Pulmonary embolism

This study explores whether combining a high-protein Mediterranean diet with resistance exercise can help people with heart disease build muscle and lower their risk of future heart problems. The trial enrolls adults who have completed cardiac rehab and may have low muscle mass w…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tested a coaching program called MACRO-I for adults aged 70 and older who had a heart event. The program used coaches to guide patients through starting cardiac rehab, either at a center, at home, or a mix of both. 416 participants were split into the coaching group or…

This study compared two blood thinners, rivaroxaban (Xarelto) and apixaban (Eliquis), in 2760 adults with new blood clots in the legs or lungs. The goal was to see which drug causes fewer bleeding problems. Results could help doctors choose the safer option for treating venous th…

This study investigates whether delivering a clot-dissolving drug directly into the lung arteries via a thin tube (catheter) can improve outcomes for people with a serious type of pulmonary embolism (a blood clot in the lung). Participants have intermediate-high risk clots, meani…

This study tested a special sheath (the Protrieve Sheath) placed in a large vein to catch any blood clots that might break loose during a procedure to remove deep vein clots (DVT). The goal was to prevent those clots from reaching the lungs and causing a pulmonary embolism. The s…

This study tested a new device called the Vertex Pulmonary Embolectomy System in 10 people with pulmonary embolism (blood clots in the lungs). The device is threaded through a blood vessel to remove clots and relieve strain on the right side of the heart. Researchers measured cha…

This study tested a once-daily pill called orforglipron against insulin glargine in nearly 2,750 adults with type 2 diabetes, obesity or overweight, and increased cardiovascular risk. The main goal was to see if orforglipron could reduce major heart events like heart attacks or s…

This study tested a new device called the Hēlo PE Thrombectomy System, which is a thin tube used to remove blood clots from the lungs in people with a serious condition called pulmonary embolism. The trial included 177 participants and aimed to see if the device is safe and works…

This study tested a special filter placed in a large vein to catch blood clots before they reach the lungs. It included 50 people who could not take blood thinners. The goal was to see how often the filter could be successfully placed and removed, and to track any problems.

This study tested a device that removes blood clots from the main lung arteries in 123 people with a sudden pulmonary embolism. The goal was to reduce strain on the right side of the heart and prevent serious complications like major bleeding or heart injury. Participants were ad…

This study tested whether intensive dental cleaning and oral hygiene advice can improve gum health and also affect markers of heart disease and type 2 diabetes. About 200 adults with gum disease and either heart disease or diabetes (or prediabetes) took part. Researchers measured…

This small completed study looked at a blood filtering procedure called double-filtration plasmapheresis (DFPP) in 5 kidney dialysis patients with very high levels of lipoprotein(a), a fatty substance linked to heart disease and blood clots. The goal was to see if DFPP could lowe…

This study looked at whether giving clot-busting drugs (thrombolysis) to people with a serious but not immediately life-threatening type of lung clot (pulmonary embolism) and a low risk of bleeding could lower their chance of dying within 30 days. The study included 100 patients …

This study tested whether a drug called alirocumab, which lowers cholesterol, can reduce heart disease risk in people with HIV. The trial involved 118 adults aged 40 and older with well-controlled HIV and high heart disease risk. Participants received either alirocumab or a place…

This completed trial looked at whether taking two cholesterol-lowering drugs (rosuvastatin and ezetimibe) is more effective and safer than taking just one (rosuvastatin) for people with heart disease. 66 adults with high cholesterol were randomly assigned to one of the two treatm…

This study tested whether adding a mechanical clot-removal device (Indigo Aspiration System) to standard blood thinners is safer and more effective than blood thinners alone for people with intermediate-high risk pulmonary embolism (a serious blood clot in the lung). About 100 ad…

This study looked at whether a low dose of the blood thinner apixaban (2.5 mg twice daily for 12 months) can safely prevent blood clots from returning in people who already had a clot triggered by a temporary risk factor. 600 high-risk adults took either apixaban or a placebo. Th…

This study tested a device called FlowTriever that mechanically removes blood clots from the lungs, comparing it to standard clot-dissolving drugs (catheter-directed thrombolysis). 692 patients with acute pulmonary embolism were enrolled. The goal was to see which treatment leads…

This study tested a device called the FlowTriever2 Catheter in 50 people with acute pulmonary embolism (blood clots in the lungs). The device was used to mechanically remove clots from the lung arteries. Researchers measured safety by tracking serious side effects and effectivene…

This study looked at a device called the FlowTriever, which is used to remove blood clots from the lungs in people with a serious condition called acute pulmonary embolism. Researchers followed 1,200 patients to see how safe and effective the device was in real-world use. The goa…

This study looks at whether the ratio of two common blood test results (APTT and fibrinogen) can help diagnose pulmonary embolism, a serious condition where a blood clot blocks an artery in the lung. Researchers will compare this ratio in 1,000 patients who are suspected of havin…

This study looked at whether an ultrasound of the leg veins can help doctors diagnose a repeat pulmonary embolism (a blood clot in the lung). About 115 adults with symptoms of a new clot were checked. The goal was to see if adding leg ultrasound to the usual tests (like blood wor…

This study tested how well a small, portable device (LumiraDx) measures blood clotting (INR) compared to standard lab tests. Researchers collected blood from 420 adults, some taking warfarin and some not, using both a fingerstick and a vein draw. The goal was to see if the device…

This study tested a new rapid D-dimer blood test (LumiraDx) in 679 people with symptoms of deep vein thrombosis or pulmonary embolism. The test uses a small blood sample from a finger prick or vein to quickly measure D-dimer levels, which can help rule out dangerous blood clots. …

This study looked at whether a ratio of two blood cell types (monocytes and large platelets) can help diagnose acute pulmonary embolism, a serious blood clot in the lungs. Researchers analyzed blood samples from 53 patients who had a CT scan to confirm or rule out the clot. The g…

This study looked at whether a special eye scan (SS-OCTA) can detect signs of cardiovascular disease. Researchers compared retinal blood vessel changes to results from a standard carotid ultrasound in 42 adults. The goal was to see if the eye scan could predict the presence or se…

This study tested whether a mobile app called ThinkSono Guidance can help healthcare workers who are not ultrasound experts (like nurses or general doctors) take good-quality ultrasound images of leg veins to check for blood clots. Over 600 adults with symptoms of deep vein throm…

This study tested a new way to decide if someone with a suspected blood clot in the lung needs a scan. The 4PEPS score uses 12 simple factors and a blood test to classify risk into four levels. Over 3,000 patients in 20 emergency departments took part. The goal was to see if usin…

This study tested a small change in how CT scans are done for people with suspected lung blood clots. By moving the scan's focus area to a different blood vessel, doctors aimed to use less contrast dye (30 ml instead of 50 ml) without losing image quality. The trial involved 72 a…

This study tested whether a simple checklist and blood test (the YEARS algorithm) can safely rule out pulmonary embolism (a blood clot in the lungs) in people with active cancer, compared to the standard approach of doing a CT scan on everyone. About 700 cancer patients with susp…

This study looked at whether measuring carbon dioxide in a person's breath (called end-tidal CO₂) can help doctors quickly identify severe blood clots in the lungs and see if treatment is working. Researchers studied 120 adults, including those with different levels of clot sever…

This study tested a new CT scan method that creates a map of blood flow in the lungs to diagnose pulmonary embolism (blood clots). Researchers compared it to the standard SPECT scan in 30 patients. The goal was to see if the new method is as accurate, while being faster and safer…

This study tested whether a special PET/CT scan (V/Q PET/CT) can accurately diagnose pulmonary embolism (a blood clot in the lungs) compared to the standard CT scan. About 100 adults with suspected first-time clots took part. The goal was to see how sensitive and specific the new…

This study looked at whether adding a CT venography scan (imaging of the pelvis and legs) to the standard chest CT can find more blood clots in women who recently gave birth and are suspected of having a pulmonary embolism. 125 women participated. The goal was to see if the combi…

This study looked at how often older adults with heart disease risk factors should exercise to improve fitness and blood pressure. Twenty-two participants did combined training either twice or three times a week for 12 weeks. The goal was to see which frequency worked better for …

This study compared three common blood thinners—aspirin, warfarin, and rivaroxaban—to prevent dangerous blood clots after hip or knee replacement surgery. Nearly 19,000 adults took part. The goal was to find which option best balances preventing clots with avoiding bleeding side …

This study tested an 8-week digital lifestyle program called MYCardio-PEER for low-income adults at risk of heart disease. Participants received weekly videos and infographics on healthy eating and exercise, plus group chats with peer leaders. The goal was to see if the program i…

This study looked at whether a home-based physical activity program and computer-based cognitive training could help prevent memory loss in older women with heart disease. 253 women aged 65 and older participated. The goal was to see if these lifestyle changes could improve memor…

This study compared two blood-thinning drugs, Bemiparin and Enoxaparin, to prevent venous thromboembolism (dangerous blood clots) in 7020 women after vaginal or cesarean delivery. All participants had risk factors for clots and received daily injections for up to 7 days after giv…

This completed study tested whether sending behavioral nudges through Denmark's official electronic letter system could increase flu vaccination among adults aged 18-64 with chronic diseases. Over 300,000 participants were randomly assigned to receive different types of letters o…

This study looked at two methods to reduce pain after heart surgery through a cut in the chest bone. 120 adults received either a nerve block near the breastbone, pain medicine injected into the wound, or standard painkillers. Researchers measured pain levels using a saliva test …

This completed trial tested an 8-week program called Healing Hearts Together (HHT) for couples where one partner has heart disease. 474 couples attended weekly group sessions focused on communication, emotional support, and heart health. The goal was to see if the program improve…

This study tested whether a 20-minute session of nurse-led spiritual care, including prayer and relaxation techniques, could help heart surgery patients feel less anxious and have more stable blood pressure and heart rate before their operation. 248 adults in Indonesia took part.…

This study tested whether a 3-month yoga program could improve physical and mental health in adults over 65 who had recently finished cardiac rehab. Participants attended yoga twice a week. Researchers measured balance, muscle strength, anxiety, and mood. The goal was to see if y…

This study tested a 9-week internet-based cognitive behavioral therapy (CBT) program designed to reduce stress, anxiety, and depression in people with stable heart disease. 215 adults with heart disease and elevated stress or mood symptoms took part. The program was personalized …

This study tested whether adding virtual reality (VR) driving simulations to standard cardiac rehabilitation helps heart surgery patients feel less anxious and depressed. Sixty adults recovering from heart surgery took part. The results suggest VR can improve emotional well-being…

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This pilot study tested whether giving inhaled nitric oxide gas during laparoscopic surgery could protect blood vessels and organs in 40 adults with heart disease. Half received the gas through their breathing tube during surgery, and half received standard care. Researchers meas…

This study reviewed the records of 150 adults who had surgery to clear blood clots from the lung arteries. Researchers wanted to see who developed kidney injury within two days after surgery and what factors raised that risk. They looked at things like how long the patient was on…

This study looked at 150 Caribbean Hispanic adults with heart disease or stroke risk who take the blood thinner clopidogrel. Researchers wanted to see if certain gene variants affect how well the drug works. The goal is to understand why some people get less benefit and to pave t…

This study checked how well over 5,000 heart patients follow their prescribed medicine routine. Researchers asked patients about their medication habits and any side effects. The goal was to understand how many patients do not take their medicines as directed.

This study looked at whether having COVID-19 makes people more likely to develop a pulmonary embolism (a blood clot in the lungs). Researchers reviewed medical records of 347 patients who had a CT scan of their lungs. They compared those who tested positive for COVID-19 with thos…

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This study checked whether the Turkish version of the Cardiac Depression Scale (CDS) works well for people with heart disease. Researchers tested 360 Turkish adults with various heart conditions to see if the scale accurately measures depression. The goal is to give doctors a rel…

This completed study looked at 400 people with both heart disease and a mental health condition (like depression or anxiety). Researchers used questionnaires, blood tests, and imaging to find shared risk factors and biological markers. The goal was to better understand how these …

This study looked at whether sending alerts to pharmacists instead of doctors helps improve how blood thinners (anticoagulants) are prescribed. Researchers tested two types of alerts with 306 healthcare providers. The goal was to see which method leads to faster and safer prescri…

This completed study tested whether semaglutide, a drug used for diabetes, could reduce inflammation in 18 people who had a blood clot in their lungs (pulmonary embolism). Researchers measured changes in blood markers of inflammation over 4 weeks. The goal was to see if the drug …

This study looked at how well hospitals follow the standard protocol for giving heparin, a blood thinner, to patients with blood clots or heart issues. Researchers checked 100 patients to see if their heparin doses were adjusted correctly based on blood test results. The goal was…

This study looked at whether wearing an activity monitor (like a Fitbit) after heart surgery helps patients get moving sooner and return to their normal activity levels faster. Researchers tracked motivation, length of hospital stay, and readmission rates in 12 adults who had car…

This study tested whether special communication training for pharmacists and general practitioners helps them involve older patients in decisions to stop or lower medications for heart disease and diabetes. Researchers enrolled 310 patients aged 75 and older who were taking certa…

This study tested whether a pop-up alert in the electronic health record could remind doctors to screen for a rare but serious lung condition called chronic thromboembolic pulmonary hypertension (CTEPH) in patients who previously had a blood clot in the lungs. The trial involved …

This study tested whether a theory-based motivational letter mailed six months in advance could increase attendance at a one-year post-cardiac rehabilitation check-up. Researchers compared 102 adults who received the letter to those who got usual care. The goal was to see if a si…

This study looked at 40 adults who had a blood clot in their lungs (pulmonary embolism). Researchers compared those who also had sleep-disordered breathing (like sleep apnea) with those who did not. The goal was to see if sleep problems affect short-term recovery and the chance o…

This study tracked 88 adults diagnosed with pulmonary embolism (a serious blood clot in the lungs) during April 2020, the peak of the COVID-19 pandemic in France. Researchers compared complications like recurrence of clots, lung scarring, and death over 6 to 12 months between pat…

This study looked at 10 people hospitalized with a blood clot in the lung (pulmonary embolism). Researchers used a special 3D CT scan technique to compare lung blood vessels before and 48 hours after standard blood thinner treatment. The goal was to measure changes in blood flow …

This study looked at how well a daily low-dose aspirin works in people who have both immune thrombocytopenia (low platelets) and heart disease. Only 4 adults took part. Researchers measured platelet function after aspirin to see if the standard dose is enough to prevent blood clo…

This study tested whether a systematic phone call from a medical student, supervised by a general practitioner, could reduce hospitalizations in patients with chronic heart or mental health conditions during the COVID-19 lockdown in France. Over 22,000 patients aged 70 and older …

This study looked at 320 adults who had heart surgery to see how well two different risk scores (EuroSCORE-II and POSPOM) predict the chance of dying in the hospital. Researchers calculated each patient's scores before surgery and compared them to what actually happened. The goal…

This study looked at whether orienteering (a navigation-based walk) is as good as regular walking for heart rehab. 40 people with stable heart disease took part. Researchers measured heart rate and enjoyment during both activities. The goal was to see if orienteering could be a f…

This study tested a decision-support tool called DOACT that helps doctors choose the right blood thinner for patients with blood clots in veins or lungs. Researchers compared how well the tool performed against artificial intelligence models and doctors' own judgment. The goal wa…

This study tested whether a device called MYOTRACE, which measures how hard a person's breathing muscles are working, can help doctors assess patients with respiratory diseases. 56 adults with conditions like COPD or asthma were included. The goal was to see if the device's readi…

This study looked at 750 people hospitalized for a COPD flare-up to find out how many also had a pulmonary embolism (a blood clot in the lung). Doctors used a standard set of tests, including a blood test and special scans, to check for clots. Participants were followed for 3 mon…

This study measured certain proteins (histones and HMGB1) in the blood of 115 pregnant women to see if they could help detect placenta-related complications like pre-eclampsia. Researchers compared women with normal pregnancies, those with complications, and healthy non-pregnant …

This study looked at 73 people who were hospitalized with severe COVID-19 pneumonia to see if their lungs still had problems 4 months later. The main focus was on how well oxygen moves from the lungs into the blood. The goal was to better understand these lasting issues so doctor…

This study measured the amount of free-floating DNA and nucleosomes in the blood of 137 women to see if these levels differ between those with pregnancy complications (like preeclampsia or blood clots) and healthy women (both pregnant and non-pregnant). The goal was to better und…

This study tested an indoor air pollution intervention called AIRWISE in 20 adults aged 55 and older with heart disease. Participants received personal air cleaners, a color-changing air quality monitor, and educational materials. The goal was to see if they would use these tools…

This study tested a step-by-step method called SEARCH to better classify what happens to people long after a pulmonary embolism (a blood clot in the lungs). Researchers looked at 150 adults to see if the method reliably identifies different outcomes, from full recovery to chronic…

This completed study tested whether healthcare claims data can predict the results of a major heart trial (SURPASS-CVOT) comparing two diabetes drugs, tirzepatide and dulaglutide. Researchers analyzed records from over 44,000 people with type 2 diabetes and heart disease to see i…

This study tested whether a home rehabilitation program, with daily activity tasks and heart rate monitoring sent by text or email, helps people recover better after a serious blood clot in the lung (pulmonary embolism). 32 adults who had been hospitalized for this condition took…

This completed study looked at 11,000 COVID-19 patients to understand how often they develop dangerous blood clots in arteries or veins. Researchers tracked clot rates, risk factors, and outcomes over 30 and 90 days. The goal was to learn more about these complications to improve…

This study investigates why people with myotonic dystrophy type 1 are 10 times more likely to develop dangerous blood clots in the legs or lungs. Researchers will compare blood samples from 130 participants—including patients with the disease, those with a history of clots, and h…

This study tracked 81 adults with pelvic or hip socket fractures to see how often they developed blood clots in their legs or lungs, even while receiving standard clot-preventing medication. All participants got ultrasound scans to find clots that might not cause symptoms. The go…

This study looked at two ways to assign care coordinators to older adults (65+) with heart disease or risk factors. One method used patients' own reports of difficulty coordinating care, while the other used usual triggers like hospital discharge. The goal was to see which approa…

This study looked at 744 people who had a blood clot before and were suspected of having another one. Researchers tested three different checklists (called clinical decision rules) to see how well they could tell if a new clot was really there. The goal was to help doctors avoid …

This completed study followed 300 patients with venous thromboembolism (blood clots in veins) to track how often clots return or cause bleeding. Researchers hope to find new risk factors and compare newer blood thinners. The study only observes, so it cannot test treatments direc…