Can a simple injection stop coughing during lung procedures?

NCT ID NCT05072236

Completed Symptom relief Sponsor: National Taiwan University Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether giving lidocaine or alfentanil before inserting a bronchoscope can reduce coughing when spraying numbing medicine into the airways. 108 adults with lung tumors received one of these drugs or a placebo before the procedure. Researchers measured cough severity, brain activity, and vital signs to see which drug worked best.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: lidocaine and alfentanil
What this could lead to: If it works, this could point toward a simple way to reduce coughing during bronchoscopy, making the procedure safer and more comfortable.
What could go wrong: This is a small, completed study with 108 participants, so results may not apply to all patients. The drugs may not significantly reduce cough or could cause side effects like drowsiness or low blood pressure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cough lung disorder lung neoplasm Respiratory Aspiration

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BRONCHOSCOPIC INTERVENTIONS LUNG DISEASES TOTAL INTRAVENOUS ANESTHESIA

Contacts and locations

Locations

National Taiwan University Cancer Center Hospital

Taipei, Taiwan

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