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Breathing Tube-Free lung surgery may be gentler on lungs and the planet

NCT ID NCT07057531

Disease control Sponsor: The First Affiliated Hospital of Guangzhou Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a new way to do lung cancer surgery without using a breathing tube or ventilator. Instead, patients breathe on their own during the operation. The goal was to see if this 'tubeless' method causes less lung injury, helps patients recover faster, and reduces pollution from anesthesia gases. The study involved 73 adults having surgery for early-stage lung cancer.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Tubeless thoracic surgery (procedure without tracheal intubation or mechanical ventilation)
What this could lead to
If successful, this approach could reduce lung injury and speed recovery after lung cancer surgery, while also lowering carbon emissions from anesthesia.
What could go wrong
This is a small, completed study with only 73 participants, so results may not apply to all patients. The tubeless technique may not be suitable for complex cases or those with poor lung function.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

73 people

The number who actually took part.

Started

Jul 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients aged ≥18 years scheduled for elective video-assisted thoracic surgery (VATS) for confirmed or suspected lung cancer. 2. Clinical stage suitable for surgical resection (lobectomy, segmentectomy, or wedge resection). 3. American Society of Anesthesiologists (ASA) physical status classification ≤III. 4. Ability to understand and willingness to provide written informed consent. 5. Agreement to adhere to scheduled postoperative clinical follow-up assessments, including pulmonary function tests and survival status evaluations. Exclusion Criteria: 1. Patients requiring bilateral pulmonary procedures or planned open thoracotomy. 2. History of severe cardiopulmonary disease or unstable medical conditions that contraindicate minimally invasive thoracic surgery. 3. Emergency surgery due to acute respiratory or cardiovascular instability. 4. Inability to cooperate with the planned anesthetic and surgical protocols or postoperative follow-up procedures. 5. Pregnancy or lactation at the time of enrollment. 6. Known allergy or contraindication to anesthetic agents or materials used in the study. 7. Enrollment in another interventional clinical study within the past 30 days.

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Conditions

The condition(s) this trial relates to.

lung cancer lung neoplasm non-small cell lung carcinoma virus-associated trichodysplasia spinulosa

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LUNG Lung cancer (NSCLC) VATS

Contacts and locations

Locations

  • the First Affiliated Hospital of Guangzhou Medical University

    Guangzhou, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.