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Can heat zap lung tumors without surgery?

NCT ID NCT00180856

Disease control Sponsor: Gustave Roussy, Cancer Campus, Grand Paris Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 17, 2026 · Last updated Aug 18, 2026 · Updated 1 time

Summary

This trial tests whether radiofrequency ablation—a procedure that uses heat to destroy cancer cells—can effectively treat lung tumors that cannot be removed with surgery. The study includes people with primary lung cancer or lung metastases, with up to five tumors each no larger than 40 mm. Researchers will measure how completely the tumors are destroyed, how long patients live without lung disease progression, and overall survival.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Radiofrequency ablation, a procedure that uses heat to destroy tumor cells
What this could lead to
If successful, this could offer a treatment option for people with lung tumors that cannot be surgically removed, potentially improving local control and survival.
What could go wrong
This is a phase II trial with a modest number of participants, so results may not be definitive. The procedure may not completely destroy all tumors, and there are risks of complications from the ablation itself.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

60 people

Start date

Jan 2002

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Unilateral or bilateral unresectable primary or metastatic lung tumors \<= 40 mm and a number of tumor \<=5 * Tumors located more than 1 cm from the hilum, and not involving soft tissues or mediastinum. * Malignancy histologically proven for pulmonary nodules in patients with no history of cancer outside the lung. * Lung tumors in patients with a known distant cancer history, has to be either histologically proven or a demonstrated change in size of at least 25% in their largest diameter is required on CT during the previous year * Pretreatment imaging work-up within 4 weeks of scheduled RF ablation (at least a chest CT and an abdomino-pelvic CT) * If a tumor is found outside the lung, it has to be amenable to complete eradication with RF or RF plus surgery * Lung spirometry within 4 weeks of treatment with a FEV1 \>= 1 liter * Written informed consent. Exclusion Criteria: * Uncorrectable coagulopathy with a prothrombin time greater than 1.5 and a platelet count below 106/mm3

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm metastatic neoplasm Neoplasm Metastasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lung cancer Metastasis

Contacts and locations

Locations

  • Institut Bergonié

    Bordeaux, 33 000, France

  • Institut Gustave Roussy

    Villejuif, 94800, France

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