ENDOMETRIAL CANCER

This study tests a drug called enfortumab vedotin in up to 12 women with advanced endometrial (uterine) cancer that has worsened after standard treatments like immunotherapy. The goal is to see if the drug can shrink tumors and how safe it is. Participants receive treatment for u…

This study tests whether a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) can shrink or eliminate tumors in women with a specific type of endometrial cancer (mismatch repair-deficient). The goal is to see if these drugs can be an alternative to surgery. Abo…

This study tests a new way to give radiation therapy for several pelvic cancers (prostate, endometrial, cervical, and rectal). The approach uses daily scans to adjust the radiation beam to the exact shape of the tumor, allowing for fewer but stronger treatments. The goal is to se…

This study tests a program for women with severe obesity (BMI 40+) and early-stage endometrial cancer. The program includes weight loss medication, a hormone-releasing IUD, diet, and exercise to help them lose weight and improve health before surgery. The goal is to see if this a…

This study tests whether adding the targeted drug fruquintinib to standard chemotherapy works better than chemotherapy alone for people with advanced or recurrent endometrial cancer that is mismatch repair-proficient (pMMR). About 128 participants will be randomly assigned to rec…

This study tests a new drug called QLS5132 given with other cancer treatments for people with advanced solid tumors, including stomach, lung, endometrial, and ovarian cancers. The goal is to find safe doses and see if the combination can shrink tumors. About 626 participants will…

This study tests whether tirzepatide, a drug used for diabetes and weight loss, can slow or stop the growth of early-stage endometrial cancer or its precursor (EIN) in women with obesity. Forty participants will either receive tirzepatide or standard care for 4 weeks before their…

This study tests a drug called Inavolisib in about 48 women with advanced endometrial cancer that has a specific change in the PIK3CA gene. The goal is to see if the drug can shrink tumors or slow cancer growth. Participants will take the drug and be monitored for response and si…

This study tests a new way to give radiation therapy to women with endometrial cancer after surgery. The approach uses MRI scans during each treatment to aim the radiation more precisely at the tumor area, which may reduce side effects. About 61 participants will receive five rad…

This early-phase study tests an experimental drug, CGT6297, in adults with advanced solid tumors (like certain breast and endometrial cancers) that have a specific genetic change called PIK3CA. The main goals are to find a safe dose and see if the drug can shrink tumors. About 90…

This study tests a program called Primary Care Connect (PC2) for cancer survivors who also have heart-related conditions like high blood pressure, diabetes, or high cholesterol. The goal is to see if the program helps them stay connected to their primary care doctor and better ma…

This study tests a new cell therapy called SL-28 for people with advanced solid tumors that have not responded to standard treatments. The therapy uses donor immune cells to attack the cancer. The goal is to see if it is safe and can shrink tumors in up to 60 participants with va…

This study compares two surgical approaches for people with early-stage, high-risk endometrial cancer that has a p53 mutation. One group will have a standard surgery that removes many lymph nodes, while the other will have a less invasive procedure that only removes a few key lym…

This study is testing a new medical device that gently collects cells from the vagina to look for signs of ovarian and endometrial cancers. The goal is to see if this less invasive method can detect these cancers early, when they are easier to treat. About 300 women, some with ca…

This study tests a new FDA-cleared vaginal speculum designed to make endometrial biopsies more comfortable and accurate. About 100 women who have had this biopsy before will try the new device. Doctors will rate how well they can see the cervix, how easy the tool is to use, and w…

This study looks at whether hand and foot exercises can reduce nerve damage (numbness, tingling) caused by chemotherapy in older adults with gynecological cancer. About 74 people aged 65 and older will take part. The goal is to see if these exercises improve quality of life and r…

This study looks at whether a blood test that detects tumor DNA can help decide if women with early-stage endometrial cancer need radiation after surgery. About 1,010 participants will be followed for two years. The goal is to see if those with negative blood tests can safely ski…

This study aims to find how often people with endometrial cancer carry inherited gene changes that could affect their health or treatment. Researchers will test blood samples from 20 adults who have a specific tumor gene mutation. The goal is to better understand the disease, not…

This study is for young adults (ages 21-45) who had certain cancers as teens or young adults. Researchers are adapting a program that helps patients manage follow-up care and feel more in control of their health. The goal is to see if the program is helpful and practical for use …

This study examines tissue samples from 50 women with type 1 endometrial cancer to measure levels of a protein called METTL-14. Researchers want to see if higher or lower amounts of this protein are linked to tumor features and patient survival. The goal is to better understand w…