ENDOMETRIAL CANCER

This early-phase study tests a new drug, BG-68501, in people with advanced solid tumors (like breast, ovarian, lung, or stomach cancer) that have not responded to standard treatments. The goal is to find a safe dose and see if the drug shrinks tumors when used alone or with other…

This study tests a combination of two or three drugs (BL-B01D1, pembrolizumab, and possibly bevacizumab) in people whose cervical or endometrial cancer has returned or spread. The goal is to see if these drugs can shrink tumors or slow the disease. About 96 adults aged 18–75 with…

This study tests a new treatment called KD01, a modified virus that targets and kills cancer cells, for women with cervical or endometrial cancer. In Phase I, it is given to patients whose cancer has not responded to other treatments. In Phase II, it is tested in younger women wh…

This study is testing whether a shorter course of radiation therapy (1 week instead of the usual 5 weeks) combined with standard chemotherapy (carboplatin and paclitaxel) is practical for people with stage III endometrial cancer. The goal is to see if most participants can comple…

This study tests a new drug called PC14586 (rezatapopt) in people with advanced solid tumors that have a specific TP53 Y220C mutation. The goal is to see if the drug is safe and shrinks tumors. About 300 adults whose cancer has worsened after prior treatment will take the drug al…

This study tests a mix of two approved drugs plus an experimental vaccine and an immune booster for people with advanced HER2-positive endometrial cancer that has returned or worsened. The vaccine is made from each participant's own blood cells and targets the HER2 protein. The g…

This study tests a drug called zanidatamab in about 200 adults with advanced HER2-positive cancers (like breast, stomach, lung, or ovarian cancer) that have worsened after at least one prior treatment. The goal is to see if the drug can shrink tumors and how long that effect last…

This early-stage study tests a new drug, ADU-1805, in people with advanced solid tumors that have not responded to standard treatments. The drug is given alone or with another cancer drug (pembrolizumab). The main goals are to check safety and how the body processes the drug. Abo…

This study tests a new drug, zanzalintinib, combined with standard chemotherapy (paclitaxel) for people with recurrent high-grade uterine or endometrial cancer. The goal is to find the best dose and see if the combination is safe and shrinks tumors. About 36 adults who have alrea…

This program offers the investigational drug selinexor to people with multiple myeloma, lymphoma, sarcoma, or other cancers who have run out of approved treatments and cannot join a clinical trial. It is not a cure but aims to control the disease. Patients must get approval from …

This study looks at whether a less invasive weight-loss procedure called Endoscopic Suture Gastroplasty (ESG) is safe and works for obese women who have finished treatment for endometrial cancer. About 74 women will be enrolled. The goal is to help them lose weight and lower thei…

This early-phase study tests a new drug called 177LuBetaBart in people with advanced solid tumors that have stopped responding to standard treatments. The drug is a radioactive antibody designed to seek out and destroy cancer cells. The study will check for safety and side effect…

This early-phase study tests whether a new drug called NRM-823 is safe and tolerable for people with advanced solid tumors that have not responded to other treatments. About 150 participants with cancers like lung, ovarian, or triple-negative breast cancer will receive NRM-823 al…

This early-phase study tests a new drug called STRO-004 in adults with advanced solid tumors that have not responded to standard treatments. The study has three parts: finding a safe dose of STRO-004 alone, testing that dose in more patients, and combining STRO-004 with another c…

This study tests whether adding sacituzumab tirumotecan (Sac-TMT) to pembrolizumab helps people with advanced or recurrent endometrial cancer live longer without the cancer growing. About 1,123 participants with a specific type of endometrial cancer (pMMR) will receive either the…

This study tests an experimental drug called ART0380, taken as a pill, for people with advanced or metastatic solid tumors (cancers that have spread). The goal is to find a safe dose and see if it works alone or with standard chemotherapies (gemcitabine or irinotecan). About 442 …

This early-stage study tests an experimental oral drug called NKT5097 in adults with advanced solid tumors, especially breast cancer and tumors with a specific gene change (CCNE1). The main goals are to find a safe dose and see how well the drug works. About 361 participants will…

This early-stage study tests a new treatment using a patient's own immune cells, modified in a lab to recognize and attack cancer cells with a specific KRAS mutation (G12D). It is for adults with advanced solid tumors (like lung, colon, or pancreatic cancer) that have not respond…

This study tests whether tirzepatide, a drug used for weight loss and diabetes, can slow tumor growth in people with obesity-driven endometrial cancer. About 20 participants will take the drug before their scheduled hysterectomy. Researchers will compare tumor cell activity from …

This study tests a drug called selinexor as a long-term maintenance treatment for people with a specific type of advanced or recurrent endometrial cancer (p53 wild-type). Participants must have already responded well to at least 12 weeks of platinum-based chemotherapy. The goal i…

This early-phase study tests a new drug called GV20-0251 in people with advanced solid tumors (like liver, lung, or skin cancer) that have stopped responding to standard therapies. The main goal is to check the drug's safety. About 10 participants will receive one of two dose lev…

This early-phase trial tests an experimental drug called ALTA2618 in about 110 adults whose advanced solid tumors (like breast or endometrial cancer) have a specific AKT1 E17K gene change. The main goal is to check the drug's safety and find the right dose. Participants must have…

This early-stage trial is testing the safety of combining two drugs, atezolizumab and ONC201, for people with advanced or recurrent endometrial cancer. The study includes both obese and non-obese participants to see how body weight affects treatment. The goal is to find the best …

This early-phase study tests a new drug called BL-M07D1 in adults with advanced HER2-positive solid tumors (including breast, lung, stomach, and ovarian cancers) that have not responded to at least two prior treatments. The main goals are to check the drug's safety, find the best…

This study tests whether a combination of two drugs, abemaciclib and letrozole, can help keep advanced or recurrent endometrial cancer from growing. The trial enrolls 32 people with a specific type of cancer that is estrogen-receptor positive and has certain genetic features. Par…

This study tests whether taking a daily pill called olaparib for one year after standard treatment can help prevent endometrial cancer from coming back. It is for people with a specific type of aggressive endometrial cancer (p53abn). About 554 participants will be randomly assign…

This study is tracking 150 women with advanced or recurrent endometrial cancer to see how well a treatment plan works in everyday medical practice. The plan starts with chemotherapy plus the drug durvalumab, followed by long-term maintenance with durvalumab alone or with another …

This study tests a new drug, MGC026, in 250 adults with advanced solid tumors that have not responded to other treatments. The goal is to check the drug's safety, find the right dose, and see if it can shrink tumors. Participants receive the drug by IV and are closely monitored f…

This early-stage study tests a new drug called TORL-1-23 in about 90 people with advanced solid tumors, including ovarian, endometrial, and lung cancers. The main goals are to check safety, find the best dose, and see if the drug can shrink tumors. Participants must have measurab…

This early-stage study tests a new drug called SLV-154 in about 70 adults with advanced solid tumors that have spread. The main goal is to find the safest dose and check for side effects. Participants have cancers like head and neck, lung, breast, or ovarian cancer that haven't r…

This study tests a new drug called IDE161, alone or with another drug (pembrolizumab), in people with advanced solid tumors (like breast, ovarian, prostate, or lung cancer). The goal is to find a safe dose and see if it can shrink tumors. About 216 adults with tumors that have sp…

This study looks at how well the drug T-DXd works for people with advanced HER2-positive solid tumors who have already tried other treatments and have no good options left. About 100 adults in the US will be followed to see if their tumors shrink or stop growing. The goal is to u…

This study tests an experimental drug called MT-4561 in people with advanced solid tumors (like lung, breast, or pancreatic cancer) who have tried at least one prior therapy. The main goals are to find a safe dose and check for early signs of tumor shrinkage. About 27 adults will…

This study compares a new drug, puxitatug samrotecan, to standard chemotherapy for people with advanced or metastatic endometrial cancer that has worsened after platinum-based chemo and immunotherapy. About 700 participants will be randomly assigned to receive either the new drug…

This study tests personalized treatments for young women with endometrial cancer who want to preserve their fertility. By analyzing the genetic makeup of each tumor, researchers aim to match patients with the most effective therapy, such as hormone therapy or immunotherapy. The g…

This study tests a drug called relacorilant combined with other treatments for people with ovarian, fallopian tube, peritoneal, or endometrial cancers. About 270 participants will receive the drug combination to see if it slows cancer growth. The goal is to find better options fo…

This study is testing a new robotic surgery system (Medtronic Hugo™) for hysterectomy, a surgery to remove the uterus. It includes 70 adult patients with conditions like fibroids, endometriosis, or certain cancers. The goal is to see if the robot can perform the surgery safely an…

This study tests a drug called Rina-S in people with advanced solid tumors that have spread or can't be removed by surgery. The goal is to check safety and see if the drug shrinks tumors. About 764 participants with cancers like ovarian, lung, breast, or endometrial cancer will t…

This early-phase trial tests a new drug called MOv18 IgE in people with advanced ovarian, endometrial, or triple-negative breast cancers that have a specific marker (folate receptor alpha). The study has two parts: first, finding a safe dose, and then checking how well that dose …

This early-phase study tests a new drug called XMT-1660 in people with advanced solid tumors, including triple-negative breast, ovarian, and endometrial cancers. The main goals are to find a safe dose and check for side effects. About 319 participants will receive the drug to see…

This study tests whether a new drug combination (trastuzumab deruxtecan plus rilvegostomig or pembrolizumab) works better than standard chemotherapy plus pembrolizumab for people with a specific type of advanced or recurrent endometrial cancer. The cancer must have high levels of…

This study compares a new drug called Rina-S to standard chemotherapy (paclitaxel or doxorubicin) in people with endometrial cancer that has come back or worsened after prior treatment. About 660 participants will be randomly assigned to receive either Rina-S or a standard chemo …

This study tests an experimental drug called AZD5335, alone or with other cancer treatments, in people with advanced ovarian, lung, or endometrial cancer. The goal is to see if it is safe and can shrink tumors. About 506 participants will take part in this early-phase trial.

This early-phase study tests whether combining chemotherapy, radiation, and the immunotherapy drug dostarlimab is safe and can help control stage IIIC endometrial cancer that has spread to lymph nodes. About 21 participants will receive chemoradiation followed by chemotherapy plu…

This study tests a new drug called TCC1727 combined with other cancer treatments (benmelstobart, olaparib, or topotecan) in people with advanced solid tumors like lung, stomach, endometrial, or melanoma. The goal is to find the safest and most effective dose and see if the combin…

This study tests a treatment called lifileucel, which uses a patient's own immune cells (tumor-infiltrating lymphocytes) to fight advanced endometrial cancer. About 60 people who have already tried other treatments will receive this cell therapy. The main goal is to see if the tr…

This study tests whether people with early-stage endometrial cancer can safely receive less intense treatment after surgery, based on the genetic makeup of their tumor. About 393 participants with specific genetic types (POLE-mutated or p53wt/NSMP) will be followed for three year…

This early-phase trial tests an experimental drug called ubamatamab, alone or with another drug (cemiplimab), in people with ovarian or uterine cancer that has come back. The main goals are to check safety, find the best dose, and see if the treatment can shrink tumors. About 890…

This study tests a 24-week digital wellness platform combined with online support from healthcare professionals to help endometrial cancer survivors reduce waist size and improve overall health. About 148 participants who have completed cancer treatment will take part. The goal i…

This study tests an experimental drug called EIK1005, alone or with another drug (pembrolizumab), in people with advanced solid tumors that have not responded to other treatments. The goal is to find a safe dose and see if the combination can shrink tumors. About 160 adults with …

This early-phase study tests a new drug called 177Lu-RAD204, which combines a targeting antibody with a radioactive particle to seek out and attack cancer cells. The trial involves 30 adults with advanced solid tumors like lung, breast, or skin cancer that have not responded to o…

This study looks at whether a blood test that detects tumor DNA (ctDNA) can guide decisions to stop maintenance immunotherapy after one year in women with advanced or recurrent endometrial cancer. About 30 participants will receive standard chemotherapy plus immunotherapy for one…

This early-phase study tests a new drug, LNCB74, in about 145 people with advanced solid tumors (ovarian, breast, lung, and others). The drug is designed to deliver a cancer-killing agent directly to tumor cells. The main goals are to check safety and find the best dose for futur…

This early-phase study tests a new drug called HWK-007 in people with advanced solid tumors, including certain ovarian, endometrial, and lung cancers. The drug is designed to target a protein (PTK7) found on cancer cells and deliver a chemotherapy-like payload directly to them. T…

This study tests a new drug called lorigerlimab in people with advanced ovarian or other gynecologic cancers that no longer respond to standard chemotherapy. About 60 participants will receive the drug by IV every 3 weeks. The goal is to see if the drug can shrink tumors and to c…

This early-phase study is testing an experimental drug called DR-0202 in people with advanced solid tumors (like breast, lung, or pancreatic cancer) that have stopped responding to standard treatments. The main goal is to check the drug's safety and find the right dose. About 96 …

This early-stage trial tests a new drug called BL0175 in postmenopausal women with advanced hormone receptor-positive breast, ovarian, or endometrial cancer. The main goals are to check safety, find the best dose, and see if it helps shrink tumors. Only 9 participants will be enr…

This study tests an investigational drug called REGN5668, alone or combined with other drugs, in people with ovarian, fallopian tube, primary peritoneal, or endometrial cancers. The goal is to find the safest dose and see if the treatment can shrink tumors. About 612 participants…

This early-phase study tests a new oral drug, MOMA-341, alone or with other treatments, in people with advanced solid tumors that have specific genetic markers (MSI-H or dMMR). The main goal is to check safety and find the best dose. About 132 adults whose cancer has not responde…

This early-phase study tests a new drug, KIVU-107, in about 76 adults with advanced solid tumors that have not responded to standard treatments. The drug is an antibody-drug conjugate designed to deliver a cancer-killing agent directly to tumor cells. The main goal is to find the…

This study tests whether the drug belzutifan can shrink or slow the growth of clear cell cancers of the ovary, uterus, cervix, vagina, or vulva that have come back or not gone away. About 32 adults will receive belzutifan pills and be monitored for tumor response and side effects…

This study is testing a new drug called CTX-10726 in people with advanced cancers (stomach, liver, endometrial, or kidney) that have not responded to standard treatments. The main goal is to check the drug's safety and find the best dose. About 70 participants will receive the dr…

This study tests whether combining targeted drugs with the immunotherapy atezolizumab can shrink tumors or slow cancer growth in people with recurrent or persistent endometrial cancer. About 148 participants whose cancer has returned after at least one prior treatment will be enr…

This phase 3 trial tests whether the targeted drug trastuzumab deruxtecan (T-DXd) works better than standard chemotherapy (with or without radiation) after surgery for HER2-positive endometrial cancer. About 710 adults with stage IIC or III disease will be enrolled. The main goal…

This early-stage study tests a new drug called XmAb541 in people with advanced ovarian, endometrial, or germ cell tumors that have not responded to prior treatments. The main goals are to check if the drug is safe and to find the best dose. About 282 participants will take part i…

This study tests a drug called ivonescimab in 50 people with advanced endometrial or cervical cancer that has worsened after standard chemotherapy. The drug targets two proteins (PD-1 and VEGF) to help the immune system fight the cancer and cut off its blood supply. The main goal…

This early-phase study tests an experimental oral drug, RGT-490, in adults with advanced solid tumors (including breast, ovarian, and endometrial cancers) that have a specific genetic change called PIK3CA. The main goals are to check safety, find the right dose, and see if the dr…

This study tests a new drug called AZD8205, alone or with other cancer drugs, for people with advanced solid tumors like breast, ovarian, or lung cancer that have stopped responding to standard treatments. The main goals are to check safety and find the right dose. About 460 adul…

This early-phase study tests a new drug called IPH5301 in people with advanced solid tumors that have spread. The drug aims to block a protein (CD73) that helps tumors hide from the immune system. The trial first finds the safest dose alone, then tests it with chemotherapy and an…

This study is testing a new drug called Dato-DXd, either alone or with other cancer drugs, in people with advanced solid tumors that have spread. The goal is to see if the drug can shrink tumors or slow cancer growth. About 454 adults with cancers like endometrial, gastric, prost…

This study tests if the drug elacestrant, alone or with abemaciclib, can shrink tumors in people with advanced or recurrent ER+ endometrial cancer. About 75 adults who have already tried platinum chemo and an immunotherapy will take part. The goal is to see how many patients resp…

This early-phase study tests a new drug called BL-B01D1 in people with advanced lung cancer and other solid tumors that have spread or cannot be removed. The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. About 470 adults will take part.

This study tests whether adding a collagen injection to standard hormone therapy can help women with early-stage endometrial cancer or atypical hyperplasia achieve remission while preserving their fertility. About 30 participants will receive either hormone therapy alone or hormo…

This study is testing an experimental drug called ETX-19477 in people with advanced solid tumors (like breast, ovarian, or prostate cancer) that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors or slow their…

This early-stage study tests a new drug called PHST001, alone or with chemotherapy, in adults with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety and find the best dose. About 272 people with cancers like ovarian, end…

This study tests a new drug called TER-2013 in people with advanced solid tumors (like breast, endometrial, ovarian, lung, head and neck, esophageal, or cervical cancer) that have specific changes in the AKT/PI3K/PTEN pathway. The goal is to see if the drug is safe and shrinks tu…

This study tests whether combining two drugs—avelumab (an immunotherapy) and M1774 (a targeted pill)—can shrink or slow the growth of recurrent endometrial cancer in people whose tumors have a specific genetic change (ARID1A mutation). About 25 participants will receive the combi…

This early-stage study tests a new drug, PF-08046054/SGN-PDL1V, in people with advanced solid tumors that have spread or can't be removed. The drug is given alone or with pembrolizumab to see if it's safe and what side effects occur. About 714 participants with cancers like lung,…

This study is for women with a specific type of endometrial cancer (MMR-D/MSI-H) who have had surgery. It tests whether adding radiation and an immunotherapy drug called Dostarlimab can help keep the cancer from returning. About 62 participants will receive the combination treatm…

This study tests a combination of two drugs, cabozantinib and dostarlimab, in 37 women whose gynecologic carcinosarcoma has returned after at least one prior chemotherapy. The goal is to see if the combination can keep the cancer from growing for at least 6 months. Participants w…

This early-phase study tests a new drug called HWK-016 in people with advanced ovarian or endometrial cancers that have not responded to standard treatments. The drug is designed to target and attack cancer cells while sparing healthy ones. The main goals are to find the safest d…

This study tests an experimental drug called patritumab deruxtecan in people with advanced solid tumors that have spread or cannot be removed. The drug targets a protein called HER3 found on some cancer cells. About 740 adults with various cancers like lung, breast, or melanoma w…

This study tests a new drug called BNT323 (also known as DB-1303) against standard chemotherapy in 480 adults whose endometrial cancer has come back after previous treatment. The cancer must have a certain protein (HER2) on its surface. The main goals are to see if BNT323 slows c…

This study tests a new oral drug, AVZO-021, in people with advanced solid tumors that have not responded to other treatments. The drug targets a protein called CDK2 to slow or stop cancer growth. The trial has two phases: first to find the safest dose, then to see if it shrinks t…

This study tests a new combination of drugs (sapanisertib and serabelisib, called PIKTOR) plus chemotherapy (paclitaxel) in people with advanced or recurrent endometrial cancer that has not been cured by prior treatments. About 40 participants will receive the drug combo, and a s…

This early-phase study tests a new drug called CTIM-76 in people with ovarian, testicular, or endometrial cancer that has come back or stopped responding to standard treatments. The drug works by helping the immune system attack cancer cells that have a specific marker called CLD…

This study tests a combination of two drugs, nab-sirolimus and letrozole, in people with advanced or recurrent endometrioid endometrial cancer. The goal is to see if the combination can shrink or control tumors. About 29 participants will receive the treatment, and researchers wi…

This study looks at how safe and effective durvalumab (with or without olaparib) is for people with endometrial cancer in everyday medical practice in Korea. About 50 patients will be followed for up to a year. The goal is to see how well the treatment works outside of a strict r…

This study is testing a new type of PET scan that targets a protein called Trop2, found on many solid tumors. The goal is to see if this scan can find and stage cancers like bladder, lung, liver, and ovarian cancer better than current methods. About 400 adults with confirmed or s…

This study compares two methods to find cancer cells in lymph nodes removed during surgery for early-stage endometrial cancer. About 1,922 women will be randomly assigned to have their lymph nodes checked by either the standard ultrastaging method or the newer OSNA method. The go…

This study aims to create a test that can find endometrial, ovarian, and cervical cancers early using a sample of vaginal fluid or blood. Researchers will look for specific DNA markers and high-risk HPV in about 3,100 women. The goal is to make cancer detection easier and more ac…

This early-stage study tests an investigational drug called CYTALUX (pafolacianine) that makes cancer cells glow under a special camera during surgery. The goal is to see if it helps surgeons find and remove all endometrial cancer tissue. About 10 adults with endometrial cancer w…

This study aims to find a non-invasive way to predict uterine cancer risk in people with abnormal bleeding. About 1,000 participants will fill out a health questionnaire and some will provide self-collected vaginal samples for genetic and microbiome testing. The goal is to see if…

This study looks at whether buying over-the-counter pain relievers or digestive aids can be an early warning sign for 10 types of cancer, including pancreatic, colon, and ovarian cancer. Researchers will compare the shopping habits of 2,900 people—some recently diagnosed with can…

This study explores whether a tampon can collect samples to detect endometrial (uterine) and ovarian cancer early. Researchers will analyze DNA and proteins from tampons used by 1,500 women before surgery. The goal is to develop a simple, non-invasive test that could catch these …

This study tests if a menstrual cup can collect enough uterine tissue to screen for endometrial cancer in women with Lynch syndrome, who have a higher risk. Participants will use a menstrual cup at home and also have a standard biopsy, then compare the samples. If it works, this …

This study is collecting vaginal fluid samples from 4,200 women to develop a new test for endometrial cancer and related conditions. Participants include those with abnormal uterine bleeding or a new diagnosis of endometrial cancer. The goal is to create a simple, swab-based test…

This study explores whether DNA testing on urine and vaginal samples collected by patients themselves can accurately detect endometrial cancer. Researchers will compare samples from 120 women—half with endometrial cancer and half healthy—to see if the test can tell them apart. If…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early and tell which type it is. In people with lung cancer, the test will also check for any cancer…

This study is creating an educational tool to help women and their doctors make informed choices about using a hormone-releasing IUD to prevent endometrial cancer. The tool will be tested with 270 women who are at risk or have had the disease. The goal is to make prevention optio…

This study compares two standard radiation treatments for early-stage endometrial cancer to see which causes less sexual side effects. About 258 women who have had surgery will receive either 3 or 6 sessions of vaginal brachytherapy. The goal is to find out which schedule better …

This study is testing a shorter course of pelvic radiation for women with endometrial cancer. The goal is to see if giving slightly higher daily doses over fewer days is safe and causes fewer bowel and bladder side effects. About 100 women who have had surgery for non-spreading c…

This study is for people who have had surgery for cervical, uterine, or endometrial cancer and need radiation to the pelvis. It uses a precise type of proton radiation to see if it causes fewer bowel side effects than standard radiation. About 25 adults will take part.

This study tests whether a 16-week virtual exercise program can help patients with ovarian or endometrial cancer maintain leg strength and reduce numbness or tingling caused by chemotherapy. About 30 adults who have had surgery and are starting chemo will participate. The goal is…

This study looks at whether alternate day fasting (eating very little every other day) before chemotherapy can help reduce side effects and improve quality of life for women with ovarian, endometrial, or uterine cancer. About 30 women who have had surgery and are about to start c…

This study tests whether a program of physical activity, nutritional advice, and psychological support before surgery can improve recovery and quality of life in patients with ovarian or endometrial cancer. 64 participants will be randomly assigned to either receive standard care…

This study looks at whether using the Headspace mindfulness app before surgery or chemoradiation can help patients with endometrial or cervical cancer use fewer opioids and feel better. About 120 participants will be randomly assigned to use the app or not. The goal is to see if …

This study tests whether Reiki, a gentle hands-on energy therapy, can reduce anxiety and pain in people receiving brachytherapy (internal radiation) for gynecologic cancers like endometrial, cervical, vaginal, or vulvar cancer. About 70 participants will be randomly assigned to r…

This study tests whether tirzepatide and semaglutide (weight loss drugs) are practical and safe for endometrial cancer patients who are overweight, obese, or have diabetes and are receiving chemotherapy. About 36 adults will take weekly doses for 24 weeks. Researchers will track …

This early-phase study is testing a new substance called RAD301 to see how it moves through the body and how much radiation it gives off. It involves 9 people: healthy volunteers and patients with certain cancers like pancreatic, lung, or ovarian cancer. The goal is to measure sa…

This study collects tumor samples from 2,000 people with various cancers to learn how to predict who will respond to immunotherapy. Participants donate tissue during a routine biopsy. The goal is to understand tumor biology and improve future treatment decisions, not to test a ne…

This study looks at whether showing short educational videos to people with ovarian or endometrial cancer can increase the number who get genetic testing. About 30 participants will watch a video about genetic testing and then fill out a satisfaction survey. Researchers will comp…

This study is testing whether an artificial intelligence tool can help match cancer patients to clinical trials they might be eligible for. Researchers will enroll up to 50,000 people with various types of cancer and use the AI to suggest trials. The goal is to see if this approa…

This study talks to women with and without endometrial cancer to learn what they know about the disease and ways to lower risk. The goal is to create a tool that helps women make informed choices about prevention. About 45 women will take part through interviews or surveys.

This study looks at two different surgical methods for checking lymph nodes in women with endometrial cancer. The goal is to see which method better prevents the cancer from coming back. About 625 women will take part, and the results will help doctors choose the best approach du…

This study looks at how 3-4 cycles of chemotherapy before surgery affects frailty in adults over 55 with advanced ovarian or endometrial cancer. Researchers will use an electronic frailty index to measure changes in fitness and cognitive function. The goal is to understand whethe…

This study looks at the best times to send messages encouraging physical activity to older cancer survivors (age 65+) who have chronic pain. Researchers will track activity levels and pain ratings to see how messages affect movement and pain episodes. The goal is to learn how to …

This study looks at whether changes in a blood marker called CRP can help predict how well immunotherapy works in women with advanced gynecologic cancers (cervical, endometrial, ovarian, or vulvar). Researchers will track CRP levels in 120 women receiving immunotherapy plus chemo…

This study tests whether 3D-printed custom applicators can deliver radiation more precisely than standard cylinder applicators for gynecologic cancers like endometrial, vaginal, and vulvar cancer. Ten participants will receive brachytherapy with a personalized 3D-printed mold. Th…

This study looks at 500 women with advanced or aggressive endometrial cancer in Russia. Researchers will test tumor samples for specific genetic changes to learn more about the disease and how it is treated. The goal is to gather information, not to test a new treatment.

This study watches 350 women with early-stage endometrial cancer to see if doctors can predict who truly needs lymph node removal. Participants get standard care and are followed for 3 years. The goal is to find a group where skipping this step is safe, reducing side effects with…

This study is watching how well a single-port robotic system (da Vinci SP) works for staging surgery in people with endometrial cancer. Researchers will track how often the surgery is completed successfully and how many complications occur. The goal is to see if this newer roboti…

This study is a large registry that will follow about 2,000 people in Germany with advanced ovarian or endometrial cancer. Researchers will collect information on treatments, side effects, and quality of life over time. The goal is to understand what really happens in everyday me…

This study is creating a huge collection of medical information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. The goal is to help researchers better understand cancer causes, improve early detection, and develop person…

This study looks at how the amount and storage of a dye called indocyanine green (ICG) affect its ability to find sentinel lymph nodes in people with cervical, endometrial, or vulvar cancer. The goal is to find the most effective and cost-saving way to use ICG during surgery. Abo…

This study will collect genetic information and health records from 25,000 people who have cancer or are at risk for it. The goal is to learn more about what drives cancer and how to better tailor treatments. Participants will not receive a new therapy, but their data may help fu…

This study looks at women who had radiation therapy for cervical or endometrial cancer. It checks for long-term side effects in the bowel and bladder up to 3 years after treatment. The goal is to see if a newer, more precise type of radiation (IG-IMRT) causes fewer problems than …

This study follows 1715 people with early-stage endometrial cancer to see how often the cancer comes back and how often standard treatment causes lymphedema (arm or leg swelling). Participants are checked every 6 months for 3 years. The goal is to better understand the real-world…

This study looks at whether people with Lynch syndrome can collect their own vaginal samples at home to check for early signs of uterine cancer. About 30 participants will use a self-collection kit and answer surveys. The goal is to see if this method is practical and acceptable,…

This study tests whether a special ultrasound (mpUS) can measure vaginal tissue changes after internal radiation (IVRT) for endometrial cancer. Ten participants will have scans before and after treatment to see if the method works. The goal is to better understand and possibly pr…

This study aims to collect tissue samples, medical data, and family histories from 1120 adults undergoing routine screening for colorectal or endometrial cancer. Researchers will use this information to discover new genes and mechanisms that increase cancer risk, and to learn how…

This study looks at whether using a uterine manipulator during minimally invasive surgery for early stage endometrial cancer causes cancer cells to appear in the abdominal fluid. About 278 women will be randomly assigned to have surgery with or without the manipulator. The goal i…

This study is testing whether tumor tissue from endometrial cancer patients can be collected during surgery at other hospitals, shipped to a central lab, and successfully grown into organoids (tiny lab-grown tumor models). About 20 adults with endometrial cancer will take part. T…

This study is testing a new computer model called ENDORISK that helps doctors predict whether early-stage endometrial cancer has spread to lymph nodes. About 735 patients will use the tool to guide treatment decisions, and researchers will compare results to standard care. The go…