New device may improve treatment for dangerous lung clots

NCT ID NCT05684796

Completed Disease control Sponsor: Penumbra Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding a mechanical clot-removal device (Indigo Aspiration System) to standard blood thinners is safer and more effective than blood thinners alone for people with intermediate-high risk pulmonary embolism (a serious blood clot in the lung). About 100 adults aged 18-80 with confirmed clots in major lung arteries participated. The main goal was to see if the combination treatment improved heart strain and reduced complications within 48 hours.

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Conditions

The condition(s) this trial relates to.

pulmonary embolism

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PULMONARY EMBOLISM ACUTE

Contacts and locations

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Locations

Ascension Seton Medical Center Austin

Austin, Texas, 78705, United States
Auckland City Hospital

Auckland, New Zealand
Baylor University Medical Center

Dallas, Texas, 75226, United States
Cedars Sinai Medical Center

Los Angeles, California, 90048, United States
Cooper Health System

Camden, New Jersey, 08103, United States
Corewell Health William Beaumont University Hospital

Royal Oak, Michigan, 48073, United States
Foothills Medical Centre

Calgary, Alberta, T2N 2T9, Canada
Joseph Maxwell Cleland Atlanta VA Medical Center

Decatur, Georgia, 30033, United States
Kingwood Medical Center

Kingwood, Texas, 77339, United States
Krakowski Szpital Specjalistyczny św. Jana Pawła II

Krakow, Poland
McLaren Bay Heart & Vascular

Bay City, Michigan, 48708, United States
Metropolitan Methodist Hospital

San Antonio, Texas, 78212, United States
Mount Sinai Hospital

New York, New York, 10029, United States
Northwestern Memorial

Chicago, Illinois, 60611, United States
Radiology and Imaging Specialists/Lakeland Regional

Lakeland, Florida, 33801, United States
Rush University Medical Center

Chicago, Illinois, 60612, United States
Sentara Norfolk General Hospital

Norfolk, Virginia, 23507, United States
St. Elizabeth Edgewood Hospital

Edgewood, Kentucky, 41017, United States
The University of Arizona - Banner

Tucson, Arizona, 85719, United States
UCLA Medical Center

Los Angeles, California, 90024, United States
University of Maryland

Baltimore, Maryland, 21201, United States
Wellstar Kennestone

Marietta, Georgia, 30060, United States

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