Could a simple score cut down on unnecessary lung scans?
NCT ID NCT06015529
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 27 times
Summary
This study tested a new way to decide if someone with a suspected blood clot in the lung needs a scan. The 4PEPS score uses 12 simple factors and a blood test to classify risk into four levels. Over 3,000 patients in 20 emergency departments took part. The goal was to see if using this score could safely reduce the number of CT scans and other imaging tests.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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AP HP Clamart
Clamart, France
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CH Agen
Agen, France
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CH Argenteuil
Argenteuil, France
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CH Arpajon
Arpajon, France
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CH La Rochelle
La Rochelle, France
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CH Rochefort
Rochefort, France
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CH Troyes
Troyes, France
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CH Versailles
Le Chesnay, France
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CHR Metz Thionville
Metz, France
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CHU Angers
Angers, 49000, France
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CHU Clermont Ferrand
Clermont-Ferrand, France
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CHU Grenoble
Grenoble, France
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CHU Limoges
Limoges, France
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CHU Liège
Liège, Belgium
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CHU Lyon
Lyon, France
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CHU Nantes
Nantes, France
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CHU Nice
Nice, France
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CHU Poitiers
Poitiers, France
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CHU Rouen
Rouen, France
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CHU Toulouse
Toulouse, France
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CHU Tours
Tours, France
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Cliniques Bruxelles
Brussels, Belgium
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GH Paris
Paris, France
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
4PEPS diagnostic strategy (a clinical scoring system using 12 variables and D-dimer levels)
What this could lead to
If successful, this strategy could reduce unnecessary chest scans and radiation exposure for patients with suspected pulmonary embolism, while maintaining safety.
What could go wrong
The trial is completed but results are not yet published. The strategy may not reduce imaging as hoped, or could miss some cases of pulmonary embolism.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.