, kidney cancer, or melanoma that has returned or not responded to other treatments. The Phase 1 trial aims to find the highest dose people can tolerate and to track side effec…

Researchers are comparing two doses of chest radiation therapy, 45 Gy and 70 Gy, in people with limited-stage small cell lung cancer. All participants also receive chemotherapy with cisplatin or carboplatin plus etoposide. The trial measures overall survival to see whether the hi…

This pilot study tested a new, non-invasive way to locate multiple small lung nodules (under 20 mm) before surgery, comparing it to the standard CT-guided needle method. Forty people with early-stage lung cancer took part. The goal was to see if the new method could help surgeons…

This phase 2 trial is testing a drug called ado-trastuzumab emtansine (Kadcyla) in 131 adults with advanced solid tumors that have a specific HER2 gene change. The drug combines an antibody that targets HER2 with a chemotherapy agent, aiming to deliver treatment directly to cance…

This trial tests whether removing lung nodules with non-intubated video-assisted thoracic surgery, which avoids a breathing tube and ventilator, helps patients recover faster and feel better than traditional intubated surgery. Researchers will compare symptom burden, quality of l…

This trial investigates whether combining two targeted drugs—erlotinib and bevacizumab—can help people with advanced non-small cell lung cancer that has specific EGFR mutations. The goal is to see if the combination extends the time before the cancer grows or spreads. Participant…

This phase II trial tests whether combining the immunotherapy drug nivolumab with the chemotherapy drug temozolomide can shrink tumors in people with small-cell lung cancer that has returned or not responded to treatment, or advanced neuroendocrine tumors. About 55 participants w…

This trial tests whether radiofrequency ablation—a procedure that uses heat to destroy cancer cells—can effectively treat lung tumors that cannot be removed with surgery. The study includes people with primary lung cancer or lung metastases, with up to five tumors each no larger …

This early-phase study tested an experimental drug called COM902, alone or with other drugs, in 94 people with advanced cancers like ovarian, lung, and colon cancer. The main goal was to check safety and find the right dose. Researchers also looked for early signs that the drug m…

This early-stage trial is testing whether an immunotherapy drug called tislelizumab can be given as a simple injection under the skin instead of through an IV drip for people with advanced non-small cell lung cancer. The study will compare how well the body absorbs the drug in bo…

This trial is testing a new radiation technique called CT-STAR for people with early-stage non-small cell lung cancer located near the center of the chest, where treatment is tricky. The approach uses a machine that takes CT images during each session and adapts the radiation pla…

This trial tests whether a single dose of risedronate, a bone-strengthening drug, given before stereotactic body radiation therapy (SBRT) for peripheral lung tumors can prevent the rapid bone loss that radiation can cause in nearby ribs. Adults with lung tumors within 2 cm of the…

This study tested a combination of two immunotherapy drugs (durvalumab and tremelimumab) plus a targeted therapy (selumetinib) in 40 people with advanced non-small cell lung cancer that had returned or spread. The goal was to find the safest dose and see if the combo could shrink…

This study tested a new drug called brigimadlin (BI 907828) in 99 adults with advanced cancers of the bile duct, pancreas, lung, or bladder that have a specific genetic change (MDM2 amplification). Participants took the drug as a tablet once every 3 weeks. The goal was to see if …

This early-phase trial is testing a combination of all-trans retinoic acid (ATRA), a substance made from vitamin A, and the immunotherapy drug atezolizumab in people with advanced non-small cell lung cancer that has spread or come back. The main goal is to find the safest dose an…

This study tests whether a new drug called RPH-075, a biosimilar of pembrolizumab (Keytruda), works as well as the original in people with skin melanoma, lung cancer, or head and neck cancer. Participants receive a single dose of either RPH-075 or Keytruda, and researchers compar…

This study tests a device called the LungVision system, which uses artificial intelligence to help surgeons locate small lung nodules during minimally invasive surgery. The system combines CT scans with live X-ray images to guide a tool to the nodule, then injects a dye to mark i…

This study tests whether combining two targeted drugs, avutometinib and adagrasib, can shrink tumors in people with advanced non-small cell lung cancer that has a specific genetic change called KRAS G12C. Participants must have already tried a KRAS G12C inhibitor and seen their c…

This early-phase trial tested an experimental drug called KVA12123, given alone or with the immunotherapy Keytruda, in 40 adults with advanced solid tumors (like lung, breast, or colon cancer) that had stopped responding to standard treatments. The main goals were to check safety…

This phase 2 study tested three different drug combinations in 151 people with advanced non-small cell lung cancer that had not been treated before. The drugs help the immune system attack cancer cells. Researchers measured how many patients' tumors shrank or stopped growing, and…

This early-phase study tested a combination of two drugs, bexarotene and Iressa, in 6 people with advanced non-small cell lung cancer who had already tried standard treatments. The goal was to see if the combination was safe and could help control the disease. The study looked at…

This early-stage trial tested a new drug called PF-07257876 in 29 people with advanced lung, head/neck, or ovarian cancers that had stopped responding to other treatments. The drug is a bispecific antibody designed to help the immune system attack cancer cells. The main goals wer…

This completed study looked at how patients with advanced EGFR-positive non-small cell lung cancer fared while taking dacomitinib in real-world settings in Taiwan. Researchers tracked 29 adults who took dacomitinib pills at home until their cancer stopped responding. The goal was…

This study tested whether a shorter course of radiation (hypofractionated) given with chemotherapy works as well as the standard longer radiation course for people with limited-stage small cell lung cancer. 860 adults aged 18-70 with early-stage disease took part. The main goal w…

This early-stage trial tested a new drug called AZD6244 combined with standard chemotherapies in 140 people with advanced solid tumors (breast, colon, lung, melanoma, kidney). The main goal was to see if the combination is safe and tolerable, and to find the best dose. Researcher…

This phase 3 study tested whether adding the immunotherapy drug sintilimab to standard chemotherapy helps people with advanced non-squamous non-small cell lung cancer. 397 participants received either sintilimab plus chemo or a placebo plus chemo. The main goal was to see if the …

This study tested a new way to deliver high-dose radiation to small lung tumors in just one day, instead of the usual two to three weeks. Ten patients with early-stage lung cancer or limited lung metastases received a single session of stereotactic body radiotherapy (SBRT) using …

This trial tested several targeted drugs in people with non-small cell lung cancer whose tumors had specific genetic changes. The goal was to see if these drugs could shrink tumors or delay cancer growth. Over 400 participants received treatment based on their tumor's genetic pro…

This study tested whether adding a precise, high-dose radiation treatment called CyberKnife after standard chemo and radiation could help people with stage III non-small cell lung cancer. It included 35 patients who had 1 to 3 small tumors left after initial treatment. The goal w…

This Phase 3 trial tested whether adding custirsen to the chemotherapy drug docetaxel helps people with advanced non-small cell lung cancer live longer. The study involved 664 patients who had already tried one platinum-based treatment. Researchers compared survival between those…

This early-phase trial tested two experimental drug combinations in 37 people with advanced EGFR-mutant lung cancer that no longer responded to the targeted therapy osimertinib. The goal was to find safe, tolerable doses of alisertib or sapanisertib when given together with osime…

This study tested a program called CEASE that helps lung cancer patients quit smoking. The program was built into regular doctor visits and included screening, counseling, and referrals. Researchers studied 263 patients to see if the program improved quit rates and how well it wo…

This study tested whether tracking daily steps with a simple pedometer could help identify cancer patients at high risk of being hospitalized during chemoradiotherapy. 40 adults with head and neck, lung, esophageal, or stomach cancer wore a pedometer and received extra support li…

This study tested a drug called capmatinib in 50 Indian adults with advanced non-small cell lung cancer that has a specific genetic change (MET exon 14 skipping mutation). The goal was to see how safe the drug is and how well it shrinks tumors. Participants took capmatinib pills,…

This study tested a combination of an immune-boosting drug (durvalumab) and a precise, high-dose radiation treatment (SBRT) for people with stage III lung cancer that hadn't spread. The goal was to see if adding SBRT after standard chemoradiation could help control the cancer lon…

This small, completed study tested whether it is possible to personalize radiation doses for people with stage II or III non-small cell lung cancer based on the genetic profile of their tumor. Three participants received either standard or higher radiation doses depending on a ra…

This study tested a combination of two targeted drugs, encorafenib and binimetinib, in 98 people with advanced non-small cell lung cancer that has a specific BRAF gene mutation. The goal was to see if the drugs could shrink tumors and how safe they were. Participants had either n…

This study looked at whether adding a structured addiction treatment program to standard cancer care helps patients with head and neck or lung cancer quit smoking and reduce alcohol use. 133 patients were randomly assigned to either the integrated program or usual care. The main …

This study compared four different smoking cessation programs to see which one works best for underserved smokers who are getting lung cancer screening. Over 3,200 participants from four U.S. health systems took part. The goal was to help them quit smoking for at least six months…

This phase 2 trial tested whether adding an experimental drug called AZD1775 to standard chemotherapy (carboplatin and paclitaxel) could help people with advanced squamous cell lung cancer. The study enrolled 42 participants and measured how long they lived without their cancer g…

This early-phase trial tested two oral drugs, palbociclib and binimetinib, in 34 people with advanced lung cancer that has a specific change in the KRAS gene. The goal was to find the safest dose and see if the combination can slow cancer growth. The study is complete, but result…

This study tested whether adding itacitinib to the standard drug osimertinib is safe and effective for people with advanced non-small cell lung cancer that has a specific EGFR gene mutation. The trial involved 59 participants and was completed. The goal was to see if the combinat…

This study followed 22 cancer patients who were already taking bintrafusp alfa in earlier trials, to see how safe it is over the long term and how long they live. Participants continued receiving the drug until it was no longer helping or became available commercially. The main g…

This early-phase trial tested an experimental drug called VS-6766, given alone or with everolimus, in 104 adults with advanced solid tumors or multiple myeloma that had stopped responding to standard treatments. The goal was to find a safe, tolerable dosing schedule and measure h…

This study tested a powered stapler used during lung cancer surgery in 61 patients. The goal was to see if the device was safe and worked well. Researchers checked for leaks and other complications. The study is complete, but results are not yet published.

This study tested a combination of three drugs—nivolumab, ipilimumab, and plinabulin—in 39 adults with recurrent small cell lung cancer that had worsened after initial chemotherapy. The goal was to find the safest dose and see if the combo could slow cancer growth. Results from t…

This study tested a new surgical stapler (easyEndo™ Lite) in 30 people undergoing lung cancer surgery. The goal was to see if the device safely cuts and seals lung tissue. Researchers checked for successful sealing, surgery time, blood loss, and complications. The study is comple…

This study tested a drug called cabozantinib, either alone or with another drug (erlotinib), in 92 people with advanced non-small cell lung cancer whose cancer had worsened after erlotinib treatment. The goal was to find a safe dose and see if the combination could shrink tumors.…

This phase 2 trial tested a combination of two oral drugs, RMC-4630 and sotorasib, in 47 adults with advanced KRASG12C-mutant non-small cell lung cancer that had progressed after standard treatments. The goal was to see if the combination could shrink tumors. The study is now com…

This study tested a new way to do lung cancer surgery without using a breathing tube or ventilator. Instead, patients breathe on their own during the operation. The goal was to see if this 'tubeless' method causes less lung injury, helps patients recover faster, and reduces pollu…

This early-stage trial tested the safety of a new drug called SGN-B6A in 6 Chinese patients with advanced solid tumors (lung, head and neck, esophageal, stomach cancers). The main goal was to identify side effects and see how the body processes the drug. It is a first step to see…

This early-phase study tested adding the drug pirfenidone to standard chemotherapy for people with advanced non-small cell lung cancer. The main goals were to find a safe dose and see if the combination could shrink tumors. 48 participants were enrolled, and the study is now comp…

This study tested a cancer vaccine called ETBX-011 in 43 people with advanced colorectal, lung, breast, or prostate cancers that produce a protein called CEA. The vaccine uses a modified virus to teach the immune system to attack cancer cells making CEA. The main goals were to ch…

This trial tested different doses of proton beam therapy combined with standard chemotherapy for people with stage 2-3 non-small cell lung cancer that cannot be surgically removed. The goal was to find the best radiation dose to control the cancer. Twenty participants received tr…

This phase 2 trial tested whether using a CT scanner during lung surgery (VATS) helps surgeons safely remove small lung nodules. 25 patients with nodules smaller than 3 cm took part. The main goals were to see if the approach is safe and feasible. Results could lead to more preci…

This study tested whether adding an immunotherapy drug (MEDI4736) to standard chemotherapy before surgery helps people with stage IIIA non-small cell lung cancer. 68 participants received the combination treatment. The goal was to see if this approach improves how long people liv…

This study tested the immunotherapy drug durvalumab in 50 patients with advanced lung cancer who were too weak for standard chemotherapy. The goal was to see if the drug is safe and helps control the disease. Researchers focused on side effects and how well patients responded.

This early-phase study tested a combination of two drugs, tarlatamab and AMG 404, in 23 adults with small cell lung cancer that had worsened after standard chemotherapy. The main goal was to check safety and find the right dose for future studies. Participants had to be in fairly…

This pilot study tested the drug Tislelizumab given before surgery in 12 people with early-stage lung cancer who also had multiple ground-glass nodules on CT scans. The goal was to see if the drug could shrink tumors before removal. Researchers measured how many patients responde…

This early-stage trial tested whether adding immunotherapy drugs (durvalumab alone or with monalizumab or oleclumab) to radiation therapy is safe for people with locally advanced non-small cell lung cancer that cannot be removed by surgery. The study enrolled 26 participants and …

This study tested whether adding an experimental immunotherapy drug (ociperlimab) to a standard immunotherapy (tislelizumab) plus chemotherapy could help people with advanced non-small cell lung cancer. The trial involved 272 patients whose cancer had spread or could not be remov…

This study tested a new drug called AZD3759 against standard targeted therapies (erlotinib or gefitinib) in 492 people with advanced EGFR-mutant lung cancer that had spread to the brain. The goal was to see if AZD3759, which is designed to better reach the brain, could keep the c…

This large Phase 3 trial tested whether adding aflibercept (a drug that blocks blood vessel growth) to standard chemotherapy (docetaxel) could help people with advanced non-small cell lung cancer live longer. Over 900 participants who had already tried one platinum-based treatmen…

This study tested an experimental drug called ESG401 in 156 people with advanced solid tumors (including breast, lung, and colorectal cancers) who had no other treatment options. The goal was to check the drug's safety, find the right dose, and see if it could shrink tumors. The …

This trial tests a blood-based test designed to detect multiple cancers early in people aged 40 to 74 who have no cancer symptoms. The study will enroll about 2,500 participants and will check how well the test identifies lung, colorectal, liver, gastric, and esophageal cancers. …

This early-phase trial tests whether a PET/CT scan using an investigational tracer called zirconium Zr 89 crefmirlimab berdoxam can safely and effectively spot CD8+ T cells—key immune cells that attack cancer—in people with metastatic non-small cell lung cancer. Participants are …

This study tests a new scanner that uses light-based imaging to quickly check whether small lung tissue samples taken during a bronchoscopy are adequate for diagnosis. The goal is to see if the scanner can accurately tell apart samples that are usable from those that aren't, comp…

This study tests a new, ultra-sensitive blood test (NGS) to detect EGFR gene mutations in patients with advanced lung cancer. Researchers will compare it to the current standard test using stored blood samples from 130 patients. The goal is to see if the new method finds more mut…

This study is testing whether a robotic system called ION, combined with real-time 3D CT imaging, can more accurately biopsy lung nodules. About 132 adults with small to medium-sized lung nodules will undergo the procedure under general anesthesia. The goal is to see how often th…

This study is testing a new breath test called OWL-EVO1 to see if it can accurately tell the difference between people who have lung cancer and those who do not. The test involves breathing into a device after taking a special probe. Researchers are enrolling adults aged 45-85 wh…

This completed Phase 1 study tested a new radioactive imaging agent called [123I]I-DARPIN-Ec1 in 10 people with lung or ovarian cancer. The goal was to see how the agent spreads in the body and whether it can help spot tumors on SPECT scans. Researchers compared the new scan resu…

This study tests a special SPECT imaging agent that seeks out a protein called LRRC15, found on many aggressive cancers like pancreatic, breast, lung, and brain tumors. The goal is to see if this scan can help doctors diagnose and stage these cancers more accurately. Healthy volu…

This study tested whether an ultra-low dose CT scan, combined with a deep-learning AI reconstruction, can detect lung nodules as accurately as the standard low-dose CT. 70 adults having a chest CT for nodule check-up or follow-up received an extra ultra-low dose scan. The goal wa…

This study investigates whether a machine that analyzes exhaled breath can identify a unique chemical signature for lung cancer. Researchers will compare breath samples from people with lung cancer (before and after surgery) and healthy controls. The goal is to develop a non-inva…

This early-stage trial tested a new fluorescent dye called LS301-IT in 24 people having lung cancer surgery. The dye is designed to attach to cancer cells and glow under a special light, helping surgeons see tumors more clearly. The main goals were to check safety and see how wel…

This study aimed to create easy, non-invasive tests using blood and saliva to find markers of certain cancers, like breast and lung cancer. Researchers worked with 250 adults who had these cancers but hadn't started treatment yet. The goal was to improve early detection and monit…

This study tested a new imaging tool called needle-based confocal laser endomicroscopy (nCLE) to help doctors locate lung nodules during robotic-assisted bronchoscopy. 53 adults with lung nodules at risk for cancer took part. The goal was to see if the tool could safely and accur…

This study tested whether specially trained dogs can identify breast, lung, prostate, or colorectal cancer by sniffing breath samples collected on masks. Over 1,300 people provided breath samples before their regular cancer screening or biopsy. The dogs' results were compared to …

This study tested a new type of PET scan (68Ga-FAPI) to see if it can find lung cancer and its spread more accurately than the standard FDG-PET scan. 58 adults with known or suspected lung cancer received both scans, and results were compared to tissue samples or follow-up. The g…

This study tested a special fluorescent dye called VGT-309 that makes lung cancer cells glow during surgery. About 89 people with known or suspected lung cancer received the dye before their operation. The goal was to see if the dye helps surgeons find tumors that are hard to see…

This study tested a new smart probe that uses electrical signals to tell the difference between healthy lung tissue and tumors during a biopsy. 30 adults with lung lesions took part. The goal was to see if the probe could help doctors make more accurate diagnoses during the proce…

This pilot study tested whether low-dose CT scans can help find lung cancer early in HIV-positive people who are heavy smokers. Researchers scanned 450 participants to see how many had lung cancer and what types were found. The goal was to learn if this screening method is useful…

This study tested whether a special PET scan (called 18F-DOPA PET-CT) can find brain metastases as well as or better than standard MRI in people with lung cancer, breast cancer, or melanoma. 32 adults with untreated brain metastases took part. The goal was to see if this PET meth…

This completed study tested a tool called MyLungHealth, delivered through a patient portal, to help more people get screened for lung cancer. Over 31,000 participants aged 50-79 with a smoking history were involved. The tool aimed to identify who was eligible for screening and en…

This study tested whether a blood test can detect ALK gene rearrangements in lung cancer patients, which currently requires an invasive tumor biopsy. Researchers analyzed circulating tumor cells from blood samples of 206 patients with advanced lung cancer. The goal was to see if …

This study looked at whether a blood test for circulating tumor cells (CTCs) can help detect lung cancer earlier in people at very high risk: smokers and ex-smokers with COPD. Researchers combined this blood test with low-dose CT scans over three yearly screenings in 683 particip…

This study looked at whether using a liquid biopsy (a blood test that detects cancer DNA) early in the diagnostic process could help doctors diagnose and recommend treatment faster for people with advanced lung or gastrointestinal cancer. 463 participants were enrolled across mul…

This study tested whether giving doctors access to a blood test called FirstLook increases lung cancer screening rates among people at high risk. The test looks for DNA fragments in the blood that may signal lung cancer. Researchers compared screening rates in practices that coul…

This study tested a new integrated device that combines two systems to help doctors biopsy small lung nodules. The goal was to see if the device could improve how often the needle hits the target and how accurately it diagnoses cancer. The study involved 155 adults with lung nodu…

This study looked at whether adding a special ultrasound procedure (EBUS-TBNA) after a standard PET/CT scan can more accurately stage early-stage non-small cell lung cancer. The 150 participants had stage I or IIa cancer and were being considered for radiation therapy. The goal w…

This study tested a special breathing technique during PET scans to get clearer images of lung tumors. 103 people with small lung nodules (under 35 mm) had both a standard PET scan and an extra scan where they held their breath. The goal was to see if this reduces blurring from b…

This study collected blood samples from 109 people with and without lung cancer to develop a blood test called OncoSweep Lung Spotlight. The test looks for genetic and other signals in the blood that might indicate lung cancer. Researchers hope this could lead to a simple, non-in…

This study tested a robotic system (Ion Endoluminal System) to see how accurately it can place a biopsy tool into lung nodules. 200 adults with lung nodules between 6 mm and 3 cm took part. The system uses real-time 3D imaging to guide the biopsy needle. The main goal was to meas…

Researchers are testing whether pirfenidone, a drug that reduces inflammation and scarring, can prevent radiation pneumonitis in people with advanced lung cancer. Participants have already received immune checkpoint inhibitors and need chest radiation. The trial gives pirfenidone…

This pilot study tests a peer-led program designed to help Black Veterans at high risk for lung cancer get screened. Veterans who have not yet had lung cancer screening will receive group orientations and one-on-one support from a peer to navigate the process. The study aims to s…

This phase II trial tested whether the immunotherapy drug pembrolizumab (Keytruda) can prevent lung cancer in 45 people with high-risk lung nodules or early-stage non-small cell lung cancer. Participants received pembrolizumab intravenously, and researchers tracked tumor response…

This early-phase study tested a vaccine called CIMAvax-EGF in 20 people at high risk for lung cancer or survivors at risk of recurrence. The vaccine works by helping the body make antibodies against a protein that can fuel cancer growth. Researchers checked for side effects and m…

This study tests whether a special infrared light can help nurses see veins better when placing IVs in lung cancer patients receiving chemotherapy. The goal is to reduce pain, improve comfort, and strengthen trust between patients and nurses. About 160 patients will take part, wi…

Researchers compare two chest drain sizes, 20-Fr and 24-Fr, in people having part of a lung removed for early-stage lung cancer. After surgery, each participant receives one of the two drains to clear fluid and air from the chest. The trial tracks complications such as collapsed …

This trial tests whether immersive virtual reality or relaxing nature videos can reduce symptom severity, distress, and improve quality of life in people with lung cancer who are starting chemotherapy. Participants will be randomly assigned to one of three groups: virtual reality…

Researchers test a guided exercise program for people aged 60 and older recovering from lung cancer surgery. The program combines breathing exercises, shoulder training, and strength work, taught through videos and a manual. The trial measures how far participants can walk in six…

Researchers compare two ultrasound-guided nerve blocks to see which one better controls pain after video-assisted thoracoscopic surgery (VATS), a minimally invasive lung operation. The trial enrolls 46 adults scheduled for VATS. Participants receive either a serratus posterior su…

This study tested a new care plan that gets people eating and moving sooner after lung surgery. 232 adults took part. The goal was to see if this approach, based on the ERAS protocol, improves recovery quality, reduces complications, and shortens hospital stays compared to standa…

Researchers are studying whether they can safely perform talc pleurodesis on both lungs at the same time in people with malignant pleural effusions, which is fluid that builds up around the lungs because of cancer. The procedure uses medical-grade talc to seal the space around th…

This study tests whether a conversation game called 'Hello' can help people with cancer and their loved ones discuss advance care planning—decisions about future medical care. Participants will play either the Hello game or a similar conversation game, complete questionnaires, an…

This study tested a structured physiotherapy program for 60 people who had lung cancer surgery. The program included breathing exercises, early walking, and posture training during their hospital stay. Researchers measured how long people stayed in the hospital and checked vital …

This study tests whether teaching family caregivers about lung cancer care—through a handbook and personalized guidance—can reduce stress and improve quality of life for patients undergoing lung cancer surgery. The trial involves 160 patients and their caregivers, with some recei…

This study tests a psychosocial program called Conquer Fear Support (CFS) for people with stage III or IV lung or gynecologic cancer who are experiencing fear of cancer progression. The program includes psychoeducation, attention training, worry management, and detached mindfulne…

This trial tests whether adding nebulized ketamine to lidocaine before a fiberoptic bronchoscopy reduces coughing and discomfort compared to lidocaine alone or standard spray. About 134 adults scheduled for bronchoscopy will receive one of three premedication approaches. The stud…

This study looks at two ways of delivering palliative care—specialized support to ease symptoms and stress—for people recently diagnosed with advanced lung cancer. One approach starts with basic palliative care and adds more if needed, while the other provides full palliative car…

This study investigates whether a 12-week program of tai chi and qigong (called Body Mind Training) can reduce fatigue in male cancer survivors aged 55 and older. Participants are randomly assigned to the mind-body training, a light exercise-only group, or a usual-care group. Res…

This trial tests whether daily bright light therapy can improve sleep and reduce biological aging in people with lung cancer. Participants wear a light visor for 4 weeks and track sleep, fatigue, and stress. The study compares bright light to usual light exposure to see if it hel…

This pilot study tests a breathing method called percussive ventilation breathhold (PVB) to help people hold still during lung cancer radiation. The goal is to see if the technique can be used successfully by healthy volunteers and lung cancer patients. If it works, it may allow …

This pilot study tested whether a smartphone-based program could help high-risk patients recover their breathing after lung surgery. Fifty-eight adults who had lung resection and were either older or had reduced lung function were split into two groups: one used a smartphone app …

This study tested whether professional socio-aesthetics (specialized beauty and well-being care) can improve quality of life, reduce pain, and ease anxiety in adults undergoing chemotherapy for lung, breast, colon, or prostate cancer. 400 participants were randomly assigned to re…

This study tested whether personalized motivational messages sent via apps like WhatsApp could improve thinking skills and physical activity in lung cancer survivors who have memory or concentration problems. 124 survivors wore activity trackers and received custom messages for t…

This study tested two ways to manage pain in 70 children undergoing chest surgery. One method, the erector spinae plane block, was compared to the standard epidural block. The goal was to see which provides better pain relief and keeps the heart rate and blood pressure more stabl…

This early-phase trial tested a treatment called photodynamic therapy for people with advanced lung cancer that blocks airways. Patients received a light-sensitive drug followed by a laser to activate it inside the tumor. The goal was to see if the treatment is safe and can shrin…

This study tested whether a mobile app with videos and written guides, given before chest surgery, helps patients recover better. 128 adults scheduled for elective chest surgery were split into two groups: one used the app, the other got standard education. Researchers measured q…

This study tested whether a brief mindfulness video could help reduce the stigma that lung cancer patients often feel, especially those from underserved groups. Researchers worked with a community advisory board of lung cancer patients to design the video. The trial enrolled 108 …

This study tested an 8-week supervised program of breathing exercises and light strength training for 30 people with advanced lung cancer (stage IIIB/IV) who were also getting chemotherapy. Those in the rehab group could walk farther, breathe better, and reported less coughing an…

This study tested whether a simple walking program, guided by a fitness tracker, could help cancer patients tolerate their chemoradiotherapy without missing treatments. 166 adults with brain, head and neck, lung, gastrointestinal, or cervical cancer participated. Patients were gi…

This study tested a 4-week nursing program based on self-efficacy theory for 300 lung cancer patients receiving CyberKnife radiation. The program included education, psychological support, and self-management training. Researchers measured changes in anxiety, pain, and quality of…

This pilot study tested a 10-week virtual group program called Mindful Self-Compassion for Lung Cancer (MSC-LC) in 79 adults with lung cancer who felt stigmatized. Participants were randomly assigned to the program or a waitlist that received mental health resources. The goal was…

This study tested a program to help lung cancer patients stop smoking and avoid starting again. 21 adults with lung cancer who smoked took part. The program included counseling, a web video, and support calls. The goal was to see if the program was easy to use and if patients lik…

This study tested a team-based nursing program for 200 people with advanced small cell lung cancer receiving chemotherapy plus immunotherapy. The program included close monitoring for side effects, help with medication adherence, nutrition and exercise support, and psychological …

This study tested whether a family-supported palliative care program could improve quality of life and emotional well-being in 110 people with advanced lung cancer. Participants were randomly assigned to either the family-supported program or standard nursing care for 8 weeks. Th…

This study tested whether practicing pranayama breathing exercises for 15-20 minutes a day, 5 days a week for 8 weeks, could help adults aged 60 and older feel less stressed, sleep better, and enjoy a higher quality of life. Researchers compared 74 participants who did the breath…

This study tested a low-cost, portable exercise program for people with non-small cell lung cancer after surgery. The goal was to help them manage severe fatigue and improve their quality of life. 235 adults took part, and the program was designed to be safe and practical for nea…

This study tested a newer, potentially safer nerve block (MTP block) against the standard one (thoracic paravertebral block) for pain after chest surgery. 180 adults having lung surgery through a large chest incision were included. The goal was to see if the newer block provides …

This completed study tested whether motivational interviewing, a supportive counseling style, delivered through online video calls could increase the intention to quit smoking in people with lung cancer. Forty-two participants who smoked were randomly assigned to receive the inte…

This study tested whether a nurse-led education session before thoracic surgery helps lung cancer patients recover better. 100 adults were split into two groups: one received structured education with a booklet, the other got standard care. Researchers measured pain, lung functio…

This completed trial tested a web-based remote monitoring platform called CONTINUUM+ CONNECT in 411 adults with metastatic breast, lung, colorectal, or prostate cancer. Patients used the platform to report symptoms and receive alerts, aiming to improve their physical health and q…

This study tested whether using a laryngeal mask with a special bronchial blocker causes less sore throat and hoarseness after lung surgery compared to the standard double-lumen tube. 270 adults having lung surgery took part. The goal was to see which device leads to fewer throat…

This study looked at whether foot reflexology—a type of foot massage—can reduce nausea and vomiting caused by platinum-based chemotherapy. Eighty people with lung or digestive cancer received reflexology sessions during their chemo infusions and were asked to do self-massage betw…

This study tested whether augmented reality (AR) can help surgeons locate small lung nodules during surgery, compared to the standard CT-guided hook-wire method. 270 patients with lung cancer were enrolled across multiple centers. The goal was to see if AR could make the procedur…

This study tested a supportive care program for adults aged 60 and older with advanced lung cancer. The program combined physical therapy and relaxation exercises to help improve physical function and emotional wellbeing. Researchers measured how well participants stuck with the …

This study tested whether giving lidocaine or alfentanil before inserting a bronchoscope can reduce coughing when spraying numbing medicine into the airways. 108 adults with lung tumors received one of these drugs or a placebo before the procedure. Researchers measured cough seve…

This study tested a new care model called BeWell360-CG, which provides health and wellness coaching to caregivers of people with advanced lung cancer. The goal was to see if the program could reduce caregiver burden and improve their quality of life. Fifty-five caregivers partici…

This study tested a therapy called Managing Cancer and Living Meaningfully (CALM) to see if it helps people with brain cancer feel less distressed. 60 adults with brain tumors or brain metastases who had high depression or death anxiety took part. The study measured how many peop…

This study tested whether watching 360° virtual reality movies can reduce fear and anxiety in cancer patients about to start radiation therapy. 292 adults with breast, lung, prostate, head and neck cancer, or brain tumors participated. Patients watched a VR movie and then filled …

This study tested a new bendable surgical tool (SurgeoFlex Grasp) against a standard rigid tool in 100 adults with early-stage lung cancer undergoing keyhole surgery. The goal was to see if the flexible tool makes lymph node removal faster, reduces instrument clashes, and eases s…

This study looks at whether closely following a standard enhanced recovery after surgery (ERAS) protocol affects nutritional status in 120 adults undergoing lung cancer surgery. Researchers will measure nutritional risk and a nutritional index before surgery and two days after, a…

This study collected and stored biological samples from nearly 10,000 tin miners in China who are at high risk for lung cancer due to workplace exposures. The goal is to use these samples to discover early markers of the disease, which could lead to better screening and preventio…

Researchers want to learn which molecules on cancer cells the immune system attacks when checkpoint inhibitor drugs work well. They collect tumor and blood samples from adults with solid tumors who respond to these drugs, either during treatment or after surgery. The team then se…

This study looks at how doctors currently diagnose lung and breast cancer using tissue samples. It will also test whether artificial intelligence (AI) can help analyze these samples faster and more accurately. Researchers will review records from 600 patients to measure diagnosis…

This study looks at why lung cancer cells stop responding to a class of drugs called EGFR inhibitors. Researchers will collect blood samples from 80 patients over time to track changes in tumor DNA and cells. The goal is to understand the early steps of drug resistance and find w…

This study tested a new cone-beam CT scanner that takes clearer pictures during radiation therapy for lung, liver, and breast cancers. 31 people participated to see if the new scanner reduces image blurring and improves accuracy. The goal is to help doctors target tumors more pre…

This study tested whether iPhones and Apple Watches can reliably collect health data from people with cancer. 49 adults undergoing cancer treatment wore an Apple Watch and used an iPhone for 4 months to track activity, fatigue, and thinking skills. The goal was to see if these de…

This study compares two breathing techniques used during robotic bronchoscopy, a procedure to biopsy lung nodules. The goal is to see which method better prevents atelectasis (lung collapse) during the procedure. About 62 adults with suspicious lung nodules will be randomly assig…

This study looked at whether a lung rehab program done over video calls can help people recover after lung cancer surgery. 36 patients aged 55-75 who had part or all of a lung removed took part. They did exercises and tests like the 6-minute walk and breathing tests, all guided b…

This study is testing whether a CT-free electromagnetic navigation system can accurately locate small lung nodules before surgery, compared to the standard CT-guided method. The goal is to see if the new approach can mark nodules within 10 millimeters of their center, which is cr…

This study tests a new AI tool called GAPS-Agent that helps doctors plan surgeries for lung cancer. The tool is designed to assist less experienced doctors in making complex decisions. Researchers will compare AI-generated plans to those from a standard AI, and expert surgeons wi…

This study looks at 248 lung cancer patients having surgery to see if the length of time they quit smoking before the operation affects their risk of complications like pneumonia or heart issues. Researchers compare recent quitters and long-term nonsmokers to find the best timing…

This study looks at how anti-tumor T-cell responses change in people with lung or head-and-neck cancer who are receiving radiochemotherapy. Researchers will collect blood and tumor samples to track immune markers. The goal is to understand whether this standard treatment can boos…

This study tests whether sending text reminders to patients and alerts to their doctors can increase the number of people who get yearly lung cancer screening or follow-up tests. About 825 patients and their clinicians are taking part. The goal is to see if these simple nudges im…

This study tests whether canakinumab, a drug that blocks inflammation, can lower certain proteins linked to cancer growth in former smokers at high risk. About 41 participants will provide cheek, nose, and blood samples before and after treatment. The goal is to see if the drug c…

This trial tests whether presenting a cancer screening appointment as a pre-selected default option (opt-out) makes people at high risk for lung or stomach cancer more likely to accept it, compared to a standard opt-in approach. Participants complete an online questionnaire and d…

This study tests whether a biopsy technique called transbronchial cryobiopsy is safer than the standard method for diagnosing lung cancer. About 100 adults with known or suspected lung cancer will undergo the procedure under general anesthesia. Researchers will track complication…

This study looks at whether using suction during a lung biopsy (EBUS-TBNA) helps get better tissue samples from people with suspected lung cancer that has spread to lymph nodes. Researchers will compare samples taken with and without suction to see which method gives more materia…

This study develops and tests a tool designed to help lung cancer nurses talk to patients about clinical trials. The tool provides information on available trials, communication tips, and practical guidance. Researchers will test it in four UK hospitals to see if it improves nurs…

This study aims to develop and test a tool that helps lung cancer nurses talk to patients about clinical trials. Only about 8% of lung cancer patients in the UK join trials, and nurses often lack the time or confidence to discuss them. The tool will be tested in four UK hospitals…

This study investigates whether a simple blood test (liquid biopsy) can track how advanced non-small cell lung cancer changes during immunotherapy or targeted therapy. Researchers will analyze tumor DNA circulating in the blood to see if it can predict treatment response and dete…

This study looked at 30 people with early-stage non-small cell lung cancer who had surgery. Researchers collected blood from a vein near the tumor and from a regular arm vein to study tiny particles called exosomes. The goal was to see if these particles could help predict whethe…

This study followed 39 lung cancer patients who received radiation therapy to see how it affected their breathing. Researchers measured lung volume and gas exchange capacity before and after treatment, looking for a 20% or greater drop in diffusion capacity at 3 months. The goal …

This study uses lung ultrasound to measure how the lungs change after surgery to remove part of a lung due to cancer. Researchers will check lung aeration before surgery, right after, and 24 hours later in about 32 adults. They aim to see if ultrasound findings relate to oxygen l…

This study tested whether a protein called GLUT1 could help doctors better classify lung neuroendocrine tumors. Researchers analyzed tumor samples from 36 patients to see if GLUT1 staining patterns matched tumor type. The goal was to find a more reliable diagnostic tool than curr…

This study watches 300 lung cancer patients to see how they recover after one of two surgeries: removing a small part of the lung (sublobar resection) or a larger section (lobectomy). Participants wear a digital device and answer questions about pain, cough, and tiredness. The go…

This completed study collected information from 101 patients and healthcare providers to design a care pathway for COPD in people also being treated for lung or head and neck cancer. The goal was to identify common burdens and barriers to COPD care in oncology clinics. The findin…

This study analyzed health records from over 229,000 people with newly diagnosed lung cancer in Korea to see if getting a brain MRI every year helps find cancer that has spread to the brain. The goal was to learn whether these scans catch brain metastases earlier, when they might…

This study enrolled 200 adults with lung adenocarcinoma that has spread to the bones. Researchers took bone biopsies, scans, and blood tests to measure bone and metabolic markers. The goal is to see if these markers are linked to how long patients live. This is an observational s…

This study reviewed the medical records of 569 adults who had surgery for lung or esophageal cancer. Researchers wanted to see if taking statins (cholesterol-lowering drugs) around the time of surgery was linked to fewer complications and better long-term outcomes. The goal is to…

This study looked at how physically active lung cancer patients are during radiation therapy. Twenty adults with lung cancer carried smartphones that counted their steps. Researchers compared step counts from the first week of treatment to the fifth week to see if activity change…

This study tested whether a special 4D PET-CT scan can help doctors better target radiation for lung cancer. Seven patients with non-small cell lung cancer received both a standard CT scan and a 4D PET-CT scan before radiotherapy. Researchers compared the tumor volumes identified…

This study looked at 24 people with lung or esophageal cancer who received radiation or chemo-radiation near the heart. Participants wore a small heart monitor to catch any heart changes that might otherwise go unnoticed. The goal was to see how often heart problems occur after s…

This completed study looked at 150 people with advanced non-small cell lung cancer to see if proteins and metabolites in blood and urine could help monitor how well immunotherapy is working. Researchers used mass spectrometry to measure these markers before, during, and after tre…

This study looked at how to best set a breathing machine during lung surgery when only one lung is being used. The goal was to see if using smaller breaths with higher pressure could keep oxygen levels stable. 88 adults having lung surgery took part. The study measured oxygen in …

This study looked at whether a lung specialist (pulmonologist) can quickly check biopsy samples during a lung cancer procedure, a job usually done by a pathologist. Researchers compared the pulmonologist's on-the-spot assessment with the pathologist's final report in 189 patients…

This study tested a smartphone app that reminds people to walk several times a day. It was designed to help lung cancer patients stay active during radiotherapy. Thirty healthy volunteers downloaded the app and rated how easy it was to use. The goal was to see if the app is user-…

This study tested a virtual navigation system that helps doctors guide a bronchoscope to lung nodules for sampling. Researchers compared results from 110 patients who used the system to historical data from standard procedures. The goal was to see if the system improves biopsy su…

This study tested a new way to help surgeons remove small lung nodules during a type of keyhole surgery called VATS. Doctors used a cone-beam CT scanner to place tiny metal markers (microcoils) near the nodules before removal. The goal was to see if this method is accurate and re…

This study looked at 77 never-smokers newly diagnosed with lung cancer to see how many also have sleep apnea and whether sleep apnea affects their cancer outlook. Participants had a sleep test before starting cancer treatment. The goal is to understand if sleep apnea is a hidden …

This study looked at chemical fingerprints (metabolites) in blood, lung tissue, and exhaled breath from 74 people with either non-small cell lung cancer or harmless lung nodules. The goal was to find differences that could help diagnose lung cancer without invasive procedures. Re…

This study tested whether sending text messages can help more people get screened for lung cancer. 65 adults aged 50-80 who were current or former smokers took part. The program used a central system to check who was eligible, offer risk assessments, and help schedule screening. …

This completed study looked at 1200 patients who had a CT-guided needle biopsy of a lung nodule at St. Olavs Hospital between 2012 and 2023. The goal was to track how often complications like a collapsed lung (pneumothorax), lung bleeding, or air embolism happen. By analyzing the…

This completed study tested whether a new biomarker called 'mass response' can predict how well a cancer therapy will work. Researchers collected tumor cells from 72 patients with various cancers through fluid drainage or biopsies. The goal was to see if this biomarker could guid…

This study analyzed blood, urine, and tissue samples from 273 adults with brain or lung cancer who were receiving radiation therapy. The goal was to find biological markers that could predict which patients are more likely to develop serious side effects from radiation, such as l…

This pilot study looked at whether cancer patients with head and neck, lung, or digestive system cancers could wear a fitness tracker during radiation therapy. The goal was to see if tracking activity levels and quality of life is practical and might relate to treatment outcomes.…

This study looks at whether the drug T-DXd works better than standard treatments for people with several types of HER2-positive solid tumors. Researchers will compare data from previous T-DXd trials with real-world medical records of patients who received standard care. The goal …

This small study tested a device that paces the diaphragm in brain dead organ donors whose lungs were too damaged for transplant. The goal was to see if this approach could improve lung function enough to make the lungs usable. Only 3 people took part, so the results are very ear…

This study looked at whether cancer survivors living in rural areas can create their own survivorship care plans and learn from telehealth education. 261 survivors of breast, colorectal, lung, lymphoma, or prostate cancer took part. The goal was to see if this approach improves t…

This study tested whether giving Hispanic/Latinx patients educational materials, financial navigation help, and reminders could increase lung cancer screening with low-dose CT scans. 60 eligible adults aged 50-80 with a smoking history took part. The goal was to see if these simp…

This study tested whether free, open-source software can create 3D models of the lungs to help surgeons during lung cancer surgery. 13 patients scheduled for lung surgery had their CT scans turned into 3D reconstructions. The goal was to see if these models were easy for surgeons…

This completed study tested whether offering free transportation and help scheduling appointments could improve attendance at lung cancer screenings in Philadelphia. Over 250 residents with upcoming or missed low-dose CT scans were offered these services. The goal was to see if s…

This completed study from City of Hope Medical Center looked at 109 people to understand how genetics and social factors like income and education may affect lung cancer risk. Participants gave blood samples, had low-dose CT scans, and filled out surveys. The goal is to find clue…

This study looked at 385 adults diagnosed with their first lung or head & neck cancer to see how many continued using tobacco or alcohol over the next year. Researchers tracked smoking and drinking habits, as well as how long patients lived without the cancer getting worse. The g…

This study tested whether helping people with social needs like housing, food, or transportation could increase lung cancer screening rates. 101 adults aged 50-80 who smoked heavily were split into two groups: one got standard education about lung screening, and the other also go…

This pilot study tested whether a short survey can help hospitalized patients with advanced lung or gastrointestinal cancers discuss their goals and preferences with their oncologist after leaving the hospital. The survey asks about treatment goals and understanding of the diseas…

This study tested a program to help more people at high risk for lung cancer get a low-dose CT scan, which can catch the disease early and save lives. The program included notifying doctors, educating patients, offering financial help, and reminding patients to talk about screeni…

This study tested whether an AI-assisted software (iCurveE) helps doctors outline organs at risk on CT scans for radiation therapy more accurately and quickly. 500 adults with lung, breast, or esophageal cancer participated. Researchers compared manual outlining, AI-only, and AI-…

This study looked at the safety and effectiveness of the drug Vizimpro in 188 adults with advanced lung cancer who had specific gene mutations. It was an observational study, meaning patients received their normal treatment and researchers simply collected data on side effects an…

This study looked at nearly 2,000 adults with lung cancer who caught COVID-19. Researchers tracked their health and checked for antibodies (immune system markers) right after infection and again 6 months after vaccination. The goal was to understand how lung cancer affects the bo…

This study looked at sexual problems in 553 adults with lung cancer. Researchers wanted to find out how common these issues are and how severe they can be. The goal is to help doctors better support patients during and after cancer treatment.

This completed study collected blood and tumor tissue from 64 patients with advanced cancers (like melanoma, breast, lung, and kidney cancer) to study genetic changes and treatment resistance. The samples are stored for future research, including genomic analysis. No new treatmen…

This study looked at whether using a CPAP machine (commonly used for sleep apnea) during radiation therapy can reduce the amount of radiation reaching the lungs. Eight people with left-sided breast cancer or lung cancer took part. Researchers compared lung radiation doses with an…

This study looked at whether the time of day affects the number of cancer cells in the blood of people with advanced lung cancer. Researchers took blood samples from 27 patients at 4 a.m. and 10 a.m. before starting treatment. The goal was to see if circadian rhythms influence ho…

This study tested a program called KanSurvive, which uses virtual education sessions and practice support to help rural primary care clinics improve follow-up care for cancer survivors. Researchers worked with 15 rural practices to see if they could better follow guidelines for m…

This study looked at medical records of over 21,000 adults with type 2 diabetes and COPD to see if a diabetes drug called SGLT2 inhibitor lowers the chance of getting lung cancer compared to an older drug, sulfonylurea. Researchers did not give anyone new medicine; they just anal…

This study tracked 51 lung cancer patients before and after video-assisted thoracoscopic surgery to see how much time they spent lying down, sitting, or standing. Researchers also looked at what prevented patients from moving more. The goal was to understand barriers to early mob…

This study tested whether telehealth coaching can help people get their yearly lung cancer screening on time. 22 participants who were overdue for a follow-up low-dose CT scan received coaching via video or phone call. The goal was to see if this approach is practical and helps p…

This study tested a new cone-beam CT scanner designed to take clearer images while patients are on the radiotherapy couch. 41 adults with head-and-neck, lung, breast, abdominal, or pelvic cancer each had one or two scans with the new device. The goal was to see if the images were…

This study looked at whether a special type of PET scan called parametric imaging can better predict if lung cancer will come back within a year after chemoradiation. Researchers compared it to standard PET scans in 40 patients with non-small cell lung cancer. The goal is to see …

This study looked at whether a simple blood test can monitor lung cancer progression without needing to sample the tumor directly. Researchers checked for genetic changes in the blood of 200 lung cancer patients. The goal was to see if this non-invasive method could track how the…

This study asked 167 people with cancer (and their caregivers) what they value most during pharmacy consultations for oral cancer drugs. Using a survey method, researchers identified key preferences to help hospitals design better support services. The goal was to improve patient…

This study tested whether inhaling iloprost, a drug that widens blood vessels in the lungs, can improve oxygen levels in obese patients during one-lung ventilation for lung surgery. 78 participants were randomly assigned to receive either iloprost or a saltwater placebo. The rese…

This study tested a special camera system that uses near-infrared light to help surgeons see blood flow during minimally invasive lung and esophagus surgery. 38 adults took part at Massachusetts General Hospital. The goal was to see if the camera could clearly show tissue blood s…

This study looked at whether firefighters have different lung scan results compared to non-firefighters, and if a blood test can help better predict lung cancer risk. Over 700 current and retired firefighters took part. The goal was to improve early detection of lung cancer and o…

This study looked at 535 people in France with advanced non-small cell lung cancer who were given nivolumab after at least one round of chemotherapy. Researchers wanted to see how well the drug worked, how long it kept cancer from getting worse, and what side effects occurred in …

This study tested whether an automated system can grow cancer cells from patient samples (blood, fluid, or tumor tissue) inside chicken eggs. Researchers aimed to see if at least half of the samples would successfully grow. The goal is to create a better, cheaper way to study can…

This study tested whether Facebook ads and a personalized online tool called LungTalk could increase awareness and knowledge about lung cancer screening among people at high risk. Over 500 participants with a history of heavy smoking were recruited through Facebook. The goal was …

This study looked at whether explaining the risks of chemotherapy more honestly to patients with incurable lung cancer could reduce the number who receive chemo in their last month of life. Researchers randomly assigned 123 patients to either standard information or a more detail…

This study tracked over 700 people in Korea who were already receiving the cancer drug Imfinzi (durvalumab) for lung or biliary tract cancer. The goal was to see how safe and effective the drug is in everyday medical practice, not just in strict clinical trials. Researchers monit…

This study tested whether a wearable device and smartphone app can monitor cancer patients' vital signs and symptoms as well as standard in-clinic checks. About 100 patients with various cancers participated, either after CAR-T cell therapy or during radiation treatment. The goal…

This completed study looked at 165 adults newly diagnosed with lung or head & neck cancer who smoked. Researchers interviewed them by phone about their smoking and drinking habits, and followed up at 3, 6, and 12 months. The goal was to understand what makes it harder or easier f…

This study looked at whether having cancer patients report their own symptoms during radiation treatment helps doctors notice and manage side effects better. About 104 adults with lung, esophageal, or other gastrointestinal cancers took part. Doctors reviewed patient-reported sym…

This completed study looked at 500 non-small cell lung cancer patients who had surgery. Researchers collected blood samples before and after surgery to detect circulating tumor cells (CTCs). They then analyzed these cells to see if their presence could predict cancer recurrence o…

This study tested two simple tools—a laser pointer and a plastic block—to help doctors pick the correct angle for inserting a biopsy needle during CT scans. Seventeen adults scheduled for a CT-guided biopsy took part. The goal was to see if these tools improved angle selection co…

This study created a registry of 149 cancer patients who received a precise type of radiation called SBRT. The goal was to track how doctors use this treatment in four different situations: for cancer that has spread to a few spots, after chemotherapy, before starting chemotherap…

This completed study followed 150 lung cancer patients to see how their treatment—surgery, chemo, radiation, or immunotherapy—affects their physical abilities, symptoms, and quality of life. Researchers measured things like walking distance, muscle strength, and daily activity le…

This completed trial with 66 participants compared two methods for marking small lung nodules before minimally invasive surgery: navigational bronchoscopy using a green dye (ICG) and CT-guided radioisotope injection. The goal was to see which method helps surgeons find and remove…

This study tested a community support program that offered free transportation to lung cancer screening appointments for West Philadelphia residents. Out of 242 participants, researchers measured how many people attended their scheduled low-dose CT scans. The goal was to see if r…

This study tested a software tool called RUS Lung that creates a 3D model of a patient's lungs from CT scans. Surgeons used it to plan and guide minimally invasive surgery for early-stage lung cancer. The study enrolled 34 adults and checked how well the tool matched the actual t…