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Could your own immune cells fight lung cancer? new trial tests safety

NCT ID NCT07202611

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial is testing whether lab-grown immune cells (dendritic and natural killer cells) are safe for people with advanced non-small cell lung cancer. Ten participants will receive injections of their own cultured cells. The main goal is to check for side effects, not yet to see if it works.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lab-grown dendritic cells and natural killer cells (immune cells)
What this could lead to
If it works, this could point toward a new immune-based treatment for advanced lung cancer that uses the patient's own cells.
What could go wrong
This is a very small, early Phase 2 trial focused on safety, not effectiveness. The treatment may not shrink tumors or improve survival, and side effects are unknown.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 10 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2022

Expected to finish

Dec 2025

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Eligibility of Participants: o Diagnosed histologically or cytologically with stage IIIB or stage IV non-small cell lung cancer (NSCLC) or patients with recurrence or progression following multimodal treatments (radiotherapy, surgical resection, or therapeutic chemoradiotherapy for locally advanced disease). * Have undergone at least two systemic therapies for advanced NSCLC, including platinum-based chemotherapy, anti-PD-1 therapy, and/or other targeted therapies. 2. At Least One Measurable Lesion: o The measurable lesion must not undergo radiotherapy during the cell therapy period. 3. Age: o ≥20 years. 4. Weight: o Between 40 and 100 kg. 5. Normal Blood Count (based on test results within 4 weeks before blood collection for cell preparation): o White blood cells (WBC): ≥3000/mm³. o Lymphocytes: ≥1000/mm³. * Hemoglobin: ≥10 g/dL. * Platelets: ≥100,000/mm³. 6. Normal Liver and Kidney Function (based on test results within 4 weeks before blood collection for cell preparation): * Creatinine: ≤1.25× the upper limit of normal (ULN). * Total bilirubin: ≤1.5× ULN. * SGOT (AST): ≤3× ULN. * SGPT (ALT): ≤3× ULN. 7. Informed Consent: o Participants must sign the consent form. 8. ECOG Performance Status: o Score of 0-1. 9. For Women of Childbearing Age: * Must agree to use effective contraception during the trial. Exclusion Criteria: 1. Positive Test Results for the Following Infections: o HCV (HCV antibody-positive). * HBV (HBsAg-positive). * HIV (HIV antibody-positive). * HTLV (HTLV antibody-positive). * Syphilis (Treponema pallidum antibody-positive). * Tuberculosis (TB culture-positive). 2. ECOG Performance Status: o Score of 2-4. 3. Albumin Intolerance: o Participants who cannot tolerate albumin. 4. Short Life Expectancy: o Life expectancy estimated by the physician to be less than 12 weeks. 5. Participation in Other Clinical Trials: o Within 30 days prior to entering this trial. 6. Pregnancy or Breastfeeding: o Positive pregnancy test or currently breastfeeding. 7. Other Medical Conditions: o Immunodeficiency, severe heart or lung dysfunction, coagulation disorders, unresolved side effects from prior cancer therapy (not recovered to CTCAE grade 1), prior transplant surgery, or deemed unsuitable by the physician. 8. Noncompliance: o Unable to adhere to follow-up or examination procedures. 9. Concurrent Cancer: o Other cancers diagnosed within the past 2 years. 10. Specific Complications: * Brain metastases, leptomeningeal disease, or spinal cord compression.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • National Taiwan University Hospital Yunlin Branch

    RECRUITING

    Huwei, YUNLIN, 640, Taiwan

More trials for these conditions

Other studies related to the condition(s) this trial covers.