Pulmonary embolism

This phase 3 trial will test three ways to treat intermediate high-risk pulmonary embolism (a serious blood clot in the lungs). The study compares two catheter-based procedures (mechanical clot removal or low-dose clot-busting drug) with standard blood-thinning heparin. About 210…

This study is testing two catheter-based devices, Symphony and Prodigy, that remove blood clots from blood vessels in the legs, arms, or lungs. Researchers want to see if these devices can safely restore blood flow and prevent serious outcomes like amputation or heart strain. The…

This study tests whether taking a daily fiber and magnesium supplement (WellBiome) for 6-8 weeks before heart surgery can improve recovery. Researchers will compare ICU time, complications, and hospital stay between 80 patients who get the supplement or a placebo. The goal is to …

This study tests two experimental drugs, REGN7508 and REGN9933, to prevent strokes in people with atrial fibrillation (an irregular heartbeat) who cannot or choose not to take standard blood thinners. About 2,628 participants will receive one of the drugs or a placebo to see if t…

This study compares a daily pill (rivaroxaban) to daily injections (low-molecular-weight heparin) for preventing blood clots in people with leg injuries that require a cast or brace. About 1,424 high-risk participants will be randomly assigned to one of the two treatments and fol…

This large phase 3 trial is testing whether adding vicadrostat to the existing drug empagliflozin can reduce the risk of heart problems in adults with type 2 diabetes, high blood pressure, and heart disease. About 11,800 participants will take either the combination or a placebo …

This study tests an experimental drug called REGN7508 (cenvacibart) against aspirin to prevent blood clots in 2000 adults having knee replacement surgery. The drug targets a clotting factor to reduce clot risk. Researchers will compare how many people develop clots or die from cl…

This study compares a device called FlowTriever (used with blood thinners) to blood thinners alone for people with intermediate-risk pulmonary embolism (blood clots in the lungs). About 1,200 adults with clots in major lung arteries and signs of heart strain will be randomly assi…

This study looks at the long-term safety of the drug pelacarsen in people with high lipoprotein(a) and heart disease. About 5,700 participants who finished a previous pelacarsen trial will receive the drug and be monitored for side effects and heart events. The goal is to see if …

This study is testing a device called FlowTriever that removes blood clots from the lungs in people with a severe, high-risk pulmonary embolism. About 200 participants will be randomly assigned to get either the device or standard care. The goal is to see if the device reduces de…

This study tests an experimental drug, REGN7508, to see if it works better than the standard blood thinner apixaban for treating and preventing blood clots in people with cancer. The trial will include about 1,600 participants with or without cancer who have deep vein thrombosis …

This study is testing a digital app called VIRTUES that provides educational resources and treatment recommendations for heart conditions like atrial fibrillation and heart failure. Researchers will enroll 2000 patients across 11 modules to see if the app is easy to use and helps…

This study compares two approaches for low-risk patients with small blood clots in the lungs (isolated subsegmental pulmonary embolism). Half will receive standard blood-thinning medication (rivaroxaban), while the other half will get a placebo and be closely monitored. The goal …

This study tests whether using a catheter to remove blood clots from the lungs, along with standard blood thinners, helps people with submassive pulmonary embolism recover better than blood thinners alone. About 500 adults with large clots and an enlarged right heart chamber will…

This study is testing a device called the Indigo Aspiration System to remove blood clots from the lungs in people with a pulmonary embolism. The goal is to see if it is safe and helps patients recover better in the long run. About 1500 adults with recent clots will take part.

This phase 3 trial is testing whether adding baxdrostat to the standard drug dapagliflozin can better prevent heart failure and cardiovascular death in people with type 2 diabetes who already have heart disease and high blood pressure. About 11,300 participants will receive eithe…

This study tests a device that removes blood clots from the lungs of people with acute pulmonary embolism and then returns the cleaned blood back to their body. The goal is to see if this approach is safe and effective at reducing blood loss and complications. About 39 adults wit…

This study looks for the best way to treat people who have a blood clot (like in the leg or lung) and also take daily aspirin or similar drugs for heart disease. Both conditions need blood thinners, but taking them together raises the risk of dangerous bleeding. The trial will co…

This study tests whether a special activity score, calculated from heart rate data, can help people who have completed cardiac rehab stick to exercise guidelines. About 318 participants will wear a smartwatch for 4 months and do an exercise test at the end. Researchers will compa…

This study tests whether text messages can help people who have finished cardiac rehab keep up healthy habits like weight management, physical activity, and taking medications. Researchers will enroll 400 people from groups often left out of heart research. The study compares dif…

This study looks at whether people with active cancer who have a blood clot in their lungs (pulmonary embolism) can be safely treated at home instead of in the hospital. About 824 participants will be randomly assigned to either go home within 24 hours or stay in the hospital for…

This study follows 82 people who receive the Celect Platinum Vena Cava Filter, a device placed in a large vein to catch blood clots and prevent them from reaching the lungs. Researchers will track safety and performance for up to 5 years, checking for problems like filter movemen…

This study tests whether a specially adjusted dose of the blood thinner apixaban can safely treat blood clots in cancer patients who also have low platelet counts. About 30 adults with active cancer and a recent clot will receive the adjusted dose. The goal is to see if this appr…

This study tracks 180 people who had a serious but stable pulmonary embolism (a blood clot in the lung) and received a treatment that uses ultrasound waves to help a clot-busting drug work better. The main goal is to see if this approach reduces the chance of developing pulmonary…

This study tests whether genetic testing can help veterans at high risk for heart disease start and stick with statin medications. About 410 veterans aged 40-75 with diabetes or heart disease who are not currently taking statins will receive either a genetic report on their stati…

This study tests whether adding digital coaching to home-based cardiac rehabilitation helps veterans complete more rehab sessions and improve their heart health. 150 veterans with heart disease will be randomly assigned to standard home rehab or home rehab plus a private social m…

This study looks at 200 people who had a bleeding stroke caused by high blood pressure. Doctors want to know if starting blood thinners (heparin) early—within 2 days—or waiting until day 3 is safer and better at preventing blood clots in the legs or lungs. Participants get brain …

This study looks at whether people at moderate risk for heart problems should continue or stop taking aspirin before a colonoscopy. About 2,500 participants will be randomly assigned to take either aspirin or a placebo for a few days around the procedure. The goal is to see which…

This study tests a treatment that uses a thin tube and ultrasound waves to break up dangerous blood clots in the lungs. It is for people with moderate-to-high risk pulmonary embolism who cannot safely receive standard clot-busting drugs due to bleeding risks. The study will track…

This study tests whether using a catheter to break up or remove blood clots early, along with standard care, can save more lives in people with a massive pulmonary embolism. About 210 participants will be randomly assigned to receive either catheter treatment within 60 minutes pl…

This study tests a program called CVD-FIT for African American adults who struggle to afford food and are at risk for heart disease. Participants get monthly income support, weekly incentives to buy healthy food, and phone-based education on heart health. The goal is to see if th…

This Phase 3 trial tests whether Kinisoquin™, a supplement-like drug made from isoquercetin plus vitamins C and B3, can prevent dangerous blood clots in 480 people with advanced pancreatic cancer. Participants receive either Kinisoquin™ or a placebo alongside their first chemothe…

This study tests a pharmacy-led program for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. After leaving the hospital, participants get their medications with no copay, delivery to their bedside and home, and help from a pharmac…

This study is testing whether giving air conditioners and a $100 electricity subsidy to older adults in Boston neighborhoods can reduce heat stress, heat strain, and related health problems. One hundred participants aged 55-95 who don't have AC will be randomly assigned to receiv…

This study is testing whether adding rosuvastatin (a common cholesterol-lowering drug) to standard blood thinner treatment can lower the risk of another blood clot in people who have recently had a deep vein thrombosis or pulmonary embolism. About 2,700 participants will receive …

This study compares two types of blood thinners taken as pills (apixaban and rivaroxaban) against a standard daily injection (enoxaparin) to prevent dangerous blood clots in people with blood cancers like lymphoma, leukemia, and multiple myeloma. About 100 participants will be ra…

This study is testing a device called the Akura Thrombectomy System, which is threaded through a blood vessel to mechanically remove clots from the lung arteries. It involves 118 adults with acute pulmonary embolism (symptoms for 14 days or less) who have a clot in a main or loba…

This study tests whether bempedoic acid, a cholesterol-lowering drug, can reduce artery inflammation and improve heart health in people with HIV. About 121 adults aged 40 and older with well-controlled HIV and at least one heart disease risk factor will receive either the drug or…

This study tests a single injection of a clot-dissolving drug (staphylokinase) in 486 adults with intermediate high-risk pulmonary embolism—a serious blood clot in the lungs. The goal is to see if it prevents death, heart collapse, or another clot compared to a placebo. Participa…

This study tests whether a shared decision-making process, which uses personalized risk scores, can help patients with unprovoked blood clots choose the best duration of blood-thinning medication. The goal is to reduce the chance of another clot or serious bleeding while improvin…

This registry is studying a drug called non-immunogenic staphylokinase (Fortelyzin®) given as a single injection to dissolve blood clots in the lungs. It will include up to 20,000 adults with massive pulmonary embolism who are already receiving the drug in routine care. The goal …

This study tests a new device called the Laguna Thrombectomy System to remove blood clots from the lungs in people with pulmonary embolism. About 107 adults with moderate to severe clots will be treated, and doctors will check for safety and effectiveness within 48 hours. The goa…

This trial is testing a device called AlphaVac that suctions blood clots out of the lung arteries in people with acute pulmonary embolism (PE). The study will enroll 256 adults with a confirmed PE and signs of heart strain. The main goals are to see if the device reduces heart st…

After hip or knee replacement, all patients currently get the same dose of blood thinners to prevent clots, but some still get clots while others bleed. This trial will test whether giving a shorter course to low-risk patients and a stronger, longer course to high-risk patients c…

This study is testing whether a simple bedside heart ultrasound can help predict which emergency patients with a pulmonary embolism (a blood clot in the lung) are likely to have serious complications within the next few days. Researchers will perform the ultrasound on 250 patient…

This study compares a new type of CT scanner (photon-counting CT) with standard CT to see if it can better detect very small blood clots in the lungs, called subsegmental pulmonary embolism. About 696 adults with suspected acute pulmonary embolism will be scanned with both method…

This study tests a new bedside tool called Adjust-Unlikely to safely reduce unnecessary imaging for pulmonary embolism (a blood clot in the lungs) in emergency patients. Researchers will enroll 4,000 adults in Canada to see if the tool accurately identifies who does not need a sc…

This study is testing a special mattress that can measure heart rate, breathing, temperature, and body position without touching the patient. It is designed for people with heart disease who are in the hospital. The goal is to see if this wireless system works as well as standard…

This study tests whether a non-invasive device called electrical impedance tomography (EIT) can accurately diagnose pulmonary hypertension, a serious lung condition. Currently, diagnosis requires an invasive procedure called right heart catheterization. Researchers will compare E…

This study looks at whether two simple checklists (PERC and YEARS) can safely reduce the number of CT scans needed to diagnose pulmonary embolism (a blood clot in the lungs). Researchers will review the records of 500 adults who came to the emergency room with suspected clots. If…

This study is looking for specific protein patterns in the blood that could help diagnose chronic thromboembolic pulmonary hypertension (CTEPH), a rare but serious complication of blood clots in the lungs. Researchers will analyze blood samples from 120 people suspected of having…

This study is testing a standard screening method to find a condition called chronic thromboembolic pulmonary hypertension (CTEPH) in people who had a blood clot in their lungs 3 to 12 months earlier. Researchers will check if certain tests, like heart ultrasound or lung scans, c…

This study is testing a new portable X-ray machine called Dynamic Digital Radiography (DDR) that takes 15 images per second to show how the lungs move and blood flows. Researchers at Brigham and Women's Hospital will use it on 230 ICU patients with various lung conditions to see …

This study checks if a quick, non-invasive finger test (QuantaFlo HD) can detect early signs of heart dysfunction. Researchers will compare the finger test results with standard heart ultrasound measurements in 600 adults who have risk factors like high blood pressure or diabetes…

This study compares a new, radiation-free bedside test using saline contrast and electrical impedance tomography (EIT) against standard CT scans (CTPA) for diagnosing acute pulmonary embolism (blood clots in the lungs). Researchers will enroll 343 patients with suspected or confi…

This trial tests whether doing ultrasound scans twice a week on critically ill patients can catch deep-vein thrombosis (DVT) early. The goal is to prevent pulmonary embolism (a clot in the lung) and reduce deaths within 90 days. The study will enroll 1,800 adults in the ICU who a…

This study tests whether taking a daily statin (rosuvastatin) for one year can safely prevent life-threatening blood clots in people with cancer. Current clot-preventing drugs raise bleeding risks, so a safer option is needed. The trial will enroll 4,000 adults with newly diagnos…

This study tests whether giving the flu vaccine to heart patients just before they leave the hospital can lower their risk of infections, heart problems, and death in the next 6 months. About 400 adults hospitalized for serious heart conditions will be randomly assigned to get th…

This phase 3 trial tests an experimental drug called REGN7508 to prevent blood clots in people with solid tumors who are receiving cancer treatment. About 1,120 participants will receive either the drug or a placebo. The study measures how well the drug prevents clots and checks …

This study tests whether a 3-month pulmonary rehabilitation program (20 sessions of exercise and education) can improve quality of life and reduce breathlessness in people who have had a pulmonary embolism. Researchers will enroll 112 adults who still have symptoms at least 3 mon…

This study tests a smartphone app designed to help people prepare for heart surgery through exercise, nutrition tips, and telehealth check-ins. About 40 adults awaiting surgery will either use the app or receive standard care. Researchers want to see if the app is easy to use, ac…

This study tests whether starting a structured exercise and education program within a month of a pulmonary embolism (a blood clot in the lungs) can prevent long-term problems like poor quality of life, shortness of breath, and reduced physical ability. About 160 hospitalized pat…

This study tests two different stitch materials (PDS and Vicryl) for closing groin incisions after planned vascular surgery. About 259 adults will be randomly assigned to one stitch type or the other. The goal is to see which material leads to fewer wound problems.

This study tests whether a daily movement program led by a kinesiologist can reduce frailty in 60 hospitalized heart patients. Frailty makes people weaker and more likely to have longer hospital stays or be readmitted. The program encourages simple activities like standing, walki…

This study tests whether getting daily texts or emails with healthy living tips can help people recover after being hospitalized for a pulmonary embolism (a blood clot in the lungs). One hundred adults will receive these tips for 8 weeks while also taking standard blood thinners.…

This study tests whether adding a program that targets sleep and stress (called RESST) to standard cardiac rehabilitation helps heart patients recover better. About 200 adults with heart conditions who also have poor sleep or high stress will take part. Researchers will measure s…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study looks at whether a computer-assisted vacuum procedure to remove blood clots from the lungs is safe and improves quality of life for cancer patients with a moderate-risk pulmonary embolism. About 25 adults with cancer and a confirmed clot in a major lung artery will tak…

This study tests whether a type of talk therapy called Behavioral Activation, delivered via home-based telehealth, can improve social functioning and mood in veterans recently discharged from the hospital for a heart condition. About 132 veterans with depression will receive eith…

This study compares a women-only cardiac rehabilitation program to the standard mixed-gender program for women with heart disease. Sixty women aged 40-80 will attend 36 sessions over 12 weeks, with extra women-focused education. Researchers will measure attendance, completion rat…

This study tests whether a 6-week outpatient pulmonary rehabilitation program helps people with post-PE syndrome (lingering symptoms after a pulmonary embolism) walk farther and breathe better. About 48 adults who had a pulmonary embolism 12 to 36 weeks earlier will be randomly a…

This study tests a program called One-Mind One-Heart that combines mindfulness and behavior change skills to help older adults with HIV reduce stress and improve heart health. The program includes text messages and covers topics like physical activity, diet, and substance use. Th…

This study tests whether a standardized, step-by-step protocol for giving blood thinner injections (low-molecular-weight heparin) can reduce bruising and pain in heart patients. About 180 patients in cardiac care units will be randomly assigned to receive injections either by the…

This registry study will enroll 200,000 high-risk cardiac patients to see how well an AI platform called Willem can detect heart problems from standard ECGs. The AI's readings will be compared to expert cardiologist diagnoses, but the AI results won't be shared with doctors, so p…

This study aims to learn more about how diseases related to blood clots, the immune system, and blood vessels start and change over time. Researchers will enroll up to 1,000 people aged 5 and older, including those with these conditions, their healthy relatives, and healthy volun…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study creates a large database of about 12,000 people with and without heart disease. Researchers collect medical information and blood samples to analyze factors that influence heart conditions like coronary artery disease, heart failure, and stroke. The goal is to better u…

This observational study will follow 1300 critically ill adults in intensive care to see if a blood test called anti-factor Xa activity can predict dangerous blood clots (deep vein thrombosis or pulmonary embolism). Researchers will also track bleeding risks, quality of life, and…

This study looks at medical records of 1,000 older heart patients in Russia to see if they were prescribed potentially harmful medications during the COVID-19 pandemic. Researchers will use a medical database to count how often these risky prescriptions happened and check for dan…

This study is creating a large collection of blood, urine, stool, and heart tissue samples from 10,000 people with and without heart or metabolic conditions. The goal is to store these samples along with medical information to speed up future research into what causes these disea…

This study is testing whether simple nutritional checks before heart surgery can predict how well patients recover. Researchers will give 250 patients questionnaires, blood and urine tests, and measure grip strength and body composition. They will then see if these measures are l…

This study is tracking 2000 patients with moderate to severe pulmonary embolism (blood clots in the lungs) who undergo a procedure called computer-aided vacuum thrombectomy, where a special tube sucks out the clot. Researchers want to see how well the procedure works and what com…

This study is collecting medical data and biological samples from people with genetic conditions affecting the heart and blood vessels, their relatives, and healthy volunteers. The goal is to better understand these diseases, improve diagnosis, and lay the groundwork for future t…

This study uses artificial intelligence to group patients who have had a pulmonary embolism (a blood clot in the lung) based on their medical information at diagnosis. Researchers will track 2,500 patients for 6 months to see how different groups recover. The goal is to help doct…

This study looks at 32 people who still have shortness of breath or reduced quality of life after a pulmonary embolism (a blood clot in the lungs). They will receive a special PET/CT scan before and after a pulmonary rehabilitation program to see how the treatment improves lung f…

This study looks at 665 people who had a pulmonary embolism (a blood clot in the lung) and are at intermediate risk of another clot. Researchers will use a special 3D lung scan (V/Q SPECT/CT) to measure leftover blockages in lung blood vessels. The goal is to see if this scan can…

This study looks at whether a simple heart ultrasound can help predict which patients with a blood clot in the lungs (pulmonary embolism) are at higher risk for serious problems. Researchers will check right heart function in 112 adults and track outcomes like breathing failure, …

This study looks at whether people with type 2 diabetes, COPD, or heart disease who join a health program in Halsnaes Municipality improve their physical function and well-being. About 194 adults will be tracked before and after the program using tests and questionnaires. The goa…

This registry will follow 1000 adults with pulmonary embolism (blood clots in the lungs) who are treated with Inari Medical devices. Researchers will track device-related complications and deaths to understand how safe these tools are in everyday use. The study is observational, …

This study follows 300 people who had hospital-acquired pneumonia to see how it affects their heart and lungs over 18 months. Researchers will take blood samples, swabs, and perform heart and lung tests to understand the link between pneumonia and later cardiovascular problems li…

This study is testing a comprehensive MRI scan to see if it can better diagnose different heart conditions. Researchers will scan 2,000 adults with suspected or confirmed heart disease. The goal is to create a standard imaging method that improves early detection and risk predict…

This study tests a training program that teaches advanced practice providers (like nurse practitioners and physician assistants) in the emergency department how to use a portable ultrasound to check the heart. About 75 providers will take a simulation course, then use the ultraso…

This study is testing whether artificial intelligence can predict if someone will develop one of five common diseases: diabetes, heart disease, breast cancer, back pain, or arthritis. Researchers will collect health data from 1,000 adults aged 30 to 60, including medical records,…

This study is testing whether a bedside imaging technique called electrical impedance tomography (EIT) can reliably measure blood flow in the lungs of patients with chronic blood clots. Thirty-six people scheduled for surgery to remove these clots will be monitored with EIT befor…

This study uses advanced heart MRI to see how bariatric surgery and cardiac rehabilitation change the heart's structure and function. Researchers will scan 150 adults before and 6-12 months after these metabolic treatments. The goal is to understand how the heart adapts to these …

This study will use a new type of cardiac MRI to look at the heart's microscopic structure in 1,000 people—both healthy volunteers and those with various heart conditions. The goal is to see if this advanced imaging can detect early signs of heart damage better than standard test…

This study is testing a software tool that uses DNA from a blood sample to predict the risk of blood clots returning in people with cancer who have finished 3-12 months of blood thinner treatment. The goal is to see if a low-risk result means it's safe to stop blood thinners with…

This study is building a huge database of up to 800,000 Korean patients with heart or brain vascular disease. By tracking their health over many years, researchers hope to understand the unique patterns and risk factors in this population. The goal is to create a platform that ca…

This study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…

This study is a registry that follows up to 10,000 people who have been diagnosed with a blood clot (deep vein thrombosis or pulmonary embolism) and started blood-thinning medication within 14 days. Researchers at the Mayo Clinic will track how many patients have another clot or …

This study aims to develop better MRI methods for imaging the heart and brain, and to describe heart diseases using these new techniques. It will also investigate whether gadolinium, a common MRI contrast agent, stays in the body long after use. Up to 5,000 healthy volunteers and…

This study will use advanced heart MRI scans on up to 100,000 people with known or suspected heart disease. The goal is to learn how these scans can help doctors better understand, diagnose, and treat different heart conditions. Researchers will track participants' health over ti…

This study looks at whether people who have a blood clot in the lungs (pulmonary embolism) are more likely to have a stroke if they also have a small hole in their heart (called a PFO). About 1 in 4 people have this hole, which can let a clot travel to the brain. Researchers will…

This study creates a large collection of blood, tissue, and medical information from up to 5,000 people with or at risk for pediatric heart disease. Researchers will use these samples to better understand the disease and find new ways to diagnose or treat it in the future. Partic…

This study follows 400 adults diagnosed with pulmonary embolism (a blood clot in the lungs) at a Swedish hospital. Researchers will repeatedly check heart tests and blood markers during the first 48 hours to see if early changes can better predict who will worsen. The goal is to …

This study is testing whether patients recovering from hip or knee replacement can safely skip elastic compression stockings and rely only on blood-thinning drugs to prevent dangerous blood clots. Over 1,200 participants will be randomly assigned to receive either drugs plus stoc…

This study is testing a tool called B-COMPASS that uses a 22-question survey to predict whether people will follow their prescribed treatments. Researchers will enroll 3100 adults with cardiovascular, endocrine, immune, nerve, cancer, or rare diseases across Europe. The goal is t…

This study is testing whether giving probiotics after heart surgery can improve recovery by changing the bacteria in the gut. Researchers will measure certain chemicals in the blood that come from gut bacteria. The trial involves 30 adults scheduled for heart surgery, who will re…

This study follows 500 people with cardiogenic shock, a life-threatening condition where the heart suddenly can't pump enough blood. Researchers will collect data from four specialized centers to understand what treatments work best and why some patients do better than others. No…

This study collects blood samples from 1500 adults at risk for heart disease to discover new biomarkers that can predict future heart attacks, strokes, or blocked leg arteries. Participants are seen at a specialized prevention center and provide samples and health data at the sta…

This study is testing whether an artificial intelligence system can predict serious complications in people hospitalized with a pulmonary embolism (a blood clot in the lungs). Researchers will analyze CT scans from 2,000 adults to see if the AI can identify who is likely to die o…

This study looks at whether information from CT scans, along with lab tests, can predict which patients with a blood clot in the lungs (pulmonary embolism) will have serious problems within 30 days. Researchers will collect data from 300 patients to build a prediction tool. The g…

This study tests whether a single PET tracer (FDG) can measure both blood flow and sugar use in the heart, instead of needing two separate tracers. Researchers will compare results from FDG with a dedicated flow tracer in 60 healthy adults and people with heart disease. The goal …

This study aims to validate the Caprini score, a tool that estimates blood clot risk, in 3,000 people undergoing varicose vein surgery. Participants will be followed for four weeks after procedures like laser treatment or vein stripping to see if the score accurately predicts who…

This study is observing 500 adults with severe pulmonary embolism (a dangerous blood clot in the lungs) to see if the timing of clot-busting treatments affects survival and complications. Researchers want to find the optimal time window to start treatment, similar to how heart at…

This study tests a program called Heart-to-Heart, where community health workers help low-income patients make informed choices about cardiac rehab after a heart event. About 50 adults from Johns Hopkins Hospital will take part. The goal is to see if the program is practical and …

This study tests whether beetroot juice, which contains natural nitrates that relax blood vessels, can safely lower lung blood pressure in people with intermediate high-risk pulmonary embolism. 36 adult patients will receive either beetroot juice or a placebo for five days, along…

This study is testing whether a simple one-minute chair stand test can help doctors predict how well patients will recover from a non-severe pulmonary embolism (a blood clot in the lungs). Researchers will compare the test results with standard risk scores that use blood tests an…

This study will enroll 5,000 adults with chronic heart conditions like heart failure, high blood pressure, or aortic stenosis. Participants will wear a Prolaio digital health patch that monitors heart rate, breathing, and other vital signs. The goal is to observe how these condit…

This study looks at whether a special blood test, called a thrombin generation assay, can predict bleeding risk in cancer patients who are taking blood thinners for blood clots. Researchers will follow 212 patients for 6 months, measuring their blood's clotting ability and tracki…

This study is reviewing medical records from 5,000 heart and blood vessel surgery patients to find factors that influence recovery and survival. Researchers are looking at data from 2001 to 2013 to identify what leads to complications or death after surgery. The goal is to improv…

This study collects small heart tissue samples from 400 adults undergoing heart procedures. Researchers will analyze these samples to find new markers that could help diagnose heart diseases earlier and better understand how the heart works in health and disease. The goal is to i…

This study uses a special type of MRI (called 129Xe gas exchange MRI) to take detailed pictures of how the lungs and heart work together. Researchers want to understand how these images change after treatments like blood transfusions or oxygen therapy. The study involves 125 adul…

This study is tracking 220 adults across Nordic countries who receive either clot-dissolving drugs or a catheter-based procedure for a severe pulmonary embolism. Researchers are comparing how often each treatment leads to serious bleeding or death within 30 days. The goal is to p…

This study uses a special eye scan called OCTA to measure the density of tiny blood vessels in the retina. Researchers will compare results from 64 people—half with cardiovascular disease and half healthy—to see if the scan can reliably detect vessel changes linked to heart probl…

This study is testing whether adding genetic and imaging information to standard risk assessments can better predict heart disease in 30,000 healthy Italian adults aged 40-80. Participants will have their risk calculated using traditional methods and then again with the added dat…

This study is testing a virtual patient navigation program for 260 English, Chinese, or Spanish speakers with breast cancer or heart disease. The goal is to see if a phone-based portal can help underserved people get the support they need, even though it won't fully replace in-pe…

This study is not testing a new drug or treatment. Instead, researchers are combining health information from 20,000 people across 14 European groups who have had blood clots (venous thromboembolism). By merging this data, they hope to better understand who is at risk for future …

This study follows over 10,000 Moroccan adults for 10 years after a heart screening. Researchers will track heart attacks, strokes, and heart-related deaths to build a risk score tailored to the Moroccan population. The goal is to better predict and prevent heart disease in Moroc…

This study is building a biobank of blood and tissue samples from 500 patients undergoing cardiac surgery. Researchers will analyze these samples to better understand the causes and progression of heart disease. The goal is to improve future diagnosis and treatment, but no new th…

This study looks at 100 adults hospitalized in the ICU for a serious pulmonary embolism (a blood clot in the lung). Researchers want to know how long it takes for the blood thinner (unfractionated heparin) to reach a level that prevents more clots. They will also check if faster …

This study aims to find out how often people develop a serious lung condition called chronic thromboembolic pulmonary hypertension (CTEPH) after having a blood clot in the lungs (pulmonary embolism). Researchers will use heart ultrasounds to look for early signs of heart strain i…

This study aims to see if voice recordings from a smartphone can help detect heart disease. Researchers will collect voice samples and health data from up to 1 million adults using the Mayo Clinic app. No treatment is given; the goal is to gather information for future AI tools.

This study looks at whether giving a paravertebral nerve block during chest surgery can lower the chance of problems like lung infections, collapsed lungs, or breathing failure. Researchers will follow 500 adults having keyhole or robotic lung surgery. The goal is to see if this …

This study looks at how well tiny blood vessels in the lungs recover after a procedure called balloon pulmonary angioplasty (BPA) in people with chronic thromboembolic pulmonary hypertension (CTEPH). CTEPH is a condition where old blood clots block lung arteries, making it hard t…

This study tests whether a set of quality improvement tools—including guidelines, care protocols, and a mobile app—can help hospitals in China better prevent blood clots in patients. About 5,800 hospitalized adults will take part across multiple hospitals. The goal is to see if t…

This study is testing whether a smartwatch, combined with artificial intelligence and remote doctor check-ins, can help detect heart issues like atrial fibrillation and unstable angina earlier than usual. Researchers at the University of Sao Paulo will enroll 520 adults with hear…

This study is observing 900 adults in Greece who have both chronic obstructive pulmonary disease (COPD) and at least one heart condition. Researchers will track their health for two years, recording lung flare-ups, heart complications, hospital visits, and quality of life. The go…