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Can a simple injection stop coughing during lung procedures?

NCT ID NCT05072236

Symptom relief Sponsor: National Taiwan University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving lidocaine or alfentanil before inserting a bronchoscope can reduce coughing when spraying numbing medicine into the airways. 108 adults with lung tumors received one of these drugs or a placebo before the procedure. Researchers measured cough severity, brain activity, and vital signs to see which drug worked best.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lidocaine and alfentanil
What this could lead to
If it works, this could point toward a simple way to reduce coughing during bronchoscopy, making the procedure safer and more comfortable.
What could go wrong
This is a small, completed study with 108 participants, so results may not apply to all patients. The drugs may not significantly reduce cough or could cause side effects like drowsiness or low blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

108 people

The number who actually took part.

Started

May 2022

Finished

Oct 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients planned to receive bronchoscopic interventions for lung tumors with intravenous anesthesia. Exclusion Criteria: * conventional bronchoscopy without interventions such as EBUS, tracheal tumore excision

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Conditions

The condition(s) this trial relates to.

Cough lung disorder lung neoplasm Respiratory Aspiration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Bronchoscopic interventions Lung diseases Total intravenous anesthesia

Contacts and locations

Locations

  • National Taiwan University Cancer Center Hospital

    Taipei, Taiwan

More trials for these conditions

Other studies related to the condition(s) this trial covers.