LUNG CANCER (NSCLC)

This trial is testing if adding targeted radiation or surgery to the standard drug osimertinib helps people with advanced lung cancer live longer without their cancer getting worse. It's for patients whose cancer has a specific genetic change (EGFR mutation) and who have only a f…

This trial tests whether a personalized immune cell therapy can help control advanced lung cancer in patients who have exhausted standard treatments. Doctors collect immune cells from each patient's tumor, grow large numbers of them in the lab, and then infuse them back into the …

This early-stage study is testing a new drug called RMC-5127, both by itself and combined with other cancer drugs, in adults with advanced solid tumors that have a specific genetic change called KRAS G12V. The main goals are to find safe doses and see how the body processes the d…

This study is testing a multi-step treatment plan for people with locally advanced non-small cell lung cancer that cannot be surgically removed. It combines chemotherapy, radiation, and two immunotherapy drugs designed to help the immune system fight cancer. The goal is to see if…

This study is testing whether a personalized immune cell therapy is safe for people with advanced non-small cell lung cancer. Doctors take a patient's own immune cells, grow large numbers of them in a lab, and then inject them back into the patient to help fight the cancer. The t…

This study is testing an inhaled therapy called KB707 for adults with advanced solid tumors in the lungs that have stopped responding to standard treatments. The therapy uses a modified, harmless virus designed to stimulate the immune system to fight the cancer directly in the lu…

This study is testing a new oral medication called JBI-802, given alone or with an existing immunotherapy drug (pembrolizumab), for people with advanced non-small cell lung cancer that has a specific genetic change called an STK11 mutation. The main goals are to see if the treatm…

This early-stage study is testing a new way to treat a serious complication of lung cancer where it spreads to the lining of the brain and spinal cord. Doctors are injecting two cancer drugs directly into the spinal fluid to see if it is safe and if it helps patients live longer.…

This is the first-ever study in people of an experimental cancer drug called TJ101. The main goal is to find a safe dose and see how the body handles it. The study will also look for early signs that the drug can shrink tumors in adults with advanced cancers who have run out of s…

This is an early safety study testing an experimental drug called SH009 injection in adults with advanced solid tumors who have run out of standard treatment options. The study aims to find a safe dose, see how the body processes the drug, and check for early signs that it might …

This study is testing whether a drug called tislelizumab can help prevent early-stage lung cancer from coming back after surgery. It will involve about 108 adults who have had surgery to remove their cancer but are at higher risk of it returning. The main goal is to see if the dr…

This is the first study in people testing a new experimental cancer drug called PHN-012. It aims to find a safe dose and see if it can shrink tumors in patients with advanced colon, lung, or pancreatic cancer who have no other standard treatments left. The study will enroll about…

This study aims to develop and validate an AI-powered blood test that can detect cancer early and monitor how well treatments are working. Researchers will analyze RNA from platelets and immune cells in blood samples from 6,000 participants, including people with various cancers …

This study aims to develop and test a new diagnostic tool that uses artificial intelligence (AI) to analyze small pieces of a patient's tumor. The goal is to predict whether a patient will respond to certain immunotherapy cancer drugs before they start treatment. Researchers will…

This study is testing a new blood test to see if it can find tiny amounts of leftover lung cancer cells after surgery, which could help predict if the cancer might come back. Researchers will track 30 patients who have had surgery for non-small cell lung cancer, taking blood samp…

This study is testing a new blood test to see if it can find tiny amounts of leftover cancer cells after a minimally invasive lung tumor treatment. Researchers will follow 30 patients who cannot have surgery, taking blood samples for two years to see if the test can predict cance…

This study is testing if a higher dose of a common steroid (dexamethasone) can better control pain after minimally invasive lung cancer surgery. It focuses on patients who are identified as being highly sensitive to pain before their operation. Researchers will compare pain level…

This study is testing whether weekly phone calls from a trained support worker can improve the quality of life for Veterans with lung cancer. About 194 Veterans will be randomly assigned to either receive these support calls in addition to their usual care, or to receive only the…

This study aims to understand how air pollution causes serious diseases like lung cancer, COPD, and leukemia. Researchers will collect and analyze samples from 300 non-smoking patients with these conditions and compare them to samples from healthy volunteers. The goal is to ident…

This study is testing a short, 15-minute health survey for adults 65+ with early-stage lung cancer. The goal is to see if using this survey makes it easier for doctors to connect patients with helpful support services like physical therapy or nutrition counseling. Researchers wil…