Pulmonary embolism

This study tested a special sheath (the Protrieve Sheath) placed in a large vein to catch any blood clots that might break loose during a procedure to remove deep vein clots (DVT). The goal was to prevent those clots from reaching the lungs and causing a pulmonary embolism. The s…

This trial tests a device called the Symphony Thrombectomy System in people with acute pulmonary embolism, a condition where blood clots block arteries in the lungs. The device is designed to restore blood flow by suctioning out or breaking up the clots. The study will check how …

This study compared two blood thinners, rivaroxaban (Xarelto) and apixaban (Eliquis), in 2760 adults with new blood clots in the legs or lungs. The goal was to see which drug causes fewer bleeding problems. Results could help doctors choose the safer option for treating venous th…

This study investigates whether delivering a clot-dissolving drug directly into the lung arteries via a thin tube (catheter) can improve outcomes for people with a serious type of pulmonary embolism (a blood clot in the lung). Participants have intermediate-high risk clots, meani…

This study tested a new device called the Vertex Pulmonary Embolectomy System in 10 people with pulmonary embolism (blood clots in the lungs). The device is threaded through a blood vessel to remove clots and relieve strain on the right side of the heart. Researchers measured cha…

This study tested a new device called the Hēlo PE Thrombectomy System, which is a thin tube used to remove blood clots from the lungs in people with a serious condition called pulmonary embolism. The trial included 177 participants and aimed to see if the device is safe and works…

This study tested a special filter placed in a large vein to catch blood clots before they reach the lungs. It included 50 people who could not take blood thinners. The goal was to see how often the filter could be successfully placed and removed, and to track any problems.

This study tested a device that removes blood clots from the main lung arteries in 123 people with a sudden pulmonary embolism. The goal was to reduce strain on the right side of the heart and prevent serious complications like major bleeding or heart injury. Participants were ad…

This study looked at whether giving clot-busting drugs (thrombolysis) to people with a serious but not immediately life-threatening type of lung clot (pulmonary embolism) and a low risk of bleeding could lower their chance of dying within 30 days. The study included 100 patients …

This study tested whether adding a mechanical clot-removal device (Indigo Aspiration System) to standard blood thinners is safer and more effective than blood thinners alone for people with intermediate-high risk pulmonary embolism (a serious blood clot in the lung). About 100 ad…

This study looked at whether a low dose of the blood thinner apixaban (2.5 mg twice daily for 12 months) can safely prevent blood clots from returning in people who already had a clot triggered by a temporary risk factor. 600 high-risk adults took either apixaban or a placebo. Th…

This study tested a device called FlowTriever that mechanically removes blood clots from the lungs, comparing it to standard clot-dissolving drugs (catheter-directed thrombolysis). 692 patients with acute pulmonary embolism were enrolled. The goal was to see which treatment leads…

This study tested a device called the FlowTriever2 Catheter in 50 people with acute pulmonary embolism (blood clots in the lungs). The device was used to mechanically remove clots from the lung arteries. Researchers measured safety by tracking serious side effects and effectivene…

This study looked at a device called the FlowTriever, which is used to remove blood clots from the lungs in people with a serious condition called acute pulmonary embolism. Researchers followed 1,200 patients to see how safe and effective the device was in real-world use. The goa…

This study tests whether a bedside ultrasound measurement called 'bubble time' can help diagnose pulmonary embolism (a blood clot in the lungs). Researchers will measure bubble time in 250 emergency department patients with suspected embolism and compare it to standard CT scans. …

This study tested whether a mobile app called ThinkSono Guidance can help healthcare workers who are not ultrasound experts (like nurses or general doctors) take good-quality ultrasound images of leg veins to check for blood clots. Over 600 adults with symptoms of deep vein throm…

This study tested a new way to decide if someone with a suspected blood clot in the lung needs a scan. The 4PEPS score uses 12 simple factors and a blood test to classify risk into four levels. Over 3,000 patients in 20 emergency departments took part. The goal was to see if usin…

This study looked at whether an ultrasound of the leg veins can help doctors diagnose a repeat pulmonary embolism (a blood clot in the lung). About 115 adults with symptoms of a new clot were checked. The goal was to see if adding leg ultrasound to the usual tests (like blood wor…

This study looks at whether the ratio of two common blood test results (APTT and fibrinogen) can help diagnose pulmonary embolism, a serious condition where a blood clot blocks an artery in the lung. Researchers will compare this ratio in 1,000 patients who are suspected of havin…

This study tested how well a small, portable device (LumiraDx) measures blood clotting (INR) compared to standard lab tests. Researchers collected blood from 420 adults, some taking warfarin and some not, using both a fingerstick and a vein draw. The goal was to see if the device…

This study tested a new rapid D-dimer blood test (LumiraDx) in 679 people with symptoms of deep vein thrombosis or pulmonary embolism. The test uses a small blood sample from a finger prick or vein to quickly measure D-dimer levels, which can help rule out dangerous blood clots. …

This study looked at whether a ratio of two blood cell types (monocytes and large platelets) can help diagnose acute pulmonary embolism, a serious blood clot in the lungs. Researchers analyzed blood samples from 53 patients who had a CT scan to confirm or rule out the clot. The g…

This study tested a small change in how CT scans are done for people with suspected lung blood clots. By moving the scan's focus area to a different blood vessel, doctors aimed to use less contrast dye (30 ml instead of 50 ml) without losing image quality. The trial involved 72 a…

This study tested whether a simple checklist and blood test (the YEARS algorithm) can safely rule out pulmonary embolism (a blood clot in the lungs) in people with active cancer, compared to the standard approach of doing a CT scan on everyone. About 700 cancer patients with susp…

This study looked at whether measuring carbon dioxide in a person's breath (called end-tidal CO₂) can help doctors quickly identify severe blood clots in the lungs and see if treatment is working. Researchers studied 120 adults, including those with different levels of clot sever…

This study tested a new CT scan method that creates a map of blood flow in the lungs to diagnose pulmonary embolism (blood clots). Researchers compared it to the standard SPECT scan in 30 patients. The goal was to see if the new method is as accurate, while being faster and safer…

This study tested whether a special PET/CT scan (V/Q PET/CT) can accurately diagnose pulmonary embolism (a blood clot in the lungs) compared to the standard CT scan. About 100 adults with suspected first-time clots took part. The goal was to see how sensitive and specific the new…

This study looked at whether adding a CT venography scan (imaging of the pelvis and legs) to the standard chest CT can find more blood clots in women who recently gave birth and are suspected of having a pulmonary embolism. 125 women participated. The goal was to see if the combi…

This study compared three common blood thinners—aspirin, warfarin, and rivaroxaban—to prevent dangerous blood clots after hip or knee replacement surgery. Nearly 19,000 adults took part. The goal was to find which option best balances preventing clots with avoiding bleeding side …

This study compared two blood-thinning drugs, Bemiparin and Enoxaparin, to prevent venous thromboembolism (dangerous blood clots) in 7020 women after vaginal or cesarean delivery. All participants had risk factors for clots and received daily injections for up to 7 days after giv…

This study analyzes data from over 3 million patients in China's Chest Pain Center registry to understand how people with acute chest pain are diagnosed and treated in real hospitals. It focuses on conditions like heart attacks, unstable angina, aortic dissection, and pulmonary e…

This study looks at health records of nearly 150,000 people who had knee replacement surgery to see if real-world data can reproduce the findings of a previous clinical trial (RECORD3). The researchers compare two blood thinners, rivaroxaban and enoxaparin, to see which better pr…

This study is not testing a new treatment. Instead, researchers are checking whether information from healthcare claims (like insurance records) can produce the same results as a famous clinical trial called RECORD1. They are looking at data from over 89,000 people who had hip re…

This study examines the best time to start blood thinners in women who have had severe bleeding after childbirth. Researchers are looking at whether starting blood thinners within 24 hours or later affects the risk of blood clots or further bleeding. The goal is to find a balance…

This study uses artificial intelligence to group patients who have had a pulmonary embolism (a blood clot in the lung) based on their medical information at diagnosis. Researchers will track 2,500 patients for 6 months to see how different groups recover. The goal is to help doct…

This study reviewed the records of 150 adults who had surgery to clear blood clots from the lung arteries. Researchers wanted to see who developed kidney injury within two days after surgery and what factors raised that risk. They looked at things like how long the patient was on…

This study looked at whether having COVID-19 makes people more likely to develop a pulmonary embolism (a blood clot in the lungs). Researchers reviewed medical records of 347 patients who had a CT scan of their lungs. They compared those who tested positive for COVID-19 with thos…

This study looked at whether sending alerts to pharmacists instead of doctors helps improve how blood thinners (anticoagulants) are prescribed. Researchers tested two types of alerts with 306 healthcare providers. The goal was to see which method leads to faster and safer prescri…

This completed study tested whether semaglutide, a drug used for diabetes, could reduce inflammation in 18 people who had a blood clot in their lungs (pulmonary embolism). Researchers measured changes in blood markers of inflammation over 4 weeks. The goal was to see if the drug …

This study looked at how well hospitals follow the standard protocol for giving heparin, a blood thinner, to patients with blood clots or heart issues. Researchers checked 100 patients to see if their heparin doses were adjusted correctly based on blood test results. The goal was…

This study tested whether a pop-up alert in the electronic health record could remind doctors to screen for a rare but serious lung condition called chronic thromboembolic pulmonary hypertension (CTEPH) in patients who previously had a blood clot in the lungs. The trial involved …

This study looked at 40 adults who had a blood clot in their lungs (pulmonary embolism). Researchers compared those who also had sleep-disordered breathing (like sleep apnea) with those who did not. The goal was to see if sleep problems affect short-term recovery and the chance o…

This study tracked 88 adults diagnosed with pulmonary embolism (a serious blood clot in the lungs) during April 2020, the peak of the COVID-19 pandemic in France. Researchers compared complications like recurrence of clots, lung scarring, and death over 6 to 12 months between pat…

This study looked at 10 people hospitalized with a blood clot in the lung (pulmonary embolism). Researchers used a special 3D CT scan technique to compare lung blood vessels before and 48 hours after standard blood thinner treatment. The goal was to measure changes in blood flow …

This study tested a decision-support tool called DOACT that helps doctors choose the right blood thinner for patients with blood clots in veins or lungs. Researchers compared how well the tool performed against artificial intelligence models and doctors' own judgment. The goal wa…

This study tested whether a device called MYOTRACE, which measures how hard a person's breathing muscles are working, can help doctors assess patients with respiratory diseases. 56 adults with conditions like COPD or asthma were included. The goal was to see if the device's readi…

This study looked at 750 people hospitalized for a COPD flare-up to find out how many also had a pulmonary embolism (a blood clot in the lung). Doctors used a standard set of tests, including a blood test and special scans, to check for clots. Participants were followed for 3 mon…

This study measured certain proteins (histones and HMGB1) in the blood of 115 pregnant women to see if they could help detect placenta-related complications like pre-eclampsia. Researchers compared women with normal pregnancies, those with complications, and healthy non-pregnant …

This study looked at 73 people who were hospitalized with severe COVID-19 pneumonia to see if their lungs still had problems 4 months later. The main focus was on how well oxygen moves from the lungs into the blood. The goal was to better understand these lasting issues so doctor…

This study measured the amount of free-floating DNA and nucleosomes in the blood of 137 women to see if these levels differ between those with pregnancy complications (like preeclampsia or blood clots) and healthy women (both pregnant and non-pregnant). The goal was to better und…

This study tested a step-by-step method called SEARCH to better classify what happens to people long after a pulmonary embolism (a blood clot in the lungs). Researchers looked at 150 adults to see if the method reliably identifies different outcomes, from full recovery to chronic…

This study tested whether a home rehabilitation program, with daily activity tasks and heart rate monitoring sent by text or email, helps people recover better after a serious blood clot in the lung (pulmonary embolism). 32 adults who had been hospitalized for this condition took…

This completed study looked at 11,000 COVID-19 patients to understand how often they develop dangerous blood clots in arteries or veins. Researchers tracked clot rates, risk factors, and outcomes over 30 and 90 days. The goal was to learn more about these complications to improve…

This study investigates why people with myotonic dystrophy type 1 are 10 times more likely to develop dangerous blood clots in the legs or lungs. Researchers will compare blood samples from 130 participants—including patients with the disease, those with a history of clots, and h…

This study tracked 81 adults with pelvic or hip socket fractures to see how often they developed blood clots in their legs or lungs, even while receiving standard clot-preventing medication. All participants got ultrasound scans to find clots that might not cause symptoms. The go…

This study looked at 744 people who had a blood clot before and were suspected of having another one. Researchers tested three different checklists (called clinical decision rules) to see how well they could tell if a new clot was really there. The goal was to help doctors avoid …

This completed study followed 300 patients with venous thromboembolism (blood clots in veins) to track how often clots return or cause bleeding. Researchers hope to find new risk factors and compare newer blood thinners. The study only observes, so it cannot test treatments direc…