New registry to test Clot-Busting injection for severe lung clots
NCT ID NCT07245927
First seen Jun 27, 2026 · Last updated Jul 07, 2026 · Updated 2 times
Summary
This registry is studying a drug called non-immunogenic staphylokinase (Fortelyzin®) given as a single injection to dissolve blood clots in the lungs. It will include up to 20,000 adults with massive pulmonary embolism who are already receiving the drug in routine care. The goal is to see how safe and effective it is in real-world settings.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Non-immunogenic staphylokinase (Fortelyzin®)
- What this could lead to
- If successful, this could confirm that a single injection of staphylokinase is a safe and effective way to dissolve blood clots in the lungs, potentially improving survival and reducing complications.
- What could go wrong
- This is an observational registry, not a controlled trial, so results may be less definitive. Bleeding risks are a concern, and the drug may not work for all patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Belgorod Regional Clinical Hospital of St. Joseph
RECRUITINGBelgorod, Russia
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Center of Neurology and Cardiology
RECRUITINGKirov, Russia
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City Clinical Hospital of Emergency medicine №25
RECRUITINGVolgograd, Russia
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E.I. Chazov National Medical Research Center of Cardiology
RECRUITINGMoscow, 121552, Russia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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F.I. Inozemtsev City Clinical Hospital
RECRUITINGMoscow, Russia
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G.A. Zakharyin Clinical hospital №6
RECRUITINGPenza, Russia
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Kuzbass Cardiology center
RECRUITINGKemerovo, Russia
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Lipetsk City Hospital No. 4 "Lipetsk-Med"
RECRUITINGLipetsk, Russia
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Moscow Multidisciplinary Clinical Center "Kommunarka"
RECRUITINGMoscow, Russia
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N.A. Semashko Nizhny Novgorod Regional Clinical Hospital
RECRUITINGNizhny Novgorod, Russia
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S.P. Botkin City Clinical Hospital
RECRUITINGMoscow, Russia
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S.S. Yudin City Clinical Hospital
RECRUITINGMoscow, Russia
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Tver Regional Clinical Hospital
RECRUITINGTver', Russia
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V.P. Polyakov Samara Regional Clinical Cardiology Dispensary
RECRUITINGSamara, Russia
Contact
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