LUNG CANCER (NSCLC)

This early-phase study tests TJ101, an experimental antibody-drug conjugate, in 200 adults with advanced solid tumors (lung, prostate, esophageal, and others) who have no standard options left. The main goals are to find a safe dose and check for early signs of tumor shrinkage. P…

This study tests a new treatment for people with advanced non-small cell lung cancer (stage IIIB or IV) who have already tried at least two other therapies. The treatment uses the patient's own immune cells—dendritic cells and natural killer cells—grown in a lab and then given ba…

This study tests a new treatment plan for people with advanced non-small cell lung cancer that cannot be removed by surgery. Participants will receive chemotherapy, radiation, and two types of immunotherapy (PD-1 and CTLA-4 blockers) along with other drugs. The goal is to see if …

This study tests a treatment using immune cells taken from a patient's own lung tumor. These cells are grown in a lab and then given back to the patient to attack the cancer. The goal is to see if this approach can stop or slow the cancer from growing for at least 6 months. The t…

This study tests whether adding the immunotherapy drug tislelizumab after surgery can help prevent early-stage lung cancer from returning in people with high-risk features. About 108 adults with stage I non-small cell lung cancer (tumors 2–4 cm) and at least one high-risk factor …

This early-phase study tests whether injecting two drugs (pemetrexed and bevacizumab) directly into the spinal fluid is safe and helps people with a specific type of lung cancer that has spread to the lining of the brain and spinal cord. About 19 adults whose cancer has not respo…

This study tests a new drug called RMC-5127 in people with advanced solid tumors that have a specific KRAS G12V gene change. The drug is given alone or with other medicines to see if it is safe and can shrink tumors. About 574 adults who have already tried other treatments will t…

This study tests whether adding local ablative therapy (such as radiation) to the standard drug osimertinib can better control advanced EGFR-mutant lung cancer. About 64 adults with stage IV non-small cell lung cancer and up to 3 remaining active tumor sites after 3-6 months of o…

This study tests an experimental drug called JBI-802, taken as a pill, either alone or with the immunotherapy pembrolizumab, in people with advanced non-small cell lung cancer that has a specific genetic change (STK11 mutation). The main goals are to check safety and see if the d…

This study tests an inhaled therapy called KB707 for people with advanced solid tumors that have spread to the lungs. KB707 is a modified virus designed to trigger the immune system to attack tumors. The trial involves 250 adults who have not responded to or cannot tolerate stand…

This early-stage study tests a new drug called PHN-012, which is designed to deliver a powerful cancer-killing agent directly to tumor cells. It is for people with advanced colon, pancreatic, or lung cancer who have tried other treatments without success. The main goals are to ch…

This early-stage study tests a new drug called SH009 in about 150 people with advanced solid tumors (like liver, lung, or breast cancer) that have not responded to standard treatments. The main goal is to see if the drug is safe and can shrink tumors. Researchers will also measur…

This study looks at whether giving veterans with lung cancer extra support can help them feel better day-to-day. About 194 veterans will take part, and researchers will track their quality of life using surveys. The goal is to see if simple added help can make a real difference.

This study tests whether a high dose of the steroid dexamethasone can reduce pain when coughing the morning after lung surgery. It includes 80 adults with lung cancer who are expected to have high pain levels. Patients receive either a high or low dose of the drug during surgery,…

This study looks at whether a simple blood test can find lung cancer early and monitor for signs of cancer coming back after surgery. Researchers will track 30 people with non-small cell lung cancer over two years, checking their blood for specific DNA changes. The goal is to see…

This study is developing a blood test that uses artificial intelligence to spot cancer early and see how well treatments are working. Researchers will analyze blood samples from 6000 adults with or without cancer to find unique signals in platelets and immune cells. The goal is a…

This study looks at how air pollution particles get into the bodies of non-smokers who have lung cancer, COPD, or leukemia. Researchers will compare these patients with healthy volunteers to find new markers that show how pollution causes disease. The goal is to better understand…

This study looks at whether a short, 10-15 minute health assessment called the Practical Geriatric Assessment (PGA) helps older adults with lung cancer get better support during their radiation treatment. The assessment checks things like physical function, nutrition, and mental …

This study looks at whether measuring certain DNA markers (SHOX2 and PTGER4) in the blood can detect leftover cancer cells after a minimally invasive procedure called co-ablation for early-stage lung cancer. About 30 people who cannot have surgery will give blood samples before a…

This study tests whether advanced MRI scans can identify different immune environments inside lung tumors. Currently, this information requires a tissue biopsy. If successful, MRI could provide a non-invasive way to understand the tumor's immune status. The study will enroll 50 a…